Minu Chaudhuri

Summary

Affiliation: Meharry Medical College
Country: USA

Publications

  1. pmc Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei
    Ujjal K Singha
    Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 159:30-43. 2008
  2. ncbi request reprint Functional characterization of the serine/threonine protein phosphatase 5 from Trypanosoma brucei
    Sedrick Anderson
    Division of Microbial Pathogenesis and Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Parasitol 92:1152-61. 2006
  3. ncbi request reprint The trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria
    Minu Chaudhuri
    Department of Microbiology, School of Medicine, Meharry Medical College, Nashville, TN, 37208, USA
    Parasitol Res 96:178-83. 2005
  4. ncbi request reprint Trypanosome alternative oxidase: from molecule to function
    Minu Chaudhuri
    Division of Microbial Pathogenesis and Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Trends Parasitol 22:484-91. 2006
  5. pmc Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages
    Shuntae Williams
    Department of Microbial Pathogenesis and Immune Response, School of Medicine, Meharry Medical College, 1005 D B Todd Jr Boulevard, Nashville, TN 37208, USA
    Exp Parasitol 118:420-33. 2008
  6. ncbi request reprint The effect of over-expression of the alternative oxidase in the procyclic forms of Trypanosoma brucei
    Robert Walker
    Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 139:153-62. 2005
  7. pmc Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import
    Melanie R Duncan
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 288:3184-97. 2013
  8. pmc Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei
    Shvetank Sharma
    Department of Microbiology and Immunology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 174:89-100. 2010
  9. pmc Protein translocase of mitochondrial inner membrane in Trypanosoma brucei
    Ujjal K Singha
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 287:14480-93. 2012
  10. pmc A type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite
    Smita Misra
    Department of Microbiology, Meharry Medical College, 1005 D B Todd, Jr Blvd, Nashville, TN 37208, USA
    Mol Biochem Parasitol 143:135-45. 2005

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Characterization of the mitochondrial inner membrane protein translocator Tim17 from Trypanosoma brucei
    Ujjal K Singha
    Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 159:30-43. 2008
    ..Together, these show that TbTim17 is the translocator of nuclear encoded mitochondrial proteins and its expression is regulated according to mitochondrial activities in T. brucei...
  2. ncbi request reprint Functional characterization of the serine/threonine protein phosphatase 5 from Trypanosoma brucei
    Sedrick Anderson
    Division of Microbial Pathogenesis and Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Parasitol 92:1152-61. 2006
    ..brucei. Taken together; these findings suggest that a serum factor (or factors) induces up-regulation of TbPP5 expression during the G1 phase, which is required for proper cell growth...
  3. ncbi request reprint The trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria
    Minu Chaudhuri
    Department of Microbiology, School of Medicine, Meharry Medical College, Nashville, TN, 37208, USA
    Parasitol Res 96:178-83. 2005
    ..However, it exists as a monomer in Trypanosoma brucei mitochondria...
  4. ncbi request reprint Trypanosome alternative oxidase: from molecule to function
    Minu Chaudhuri
    Division of Microbial Pathogenesis and Immune Response, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Trends Parasitol 22:484-91. 2006
    ..Alternative oxidases similar to TAO have been found in a wide variety of organisms but not in mammals, thus rendering TAO an important chemotherapeutic target for African trypanosomiasis...
  5. pmc Trypanosoma brucei: differential requirement of membrane potential for import of proteins into mitochondria in two developmental stages
    Shuntae Williams
    Department of Microbial Pathogenesis and Immune Response, School of Medicine, Meharry Medical College, 1005 D B Todd Jr Boulevard, Nashville, TN 37208, USA
    Exp Parasitol 118:420-33. 2008
    ..Differential import conditions of nuclear encoded mitochondrial proteins of T. brucei possibly help it to adapt to different life forms...
  6. ncbi request reprint The effect of over-expression of the alternative oxidase in the procyclic forms of Trypanosoma brucei
    Robert Walker
    Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 139:153-62. 2005
    ..This suggests that the expression of two terminal oxidases and the coat protein is linked in T. brucei...
  7. pmc Tim50 in Trypanosoma brucei possesses a dual specificity phosphatase activity and is critical for mitochondrial protein import
    Melanie R Duncan
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 288:3184-97. 2013
    ..Overall, our results show that TbTim50 plays additional roles in mitochondrial activities besides preprotein translocation...
  8. pmc Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei
    Shvetank Sharma
    Department of Microbiology and Immunology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA
    Mol Biochem Parasitol 174:89-100. 2010
    ....
  9. pmc Protein translocase of mitochondrial inner membrane in Trypanosoma brucei
    Ujjal K Singha
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 287:14480-93. 2012
    ..Overall, our data reveal that TbTim17, the single homolog of Tim17/22/23 family proteins, is present in a unique TIM complex consisting of novel proteins in T. brucei and is critical for mitochondrial protein import...
  10. pmc A type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite
    Smita Misra
    Department of Microbiology, Meharry Medical College, 1005 D B Todd, Jr Blvd, Nashville, TN 37208, USA
    Mol Biochem Parasitol 143:135-45. 2005
    ..This study not only reveals the significance of the LRNase HIIC in the kinetoplast biology but also identifies a potential molecular target for antileishmanial chemotherapy...
  11. pmc Peptide aptamer mimicking RAD51-binding domain of BRCA2 inhibits DNA damage repair and survival in Trypanosoma brucei
    Mack Hall
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN 37208, USA
    Microb Pathog 50:252-62. 2011
    ..Expression of a single BRC motif led to MMS sensitivity and inhibited cellular proliferation in T. brucei...
  12. pmc Downregulation of mitochondrial porin inhibits cell growth and alters respiratory phenotype in Trypanosoma brucei
    Ujjal K Singha
    Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN 37208, USA
    Eukaryot Cell 8:1418-28. 2009
    ..We also found that the expressions of TAO and CP proteins are coordinately regulated in T. brucei according to mitochondrial energy demand...
  13. ncbi request reprint Trypanosome alternative oxidase is regulated post-transcriptionally at the level of RNA stability
    Minu Chaudhuri
    Department of Microbiology, Meharry Medical College, Nashville, Tennessee 37208 3599, USA
    J Eukaryot Microbiol 49:263-9. 2002
    ..Thus, TAO is regulated at the level of mRNA stability and de novo protein synthesis is required for the reduction of the TAO mRNA pool in the procyclic form...
  14. pmc Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae
    Ebony Weems
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, USA
    Eukaryot Cell 14:286-96. 2015
    ..In addition, ScTim22 could not be sorted properly in the T. brucei mitochondrion and thus failed to complement the function of TbTim17. ..
  15. pmc Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections
    Galina I Lepesheva
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:1773-80. 2010
    ..The structures shed new light on 14DM functional conservation and open an excellent opportunity for directed design of novel antiparasitic drugs...
  16. pmc Trypanosome alternative oxidase possesses both an N-terminal and internal mitochondrial targeting signal
    Vanae Hamilton
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, USA
    Eukaryot Cell 13:539-47. 2014
    ..Together, these results show that TAO possesses a cleavable N-terminal MTS as well as an internal MTS and that these signals act together for efficient import of TAO into mitochondria. ..
  17. ncbi request reprint Import and assembly of Neurospora crassa Tom40 into mitochondria of Trypanosoma brucei in vivo
    Minu Chaudhuri
    Department of Microbiology, Meharry Medical College, Nashville, TN 37208, USA
    Curr Genet 44:85-94. 2003
    ..brucei mitochondria containing NcTom40 using antisera developed against the N. crassa protein. The 16 kDa protein may represent a component of the T. brucei TOM complex that associates with NcTom40...
  18. pmc Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress
    Marjorie Fullerton
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN, USA
    Mol Biochem Parasitol 199:9-18. 2015
    ..Together, these results suggest that TbTim50 acts as a stress sensor and that down regulation of Tim50 could be a survival mechanism for T. brucei exposed to oxidative stress. ..
  19. pmc Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex
    Ujjal K Singha
    From the Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208
    J Biol Chem 290:23226-39. 2015
    ..TbTim62 KD destabilizes this complex, and unassembled TbTim17 degrades. Therefore, TbTim62 acts as a novel regulatory factor to maintain the levels of TIM in T. brucei mitochondria. ..
  20. ncbi request reprint Site-directed mutagenesis reveals the essentiality of the conserved residues in the putative diiron active site of the trypanosome alternative oxidase
    Wilfred U Ajayi
    School of Medicine, Department of Microbiology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 277:8187-93. 2002
    ..This work demonstrates that His-165, Glu-214, Glu-266, and His-269 and the presence of iron are essential for the activity of TAO...
  21. ncbi request reprint Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration
    Robert Ott
    Vanderbilt University School of Medicine, Department of Microbiology and Immunology, Nashville, TN 37232, United States
    Acta Trop 100:172-84. 2006
    ..Collectively, the results suggest we have identified a new class of compounds that are inhibitors of TAO, have trypanocidal properties in vitro, and warrant further investigation in vivo...
  22. ncbi request reprint Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target
    Craig W Roberts
    Department of Immunology, Strathclyde Institute for Biomedical Life Sciences, University of Strathclyde, Glasgow, Scotland, UK
    Int J Parasitol 34:297-308. 2004
    ..These results give insight into the evolution of AOX and demonstrate the potential of targeting the alternative pathway of respiration in apicomplexans...
  23. doi request reprint Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei
    Candace Jones
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Parasitol Res 102:835-44. 2008
    ..Together, these results suggest that TbPP5 positively regulates the function of Hsp90 to maintain cellular homeostasis during proteotoxic stresses in T. brucei...

Research Grants1

  1. MITOCHONDRIAL PROTEIN IMPORT IN AFRICAN TRYPANOSOMES
    Minu Chaudhuri; Fiscal Year: 2002
    ..Understanding of this developmental process will elucidate one of the major aspects of trypanosomal parasitism. This in turn will help us to design rational trypanocidal chemotherapeutic strategies. ..