Z M Zheng

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers
    Z M Zheng
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Virol 71:9096-107. 1997
  2. pmc Function of a bovine papillomavirus type 1 exonic splicing suppressor requires a suboptimal upstream 3' splice site
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Virol 73:29-36. 1999
  3. ncbi request reprint Parameters that affect in vitro splicing of bovine papillomavirus type 1 late pre-mRNAs
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    J Virol Methods 85:203-14. 2000
  4. pmc Optimization of a weak 3' splice site counteracts the function of a bovine papillomavirus type 1 exonic splicing suppressor in vitro and in vivo
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 74:5902-10. 2000
  5. pmc A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 41, Room D305, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 95:14088-93. 1998
  6. pmc Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:10612-22. 2000
  7. doi request reprint Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
    Y Tang
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Oncogene 32:2792-8. 2013
  8. pmc Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells
    S Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Oncogene 25:2094-104. 2006

Collaborators

Detail Information

Publications8

  1. pmc Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers
    Z M Zheng
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Virol 71:9096-107. 1997
    ....
  2. pmc Function of a bovine papillomavirus type 1 exonic splicing suppressor requires a suboptimal upstream 3' splice site
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 5055, USA
    J Virol 73:29-36. 1999
    ..Mutational analyses demonstrated that the function of the ESS is sequence dependent and that only the C-rich region of the ESS is essential for suppression of splicing in all the pre-mRNAs tested...
  3. ncbi request reprint Parameters that affect in vitro splicing of bovine papillomavirus type 1 late pre-mRNAs
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute National Institutes of Health, Bethesda, MD 20892, USA
    J Virol Methods 85:203-14. 2000
    ..RNA transcribed from the pSP72 polylinker region, when supplied in trans, also suppressed splicing. These results suggest that a DNA template used to make RNA transcripts should avoid these sequences as much as possible...
  4. pmc Optimization of a weak 3' splice site counteracts the function of a bovine papillomavirus type 1 exonic splicing suppressor in vitro and in vivo
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 74:5902-10. 2000
    ..These data confirm that the function of the ESS requires a suboptimal upstream 3' splice site. A surprising finding of our study is the observation that SE1 can stimulate both the first and the second steps of splicing...
  5. pmc A pyrimidine-rich exonic splicing suppressor binds multiple RNA splicing factors and inhibits spliceosome assembly
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 41, Room D305, Bethesda, MD 20892 5055, USA
    Proc Natl Acad Sci U S A 95:14088-93. 1998
    ..The inhibition of splicing by the ESS can be partially relieved by excess purified HeLa SR proteins, suggesting that the ESS suppresses pre-mRNA splicing by interfering with normal bridging and recruitment activities of SR proteins...
  6. pmc Utilization of the bovine papillomavirus type 1 late-stage-specific nucleotide 3605 3' splice site is modulated by a novel exonic bipartite regulator but not by an intronic purine-rich element
    Z M Zheng
    Basic Research Laboratory, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 74:10612-22. 2000
    ..Our data indicate that BPV-1 splicing regulation is very complex and is likely to be controlled by multiple splicing factors during keratinocyte differentiation...
  7. doi request reprint Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
    Y Tang
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Oncogene 32:2792-8. 2013
    ..This study uncovers the role for general splicing machinery in tumorigenesis, and suggests that SRSF3 is a direct regulator of p53...
  8. pmc Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells
    S Tang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Oncogene 25:2094-104. 2006
    ..Altogether, our data indicate that a potent siRNA targeting to an essential or regulatory gene might induce a cell to develop siRNA-suppressive function...