Susan H Benoff

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. ncbi request reprint Voltage dependent calcium channels in mammalian spermatozoa
    S Benoff
    Division of Human Reproduction, Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset, New York 11030, USA
    Front Biosci 3:D1220-40. 1998
  2. pmc Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model
    Susan Benoff
    Fertility Research Laboratories, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Fertil Steril 89:e73-9. 2008
  3. ncbi request reprint Voltage-dependent calcium channels in mammalian spermatozoa revisited
    Susan Benoff
    Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Front Biosci 12:1420-49. 2007
  4. ncbi request reprint Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele
    Susan H Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Hum Reprod 19:616-27. 2004
  5. ncbi request reprint Increased seminal plasma lead levels adversely affect the fertility potential of sperm in IVF
    Susan Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, Manhasset, NY, USA
    Hum Reprod 18:374-83. 2003
  6. ncbi request reprint Metal ions and human sperm mannose receptors
    S Benoff
    Center for Human Reproduction, Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
    Andrologia 32:317-29. 2000
  7. ncbi request reprint Male infertility and environmental exposure to lead and cadmium
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset 11032, USA
    Hum Reprod Update 6:107-21. 2000
  8. ncbi request reprint Numerical dose-compensated in vitro fertilization inseminations yield high fertilization and pregnancy rates
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicne, Manhasset 11030, USA
    Fertil Steril 71:1019-28. 1999
  9. pmc Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers)
    Susan Benoff
    Fertility Research Laboratories, The Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America
    Mol Med 15:248-62. 2009
  10. ncbi request reprint Seminal lead concentrations negatively affect outcomes of artificial insemination
    Susan Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, and Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset, New York, USA
    Fertil Steril 80:517-25. 2003

Research Grants

  1. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
  2. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
  3. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
  4. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006

Detail Information

Publications12

  1. ncbi request reprint Voltage dependent calcium channels in mammalian spermatozoa
    S Benoff
    Division of Human Reproduction, Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset, New York 11030, USA
    Front Biosci 3:D1220-40. 1998
    ..Knowledge of calcium channels structure will also contribute to design of new male contraceptives based on existing calcium channel antagonists...
  2. pmc Link between low-dose environmentally relevant cadmium exposures and asthenozoospermia in a rat model
    Susan Benoff
    Fertility Research Laboratories, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Fertil Steril 89:e73-9. 2008
    ..To define the mechanism(s) underlying an association between asthenozoospermia and elevated blood, seminal plasma, and testicular cadmium levels in infertile human males using a rat model of environmentally relevant cadmium exposures...
  3. ncbi request reprint Voltage-dependent calcium channels in mammalian spermatozoa revisited
    Susan Benoff
    Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Front Biosci 12:1420-49. 2007
    ..In this review, the genetics, structure and function of voltage-dependent calcium channels and related CatSper molecules will be discussed, and several practical clinical applications associated with these channels will be reported...
  4. ncbi request reprint Bilateral increased apoptosis and bilateral accumulation of cadmium in infertile men with left varicocele
    Susan H Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Hum Reprod 19:616-27. 2004
    ..Can such markers predict the outcome of varicocele repair? Can these markers be demonstrated bilaterally in unilateral left varicocele?..
  5. ncbi request reprint Increased seminal plasma lead levels adversely affect the fertility potential of sperm in IVF
    Susan Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, Manhasset, NY, USA
    Hum Reprod 18:374-83. 2003
    ..Lead remains in high levels in the environment and is known to reduce fertility in animal models, but a direct link between lead exposures and human infertility has not yet been established...
  6. ncbi request reprint Metal ions and human sperm mannose receptors
    S Benoff
    Center for Human Reproduction, Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset 11030, USA
    Andrologia 32:317-29. 2000
    ..Mannose receptor expression on the external surface of the human sperm plasma membrane is a biomarker for the effects of transition and heavy metals and organic toxicants on sperm fertility potential...
  7. ncbi request reprint Male infertility and environmental exposure to lead and cadmium
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset 11032, USA
    Hum Reprod Update 6:107-21. 2000
    ..Reverse transcriptase-polymerase chain reaction assays for Ca2+ and K+ channel isoforms may identify susceptibility subgroups with lower resistance to environmental exposures...
  8. ncbi request reprint Numerical dose-compensated in vitro fertilization inseminations yield high fertilization and pregnancy rates
    S Benoff
    Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicne, Manhasset 11030, USA
    Fertil Steril 71:1019-28. 1999
    ..To evaluate in cases with morphologically abnormal sperm whether fertilization and pregnancy rates are increased by normalizing the number of sperm inseminated and whether biomarkers can identify cases of reduced or failed fertilization...
  9. pmc Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers)
    Susan Benoff
    Fertility Research Laboratories, The Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America
    Mol Med 15:248-62. 2009
    ..Our human and rat study results are consistent with the hypothesis that environmental cadmium exposures may contribute significantly to reduced human male sperm concentration and sperm motility...
  10. ncbi request reprint Seminal lead concentrations negatively affect outcomes of artificial insemination
    Susan Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, and Department of Obstetrics and Gynecology, North Shore University Hospital New York University School of Medicine, Manhasset, New York, USA
    Fertil Steril 80:517-25. 2003
    ..To determine the relationships among seminal lead levels, acrosome status, and artificial insemination cycle fecundity (AI f) in semen donors...
  11. ncbi request reprint Deletions in L-type calcium channel alpha1 subunit testicular transcripts correlate with testicular cadmium and apoptosis in infertile men with varicoceles
    Susan Benoff
    Fertility Research Laboratories, North Shore Long Island Jewish Research Institute, North Shore University Hospital, Manhasset, New York, USA
    Fertil Steril 83:622-34. 2005
    ..To identify and understand predictors of successful varicocelectomy...
  12. ncbi request reprint Molecular and other predictors for infertility in patients with varicoceles
    Susan Benoff
    Fertility Research Laboratories, Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Front Biosci (Landmark Ed) 14:3641-72. 2009
    ..In this review we summarize our current understanding of the pathophysiology of varicoceles, and discuss some of the new findings that may be applicable to specific clinical situations...

Research Grants4

  1. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  2. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  3. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  4. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. [unreadable] [unreadable] [unreadable] [unreadable]..