N Azimi

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:2452-7. 1998
  2. ncbi request reprint Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 163:4064-72. 1999
  3. pmc Viral activation of interleukin-15 (IL-15): characterization of a virus-inducible element in the IL-15 promoter region
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1374, USA
    J Virol 74:7338-48. 2000
  4. ncbi request reprint How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?
    N Azimi
    Metabolism Branch, National Cancer Institutes, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 16:1717-22. 2000
  5. pmc IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients
    N Azimi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1374, USA
    Proc Natl Acad Sci U S A 98:14559-64. 2001
  6. ncbi request reprint Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site
    J M Mariner
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2602-9. 2001
  7. pmc Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides
    Y Tagaya
    Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:14444-9. 1997
  8. pmc Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway
    G Baldassarre
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:7970-5. 2001

Collaborators

Detail Information

Publications8

  1. pmc Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:2452-7. 1998
    ....
  2. ncbi request reprint Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: implications for therapy with a monoclonal antibody directed to the IL-2/15R beta receptor
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 163:4064-72. 1999
    ..These data suggest the existence of two autocrine loops involving IL-15/IL-15R and IL-2/IL-2R, both contributing to the spontaneous proliferation of HAM/TSP PBMC...
  3. pmc Viral activation of interleukin-15 (IL-15): characterization of a virus-inducible element in the IL-15 promoter region
    N Azimi
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1374, USA
    J Virol 74:7338-48. 2000
    ..The presence of a virus-inducible region in the IL-15 promoter suggests a role for IL-15 as a component of host antiviral defense mechanisms...
  4. ncbi request reprint How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?
    N Azimi
    Metabolism Branch, National Cancer Institutes, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 16:1717-22. 2000
    ..On the basis of these studies, we propose a model in which HTLV-1 infection of T cells results in the production of both IL-2 and IL-15 cytokines, growth factors that support the proliferation of T cells...
  5. pmc IL-15 plays a major role in the persistence of Tax-specific CD8 cells in HAM/TSP patients
    N Azimi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1374, USA
    Proc Natl Acad Sci U S A 98:14559-64. 2001
    ..This decrease was caused by both inhibition of proliferation and induction of apoptosis in these cells. The data indicate that IL-15 plays a major role in the maintenance of viral-specific CD8 cells in HAM/TSP...
  6. ncbi request reprint Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site
    J M Mariner
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 166:2602-9. 2001
    ..These findings suggest a role for IL-15Ralpha in aberrant T cell proliferation observed in HTLV-I-associated diseases...
  7. pmc Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides
    Y Tagaya
    Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:14444-9. 1997
    ..Such production of an intracellular lymphokine is not typical of other soluble interleukin systems, suggesting a biological function for IL-15 as an intracellular molecule...
  8. pmc Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway
    G Baldassarre
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:7970-5. 2001
    ..Therefore, the HMGI-C/T-mediated chronic stimulation of the IL-2/IL-15 pathway could be responsible for the onset of NK-T/NK cell lymphomas in HMGI-C/T TG mice...