Genomes and Genes
Rahul P Bakshi
Affiliation: Johns Hopkins University
- American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assayRahul P Bakshi
Division of Infectious Diseases, Johns Hopkins University, 1830 E, Monument Street, Suite 8074, Baltimore, MD 21205, USA
BMC Complement Altern Med 14:427. 2014..Previous data indicate that purified components of ginseng can inhibit HIV reverse transcriptase in vitro, suggesting that ginseng components in plasma may interfere with HIV-1 RNA detection assays...
- Activity of indenoisoquinolines against African trypanosomesRahul P Bakshi
Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Antimicrob Agents Chemother 53:123-8. 2009..The indenoisoquinolines provide a promising lead for the development of drugs against sleeping sickness...
- Model system to define pharmacokinetic requirements for antimalarial drug efficacyRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Sci Transl Med 5:205ra135. 2013..The apparatus can also be used to explore the kinetic dependence of other pharmacodynamic endpoints in parasites. ..
- Membrane active chelators as novel anti-African trypanosome and anti-malarial drugsDennis J Grab
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Parasitol Int 62:461-3. 2013..While the exact mechanism of action of MACs against intracellular malaria and extracellular African trypanosome parasites has yet to be determined, their potential as antiparasitic agents warrants further investigation...
- Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmissionEdward J Fuchs
Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 5554, USA
J Infect Dis 195:703-10. 2007..To inform the development of rectal microbicide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa...
- Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial CompoundsEmily Caton
Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, and the Johns Hopkins Malaria Research Institute, The Johns Hopkins University, Baltimore, Maryland
Curr Protoc Chem Biol 8:29-58. 2016..This protocol describes the materials and procedures for determining the PK/PD relationships of antimalarial compounds. © 2016 by John Wiley & Sons, Inc. ..
- RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essentialRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Mol Biochem Parasitol 136:249-55. 2004..These findings underscore the essential nature of type IB topoisomerase activity in Trypanosoma brucei and its suitability as a target for rational drug design...
- Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoitesMyaing M Nyunt
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Trop Med Hyg 80:528-35. 2009..We conclude that a single dose of 100 mg pafuramidine does not adequately protect non-immune individuals against P. falciparum and shows no clinically or statistically significant evidence of causal prophylactic activity...
- Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourseEdward J Fuchs
Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5554, USA
J Infect Dis 207:1389-96. 2013..Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development...
- Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patientsRahul P Bakshi
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
AIDS Res Hum Retroviruses 23:1360-5. 2007..Since a significant reduction in dATP was measurable only when ddI was combined with HU, the antiretroviral activity of ddI may be more complex than previously assumed...