Jiang H Ye

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Salsolinol modulation of dopamine neurons
    Guiqin Xie
    Department of Anesthesiology, Pharmacology, and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey Newark, NJ, USA Department of Physiology, Nanjing Medical University Nanjing, China
    Front Behav Neurosci 7:52. 2013
  2. pmc Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions
    Jing Li
    Department of Anesthesiology, Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 7:e40347. 2012
  3. pmc Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats
    Guiqin Xie
    Department of Anesthesiology, Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 7:e36716. 2012
  4. pmc Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption
    Jing Li
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:196-204. 2012
  5. pmc GABAergic actions mediate opposite ethanol effects on dopaminergic neurons in the anterior and posterior ventral tegmental area
    Yanzhong Guan
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:33-42. 2012
  6. pmc Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors
    Guiqin Xie
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:43-50. 2012
  7. ncbi request reprint Kainate-activated currents in the ventral tegmental area of neonatal rats are modulated by interleukin-2
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark, NJ 07103 2714, USA
    Brain Res 1049:227-33. 2005
  8. ncbi request reprint Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    J Neurosci Methods 158:251-9. 2006
  9. ncbi request reprint Regulation of excitation by glycine receptors
    Jiang Hong Ye
    Department of Anesthesiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA
    Results Probl Cell Differ 44:123-43. 2008
  10. ncbi request reprint Cocaine inhibition of GABA(A) current: role of dephosphorylation
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Crit Rev Neurobiol 18:85-94. 2006

Research Grants

  1. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
  2. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
  3. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. pmc Salsolinol modulation of dopamine neurons
    Guiqin Xie
    Department of Anesthesiology, Pharmacology, and Physiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey Newark, NJ, USA Department of Physiology, Nanjing Medical University Nanjing, China
    Front Behav Neurosci 7:52. 2013
    ..These novel mechanisms may contribute to the rewarding/reinforcing properties of salsolinol observed in vivo...
  2. pmc Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB/ΔFosB levels in reward-related brain regions
    Jing Li
    Department of Anesthesiology, Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 7:e40347. 2012
    ..This effect of electroacupuncture may be mediated by down-regulation of FosB/ΔFosB in reward-related brain regions...
  3. pmc Salsolinol facilitates glutamatergic transmission to dopamine neurons in the posterior ventral tegmental area of rats
    Guiqin Xie
    Department of Anesthesiology, Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 7:e36716. 2012
    ..This appears to be a novel mechanism which contributes toward rewarding properties of salsolinol...
  4. pmc Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption
    Jing Li
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:196-204. 2012
    ..Thus, GlyRs in the VTA may play a critical role in ethanol self-administration in animals chronically exposed to ethanol. Therefore, drugs targeting GlyRs may be beneficial for alcoholics...
  5. pmc GABAergic actions mediate opposite ethanol effects on dopaminergic neurons in the anterior and posterior ventral tegmental area
    Yanzhong Guan
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:33-42. 2012
    ..The differential effects of ethanol on sIPSCs and neuronal firing in the p-VTA and a-VTA could be the basis for ethanol reinforcement via the p-VTA...
  6. pmc Salsolinol stimulates dopamine neurons in slices of posterior ventral tegmental area indirectly by activating μ-opioid receptors
    Guiqin Xie
    Department of Anesthesiology, Pharmacology, and Physiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Pharmacol Exp Ther 341:43-50. 2012
    ..Thus, salsolinol excites VTA-dopamine neurons indirectly by activating MORs, which inhibit GABA neurons in the VTA. This form of disinhibition seems to be a novel mechanism underlying the effects of salsolinol...
  7. ncbi request reprint Kainate-activated currents in the ventral tegmental area of neonatal rats are modulated by interleukin-2
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark, NJ 07103 2714, USA
    Brain Res 1049:227-33. 2005
    ..IL-2 might thus be required for normal cell development in the mesolimbic and mesostriatal systems...
  8. ncbi request reprint Patch-clamp studies in the CNS illustrate a simple new method for obtaining viable neurons in rat brain slices: glycerol replacement of NaCl protects CNS neurons
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    J Neurosci Methods 158:251-9. 2006
    ..Due to the increase in the number of viable neurons, the new ACSF increases the productivity of experiments. Based on our data, we propose that this glycerol-based solution may protect CNS neurons...
  9. ncbi request reprint Regulation of excitation by glycine receptors
    Jiang Hong Ye
    Department of Anesthesiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA
    Results Probl Cell Differ 44:123-43. 2008
    ..This chapter is an overview of selective studies on the newly discovered roles of GlyRs in regulating neuronal excitation, and inhibition, particularly in the upper brain areas...
  10. ncbi request reprint Cocaine inhibition of GABA(A) current: role of dephosphorylation
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    Crit Rev Neurobiol 18:85-94. 2006
    ..This dephosphorylation-mediated disinhibitory action may play a role in cocaine-induced convulsant states...
  11. pmc Glycine receptors contribute to hypnosis induced by ethanol
    Jiang H Ye
    The Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Alcohol Clin Exp Res 33:1069-74. 2009
    ..Previous in vitro studies have demonstrated that ethanol potentiates the function of these brain GlyRs, yet the behavioral role of the brain GlyRs has not been well explored...
  12. ncbi request reprint Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area
    Jiang Hong Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Neurosci 24:8961-74. 2004
    ..Furthermore, glycine (1-3 microm) reduced the amplitude of eIPSCs and the frequency of sIPSCs. Hence, the overall effect of the presynaptic action of glycine is to enhance the firing of DA cells, both in very young and older rats...
  13. ncbi request reprint Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons
    J H Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark 07103 2714, USA
    Neuropharmacology 43:788-98. 2002
    ....
  14. ncbi request reprint Ethanol inhibition of glycine-activated responses in neurons of ventral tegmental area of neonatal rats
    J H Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Neurophysiol 86:2426-34. 2001
    ..In conclusion, by altering VTA neuronal function, ethanol-induced changes in glycine receptors may contribute to neurobehavioral manifestations of the fetal alcohol syndrome...
  15. ncbi request reprint Ondansetron exhibits the properties of a local anesthetic
    J H Ye
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, Newark 07103 2714, USA
    Anesth Analg 85:1116-21. 1997
    ..This effect was dose-related, lasting from 10 to 25 min. These preliminary data indicate that OND, a selective 5-HT3 receptor antagonist, might serve as a prototype molecule for development of a novel series of local anesthetics...
  16. ncbi request reprint Cocaine depresses GABAA current of hippocampal neurons
    J H Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark 07103 2714, USA
    Brain Res 770:169-75. 1997
    ..This effect of cocaine appeared to be independent of voltage. The present study suggests that the GABA receptor/channel complex is also a target for cocaine's action. The suppression of IGABA may contribute to cocaine-induced seizures...
  17. ncbi request reprint Ondansetron modulates GABA(A) current of rat central nervous system neurons
    J H Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark 07103 2714, USA
    Eur J Pharmacol 337:87-94. 1997
    ..The present data suggest that ondansetron's suppression of GABA-activated current may be the molecular basis of ondansetron-induced seizures observed in vivo...
  18. ncbi request reprint Glycine-activated chloride currents of neurons freshly isolated from the ventral tegmental area of rats
    J H Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark 07103 2714, USA
    Brain Res 796:53-62. 1998
    ..In contrast to STR, 1 min preincubation with PTX had no effect on IGly. Thus, PTX acts on the open channel. The inhibitory effects of both STR and PTX on IGly did not depend on the membrane potential...
  19. ncbi request reprint Cocaine and lidocaine have additive inhibitory effects on the GABAA current of acutely dissociated hippocampal pyramidal neurons
    J H Ye
    Departments of Anesthesiology and Pharmacology and Physiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    Brain Res 821:26-32. 1999
    ..05) indicates additive effects on the GABA receptor/channel complex, which are likely to contribute to the additive convulsant effects noted when these drugs are abused in combination...
  20. ncbi request reprint 2,3-Butanedione monoxime modifies the glycine-gated chloride current of acutely isolated murine hypothalamic neurons
    J H Ye
    Department of Pharmacology and Physiology, New Jersey Medical School UMDNJ, Newark 07103 2714, USA
    Brain Res 735:20-9. 1996
    ..These findings suggest that BDM alters protein kinase activity and acts as a phosphatase to regulate the activity of the glycine receptor/channel complex...
  21. ncbi request reprint Inhibitory effect of ondansetron on glycine response of dissociated rat hippocampal neurons
    J H Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey, USA
    J Pharmacol Exp Ther 290:104-11. 1999
    ..The data suggest that ondansetron competitively inhibits the glycine receptor...
  22. ncbi request reprint Physiology and pharmacology of native glycine receptors in developing rat ventral tegmental area neurons
    J Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ, USA
    Brain Res 862:74-82. 2000
    ..The IC(50) values were 17 and 231 microM for the neonatal and adult neurons, respectively. These observations are discussed in terms of developmental changes of subunit composition of GlyRs and of intracellular Cl(-) concentrations...
  23. ncbi request reprint Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area
    J H Ye
    Department of Anesthesiology, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Pharmacol Exp Ther 296:77-83. 2001
    ..This action of EtOH may contribute to the neurobehavioral disturbances associated with fetal alcohol syndrome...
  24. ncbi request reprint Interleukin-2 modulates N-methyl-D-aspartate receptors of native mesolimbic neurons
    J H Ye
    Department of Anesthesiology, New Jersey Medical School UMDNJ, Newark, NJ 07103 2714, USA
    Brain Res 894:241-8. 2001
    ..IL-2 thus acts as a potent modulator of the NMDAR. IL-2-induced alterations of responses to NMDAR activation may contribute to synaptic plasticity in the mesolimbic system and to pathological outcomes associated with this system...
  25. ncbi request reprint Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders
    J H Ye
    Department of Anesthesiology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    CNS Drug Rev 7:199-213. 2001
    ..In addition, new discoveries relating to the effects of ondansetron on other receptors/channels and their possible therapeutic applications are presented...
  26. pmc Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus
    Ke Y Li
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
    Anesthesiology 111:1271-8. 2009
    ..The authors explored the possibility that propofol also promotes sedation less directly by facilitating excitatory inputs to the VLPO GABAergic neurons...
  27. pmc Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors
    Hai T Nguyen
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Anesthesiology 110:326-32. 2009
    ..Furthermore, glycine receptors exist throughout the central nervous system, including areas of the brain thought to be involved in sleep. However, the role of glycine receptors in anesthetic-induced hypnosis has not been determined...
  28. pmc Upregulation of DeltaFosB by propofol in rat nucleus accumbens
    Ming Xiong
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07101, USA
    Anesth Analg 113:259-64. 2011
    ..In this study, we determined the effect of propofol on the expression of DeltaFosB in rat nucleus accumbens (NAc) and the potential mechanism involved...
  29. pmc Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action
    Cheng Xiao
    Department of Anesthesiology, Pharmacology and Physiology, New Jersey Medical School UMDNJ, 185 South Orange Avenue, Newark, NJ 07103 2714, USA
    J Pharmacol Exp Ther 327:196-205. 2008
    ..These findings are also consistent with the notion that P2Rs at GABA-releasing terminals on VTA dopaminergic neurons are important targets for ethanol action...

Research Grants3

  1. ETHANOL EFFECTS ON GLYCINE RECEPTOR/CHANNEL FUNCTION
    Jiang Hong Ye; Fiscal Year: 2003
    ....
  2. Neurobiol mechanism/acupuncture therapy/alcoholism
    Jiang Hong Ye; Fiscal Year: 2004
    ..This new knowledge will have a major impact on our understanding of how acupuncture works. The application of this knowledge is expected to improve the effectiveness of acupuncture treatment in alcohol addiction. ..
  3. Ethanol and mesolimbic GABAergic neurons
    Jiang Hong Ye; Fiscal Year: 2007
    ..Such results will provide valuable information on novel mechanisms underlying the addictive properties of alcohol and a firm scientific foundation for future neurobiological studies. [unreadable] [unreadable] [unreadable]..