Fu An Kang

Summary

Affiliation: Johnson and Johnson Pharmaceutical Research and Development
Country: USA

Publications

  1. ncbi request reprint Efficient conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-one to pyrimidines via PyBroP-mediated coupling
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, New Jersey 08869, USA
    J Org Chem 70:1957-60. 2005
  2. ncbi request reprint Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:907-10. 2007
  3. ncbi request reprint Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:2531-4. 2007
  4. doi request reprint Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 18:3687-90. 2008
  5. doi request reprint Pd-catalyzed direct arylation of tautomerizable heterocycles with aryl boronic acids via C-OH bond activation using phosphonium salts
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, Pennsylvania 19341, USA
    J Am Chem Soc 130:11300-2. 2008
  6. doi request reprint Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA
    Chem Commun (Camb) 46:1347-9. 2010
  7. doi request reprint The discovery of novel cyclohexylamide CCR2 antagonists
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19002, USA
    Bioorg Med Chem Lett 21:7496-501. 2011
  8. ncbi request reprint Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: stoichiometric process
    Zhao Kui Wan
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Org Lett 4:4431-4. 2002
  9. ncbi request reprint Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process
    Hyeong Wook Choi
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Org Lett 4:4435-8. 2002

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Efficient conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-one to pyrimidines via PyBroP-mediated coupling
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, New Jersey 08869, USA
    J Org Chem 70:1957-60. 2005
    ....
  2. ncbi request reprint Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:907-10. 2007
    ..4nM. In contrast to the equipotent mifepristone toward the progesterone receptor (PR) and glucocorticoid receptor (GR), compound 6i had over 200-fold selectivity for PR over GR...
  3. ncbi request reprint Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 17:2531-4. 2007
    ..oxa-Steroids 4a and 4b were found to be more efficacious than mifepristone in vivo in a rat uterine complement C3 assay via the oral route, although they were less than or equally potent to mifepristone in the T47D assay...
  4. doi request reprint Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA
    Bioorg Med Chem Lett 18:3687-90. 2008
    ..The unnatural 7-oxa-steroids were orally active in a rat complement C3 assay and showed comparable pharmacokinetic and metabolic profiles to those of the natural steroid, mifepristone...
  5. doi request reprint Pd-catalyzed direct arylation of tautomerizable heterocycles with aryl boronic acids via C-OH bond activation using phosphonium salts
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, Pennsylvania 19341, USA
    J Am Chem Soc 130:11300-2. 2008
    ....
  6. doi request reprint Direct dehydrative cross-coupling of tautomerizable heterocycles with alkynes via Pd/Cu-catalyzed phosphonium coupling
    Fu An Kang
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Spring House, PA 19477, USA
    Chem Commun (Camb) 46:1347-9. 2010
    ....
  7. doi request reprint The discovery of novel cyclohexylamide CCR2 antagonists
    James C Lanter
    Johnson and Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, PA 19002, USA
    Bioorg Med Chem Lett 21:7496-501. 2011
    ..While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT prolongation. In addition, it showed excellent efficacy when dosed orally in a transgenic murine model of acute inflammation...
  8. ncbi request reprint Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: stoichiometric process
    Zhao Kui Wan
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Org Lett 4:4431-4. 2002
    ..A possible mechanism is suggested for the process...
  9. ncbi request reprint Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: catalytic process
    Hyeong Wook Choi
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Org Lett 4:4435-8. 2002
    ..A possible mechanism is suggested for the process. 1a is also effective for other Cr-mediated coupling reactions. With this catalyst, a concise and efficient synthesis of the C14-C26 segment of halichondrins has been developed...