Chunxiang Zhang

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. doi MicroRNomics: a newly emerging approach for disease biology
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101 1709, USA
    Physiol Genomics 33:139-47. 2008
  2. doi MicroRNAs: role in cardiovascular biology and disease
    Chunxiang Zhang
    Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101 1709, USA
    Clin Sci (Lond) 114:699-706. 2008
  3. pmc MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Genome Med 1:85. 2009
  4. pmc MicroRNAs in vascular biology and vascular disease
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    J Cardiovasc Transl Res 3:235-40. 2010
  5. pmc MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Cell Cycle 8:3469-73. 2009
  6. pmc Novel functions for small RNA molecules
    Chunxiang Zhang
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, RNA Research Laboratory, Department of Anesthesiology, 185 South Orange Avenue, MSB Room E548, Newark, NJ 07101, USA
    Curr Opin Mol Ther 11:641-51. 2009
  7. pmc An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease
    Xiaojun Liu
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Am J Physiol Cell Physiol 298:C1481-8. 2010
  8. pmc Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    Cardiovasc Res 87:431-9. 2010
  9. pmc Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells
    Ying Lin
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    J Biol Chem 284:7903-13. 2009
  10. doi Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs
    Caron M Hong
    Department of Anesthesiology, University of Maryland, 22 S Greene St, S11C, Baltimore, MD 21201, USA
    Anesth Analg 115:118-21. 2012

Research Grants

  1. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. doi MicroRNomics: a newly emerging approach for disease biology
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101 1709, USA
    Physiol Genomics 33:139-47. 2008
    ..microRNomics may be a newly emerging approach for human disease biology...
  2. doi MicroRNAs: role in cardiovascular biology and disease
    Chunxiang Zhang
    Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101 1709, USA
    Clin Sci (Lond) 114:699-706. 2008
    ..miRNAs may represent a new layer of regulators for cardiovascular biology and a novel class of therapeutic targets for cardiovascular diseases...
  3. pmc MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Genome Med 1:85. 2009
    ..Because phenotypic modulation of VSMCs is an initial cellular event in the development of atherosclerosis, miRNAs, and miR-145 in particular, may represent new therapeutic targets for atherosclerosis...
  4. pmc MicroRNAs in vascular biology and vascular disease
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    J Cardiovasc Transl Res 3:235-40. 2010
    ..miRNAs may serve as novel biomarkers and therapeutic targets for vascular disease. This review article summarizes the research progress regarding the roles of miRNAs in vascular biology and vascular disease...
  5. pmc MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease
    Chunxiang Zhang
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Cell Cycle 8:3469-73. 2009
    ..This review article summarizes the current research progress regarding the roles of miR-145 in VSMC biology and discusses the potential therapeutic opportunities surrounding this miRNA in vascular disease...
  6. pmc Novel functions for small RNA molecules
    Chunxiang Zhang
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, RNA Research Laboratory, Department of Anesthesiology, 185 South Orange Avenue, MSB Room E548, Newark, NJ 07101, USA
    Curr Opin Mol Ther 11:641-51. 2009
    ..More than 20 clinical trials are ongoing to evaluate therapies based on small RNA. Additionally, small RNAs may serve as novel biomarkers and therapeutic targets for the majority of diseases...
  7. pmc An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease
    Xiaojun Liu
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Am J Physiol Cell Physiol 298:C1481-8. 2010
    ..The results indicate that PDCD4 may be a new therapeutic target in proliferative vascular diseases...
  8. pmc Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    Cardiovasc Res 87:431-9. 2010
    ....
  9. pmc Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells
    Ying Lin
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    J Biol Chem 284:7903-13. 2009
    ..miRN-21 participates in H(2)O(2)-mediated gene regulation and cellular injury response through PDCD4 and the activator protein 1 pathway. miRNAs might play a role in vascular diseases related to ROS...
  10. doi Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs
    Caron M Hong
    Department of Anesthesiology, University of Maryland, 22 S Greene St, S11C, Baltimore, MD 21201, USA
    Anesth Analg 115:118-21. 2012
    ..There is controversy regarding the associated systemic inflammatory response. In this report, we demonstrate the effects of MV on systemic inflammation...
  11. pmc Cell-specific effects of miR-221/222 in vessels: molecular mechanism and therapeutic application
    Xiaojun Liu
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    J Mol Cell Cardiol 52:245-55. 2012
    ..The opposite cellular effects of miR-221/222 on VSMCs and ECs may have important therapeutic applications in many vascular diseases such as atherosclerosis and restenosis after angioplasty...
  12. pmc MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction
    Shimin Dong
    Department of Anesthesiology, RNA and Cardiovascular Research Laboratory, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    J Biol Chem 284:29514-25. 2009
    ..The results suggest that miRNAs such as miR-21 may play critical roles in the early phase of AMI...
  13. pmc MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    Yunhui Cheng
    Department of Anesthesiology, New Jersey Medical School, UMDNJ, 185 South Orange Ave, MSB E548, Newark, NJ 07101, USA
    Circ Res 105:158-66. 2009
    ..These novel findings may have extensive implications for the diagnosis and therapy of a variety of proliferative vascular diseases...
  14. pmc A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    Xiaojun Liu
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Circ Res 104:476-87. 2009
    ..The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hyperplasia. These findings may also represent promising therapeutic targets in proliferative vascular diseases...
  15. pmc MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?
    Yunhui Cheng
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, TN 38163, USA
    Am J Pathol 170:1831-40. 2007
    ..miRNAs might be a new therapeutic target for cardiovascular diseases involving cardiac hypertrophy such as hypertension, ischemic heart disease, valvular diseases, and endocrine disorders...
  16. pmc Unexpected pro-injury effect of propofol on vascular smooth muscle cells with increased oxidative stress
    Xiaobin Wang
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
    Crit Care Med 39:738-45. 2011
    ..In this study, the authors determined the effect of propofol on hydrogen peroxide-induced injury in vascular smooth muscle cells and the potential molecular mechanisms involved...
  17. pmc MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101 1709, USA
    J Mol Cell Cardiol 47:5-14. 2009
    ..miR-21 might play an essential role in heart diseases related to ROS such as cardiac hypertrophy, heart failure, myocardial infarction, and myocardial ischemia/reperfusion injury...
  18. pmc MicroRNA-21 in cardiovascular disease
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
    J Cardiovasc Transl Res 3:251-5. 2010
    ..miR-21 might be a novel therapeutic target in cardiovascular diseases. This review article summarizes the research progress regarding the roles of miR-21 in cardiovascular disease...
  19. pmc MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2
    Xiaojun Liu
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101, USA
    J Biol Chem 286:42371-80. 2011
    ..The results suggest that MAPK/ERK/miR-31/LATS2 may represent a novel signaling pathway in VSMC growth. miR-31 is able to enhance VSMC proliferation via its downstream target gene product, LATS2...
  20. pmc A translational study of circulating cell-free microRNA-1 in acute myocardial infarction
    Yunhui Cheng
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    Clin Sci (Lond) 119:87-95. 2010
    ..In conclusion, the results suggest that serum miR-1 could be a novel sensitive diagnostic biomarker for AMI...
  21. pmc MicroRNAs in vascular disease
    Shanshan Qin
    RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA
    J Cardiovasc Pharmacol 57:8-12. 2011
    ..This review article summarizes the research progress regarding the roles of miRNAs in vascular diseases...
  22. doi Low tidal volume and high positive end-expiratory pressure mechanical ventilation results in increased inflammation and ventilator-associated lung injury in normal lungs
    Caron M Hong
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    Anesth Analg 110:1652-60. 2010
    ..We performed an animal study comparing 3 ventilation strategies used in the operating room in normal lungs. We compared the effects on pulmonary mechanics, inflammatory mediators, and lung tissue injury...
  23. pmc Upregulation of DeltaFosB by propofol in rat nucleus accumbens
    Ming Xiong
    Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07101, USA
    Anesth Analg 113:259-64. 2011
    ..In this study, we determined the effect of propofol on the expression of DeltaFosB in rat nucleus accumbens (NAc) and the potential mechanism involved...
  24. doi A prospective controlled study to determine the blood propofol concentration in anesthesiologists exposed to propofol vapor in the expired gases of patients receiving propofol-based intravenous sedation
    Ming Xiong
    Department of Anesthesiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Clin Anesth 23:549-51. 2011
    ..To determine the blood propofol concentration of anesthesiologists who were exposed to the expired gases of patients receiving propofol-based intravenous (IV) sedation...
  25. pmc Region-specific induction of FosB/ΔFosB by voluntary alcohol intake: effects of naltrexone
    Jing Li
    Department of Anesthesiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA
    Alcohol Clin Exp Res 34:1742-50. 2010
    ..Here, we examined the effects of chronic voluntary ethanol intake and naltrexone on FosB/ΔFosB IR in striatal region and prefrontal cortex, and the effect of naltrexone on voluntary ethanol intake...
  26. ncbi MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    Ruirui Ji
    Cardiovascular Research Laboratory, Vascular Biology Center and Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Circ Res 100:1579-88. 2007
    ..MiRNAs may be a new therapeutic target for proliferative vascular diseases such as atherosclerosis, postangioplasty restenosis, transplantation arteriopathy, and stroke...
  27. doi Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder
    Xiaobin Wang
    Department of Anesthesiology, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
    J ECT 28:128-32. 2012
    ..The purpose of this study was to investigate the effects of the combined agents for patients undergoing ECT...
  28. ncbi Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets
    Ajit S Narang
    Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 26 South Dunlap Street, Feurt Building RM 406, Memphis, Tennessee 38163, USA
    Pharm Res 21:15-25. 2004
    ..Human vascular endothelial growth factor (hVEGF) gene delivery is likely to promote islet revascularization and survival...

Research Grants1

  1. MPO and NO signaling in neointima formation
    Chunxiang Zhang; Fiscal Year: 2010
    ..The current proposal will identify a novel mediator, leukocyte-derived MPO, in neointima formation and its molecular mechanism(s). Blocking the MPO pathway might be a new therapeutic approach to restenosis after balloon angioplasty. ..