- HIV-1 Vpr inhibits cytokinesis in human proximal tubule cellsPaul E Rosenstiel
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Kidney Int 74:1049-58. 2008..Our study provides evidence of a new clinical phenotype in HIVAN that may result from the ability of Vpr to impair cytokinesis...
- HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cellsPaul E Rosenstiel
Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
AIDS 23:2054-6. 2009..Here, we report that Vpr activates the DNA damage response resulting in the observed renal phenotype. Renal sections from the HIVAN transgenic mouse model and human biopsies both show an abundant DNA damage response...
- HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cellsAlexandra Snyder
Department of Nephrology, Mount Sinai School of Medicine, New York, New York 10029, USA
AIDS 24:1107-19. 2010..HIV-1 viral protein r (Vpr) has been implicated in HIV-induced RTEC apoptosis but the mechanisms of Vpr-induced RTEC apoptosis are unknown. The aim of this study was therefore to determine the mechanisms of Vpr-induced apoptosis in RTEC...
- FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathyAlexandra Snyder
Mount Sinai School of Medicine, Division of Nephrology, Box 1243, 1 Gustave L Levy Place, New York, New York 10029, USA
J Virol 83:11983-8. 2009..Moreover, we found that Vpr interacts with FAT10 and that these proteins colocalize at mitochondria. These studies establish FAT10 as a novel mediator of Vpr-induced cell death...
- HIV-associated nephropathyChristina M Wyatt
Department of Medicine, Mount Sinai School of Medicine, New York, N Y 10029, USA
Contrib Nephrol 159:151-61. 2008..Future therapies could also target different steps in the pathogenesis of HIVAN, including viral replication, epithelial cell entry and viral gene expression, and downstream cellular pathways...