Ana P Goncalvez

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention
    Ana P Goncalvez
    Molecular Viral Biology Section and Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9422-7. 2007
  2. pmc Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Virol 82:7009-21. 2008
  3. pmc Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody
    CHING JUH LAI
    Laboratory of Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8005, Bethesda, MD 20892, USA
    J Virol 81:12766-74. 2007
  4. pmc Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6349, 50 South Dr, MSC 8009, Bethesda, MD 20892, USA
    J Virol 78:12919-28. 2004
  5. pmc Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus
    Ruhe Men
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:4665-74. 2004
  6. pmc Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6349, 50 South Dr, MSC 8009, Bethesda, MD 20892, USA
    J Virol 78:12910-8. 2004
  7. ncbi request reprint Diversity and evolution of the envelope gene of dengue virus type 1
    Ana P Goncalvez
    Instituto Venezolano de Investigaciones Cienti ficas, Caracas, Venezuela
    Virology 303:110-9. 2002

Detail Information

Publications7

  1. pmc Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention
    Ana P Goncalvez
    Molecular Viral Biology Section and Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:9422-7. 2007
    ..Importantly, a 9-aa deletion at the N terminus of the CH(2) domain in the Fc region abrogated the enhancing activity...
  2. pmc Humanized monoclonal antibodies derived from chimpanzee Fabs protect against Japanese encephalitis virus in vitro and in vivo
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Virol 82:7009-21. 2008
    ....
  3. pmc Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4)-neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively transferred humanized antibody
    CHING JUH LAI
    Laboratory of Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8005, Bethesda, MD 20892, USA
    J Virol 81:12766-74. 2007
    ..This substitution was also present in all naturally occurring isolates belonging to DENV-4 genotype III. These studies have important implications for possible antibody-mediated prevention of DENV infection...
  4. pmc Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6349, 50 South Dr, MSC 8009, Bethesda, MD 20892, USA
    J Virol 78:12919-28. 2004
    ..From the locations of these amino acids, Fab 1A5 appears to recognize a novel epitope that has not been mapped before with a flavivirus monoclonal antibody...
  5. pmc Identification of chimpanzee Fab fragments by repertoire cloning and production of a full-length humanized immunoglobulin G1 antibody that is highly efficient for neutralization of dengue type 4 virus
    Ruhe Men
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 78:4665-74. 2004
    ..03 to 0.05 micro g/ml. The DENV-4 binding affinities were 0.42 nM for Fab 5H2 and 0.24 nM for full-length IgG1 5H2. Monoclonal antibody IgG1 5H2 may prove valuable for passive immunoprophylaxis against dengue virus in humans...
  6. pmc Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses
    Ana P Goncalvez
    Molecular Viral Biology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6349, 50 South Dr, MSC 8009, Bethesda, MD 20892, USA
    J Virol 78:12910-8. 2004
    ..2 to 4.2 microg/ml. This humanized antibody represents an attractive candidate for further development of immunoprophylaxis against DENV and perhaps other flavivirus-associated diseases...
  7. ncbi request reprint Diversity and evolution of the envelope gene of dengue virus type 1
    Ana P Goncalvez
    Instituto Venezolano de Investigaciones Cienti ficas, Caracas, Venezuela
    Virology 303:110-9. 2002
    ..Very low average value of the ratio of nonsynonymous-to-synonymous nucleotide substitutions, relative to the respective sites (0.046), indicated that the evolution of the E gene of the DV-1 is subject mostly to purifying selection...