Lance M Optican

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 133:923-40. 2010
  2. pmc Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease
    Lance M Optican
    National Eye Institute, Bethesda, MD, USA
    Prog Brain Res 171:567-70. 2008
  3. pmc The role of omnipause neurons: why glycine?
    Lance M Optican
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, DHHS, Bethesda, MD, USA
    Prog Brain Res 171:115-21. 2008
  4. ncbi request reprint Sensorimotor transformation for visually guided saccades
    Lance M Optican
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892 4435, USA
    Ann N Y Acad Sci 1039:132-48. 2005
  5. ncbi request reprint Acute superior oblique palsy in monkeys: II. Changes in dynamic properties during vertical saccades
    Xiaoyan Shan
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2612-20. 2007
  6. pmc The effect of acute superior oblique palsy on torsional optokinetic nystagmus in monkeys
    Xiaoyan Shan
    Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 49:1421-8. 2008
  7. ncbi request reprint Acute superior oblique palsy in monkeys: III. Relationship to Listing's Law
    Jing Tian
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltiomre, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2621-5. 2007
  8. ncbi request reprint A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
    Aasef G Shaikh
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 130:3020-31. 2007
  9. pmc Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neuroophthalmol 28:329-36. 2008
  10. doi request reprint Impulsive head rotation resets oculopalatal tremor: examination of a model
    Ke Liao
    Daroff Dell Osso Laboratory, Veterans Affairs Medical Center and Case Western Reserve University, Department of Neurology, University Hospitals, Cleveland, OH, USA
    Prog Brain Res 171:227-34. 2008

Detail Information

Publications45

  1. pmc Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 133:923-40. 2010
    ..We conclude that oculopalatal tremor oscillations originate in the hypertrophic inferior olive and are amplified by learning in the cerebellum...
  2. pmc Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease
    Lance M Optican
    National Eye Institute, Bethesda, MD, USA
    Prog Brain Res 171:567-70. 2008
    ..We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs)...
  3. pmc The role of omnipause neurons: why glycine?
    Lance M Optican
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, DHHS, Bethesda, MD, USA
    Prog Brain Res 171:115-21. 2008
    ..We propose a new hypothesis: the OPNs play a general role as a modulator of arousal in orienting subsystems, such as saccades, pursuit, head movements, etc...
  4. ncbi request reprint Sensorimotor transformation for visually guided saccades
    Lance M Optican
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD 20892 4435, USA
    Ann N Y Acad Sci 1039:132-48. 2005
    ..Thus, the information needed to make accurate movements must come from another part of the brain, which is proposed to be the cerebellum. Here it is shown how the cerebellum could perform the sensorimotor transformation...
  5. ncbi request reprint Acute superior oblique palsy in monkeys: II. Changes in dynamic properties during vertical saccades
    Xiaoyan Shan
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2612-20. 2007
    ..To investigate vertical and torsional eye motion during and immediately after vertical saccades with acute acquired superior oblique palsy (SOP) in monkeys...
  6. pmc The effect of acute superior oblique palsy on torsional optokinetic nystagmus in monkeys
    Xiaoyan Shan
    Department of Neurology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 49:1421-8. 2008
    ..To investigate the effects of acquired superior oblique palsy (SOP) and corrective strabismus surgery on torsional optokinetic nystagmus (tOKN) in monkeys...
  7. ncbi request reprint Acute superior oblique palsy in monkeys: III. Relationship to Listing's Law
    Jing Tian
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltiomre, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2621-5. 2007
    ..To investigate the three-dimensional orientation of the eye and its relationship to Listing's Law in monkeys with acute acquired superior oblique palsy (SOP)...
  8. ncbi request reprint A new familial disease of saccadic oscillations and limb tremor provides clues to mechanisms of common tremor disorders
    Aasef G Shaikh
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 130:3020-31. 2007
    ....
  9. pmc Saccadic burst cell membrane dysfunction is responsible for saccadic oscillations
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neuroophthalmol 28:329-36. 2008
    ..Our simulations suggest that alterations in membrane properties that lead to an increase in PIR, a reduction in external glycinergic inhibition, or both can cause saccadic oscillations...
  10. doi request reprint Impulsive head rotation resets oculopalatal tremor: examination of a model
    Ke Liao
    Daroff Dell Osso Laboratory, Veterans Affairs Medical Center and Case Western Reserve University, Department of Neurology, University Hospitals, Cleveland, OH, USA
    Prog Brain Res 171:227-34. 2008
    ..Thus, the experimental tests supported the prediction of our model for OPT...
  11. pmc Terminator disparity contributes to stereo matching for eye movements and perception
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892
    J Neurosci 33:18867-79. 2013
    ..These findings prove that terminators contribute to stereo matching, and constrain the type of neuronal mechanisms that might be responsible for the detection of terminator disparity. ..
  12. ncbi request reprint Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons
    Stefano Ramat
    Department of Neurology, The Johns Hopkins University, Pathology Building, Suite 2 210, 600 N Wolfe Str, Baltimore, MD 21231, USA
    Exp Brain Res 160:89-106. 2005
    ..Our model proposes a novel mechanism for generating oscillations in the oculomotor system and perhaps in other motor systems too...
  13. pmc The nonlinearity of passive extraocular muscles
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, United States
    Ann N Y Acad Sci 1233:17-25. 2011
    ..We argue against this common belief: the specific nonlinearity of passive EOMs may actually make it easier for the brain to control the plant than if muscles were linear...
  14. doi request reprint Inferior olive hypertrophy and cerebellar learning are both needed to explain ocular oscillations in oculopalatal tremor
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, USA
    Prog Brain Res 171:219-26. 2008
    ..Since electrotonic coupling of IO cells depends on connexin proteins, drugs that block gap junctions, such as anti-malarial agents, might provide a novel therapy for OPT...
  15. pmc Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities
    Aasef G Shaikh
    Department of Neurology, Case Western Reserve University, Cleveland, OH 44106 5040, USA
    Cerebellum 12:97-107. 2013
    ....
  16. pmc Sustained eye closure slows saccades
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, United States
    Vision Res 50:1665-75. 2010
    ..These results indicate a role for OPNs in generating the abrupt onset and high velocities of saccades. We hypothesize that the mechanism involved is PIR in pre-motor burst neurons...
  17. pmc Neuromimetic model of saccades for localizing deficits in an atypical eye-movement pathology
    Pierre M Daye
    Laboratory of Sensorimotor Research, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 11:125. 2013
    ..We sought to demonstrate that neuromimetic models of the ocular motor brainstem could be used to test assumptions of the neural deficits linked to a patient's behavior...
  18. ncbi request reprint Effects of tenotomy surgery on congenital nystagmus waveforms in adult patients. Part II. Dynamical systems analysis
    Kenichiro Miura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bldg 49, Rm 2A50, Bethesda, MD 20892, USA
    Vision Res 43:2357-62. 2003
    ..The change in dimensionality was less than 5% on average. The results suggest that the tenotomy has no effect, or only a quite small effect, on the underlying mechanism of the CN beats...
  19. pmc The viscoelastic properties of passive eye muscle in primates. III: force elicited by natural elongations
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e9595. 2010
    ..This model is able to account reasonably well for our data, and could thus be incorporated into models of the eye plant...
  20. ncbi request reprint Acute superior oblique palsy in monkeys: I. Changes in static eye alignment
    Xiaoyan Shan
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:2602-11. 2007
    ..To investigate immediate and long-term changes in static ocular alignment with acute acquired superior oblique palsy (SOP) in monkeys...
  21. pmc OrbitView: Eye movement visualization software
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD, USA
    J Neurosci Methods 200:181-4. 2011
    ..Having useful functions such as slow-play, pause and exaggeration of the movements, this new software provides a research and teaching tool to aid interpretation of the recorded eye movements...
  22. doi request reprint Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye, Institute, Bethesda, MD, USA
    Prog Brain Res 171:47-52. 2008
    ..The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits...
  23. pmc The viscoelastic properties of passive eye muscle in primates. I: static forces and step responses
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD, USA
    PLoS ONE 4:e4850. 2009
    ..Eye plant models, which for lack of data had to rely on (erroneous) assumptions, will have to be updated to incorporate these properties...
  24. pmc Interaction between Purkinje cells and inhibitory interneurons may create adjustable output waveforms to generate timed cerebellar output
    Simon Hong
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2770. 2008
    ..We show that the suggested mechanism can endow the cerebellar cortex with the versatility to learn almost any temporal pattern, in addition to those that arise in classical conditioning...
  25. pmc pyElectrode: an open-source tool using structural MRI for electrode positioning and neuron mapping
    Pierre M Daye
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA
    J Neurosci Methods 213:123-31. 2013
    ..It also allows the experimenter to visualize recording or stimulation sites during experiments. Finally, it can display and output those sites on an MRI slice background in a format suitable for publication...
  26. ncbi request reprint Dynamic eye plant models and the control of eye movements
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Strabismus 11:17-31. 2003
    ..This difference arises because muscle force is a function of both innervation and muscle length...
  27. pmc Ocular following in humans: spatial properties
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD 20815, USA
    J Vis 12:. 2012
    ....
  28. ncbi request reprint Recovery of saccadic dysmetria following localized lesions in monkey superior colliculus
    Doug P Hanes
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 4435, USA
    Exp Brain Res 160:312-25. 2005
    ..The persistence of the latency and velocity deficits despite the recovery of amplitude deficits indicates that saccadic latency and peak velocity are dependent upon the SC whereas saccadic amplitude is not...
  29. ncbi request reprint Distributed model of collicular and cerebellar function during saccades
    Lance M Optican
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 956:164-77. 2002
    ..No explicit spatial-to-temporal transformation with a normalization step is needed...
  30. pmc Short-term memory trace in rapidly adapting synapses of inferior temporal cortex
    Yasuko Sugase-Miyamoto
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS Comput Biol 4:e1000073. 2008
    ..Simulations of a matched filter model match the experimental results, suggesting that area TE neurons store a synaptic memory trace during short-term visual memory...
  31. pmc Eye movement sequence generation in humans: Motor or goal updating?
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, Bethesda, MD, USA
    J Vis 10:. 2010
    ..This finding suggests that the human saccadic system is capable of executing sequences of saccades to multiple targets by planning multiple motor commands, which are then updated by serial subtraction of ongoing motor output...
  32. pmc A Motion-from-Form Mechanism Contributes to Extracting Pattern Motion from Plaids
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892
    J Neurosci 36:3903-18. 2016
    ..At least for the eye movements reported here, a motion-from-form mechanism is thus involved in one of the most basic functions of the visual motion system: extracting motion direction from complex scenes...
  33. pmc The viscoelastic properties of passive eye muscle in primates. II: testing the quasi-linear theory
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, NIH, Bethesda, MD, USA
    PLoS ONE 4:e6480. 2009
    ..It is currently unknown whether other passive biological tissues behave similarly...
  34. pmc Hypothetical membrane mechanisms in essential tremor
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    J Transl Med 6:68. 2008
    ..Such instability is enhanced by increased neural membrane excitability and the circuit begins to oscillate. These oscillations manifest as tremor...
  35. pmc Action and perception are temporally coupled by a common mechanism that leads to a timing misperception
    Elena Pretegiani
    Laboratory of Sensorimotor Research, NEI, NIH, DHHS, Bethesda, Maryland, 20892 4435, EVA Laboratory, University of Siena, 53100 Siena, Italy
    J Neurosci 35:1493-504. 2015
    ..This common source of modulation determines how competition between stimuli is resolved, causes the TA dependence of action and perception to be the same, and causes the misperception. ..
  36. pmc Vestibulo-ocular reflex suppression during head-fixed saccades reveals gaze feedback control
    Pierre M Daye
    Pierre et Marie Curie Paris 6 Université, INSERM UMRS 975, CNRS 7225, Paris, France, Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435
    J Neurosci 35:1192-8. 2015
    ..We propose that the brain always programs a change in gaze using feedback based on gaze and head signals, rather than on separate eye and head trajectories. ..
  37. pmc Temporal evolution of pattern disparity processing in humans
    Christian Quaia
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 33:3465-76. 2013
    ....
  38. doi request reprint Saccade detection using a particle filter
    Pierre M Daye
    ICM, Pierre et Marie Curie Paris 6 Université, INSERM UMRS 975, CNRS 7225, F 75013, Paris, France Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA Electronic address
    J Neurosci Methods 235:157-68. 2014
    ..This task is especially difficult, because the range of saccadic amplitudes goes from microsaccades (less than 1°) to large exploratory saccades (40°)...
  39. pmc Hierarchical control of two-dimensional gaze saccades
    Pierre M Daye
    NIH, NEI, Laboratory of Sensorimotor Research, 49 Convent Drive, Room 2A50, Bethesda, MD, 20892 4435, USA
    J Comput Neurosci 36:355-82. 2014
    ..We conclude by showing how our model can be easily extended to control structures with more linked segments, such as the control of coordinated eye on head on trunk movements. ..
  40. ncbi request reprint Effects of tenotomy surgery on congenital nystagmus waveforms in adult patients. Part I. Wavelet spectral analysis
    Kenichiro Miura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bldg 49, Rm 2A50, Bethesda, MD 20892, USA
    Vision Res 43:2345-56. 2003
    ..No common effect was found across the patients on the wavelet spectra of the CN beat, suggesting that tenotomy surgery has no effect, or only a quite small effect, on the waveform structure of CN...
  41. ncbi request reprint Saccade-related spread of activity across superior colliculus may arise from asymmetry of internal connections
    Hiroyuki Nakahara
    Laboratory for Mathematical Neuroscience and for Integrated Theoretical Neuroscience, RIKEN Brain Science Institute, Saitama, Japan
    J Neurophysiol 96:765-74. 2006
    ..Other sensory maps in the brain (e.g., visual cortex) are also nonlinear and our analysis suggests that the consequences of asymmetric connections in those areas should be considered...
  42. ncbi request reprint Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons
    Kenichiro Miura
    Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comput Neurosci 20:25-41. 2006
    ..Thus, we propose that two biophysical mechanisms are responsible for saccade slowing after OPN lesions: reduced T-current and reduced NMDA current, both of which are caused by the loss of glycine from OPNs...
  43. ncbi request reprint Properties of saccades in Duane retraction syndrome
    Demet Yuksel
    Laboratory of Neurophysiology, Universite Catholique de Louvain, Avenue Georges Lemaître 4, 1348 Louvain la Neuve, Belgium
    Invest Ophthalmol Vis Sci 46:3144-51. 2005
    ..To improve understanding of the binocular control of saccades by making high-resolution eye movement recordings in patients with unilateral Duane retraction syndrome (DRS) type I (marked by congenital absence of the sixth cranial nerve)...
  44. ncbi request reprint A model that integrates eye velocity commands to keep track of smooth eye displacements
    Gunnar Blohm
    CESAME, Universite Catholique de Louvain, 4, Avenue G Lemaître, 1348, Louvain la Neuve, Belgium
    J Comput Neurosci 21:51-70. 2006
    ..Thus, this model reconciles the earlier contradictory reports from the literature about compensation for smooth eye movements before saccades because it involves a slow integration process...
  45. ncbi request reprint What clinical disorders tell us about the neural control of saccadic eye movements
    Stefano Ramat
    University of Pavia, Pavia, Italy
    Brain 130:10-35. 2007
    ..We raise general questions for both scientists and clinicians that will assist in their efforts to understand the neural control of movement, improve diagnostic criteria and develop new treatments...