Li Hua Wang

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, National Institutes of Health, PO Box B, Frederick, Maryland 21702, USA
    Nat Med 10:40-7. 2004
  2. pmc Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice
    Xulong Zhang
    Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    BMC Cancer 7:149. 2007
  3. ncbi request reprint Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Cancer Cell 10:487-99. 2006
  4. ncbi request reprint Nuclear receptors as negative modulators of STAT3 in multiple myeloma
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
    Cell Cycle 4:242-5. 2005
  5. ncbi request reprint Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Immunity 20:205-18. 2004
  6. ncbi request reprint The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity
    Li Hua Wang
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Maryland 21702, USA
    Cancer Res 63:2046-51. 2003
  7. pmc Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP
    Li Hua Wang
    Basic Research Program, SAIC Frederick, Frederick, MD, USA
    Blood 110:4373-84. 2007
  8. pmc Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 3:e88. 2007
  9. ncbi request reprint 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain
    Han Jong Kim
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, Science Applications International Corporation Frederick, Maryland, USA
    Cancer Res 67:2595-602. 2007
  10. ncbi request reprint Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cancer Biol Ther 3:188-94. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, National Institutes of Health, PO Box B, Frederick, Maryland 21702, USA
    Nat Med 10:40-7. 2004
    ..Our results provide the proof of principle for a new strategy to inhibit breast cancer at the level of DNA binding, rather than the classical antagonism of estrogen binding...
  2. pmc Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice
    Xulong Zhang
    Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
    BMC Cancer 7:149. 2007
    ..To explore the possibility of a double-stranded decoy oligodeoxynucleotide (ODN) targeted blocking STAT3 over-activated tumor cells, we, here, evaluate the efficacy of STAT3 decoy ODN on human lung cancer cells in vitro and in vivo...
  3. ncbi request reprint Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland 21702, USA
    Cancer Cell 10:487-99. 2006
    ..DIBA does not affect phosphorylation of HER2, MAPK, AKT, and AIB1, suggesting that DIBA-modified ERalpha may induce a switch from agonistic to antagonistic effects of TAM on resistant breast cancer cells...
  4. ncbi request reprint Nuclear receptors as negative modulators of STAT3 in multiple myeloma
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, Maryland, USA
    Cell Cycle 4:242-5. 2005
    ..Given the importance of IL-6 in multiple myeloma, the estrogen receptor-STAT3 or PPARgamma-STAT3 interaction may have significant therapeutic implications in multiple myeloma...
  5. ncbi request reprint Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells
    Li Hua Wang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Immunity 20:205-18. 2004
    ....
  6. ncbi request reprint The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity
    Li Hua Wang
    Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Maryland 21702, USA
    Cancer Res 63:2046-51. 2003
    ....
  7. pmc Inhibition of adhesive interaction between multiple myeloma and bone marrow stromal cells by PPARgamma cross talk with NF-kappaB and C/EBP
    Li Hua Wang
    Basic Research Program, SAIC Frederick, Frederick, MD, USA
    Blood 110:4373-84. 2007
    ..These studies provide the framework for PPARgamma-based pharmacological strategies targeting adhesive interactions of MM cells with the bone marrow microenvironment...
  8. pmc Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS
    Ping An
    Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, Maryland, United States of America
    PLoS Pathog 3:e88. 2007
    ..These results implicate regulatory PPIA polymorphisms as a component of genetic susceptibility to HIV-1 infection or disease progression, affirming the important role of PPIA in HIV-1 pathogenesis...
  9. ncbi request reprint 15-deoxy-Delta12,14-prostaglandin J2 inhibits transcriptional activity of estrogen receptor-alpha via covalent modification of DNA-binding domain
    Han Jong Kim
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, Science Applications International Corporation Frederick, Maryland, USA
    Cancer Res 67:2595-602. 2007
    ....
  10. ncbi request reprint Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells
    David R Hodge
    Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Cancer Biol Ther 3:188-94. 2004
    ..Our data suggests that mechanisms of resistance to induced apoptosis and cellular proliferation are separate and distinct in cytokine dependent myeloma cells...
  11. ncbi request reprint Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor gamma activated by macrophage-derived 12/15-lipoxygenase ligands
    Xiao Yi Yang
    Intramural Research Support Program, Science Applications International Corporation, Frederick, MD 21702, USA
    J Biol Chem 277:3973-8. 2002
    ..These data provide a mechanism whereby IL-4 may indirectly affect Thp function via PPARgamma activated by macrophage products of the 12/15-LO pathway...
  12. pmc Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individuals
    Ping An
    Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Genet 3:e19. 2007
    ....
  13. pmc A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer
    Xiao Yi Yang
    Basic Research Program, SAIC Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    PPAR Res 2008:961753. 2008
    ....
  14. ncbi request reprint Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways
    Zsuzsanna S Nagy
    Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 77030, USA
    J Leukoc Biol 72:819-28. 2002
    ..We conclude that IL-2 family cytokines tightly control Stat5 serine phosphorylation through a kinase distinct from the Stat3 serine kinase...