Tam Luong Nguyen

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Targeting RSK: an overview of small molecule inhibitors
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Anticancer Agents Med Chem 8:710-6. 2008
  2. ncbi request reprint Three-dimensional model of the pore form of anthrax protective antigen. Structure and biological implications
    T L Nguyen
    Developmental Therapeutics Program, National Cancer Institute, 378 Ware Drive, Frederick, MD 21702, USA
    J Biomol Struct Dyn 22:253-65. 2004
  3. ncbi request reprint A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Med Chem 48:6107-16. 2005
  4. pmc Interaction of pseudolaric acid B with the colchicine site of tubulin
    Taradas Sarkar
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 USA
    Biochem Pharmacol 84:444-50. 2012
  5. pmc Interactions of halichondrin B and eribulin with tubulin
    Ruoli Bai
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, United States
    J Chem Inf Model 51:1393-404. 2011
  6. pmc Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, Frederick, Maryland, USA
    Mol Cancer Ther 11:1103-11. 2012
  7. ncbi request reprint Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Bioorg Med Chem 14:6097-105. 2006
  8. ncbi request reprint An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, Developmental Therapeutics Program, SAIC, National Cancer Institute, Frederick, MD 21702, USA
    J Struct Biol 151:30-40. 2005
  9. ncbi request reprint Identification of small molecule inhibitors of anthrax lethal factor
    Rekha G Panchal
    Developmental Therapeutics Program, NCI Frederick, Frederick, Maryland 21702 1201, USA
    Nat Struct Mol Biol 11:67-72. 2004
  10. ncbi request reprint Structural model of the pre-pore ring-like structure of Panton-Valentine leukocidin: providing dimensionality to biophysical and mutational data
    M Javad Aman
    Integrated BioTherapeutics, Inc, Germantown, MD 20876, USA
    J Biomol Struct Dyn 28:1-12. 2010

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Targeting RSK: an overview of small molecule inhibitors
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Anticancer Agents Med Chem 8:710-6. 2008
    ..Because each compound may have therapeutic potential, the nonspecific kinase inhibitors as well as the RSK specific inhibitors will be discussed...
  2. ncbi request reprint Three-dimensional model of the pore form of anthrax protective antigen. Structure and biological implications
    T L Nguyen
    Developmental Therapeutics Program, National Cancer Institute, 378 Ware Drive, Frederick, MD 21702, USA
    J Biomol Struct Dyn 22:253-65. 2004
    ....
  3. ncbi request reprint A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland 21702, USA
    J Med Chem 48:6107-16. 2005
    ....
  4. pmc Interaction of pseudolaric acid B with the colchicine site of tubulin
    Taradas Sarkar
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702 USA
    Biochem Pharmacol 84:444-50. 2012
    ..The binding model of PAB revealed common pharmacophoric features between PAB and colchicinoids, not readily apparent from their chemical structures...
  5. pmc Interactions of halichondrin B and eribulin with tubulin
    Ruoli Bai
    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, United States
    J Chem Inf Model 51:1393-404. 2011
    ..Overall, these results established a mechanistic basis for the antimitotic activity of the halichondrin class of compounds...
  6. pmc Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, Frederick, Maryland, USA
    Mol Cancer Ther 11:1103-11. 2012
    ....
  7. ncbi request reprint Homology model of RSK2 N-terminal kinase domain, structure-based identification of novel RSK2 inhibitors, and preliminary common pharmacophore
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
    Bioorg Med Chem 14:6097-105. 2006
    ..The RSK2 NTD model was used to identify two novel RSK2 inhibitors from the National Cancer Institute open chemical repository and to develop a preliminary structure-based pharmacophore model...
  8. ncbi request reprint An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, Developmental Therapeutics Program, SAIC, National Cancer Institute, Frederick, MD 21702, USA
    J Struct Biol 151:30-40. 2005
    ....
  9. ncbi request reprint Identification of small molecule inhibitors of anthrax lethal factor
    Rekha G Panchal
    Developmental Therapeutics Program, NCI Frederick, Frederick, Maryland 21702 1201, USA
    Nat Struct Mol Biol 11:67-72. 2004
    ..Three of these compounds have K(i) values in the 0.5-5 microM range and show competitive inhibition. These molecular scaffolds may be used to develop therapeutically viable inhibitors of LF...
  10. ncbi request reprint Structural model of the pre-pore ring-like structure of Panton-Valentine leukocidin: providing dimensionality to biophysical and mutational data
    M Javad Aman
    Integrated BioTherapeutics, Inc, Germantown, MD 20876, USA
    J Biomol Struct Dyn 28:1-12. 2010
    ..Here, we report an all-atom model of the macromolecular structure of Panton-Valentine leukocidin in its octameric, pre-pore conformation that confirms and extends our understanding of the toxin's mechanism of action...
  11. pmc The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A
    Tam Luong Nguyen
    Target Structure Based Drug Discovery Group, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Chem Inf Model 50:2019-28. 2010
    ....