Azizul Haque

Summary

Affiliation: Medical University of Soutrh Carolina
Location: Summerville, Summerville

Publications

  1. pmc Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol
    Faisal F Y Radwan
    Department of Microbiology and Immunology, Hollings Cancer Center and Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Leuk Lymphoma 53:305-14. 2012
  2. pmc A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma
    Azim Hossain
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, BSB 201, Charleston, SC 29425, USA
    Apoptosis 17:1066-78. 2012
  3. doi request reprint HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition
    Shereen Amria
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Eur J Immunol 38:1961-70. 2008
  4. ncbi request reprint Emerging role of combination of all-trans retinoic acid and interferon-gamma as chemoimmunotherapy in the management of human glioblastoma
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurochem Res 32:2203-9. 2007
  5. pmc Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients
    Amena W Smith
    Department of Neurosciences, Division of Neurology, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    J Neuroimmunol 232:179-85. 2011
  6. pmc Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1
    Dan Zhao
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Immunol 271:392-400. 2011
  7. pmc HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition
    Azim Hossain
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Dev Immunol 2011:780839. 2011
  8. pmc Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma
    Oliver G Goldstein
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer Immunol Immunother 57:1461-70. 2008
  9. pmc Molecular alterations in glioblastoma: potential targets for immunotherapy
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA
    Prog Mol Biol Transl Sci 98:187-234. 2011
  10. pmc Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid
    Faisal F Y Radwan
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina Children s Research Institute, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina
    J Cell Biochem 116:102-14. 2015

Collaborators

  • Dan Zhao
  • Jun Inoue
  • Georg W Bornkamm
  • Ping Li
  • Swapan K Ray
  • Peter Komlosi
  • Janice S Blum
  • Arabinda Das
  • Arthur Vandenbark
  • Mythily Srinivasan
  • Mark H Kaplan
  • Mitzi Nagarkatti
  • Jason M God
  • Shereen Amria
  • Azim Hossain
  • Faisal F Y Radwan
  • Bently P Doonan
  • Naren L Banik
  • Yuvaraj Sambandam
  • Nicole Trager
  • Jennifer R Bethard
  • Lixia Zhang
  • Christine Cameron
  • Amena W Smith
  • Sakamuri V Reddy
  • Duncan L Norton
  • William R Tyor
  • Laela M Hajiaghamohseni
  • A R Younger
  • Oliver G Goldstein
  • Sarah A Imam
  • Patrick W O'Donnell
  • Bettina Kempkes
  • Robert K Stuart
  • Janette Figueroa
  • Michelle Elvington
  • Nathan Leaphart
  • Stephen Tomlinson
  • Jason J Pierce
  • Christine A Cameron
  • Amena Smith
  • Craig Beeson
  • Cecilia M Lipman
  • Ted A Bateman
  • Molly T Townsend
  • Mitsuyoshi Azuma
  • Gerald Wallace Iv
  • P Darwin Bell
  • Nada Abou-Fayssal
  • J S Norris
  • Robert Stuart
  • S Amria
  • W A Jeffrey
  • O G Goldstein
  • Caroline Harbeson
  • Oliver Goldstein
  • Kumaran Sundaram
  • A E M Mahdy
  • Mary K Guyton
  • Michael J Klemsz

Detail Information

Publications28

  1. pmc Mechanisms regulating enhanced human leukocyte antigen class II-mediated CD4 + T cell recognition of human B-cell lymphoma by resveratrol
    Faisal F Y Radwan
    Department of Microbiology and Immunology, Hollings Cancer Center and Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425, USA
    Leuk Lymphoma 53:305-14. 2012
    ..These findings suggest that HLA class II-mediated immune recognition of malignant B-cells can be improved by Resv treatment, thus encouraging its potential use in chemoimmunotherapy of B-cell lymphoma...
  2. pmc A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma
    Azim Hossain
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, BSB 201, Charleston, SC 29425, USA
    Apoptosis 17:1066-78. 2012
    ....
  3. doi request reprint HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition
    Shereen Amria
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Eur J Immunol 38:1961-70. 2008
    ..These findings suggest that HLA-DM expression in APC controls class II-mediated CII(261-273) peptide/epitope presentation and regulates CD4+ T cell responses to this self epitope, thus potentially influencing CII-dependent autoimmunity...
  4. ncbi request reprint Emerging role of combination of all-trans retinoic acid and interferon-gamma as chemoimmunotherapy in the management of human glioblastoma
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurochem Res 32:2203-9. 2007
    ..We propose that combination of ATRA and IFN-gamma can become an efficacious chemoimmunotherapy for the treatment of human glioblastoma...
  5. pmc Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients
    Amena W Smith
    Department of Neurosciences, Division of Neurology, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
    J Neuroimmunol 232:179-85. 2011
    ..These results suggest that calpain inhibition may attenuate MS pathology and augment the efficacy of standard immunomodulatory agents used to treat this disease...
  6. pmc Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1
    Dan Zhao
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Immunol 271:392-400. 2011
    ..These data suggest that bryostatin-1 could be used as a chemo-immunotherapeutic agent for reducing tumorigenic potential of melanoma cells while enhancing CD4+ T cell recognition to prevent tumor recurrence...
  7. pmc HLA class II defects in Burkitt lymphoma: bryostatin-1-induced 17 kDa protein restores CD4+ T-cell recognition
    Azim Hossain
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Clin Dev Immunol 2011:780839. 2011
    ..These results demonstrate the presence of a specific defect in HLA class II-mediated Ag presentation in BL and reveal that treatment with bryostatin-1 could lead to enhanced immunogenicity...
  8. pmc Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma
    Oliver G Goldstein
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer Immunol Immunother 57:1461-70. 2008
    ..These data suggest that GILT-expressing melanoma cells could prove to be very promising for direct antigen presentation and CD4+ T cell recognition, and may have direct implications for the design of cancer vaccines...
  9. pmc Molecular alterations in glioblastoma: potential targets for immunotherapy
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA
    Prog Mol Biol Transl Sci 98:187-234. 2011
    ..This review provides a detailed overview concerning genetic alterations in glioblastoma, their effects on Ag and biomarker expression, and the future design of chemoimmunotherapeutics against glioblastoma...
  10. pmc Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid
    Faisal F Y Radwan
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina Children s Research Institute, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, South Carolina
    J Cell Biochem 116:102-14. 2015
    ..The demonstrated therapeutic benefit indicates that GA-A is a candidate for future drug design for the treatment of lymphoma...
  11. pmc Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors
    Jason M God
    Department of Microbiology and Immunology, Hollings Cancer Center and Children s Research Institute, Medical University of South Carolina, Charleston, SC 29425
    J Immunol 194:1434-45. 2015
    ..Taken together, these results reveal c-MYC exerts suppressive effects at several critical checkpoints in Ag presentation, which contribute to the immunoevasive properties of BL tumors. ..
  12. pmc Disruption of HLA class II antigen presentation in Burkitt lymphoma: implication of a 47,000 MW acid labile protein in CD4+ T-cell recognition
    Jason M God
    Department of Microbiology and Immunology, Hollings Cancer Center, and Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Immunology 142:492-505. 2014
    ..These findings demonstrate that BL likely has multiple defects in HLA class II-mediated antigen presentation and immune recognition, which may be exploited for future immunotherapies...
  13. ncbi request reprint New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    CNS Neurol Disord Drug Targets 7:270-7. 2008
    ..This article also focused on the role of cathepsin inhibitors as disease-modifying treatment strategies that could halt, or even prevent, this devastating neurological disorder...
  14. pmc Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients
    Sarah A Imam
    Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Neuroimmunol 190:139-45. 2007
    ..Calpain inhibitor also reduced degradation of myelin basic protein (MBP) by inhibiting the calpain secreted from MBP-specific T cells. Taken together, these results suggested calpain involvement in Th1/Th2 dysregulation in MS patients...
  15. pmc Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis
    Nicole Trager
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA
    J Neurochem 130:268-79. 2014
    ....
  16. pmc Microgravity control of autophagy modulates osteoclastogenesis
    Yuvaraj Sambandam
    Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Bone 61:125-31. 2014
    ..Thus, our results suggest that μXg induced autophagy plays an important role in enhanced osteoclast differentiation and could be a potential therapeutic target to prevent bone loss in astronauts during space flight missions. ..
  17. ncbi request reprint Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human malignant glioblastoma T98G and U87MG cells
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Cancer Immunol Immunother 56:615-25. 2007
    ..Taken together, this study suggests that induction of apoptosis and immune components of the HLA class II pathway by ATRA plus IFN-gamma may be a promising chemoimmunotherapeutic strategy for treatment of human malignant glioblastoma...
  18. ncbi request reprint HLA class II antigen presentation by prostate cancer cells
    A R Younger
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC29425, USA
    Prostate Cancer Prostatic Dis 11:334-41. 2008
    ..Prostate Cancer and Prostatic Diseases (2008) 11, 334-341; doi:10.1038/sj.pcan.4501021; published online 16 October 2007...
  19. doi request reprint New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection.
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29401, USA
    Brain Sci 8:. 2018
    ..This review discusses possible implications of NSE expression and activity in neuroinflammation, neurodegeneration, and neuroprotection in SCI and various neurodegenerative diseases for prognostic and therapeutic potential...
  20. doi request reprint Targeting Enolase in Reducing Secondary Damage in Acute Spinal Cord Injury in Rats
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, BSB 201, Charleston, SC, 29425, USA
    Neurochem Res . 2017
    ..Thus, reduction of NSE by ENOblock may have potential therapeutic implications in acute SCI...
  21. pmc Neuron specific enolase: a promising therapeutic target in acute spinal cord injury
    Azizul Haque
    Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, BSB 201, Charleston, SC, 29425, USA
    Metab Brain Dis 31:487-95. 2016
    ..This review article gives an overview of the current basic research and clinical studies on the role of multifunctional enolase in neurotrauma, with a special emphasis on NSE in acute SCI. ..
  22. pmc Insights into the Role of GILT in HLA Class II Antigen Processing and Presentation by Melanoma
    Duncan L Norton
    Department of Microbiology and Immunology, Charles Darby Children s Research Institute and Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Oncol 2009:142959. 2009
    ..At the end, we propose a strategy employing GILT in the development of a potential whole cell vaccine for combating metastatic melanoma...
  23. pmc Invariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cells
    Azizul Haque
    Department of Microbiology and Immunology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Cell Immunol 249:20-9. 2007
    ..Endocytosis of class II molecules was enhanced in cells lacking Ii compared with Ii-expressing APC. These results suggest enhanced reliance on the endocytic recycling pathway for functional class II presentation in nonprofessional APC...
  24. ncbi request reprint New insights in antigen processing and epitope selection: development of novel immunotherapeutic strategies for cancer, autoimmunity and infectious diseases
    A Haque
    Department of Microbiology and Immunology, and Hollings Cancer Center, Medical University of South Carolina, Charleston 29403, USA
    J Biol Regul Homeost Agents 19:93-104. 2005
    ..Here we describe new insights in antigen processing and epitope selection with relevance to immunotherapeutic strategies for cancer, autoimmunity and infectious diseases...
  25. doi request reprint Defects in HLA class II antigen presentation in B-cell lymphomas
    Shereen Amria
    Leuk Lymphoma 49:353-5. 2008
  26. ncbi request reprint CD80 binding polyproline helical peptide inhibits T cell activation
    Mythily Srinivasan
    Department of Oral Pathology, School of Dentistry, 1121 W Michigan St, Indianapolis 46202, USA
    J Biol Chem 280:10149-55. 2005
    ..Structural and functional studies suggest potential therapeutic value for select CD80 competitive antagonist peptides...
  27. ncbi request reprint Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent
    Patrick W O'Donnell
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 173:731-5. 2004
    ..Rather, studies revealed STAT1 plays a direct role in IFN-gamma-inducible GILT expression. These results define a molecular mechanism for the uncoupled regulation of MHC class II genes and the processing enzyme GILT in human melanomas...