Rafael Guerrero-Preston

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes
    Rafael Guerrero-Preston
    Johns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland
    Cancer Prev Res (Phila) 9:915-924. 2016
  2. ncbi request reprint Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Epigenetics 2:223-6. 2007
  3. ncbi request reprint Determinants of compliance with drinking water standards in rural Puerto Rico between 1996 and 2000: a multilevel approach
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    P R Health Sci J 27:229-35. 2008
  4. ncbi request reprint Pharmaceutical residues in the drinking water supply: modeling residue concentrations in surface waters of drugs prescribed in the United States
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    P R Health Sci J 27:236-40. 2008
  5. ncbi request reprint Global epigenetic screening technologies: a novel tool to address cancer health disparities in high-risk population groups
    Rafael Guerrero-Preston
    Department of Otolaryngology, Head and Neck Cancer Research, Johns Hopkins School of Medicine, USA
    P R Health Sci J 27:350-6. 2008
  6. ncbi request reprint Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents
    R Guerrero-Preston
    Otolaryngology Department, Head and Neck Cancer Research Division, Johns Hopkins School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 5N03, Baltimore, MD 21231, USA
    P R Health Sci J 28:24-9. 2009
  7. pmc Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds
    Rafael Guerrero-Preston
    Otolaryngology Department, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 5:539-46. 2010
  8. doi request reprint HCV infection and cryptogenic cirrhosis are risk factors for hepatocellular carcinoma among Latinos in New York City
    Rafael Guerrero-Preston
    Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Community Health 34:500-5. 2009
  9. doi request reprint Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age
    Francesca Pirini
    a Head and Neck Cancer Research Division, Otolaryngology Department, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Int J Environ Health Res 27:52-67. 2017
  10. pmc 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, Human Papilloma Virus infection and surgical treatment
    Rafael Guerrero-Preston
    Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Oncotarget . 2016

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes
    Rafael Guerrero-Preston
    Johns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland
    Cancer Prev Res (Phila) 9:915-924. 2016
    ..Cancer Prev Res; 9(12); 915-24. ©2016 AACR...
  2. ncbi request reprint Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Epigenetics 2:223-6. 2007
    ..Global genomic DNA hypomethylation may be the earliest epigenetic change from a normal to a pre-malignant cell...
  3. ncbi request reprint Determinants of compliance with drinking water standards in rural Puerto Rico between 1996 and 2000: a multilevel approach
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    P R Health Sci J 27:229-35. 2008
    ..Population served estimates by Non-PRASA systems are in the 100,000 to 300,000 range...
  4. ncbi request reprint Pharmaceutical residues in the drinking water supply: modeling residue concentrations in surface waters of drugs prescribed in the United States
    Rafael Guerrero-Preston
    Department of Epidemiology, Mailman School of Public Health, Columbia University, USA
    P R Health Sci J 27:236-40. 2008
    ..Pharmaceutical residues and other organic wastewater contaminants (OWC) have been shown to survive conventional water-treatment processes and persist in potable water supplies...
  5. ncbi request reprint Global epigenetic screening technologies: a novel tool to address cancer health disparities in high-risk population groups
    Rafael Guerrero-Preston
    Department of Otolaryngology, Head and Neck Cancer Research, Johns Hopkins School of Medicine, USA
    P R Health Sci J 27:350-6. 2008
    ....
  6. ncbi request reprint Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents
    R Guerrero-Preston
    Otolaryngology Department, Head and Neck Cancer Research Division, Johns Hopkins School of Medicine, Cancer Research Building II, 1550 Orleans Street, Room 5N03, Baltimore, MD 21231, USA
    P R Health Sci J 28:24-9. 2009
    ....
  7. pmc Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds
    Rafael Guerrero-Preston
    Otolaryngology Department, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 5:539-46. 2010
    ..01) but not PFOS levels. Serum Y chromosome analyses did not detect maternal DNA cross-contamination. This study supports the use of global DNA methylation status as a biomarker of in utero exposure to cigarette smoke and PFCs...
  8. doi request reprint HCV infection and cryptogenic cirrhosis are risk factors for hepatocellular carcinoma among Latinos in New York City
    Rafael Guerrero-Preston
    Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Community Health 34:500-5. 2009
    ..Although more advanced disease may signal delay in access to care or more aggressive disease, HCV infection and cryptogenic cirrhosis at presentation are likely key factors for the greater burden of HCC among Latinos in New York City...
  9. doi request reprint Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age
    Francesca Pirini
    a Head and Neck Cancer Research Division, Otolaryngology Department, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Int J Environ Health Res 27:52-67. 2017
    ..01) and inverse associations with gestational age (p = 0.02) and IGF-1 (p < 0.01). We identified a dose-dependent increase in the level of MT-CO1 and MT-CO2 associated to increased cord serum cotinine and decreased gestational age...
  10. pmc 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, Human Papilloma Virus infection and surgical treatment
    Rafael Guerrero-Preston
    Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Oncotarget . 2016
    ..05). These results suggest that microbiota may be used as HNSCC diagnostic and prognostic biomonitors...
  11. pmc Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity
    Rafael Guerrero-Preston
    Department of Otolaryngology Head and Neck Cancer Research Division, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Oncol Rep 32:505-12. 2014
    ..The potential diagnostic utility of these biomarkers and their relevance for breast cancer risk prediction should be examined in larger cohorts...
  12. pmc Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma
    Mariana Brait
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 12:1058-70. 2013
    ..Therefore, our findings suggest that a tobacco signature could emerge from distinctive patterns of genetic and epigenetic alterations and can be identified using an in vitro cellular model for the development of smoking-induced cancer...
  13. pmc Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile
    Luciane Tsukamoto Kagohara
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Future Oncol 11:233-49. 2015
    ..The aim of the study was to evaluate the use of global and gene-specific DNA methylation changes as potential biomarkers for gallbladder cancer (GBC) in a cohort from Chile...
  14. pmc Cold atmospheric plasma treatment selectively targets head and neck squamous cell carcinoma cells
    Rafael Guerrero-Preston
    Department of Otolaryngology, Division of Head and Neck Cancer Research, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Int J Mol Med 34:941-6. 2014
    ..In conclusion, our results suggest that cold plasma application selectively impairs HNSCC cell lines through non-apoptotic mechanisms, while having a minimal effect on normal oral cavity epithelial cell lines...
  15. pmc The environmental health of Latino children
    Olivia Carter-Pokras
    Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD, USA
    J Pediatr Health Care 21:307-14. 2007
    ..Targeted research, education, prevention and intervention efforts, and economic development initiatives are needed...
  16. pmc Clinical and public health research using methylated DNA immunoprecipitation (MeDIP): a comparison of commercially available kits to examine differential DNA methylation across the genome
    Priscilla Brebi-Mieville
    Head and Neck Cancer Research Division, Otolaryngology Department, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 7:106-12. 2012
    ..In addition, the DNA was successfully enriched from a 1:4 to 10:1 ratio. Therefore, the MagMeDIP kit is a useful research tool that will enable clinical and public health genome-wide DNA methylation studies...
  17. pmc Nuclear and mitochondrial DNA alterations in newborns with prenatal exposure to cigarette smoke
    Francesca Pirini
    Head and Neck Cancer Research Division, Otolaryngology Department, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Int J Environ Res Public Health 12:1135-55. 2015
    ....
  18. pmc Paired box 5 methylation detection by droplet digital PCR for ultra-sensitive deep surgical margins analysis of head and neck squamous cell carcinoma
    Masamichi Hayashi
    Departments of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cancer Prev Res (Phila) 8:1017-26. 2015
    ..PAX5 methylation appears to be an excellent tumor-specific marker for molecular deep surgical margin analysis of HNSCC. Moreover, the ddQMSP assay displays increased sensitivity for methylation marker detection...
  19. pmc Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer
    Myoung Sook Kim
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e6555. 2009
    ..Moreover, detection and quantification of OSMR promoter methylation in fecal DNA is a highly specific diagnostic biomarker for CRC...
  20. doi request reprint Cellular FLICE-like inhibitory protein long form (c-FLIPL) overexpression is related to cervical cancer progression
    Carmen Gloria Ili
    Molecular Pathology Laboratory, Department of Pathology, BIOREN CEGIN, School of Medicine Universidad de La Frontera, Temuco, Chile
    Int J Gynecol Pathol 32:316-22. 2013
    ..This finding could aid in identifying patients with preneoplastic lesions at greater risk of developing cervical cancer. c-FLIP expression in cervical tissue may be a potential cervical cancer progression marker...
  21. ncbi request reprint Previous cancer screening behavior as predictor of endoscopic colon cancer screening among women aged 50 and over, in NYC 2002
    Rafael Guerrero-Preston
    Department of Epidemiology, Joseph A Mailman School of Public Health at Columbia University, 722 West 168th St, 720, New York, NY 10032, USA
    J Community Health 33:10-21. 2008
    ..38; CI = 1.17, 1.61). Colorectal cancer screening remains low, even among women who undergo other cancer screening tests. Opportunities to link cancer screening tests to encourage colon cancer screening merit closer attention...
  22. pmc Innovative rapid gene methylation analysis of surgical margin tissues in head and neck cancer
    Masamichi Hayashi
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 21:3124-31. 2014
    ..However, tumor recurrence sometimes occurs even with histologically negative surgical margins. To detect minimal residual cancer cells in the deep margin intraoperatively, a time-efficient molecular approach is required...
  23. doi request reprint Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays
    Cynthia LeBron
    Johns Hopkins University, School of Medicine, Department of Otolaryngology, Head and Neck Cancer Research, Baltimore MD, USA
    Genomics 97:341-9. 2011
    ..Furthermore, high correlations (40-75%) were observed between CNV by SNP analysis and quantitative PCR. Our findings may lead to better understanding of TGTC's pathogenesis...