S J Conway

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Neural crest is involved in development of abnormal myocardial function
    S J Conway
    Developmental Biology Program, Institute of Molecular Medicine and Genetics, Augusta, GA 30912 2640, USA
    J Mol Cell Cardiol 29:2675-85. 1997
  2. ncbi request reprint Role of cardiac neural crest cells in cardiovascular development
    T L Creazzo
    Institute of Molecular Medicine and Genetics, Developmental Biology Program, Augusta, Georgia 30912 2640, USA
    Annu Rev Physiol 60:267-86. 1998
  3. pmc The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans
    Wenhu Pi
    Department of Biochemistry and Molecular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 101:805-10. 2004
  4. pmc Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5225, USA
    Birth Defects Res C Embryo Today 72:151-61. 2004
  5. pmc Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Indiana Medical School, 1044 W Walnut R4 371, Indianapolis, Indiana 46202 5225, USA
    Nat Genet 37:373-81. 2005
  6. ncbi request reprint Novel expression of the goosecoid transcription factor in the embryonic mouse heart
    S J Conway
    Institute of Molecular Medicine and Genetics, Department of Cell Biology and Anatomy, Medical College of Georgia, 1120 15th Street, CB2803, Augusta, GA 30912 2640, USA
    Mech Dev 81:187-91. 1999
  7. ncbi request reprint Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse
    S J Conway
    Developmental Biology Program, Medical College of Georgia, Augusta 30912 2640, USA
    Cardiovasc Res 36:163-73. 1997
  8. ncbi request reprint Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue?
    Simon J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann N Y Acad Sci 976:268-81. 2002
  9. ncbi request reprint What cardiovascular defect does my prenatal mouse mutant have, and why?
    Simon J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Georgia
    Genesis 35:1-21. 2003
  10. ncbi request reprint Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant
    S J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta 30912 2640, USA
    Cardiovasc Res 47:314-28. 2000

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Neural crest is involved in development of abnormal myocardial function
    S J Conway
    Developmental Biology Program, Institute of Molecular Medicine and Genetics, Augusta, GA 30912 2640, USA
    J Mol Cell Cardiol 29:2675-85. 1997
    ....
  2. ncbi request reprint Role of cardiac neural crest cells in cardiovascular development
    T L Creazzo
    Institute of Molecular Medicine and Genetics, Developmental Biology Program, Augusta, Georgia 30912 2640, USA
    Annu Rev Physiol 60:267-86. 1998
    ..The continued study of experimental and genetically defined models with neural crest-associated heart defects will prove useful in identifying the common pathways by which the neural crest contributes to normal heart development...
  3. pmc The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans
    Wenhu Pi
    Department of Biochemistry and Molecular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 101:805-10. 2004
    ....
  4. pmc Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation
    Anthony B Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indianapolis, Indiana 46202 5225, USA
    Birth Defects Res C Embryo Today 72:151-61. 2004
    ....
  5. pmc Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
    Beth A Firulli
    Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Department of Pediatrics, Indiana Medical School, 1044 W Walnut R4 371, Indianapolis, Indiana 46202 5225, USA
    Nat Genet 37:373-81. 2005
    ....
  6. ncbi request reprint Novel expression of the goosecoid transcription factor in the embryonic mouse heart
    S J Conway
    Institute of Molecular Medicine and Genetics, Department of Cell Biology and Anatomy, Medical College of Georgia, 1120 15th Street, CB2803, Augusta, GA 30912 2640, USA
    Mech Dev 81:187-91. 1999
    ..We have shown, for the first time, that gsc mRNA is expressed in the developing mouse heart, and is localized to the sites that divide the primitive heart tube into a four chambered heart...
  7. ncbi request reprint Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse
    S J Conway
    Developmental Biology Program, Medical College of Georgia, Augusta 30912 2640, USA
    Cardiovasc Res 36:163-73. 1997
    ..The splotch (Sp2h) mutation disrupts the Pax3 gene and is lethal in homozygotes. The aim of the present study was to investigate the cause of lethality...
  8. ncbi request reprint Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue?
    Simon J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Ann N Y Acad Sci 976:268-81. 2002
    ..Furthermore, our in situ results indicate that both known adult Ncx1 isoforms are coexpressed within the embryonic heart, suggesting that effective transgenic rescue may require the presence of both isoforms within the developing heart...
  9. ncbi request reprint What cardiovascular defect does my prenatal mouse mutant have, and why?
    Simon J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Georgia
    Genesis 35:1-21. 2003
    ..The purpose of this review is both to review the literature and to provide a beginner's guide for analysing cardiovascular defects in mouse mutants...
  10. ncbi request reprint Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutant
    S J Conway
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta 30912 2640, USA
    Cardiovasc Res 47:314-28. 2000
    ..Our objective was to investigate the underlying mechanisms resulting in outflow tract defects and why insufficient cardiac NCC reach the heart of the Splotch (Sp(2H)) mouse mutant embryo...
  11. ncbi request reprint Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
    X Wu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Physiol Renal Physiol 279:F449-58. 2000
    ..The transport process was electrogenic. We conclude that OCT3 is expressed in mammalian kidney and that it plays an important role in the renal clearance of cationic drugs...
  12. ncbi request reprint Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization
    S V Koushik
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912 2640, USA
    FASEB J 15:1209-11. 2001
  13. ncbi request reprint Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta
    X Wu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912, USA
    Biochim Biophys Acta 1466:315-27. 2000
    ....
  14. ncbi request reprint Expression of folate receptor alpha in the mammalian retinol pigmented epithelium and retina
    S B Smith
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912 2000, USA
    Invest Ophthalmol Vis Sci 40:840-8. 1999
    ....
  15. ncbi request reprint Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    X Wu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USA
    J Pharmacol Exp Ther 290:1482-92. 1999
    ..This is the first report that OCTN2 is a Na(+)-independent organic cation transporter as well as a Na(+)-dependent carnitine transporter and that OCTN2 is expressed not only in the heart, kidney, and placenta but also in the brain...
  16. ncbi request reprint Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain
    W Huang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USA
    J Pharmacol Exp Ther 295:392-403. 2000
    ..This transporter is likely to be an essential component in the metabolic role of N-acetylaspartate in the process of myelination...
  17. ncbi request reprint Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter
    D P Rajan
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 275:14331-5. 2000
    ..The pattern of rBAT mRNA expression is different from that of b(0,+)AT mRNA and 4F2hc mRNA, but there are regions in the kidney where b(0,+)AT mRNA expression overlaps with rBAT mRNA expression as well as with 4F2hc mRNA expression...
  18. ncbi request reprint Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor
    P Seth
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912, USA
    Biochim Biophys Acta 1540:59-67. 2001
    ..The results also provide important information on the chemical nature of the ligand-binding site of sigmaR1 that may be of use in the design of sigmaR1-specific ligands with potential for modulation of sigmaR1-related brain functions...
  19. ncbi request reprint Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium
    S Miyauchi
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    Placenta 27:550-9. 2006
    ..We conclude that NaS2 is a placenta-specific Na+-coupled, electrogenic, transporter for sulfate expressed in trophoblasts and that it is also responsible for the transport of oxyanions of the micronutrients selenium and chromium...
  20. ncbi request reprint Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice
    N Bora
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912 2000, USA
    Dev Dyn 213:283-92. 1998
    ..This is the first report of transient elevation of Mitf in any of the Mitf mutants, and the elevation may be relevant to altered levels of pigmentation proteins as well as to the RPE abnormalities observed in the Mitfvit mutant...
  21. ncbi request reprint Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation
    A Kruzynska-Frejtag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Mech Dev 103:183-8. 2001
    ....
  22. ncbi request reprint Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: putative roles for Pax3 and PDGFRalpha in rib patterning
    E D Dickman
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta 30912, USA
    Anat Rec 255:353-61. 1999
    ..We suggest that Pax3 may influence the expression of PDGFRalpha, and that the reduced and/or deficient thoracic muscles may contribute to the resulting rib abnormalities...
  23. ncbi request reprint Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo
    S V Koushik
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta 30912, USA
    Mech Dev 88:119-22. 1999
    ..However, in more developed embryos (11.0 dpc and older) NCX1 is expressed in other tissues...
  24. ncbi request reprint HLA-G transgenic mice
    A Mellor
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912 2600, USA
    J Reprod Immunol 43:253-61. 1999
    ....
  25. ncbi request reprint Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain
    X Wu
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 273:32776-86. 1998
    ..OCT3 is likely to play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain...
  26. ncbi request reprint Prevention of allogeneic fetal rejection by tryptophan catabolism
    D H Munn
    Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Science 281:1191-3. 1998
    ..Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection...
  27. pmc Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation
    Lin Xu
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:34430-40. 2006
    ..This work is the first in vivo study that demonstrates which cis elements are important for Ncx1 regulation...
  28. pmc Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro
    Guohong Li
    Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, USA
    Atherosclerosis 188:292-300. 2006
    ..The objective of the present study was to understand mechanisms underlying periostin upregulation in balloon-injured rat carotid arteries and in cultured vascular smooth muscle cells (VSMCs)...
  29. pmc periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype
    Hector Rios
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Mol Cell Biol 25:11131-44. 2005
    ....
  30. ncbi request reprint Intragenic deletion of Tgif causes defectsin brain development
    Chenzhong Kuang
    Department of Medical and Molecular Genetics, Indiana University School of Medicine and the Walther Cancer Institute, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:3508-19. 2006
    ..The intragenic Tgif deletion mouse, therefore, would serve as a useful model that can be used to unravel the genetic complexity implicated in the pathogenesis of HPE...
  31. pmc Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
    Russell A Norris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Cell Biochem 101:695-711. 2007
    ..Collectively, these data demonstrate for the first time that periostin can regulate collagen I fibrillogenesis and thereby serves as an important mediator of the biomechanical properties of fibrous connective tissues...
  32. pmc Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure
    Femke Zwerts
    Center for Transgene Technology and Gene Therapy, University of Leuven, Gasthuisberg O and N1, Herestraat 49, 3000 Leuven, Belgium
    Blood 109:4742-52. 2007
    ..Thus, regulation of endothelial cell survival, and maintenance of vascular integrity by survivin are crucial for normal embryonic angiogenesis, cardiogenesis, and neurogenesis...
  33. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..These are the first genetic data detailing the function of Pn in the adult heart as a regulator of cardiac remodeling and hypertrophy...
  34. pmc Cardiovascular development and the colonizing cardiac neural crest lineage
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    ScientificWorldJournal 7:1090-113. 2007
    ..Here we review the current literature, the neural crest-related role of the Pax3 transcription factor, and discuss potential function/s of cardiac neural crest-derived cells during cardiovascular developmental remodeling...
  35. ncbi request reprint Developmental biology: the power of blood
    Paige Snider
    Nature 450:180-1. 2007
  36. pmc Lineage-specific responses to reduced embryonic Pax3 expression levels
    Hong Ming Zhou
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 315:369-82. 2008
    ..Thus, we have established that there are different minimum threshold requirements for Pax3 within different Pax3-expressing lineages...
  37. pmc An absence of Twist1 results in aberrant cardiac neural crest morphogenesis
    Joshua W Vincentz
    Riley Heart Research Center, Riley Hospital for Children, Department of Pediatrics Pediatric Cardiology, Indiana Medical School, 1044 W Walnut St, Indianapolis, IN 46202 5225, USA
    Dev Biol 320:131-9. 2008
    ..Within the Twist1(-/-) neural crest cell populations that do emigrate to the OFT, a Hand-expressing subpopulation displays defective maturation, tracking, and, presumably, cell-cell adhesion, further compromising cNCC morphogenesis...
  38. pmc All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac
    Christopher T Lux
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    Blood 111:3435-8. 2008
    ..Thus, primitive erythroblasts and essentially all definitive HPCs destined to initially seed the fetal liver after E9.5 are generated in the YS between E7.0-E9.5 and are redistributed into the EP via the systemic circulation...
  39. pmc Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus
    Vinciane Gaussin
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, MSB Room G 609, Newark, NJ 07103, USA
    Circ Res 97:219-26. 2005
    ..In conclusion, our mouse model demonstrated critical roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus...
  40. ncbi request reprint Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model
    Joachim G Muller
    Gazes Cardiac Research Institute and Division of Cardiology, Medical University of South Carolina, Ralph H Johnson Department of Veterans Affairs, Charleston, SC 29425, USA
    Circ Res 90:158-64. 2002
    ..This work demonstrates that the NCX1H1 promoter directs cardiac-specific expression of the exchanger in both the embryo and adult and is also sufficient for the upregulation of NCX1 in response to pressure overload...
  41. ncbi request reprint Generation of a conditional loxP allele of the Pax3 transcription factor that enables selective deletion of the homeodomain
    Srinagesh V Koushik
    Institute of Molecular Medicine and Genetics and Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2640, USA
    Genesis 32:114-7. 2002
  42. pmc Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors
    Irina Lagutina
    Department of Genetics Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 22:7204-16. 2002
    ..We conclude that the Pax3-FKHR allele causes lethal developmental defects in knock-in mice but might be insufficient to cause muscle tumors...
  43. ncbi request reprint Pathways regulating Na+/Ca2+ exchanger expression in the heart
    Donald R Menick
    Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 976:237-47. 2002
    ....
  44. pmc Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer
    Hiroyuki Yamagishi
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genes Dev 17:269-81. 2003
    ..We propose that Tbx1 is a direct transcriptional target of Fox proteins and that Fox proteins may serve an intermediary role in Shh regulation of Tbx1...
  45. ncbi request reprint SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury
    William D Hill
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912 2000, USA
    J Neuropathol Exp Neurol 63:84-96. 2004
    ..These findings suggest SDF-1 is important in the homing of bone marrow-derived cells, especially monocytes, to areas of ischemic injury...
  46. ncbi request reprint Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction
    Agnieszka Kruzynska-Frejtag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
    Dev Dyn 229:857-68. 2004
    ....
  47. pmc BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 131:2219-31. 2004
    ..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects...
  48. pmc Regulation of Ncx1 gene expression in the normal and hypertrophic heart
    Donald R Menick
    Division of Cardiology, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425, USA
    Ann N Y Acad Sci 1099:195-203. 2007
    ....
  49. pmc Nf1+/- mice have increased neointima formation via hyperactivation of a Gleevec sensitive molecular pathway
    Elisabeth A Lasater
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:2336-44. 2008
    ....
  50. doi request reprint Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Genesis 46:167-76. 2008
    ..This ECsrp1(Cre) transgenic line should thus prove useful for genetic analysis of diverse aspects of cardiovascular morphogenesis and as a general smooth muscle lineage deletor line...
  51. pmc Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
    ..Thus, peri(lacZ) knockouts provide a new model of viable latent valve disease...
  52. ncbi request reprint VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
    Ingeborg Stalmans
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium
    Nat Med 9:173-82. 2003
    ..These genetic data in mouse, fish and human indicate that VEGF is a modifier of cardiovascular birth defects in the del22q11 syndrome...
  53. pmc The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells
    Nancy M Joseph
    Center for Stem Cell Biology, Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cancer Cell 13:129-40. 2008
    ..Tumors appeared to arise from differentiated glia, not NCSCs...
  54. pmc Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer
    Andrew Lindsley
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 307:340-55. 2007
    ....
  55. ncbi request reprint Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis
    Andrew Lindsley
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, 46202, USA
    Gene Expr Patterns 5:593-600. 2005
    ....