L Wolff

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Meeting report: Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, MD, May 13-16, 2007
    Linda Wolff
    National Cancer Institute, Bethesda, MD 20892, USA
    Exp Hematol 36:523-32. 2008
  2. ncbi request reprint Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice
    Linda Wolff
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Oncogene 22:9265-74. 2003
  3. ncbi request reprint Three genes with different functions in transformation are regulated by c-Myb in myeloid cells
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Blood Cells Mol Dis 27:483-8. 2001
  4. ncbi request reprint A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo
    Linda Wolff
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Blood Cells Mol Dis 32:226-31. 2004
  5. pmc A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms
    Linda Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Virol 77:4965-71. 2003
  6. ncbi request reprint Myb-induced transformation
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Crit Rev Oncog 7:245-60. 1996
  7. ncbi request reprint Meeting report: Sixth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, May 1-4, 2005
    Linda Wolff
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Hematol 33:1436-42. 2005
  8. ncbi request reprint Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation
    M Schmidt
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA
    Oncogene 20:6205-14. 2001
  9. ncbi request reprint Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10
    R Koller
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Virology 224:224-34. 1996
  10. ncbi request reprint Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia
    J Bies
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA
    Leukemia 13:S116-7. 1999

Collaborators

Detail Information

Publications29

  1. doi request reprint Meeting report: Seventh International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, MD, May 13-16, 2007
    Linda Wolff
    National Cancer Institute, Bethesda, MD 20892, USA
    Exp Hematol 36:523-32. 2008
  2. ncbi request reprint Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice
    Linda Wolff
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Oncogene 22:9265-74. 2003
    ..Mice deficient in both alleles were not more susceptible to myeloid disease than those deficient in one allele, raising the possibility that there are opposing forces related to the development of myeloid leukemia in Ink4b null mice...
  3. ncbi request reprint Three genes with different functions in transformation are regulated by c-Myb in myeloid cells
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4255, USA
    Blood Cells Mol Dis 27:483-8. 2001
    ..c-Myb inhibits expression of this gene, however, and therefore acts to promote a pathway which is abnormal in mature cells. This activity of c-Myb collaborates with its maintenance of c-myc expression to promote growth...
  4. ncbi request reprint A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo
    Linda Wolff
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Blood Cells Mol Dis 32:226-31. 2004
    ....
  5. pmc A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms
    Linda Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Virol 77:4965-71. 2003
    ..Interesting, MCF recombinant envelope was expressed in the lymphoid but not the myeloid neoplasms of BALB/c mice. This retrovirus has the potential for accelerating myeloid disease in genetically engineered mice...
  6. ncbi request reprint Myb-induced transformation
    L Wolff
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Crit Rev Oncog 7:245-60. 1996
    ..Although c-myb's involvement in human leukemia has been suggested, it has never been clearly established and should be investigated further...
  7. ncbi request reprint Meeting report: Sixth International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, May 1-4, 2005
    Linda Wolff
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Hematol 33:1436-42. 2005
  8. ncbi request reprint Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation
    M Schmidt
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA
    Oncogene 20:6205-14. 2001
    ..Therefore, the transcriptional regulator c-Myb appears to prevent activation of a growth arrest pathway that normally accompanies monocyte maturation...
  9. ncbi request reprint Mml1, a new common integration site in murine leukemia virus-induced promonocytic leukemias maps to mouse chromosome 10
    R Koller
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Virology 224:224-34. 1996
    ..It is anticipated that future experiments will determine whether Mml1 integration prevents down regulation of c-myb expression or activates another gene on chromosome 10...
  10. ncbi request reprint Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia
    J Bies
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA
    Leukemia 13:S116-7. 1999
  11. ncbi request reprint Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo
    R Opavsky
    Laboratory of Cellular Oncology, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 276:38795-807. 2001
    ..The ubiquitous expression in vivo is in contrast to previously reported expression limited to corpus luteum and highly angiogenic tissues such as tumors and wound tissue...
  12. pmc Moloney murine leukemia virus-induced myeloid tumors in adult BALB/c mice: requirement of c-myb activation but lack of v-abl involvement
    G L Shen-Ong
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 61:3721-5. 1987
    ..Our results also indicate that tumor-specific alteration at the 5' end of the myb gene plays an important role in the development of these tumors...
  13. ncbi request reprint Retroviral insertional mutagenesis in murine promonocytic leukemias: c-myb and Mml1
    L Wolff
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892 4255, USA
    Curr Top Microbiol Immunol 211:191-9. 1996
    ..Recently we identified a new target of integration, Mml1, which is rearranged in ten promonocytic leukemias that do not have c-myb rearrangements. This locus which was mapped to chromosome 10 is presently being characterized...
  14. pmc The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia
    L Wolff
    Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland 20892
    J Virol 62:2158-63. 1988
    ....
  15. ncbi request reprint Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines
    C Maucher
    Institut für Klinische Molekularbiologie und Tumorgenetik, GSF, Munich, Germany
    FEBS Lett 427:29-35. 1998
    ....
  16. pmc Transmembrane domain of the envelope gene of a polycythemia-inducing retrovirus determines erythropoietin-independent growth
    S W Chung
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 86:7957-60. 1989
    ..Our results indicate that the 113-base-pair Fok I-Cla I fragment, which encodes primarily the transmembrane domain of the envelope protein, determines erythropoietin-independent growth...
  17. pmc Activation of c-myb is an early bone-marrow event in a murine model for acute promonocytic leukemia
    K Nason-Burchenal
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:1619-23. 1993
    ..This approach for detecting preleukemic cells will now allow the study of mechanisms by which these preleukemic cells progress to a more transformed state and, perhaps, to a more differentiated state...
  18. ncbi request reprint Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells
    C Nicot
    Division of Basic Sciences, Basic Research Laboratory, NIH, Bethesda, Maryland 20892, USA
    AIDS Res Hum Retroviruses 16:1629-32. 2000
    ....
  19. ncbi request reprint Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc
    Peter Haviernik
    Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Oncogene 22:1600-10. 2003
    ..These data overall supports the hypothesis that the critical inactivation event in these hematopoietic neoplasms is elimination of p19(Arf), and not Ink4 function...
  20. ncbi request reprint The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells
    Martina Schmidt
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Blood 103:4142-9. 2004
    ....
  21. ncbi request reprint Activation of c-myb by 5' retrovirus promoter insertion in myeloid neoplasms is dependent upon an intact alternative splice donor site (SD') in gag
    Jean Marie Ramirez
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS UMR5121, UMI, IFR122, Montpellier, France
    Virology 330:398-407. 2004
    ..Importantly, there was a complete lack of myeloid tumors associated with 5' insertional mutagenic activation of c-myb, suggesting the specific requirement of the SD' site in this mechanism...
  22. ncbi request reprint Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains
    Jan Markus
    Laboratory of Molecular Virology, Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 833 91, Bratislava, Slovakia
    Gene 319:117-26. 2003
    ....
  23. ncbi request reprint p15Ink4b: dual function in myelopoiesis and inactivation in myeloid disease
    Michael Rosu-Myles
    Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 4124A, 37 Convent Drive MSC 4263, Bethesda, MD 20892 4263, USA
    Blood Cells Mol Dis 40:406-9. 2008
    ..Here we outline the mechanisms by which p15 is silenced and the functions of this CDKI in myelopoiesis as well as discuss the implications of these findings to myeloid disease...
  24. ncbi request reprint Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors
    Michael Rosu-Myles
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4263, USA
    Exp Hematol 35:394-406. 2007
    ..Despite this, the role of Ink4b in hematopoiesis remains unclear. Here we examined the role of Ink4b in blood cell formation using Ink4b-deficient (Ink4b(-/-)) mice...
  25. pmc Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation
    Christopher Slape
    Genetics Branch, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20889 5105, USA
    Cancer Res 67:5148-55. 2007
    ..Our data provide new insights into NHD13-mediated leukemogenesis as well as retroviral insertional mutagenesis mechanisms...
  26. pmc Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia
    Rose M Ko
    Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Leuk Res 32:1101-11. 2008
    ..These results strongly suggest that p15(Ink4b) loss must be accompanied by additional oncogenic changes for RUNX1-ETO-associated AML to develop...
  27. ncbi request reprint Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16)
    Jan Markus
    Laboratory of Cellular Oncology, National Cancer Institute and National Human Genome Research Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:992-1000. 2007
    ....
  28. ncbi request reprint Interferon beta increases c-Myc proteolysis in mouse monocyte/macrophage leukemia cells
    Xinrong Hu
    Leukemogenesis Section, Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Leuk Res 29:1307-14. 2005
    ..Our data, as well as that of others, indicate that multiple levels of c-Myc expression can be affected by IFN treatment and this contributes to rapid growth arrest in the G1 phase of the cell cycle...
  29. ncbi request reprint Linkage on chromosome 10 of several murine retroviral integration loci associated with leukaemia
    Peter Haviernik
    Leukemogenesis Section, Laboratory of Cellular Oncology, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    J Gen Virol 83:819-27. 2002
    ..These genes could not be linked to tumour formation by the virus but their homologous sequences were found on human chromosome 6, thus allowing extension of the syntenic region on mouse chromosome 10 to approximately 250 kb...