Shoba Amarnath

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:523-41. 2010
  2. pmc The PDL1-PD1 axis converts human TH1 cells into regulatory T cells
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Transl Med 3:111ra120. 2011
  3. pmc Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells
    Shoba Amarnath
    Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
    Retrovirology 4:57. 2007
  4. pmc Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 8:e1000302. 2010
  5. pmc Host-based Th2 cell therapy for prolongation of cardiac allograft viability
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e18885. 2011
  6. pmc The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 17:620-31. 2011
  7. pmc Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
    Courtney W Mangus
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e72305. 2013
  8. pmc STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:209-22. 2012
  9. pmc Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:4765-75. 2008
  10. pmc Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo
    Shoba Amarnath
    Cytokine Biology Section, Experimental Transplantation and Immunology Branch, National Cancer Institute, Newcastle upon Tyne, United Kingdom
    Stem Cells 33:1200-12. 2015

Collaborators

Detail Information

Publications15

  1. pmc Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Autophagy 6:523-41. 2010
    ..Rapamycin therefore does not impair human T cell capacity for type I differentiation. Rather, rapamycin yields an anti-apoptotic Th1/Tc1 effector phenotype by promoting autophagy...
  2. pmc The PDL1-PD1 axis converts human TH1 cells into regulatory T cells
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Transl Med 3:111ra120. 2011
    ..Moreover, because this conversion can be prevented by blocking PD1 expression or pharmacologically inhibiting SHP1/2, this pathway provides a new therapeutic direction for enhancing T cell immunity to cancer and infection...
  3. pmc Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells
    Shoba Amarnath
    Mucosal Immunology Unit, OIIB, NIDCR, NIH, Bethesda, MD 20895, USA
    Retrovirology 4:57. 2007
    ..We also explored the effects of TGF-beta on HIV-1 infection mediated induction of human Tregs since recent evidence has suggested that HIV-1 infection may also impact the generation of Tregs in infected patients...
  4. pmc Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 8:e1000302. 2010
    ..This identification of a human Treg downstream cellular effector (DC) and molecular mechanism (PD-L1) will facilitate the rational design of clinical trials to modulate alloreactivity...
  5. pmc Host-based Th2 cell therapy for prolongation of cardiac allograft viability
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e18885. 2011
    ..These results provide further support for the rationale to use "direct" host T cell therapy for prolongation of allograft viability as an alternative to "indirect" therapy mediated by donor T cell infusion...
  6. pmc The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Blood Marrow Transplant 17:620-31. 2011
    ..These data suggest that host T cell suppression, distinct from T cell depletion, may be a critical determinant of engraftment after purine analog-based regimens and also may be preferentially attained by the use of pentostatin...
  7. pmc Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
    Courtney W Mangus
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 8:e72305. 2013
    ..As such, Th9 differentiation proceeds in the presence of rapamycin to generate a cell therapy product that maintains high IL-9 expression in vivo while inhibiting IFN-γ driven alloreactivity. ..
  8. pmc STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
    Arian Laurence
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 37:209-22. 2012
    ....
  9. pmc Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathway
    Jacopo Mariotti
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 112:4765-75. 2008
    ....
  10. pmc Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo
    Shoba Amarnath
    Cytokine Biology Section, Experimental Transplantation and Immunology Branch, National Cancer Institute, Newcastle upon Tyne, United Kingdom
    Stem Cells 33:1200-12. 2015
    ..In conclusion, BMSC effectively modulate experimental GVHD through a paracrine mechanism that promotes adenosine-based immune suppression...
  11. pmc Hydrogen sulfide is an endogenous potentiator of T cell activation
    Thomas W Miller
    Laboratory of Pathology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:4211-21. 2012
    ..Thus, H(2)S represents a novel autocrine immunomodulatory molecule in T cells...
  12. ncbi request reprint Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4+CD25+ Tregs from thymic CD4+CD25- single positive T cells
    Yongzhong Liu
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20895, USA
    Transplantation 82:953-64. 2006
    ..However, the detailed pathway(s) by which Tregs are developed remain a mystery. CD28-/- mice have profound decrease in Tregs, but the underlying molecular events remain largely undefined...
  13. ncbi request reprint Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands
    Seshagiri R Nandula
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 56:1798-805. 2007
    ..The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation...
  14. pmc c-Rel in GVHD biology: a missing link
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 43:2255-8. 2013
    ..These data suggest that specific targeting of the T-cell-specific transcription factor c-Rel can inhibit GVHD while maintaining GVL effects. ..
  15. pmc Modulation of innate host factors by Mycobacterium avium complex in human macrophages includes interleukin 17
    Nancy Vazquez
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892 4352, USA
    J Infect Dis 206:1206-17. 2012
    ..Our study examines the ability of MAC to regulate interleukin 17 (IL-17), a proinflammatory cytokine involved in host cell recruitment...