Carol S Lutz

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Alternative polyadenylation of cyclooxygenase-2
    Tyra Hall-Pogar
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School Newark, NJ 07101, USA
    Nucleic Acids Res 33:2565-79. 2005
  2. pmc mRNA 3' end processing factors: a phylogenetic comparison
    Sarah K Darmon
    Department of Biochemistry and Molecular Biology and Graduate School of Biomedical Sciences, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Comp Funct Genomics 2012:876893. 2012
  3. doi request reprint Alternative polyadenylation: a twist on mRNA 3' end formation
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New JerseyMedical School, MSB E671, 185 South Orange Avenue, Newark, New Jersey 07101, USA
    ACS Chem Biol 3:609-17. 2008
  4. ncbi request reprint Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Mol Recognit 15:163-70. 2002
  5. pmc Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, MSB E671, 185 South Orange Ave, Newark, NJ 07103, USA
    Wiley Interdiscip Rev RNA 2:23-31. 2011
  6. doi request reprint Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Wiley Interdiscip Rev RNA 2:22-31. 2011
  7. pmc Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR
    Tyra Hall-Pogar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    RNA 13:1103-15. 2007
  8. doi request reprint In vivo methods to assess polyadenylation efficiency
    Lisa K Hague
    Department of Biochemistry and Molecular Biology, New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ, USA
    Methods Mol Biol 419:171-85. 2008
  9. pmc Novel upstream and downstream sequence elements contribute to polyadenylation efficiency
    Sarah K Darmon
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, and The Graduate School of Biomedical Sciences, Newark, NJ, USA
    RNA Biol 9:1255-65. 2012
  10. pmc Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation
    Jun Hu
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    RNA 11:1485-93. 2005

Collaborators

  • Alexandra Moreira
  • Jun Hu
  • Bin Tian
  • Haibo Zhang
  • Jeffrey Wilusz
  • Micah T McClain
  • J A James
  • Ashley L Cornett
  • Sarah K Darmon
  • Tyra Hall-Pogar
  • Lisa K Hague
  • Smita Shukla
  • Songchun Liang
  • S Joseph Leibovich
  • Zhenhua Pan
  • Zoltán H Németh
  • Perry J Blackshear
  • Genie Elson
  • Christine Milcarek
  • Devi Mukherjee
  • Ju Youn Lee
  • Edwin A Deitch
  • Gyorgy Hasko
  • Pal Pacher
  • Balázs Csóka
  • Masahide Tone
  • E Sylvester Vizi
  • William C Gause
  • Kathleen Martincic
  • Ling Hsiu Chung-Ganster
  • Min Gao
  • Reinout Raijmakers
  • Ger Pruijn
  • J Patrick O'Connor

Detail Information

Publications21

  1. pmc Alternative polyadenylation of cyclooxygenase-2
    Tyra Hall-Pogar
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School Newark, NJ 07101, USA
    Nucleic Acids Res 33:2565-79. 2005
    ..5-fold. Our data suggest for the first time that alternative polyadenylation of COX-2 is an important post-transcriptional regulatory event...
  2. pmc mRNA 3' end processing factors: a phylogenetic comparison
    Sarah K Darmon
    Department of Biochemistry and Molecular Biology and Graduate School of Biomedical Sciences, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Comp Funct Genomics 2012:876893. 2012
    ..These data suggest that polyadenylation of mRNAs is an ancient process...
  3. doi request reprint Alternative polyadenylation: a twist on mRNA 3' end formation
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New JerseyMedical School, MSB E671, 185 South Orange Avenue, Newark, New Jersey 07101, USA
    ACS Chem Biol 3:609-17. 2008
    ..It covers results from bioinformatics, as well as those from investigations of viral and tissue-specific studies and, importantly, will set the stage for what is yet to come...
  4. ncbi request reprint Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Mol Recognit 15:163-70. 2002
    ..These findings suggest that the structure of the U1A protein may be different when not part of the U1snRNP...
  5. pmc Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, MSB E671, 185 South Orange Ave, Newark, NJ 07103, USA
    Wiley Interdiscip Rev RNA 2:23-31. 2011
    ....
  6. doi request reprint Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ, USA
    Wiley Interdiscip Rev RNA 2:22-31. 2011
    ....
  7. pmc Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR
    Tyra Hall-Pogar
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    RNA 13:1103-15. 2007
    ..Finally, we suggest that these proteins (p54(nrb), PTB, PSF, and U1A) may interact as a complex since immunoprecipitations of the transfected MS2 fusion proteins coprecipitate the other proteins...
  8. doi request reprint In vivo methods to assess polyadenylation efficiency
    Lisa K Hague
    Department of Biochemistry and Molecular Biology, New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, NJ, USA
    Methods Mol Biol 419:171-85. 2008
    ..These regulatory events are frequently not reproducible in in vitro assays. Therefore, in vivo methods to measure mRNA pA were developed to meet this need and are described here...
  9. pmc Novel upstream and downstream sequence elements contribute to polyadenylation efficiency
    Sarah K Darmon
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, and The Graduate School of Biomedical Sciences, Newark, NJ, USA
    RNA Biol 9:1255-65. 2012
    ..Therefore, we conclude that RNA structure has an important role in polyadenylation efficiency...
  10. pmc Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation
    Jun Hu
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    RNA 11:1485-93. 2005
    ..Thus, we suggest that many cis elements are evolutionarily conserved among eukaryotes, and human poly(A) sites have an additional set of cis elements that may be involved in the regulation of mRNA polyadenylation...
  11. pmc p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation
    Songchun Liang
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School MSB E671, 185 S Orange Avenue, Newark, NJ 07103, USA
    RNA 12:111-21. 2006
    ..We have explored the function of this complex in RNA processing, specifically cleavage and polyadenylation, by performing immunodepletions followed by reconstitution experiments, and have found that p54(nrb) is critical...
  12. pmc Regulation of COX-2 expression by miR-146a in lung cancer cells
    Ashley L Cornett
    Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, New Jersey Medical School and the Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA
    RNA 20:1419-30. 2014
    ....
  13. pmc A large-scale analysis of mRNA polyadenylation of human and mouse genes
    Bin Tian
    Department of Biochemistry and Molecular Biology, New Jersey Medical School UMDNJ, Newark, NJ 07101, USA
    Nucleic Acids Res 33:201-12. 2005
    ..This large-scale study provides important insights into the mechanism of polyadenylation in mammalian species and represents a genomic view of the regulation of gene expression by alternative polyadenylation...
  14. doi request reprint 3'UTR AU-Rich Elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) Are Not Required for the LPS-Mediated Destabilization of Phospholipase-Cβ-2 mRNA in Murine Macrophages
    Smita Shukla
    Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers University School of Biomedical and Health Sciences, 185 South Orange Avenue, Newark, NJ, 07103, USA
    Inflammation . 2017
    ....
  15. ncbi request reprint An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism
    Zhenhua Pan
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Gene 366:325-34. 2006
    ..This finding indicates that vertebrates may employ a similar alternative polyadenylation mechanism to modulate CstF-77, highlighting the importance of the regulation of CstF-77 in various species...
  16. doi request reprint RHAPA: a new method to quantify alternative polyadenylation
    Ashley L Cornett
    Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ, 07103, USA
    Methods Mol Biol 1125:157-67. 2014
    ..Ultimately, it can be used to further examine posttranscriptional regulation of gene expression...
  17. doi request reprint Regulation of genes in the arachidonic acid metabolic pathway by RNA processing and RNA-mediated mechanisms
    Carol S Lutz
    Department of Biochemistry and Molecular Biology, New Jersey Medical School and the Graduate School of Biomedical Sciences, Rutgers, NJ, USA
    Wiley Interdiscip Rev RNA 4:593-605. 2013
    ..This review article will highlight these mechanisms of mRNA modulation...
  18. pmc Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
    Zoltán H Németh
    Department of Surgery, University of Medicine and Dentistry of New Jersey UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 175:8260-70. 2005
    ..Collectively, these studies identify a novel pathway in which activation of a G protein-coupled receptor augments translation of an anti-inflammatory gene...
  19. pmc The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements
    Devi Mukherjee
    Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    EMBO J 21:165-74. 2002
    ..Finally, PM-Scl75 protein was found to interact specifically with AREs. These data suggest that the interaction between the exosome and AREs plays a key role in regulating the efficiency of ARE-containing mRNA turnover...
  20. pmc Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response
    Micah T McClain
    Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, and Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 101:3551-6. 2004
    ....
  21. ncbi request reprint The snRNP-associated U1A levels change following IL-6 stimulation of human B-cells
    Christine Milcarek
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Immunol 39:809-14. 2003
    ..Our results suggest that the changing level of U1A in the snRNP fraction may be important for influencing Ig heavy chain mRNA processing...

Research Grants3

  1. Mechanisms of post-transcriptional regulation of MeCP2
    CAROL LUTZ; Fiscal Year: 2003
    ..These studies represent under-explored areas of MeCP2 expression that may have a critical influence in the tissue-specific effects observed in Rett syndrome. ..
  2. 3' end formation of human type I and II collagen mRNAs
    CAROL LUTZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Mechanisms of MeCP2 gene expression regulation
    CAROL LUTZ; Fiscal Year: 2008
    ..These studies represent an under-explored area of research on MeCP2 gene expression that may have a critical influence in the tissue-specific effects observed in Rett syndrome. [unreadable] [unreadable] [unreadable]..