Q Khai Huynh

Summary

Affiliation: Pharmacia Corporation
Country: USA

Publications

  1. ncbi Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism
    Q Khai Huynh
    Research and Development, Myogen, Inc, 7575 West 103 rd Ave, Westminster, CO 80021, USA
    Arch Biochem Biophys 450:141-8. 2006
  2. ncbi Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer
    Q Khai Huynh
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, Mailzone T3M, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    J Biol Chem 277:12550-8. 2002
  3. ncbi IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, St Louis, Missouri 63167, USA
    J Biol Chem 277:13840-7. 2002

Collaborators

  • Nandini Kishore
  • Kuniko Kretzmer
  • Rodney G Combs
  • Hymavathi Boddupalli
  • David Creely
  • Troii Hall
  • Ann Donnelly
  • Sharon Rouw
  • Beverley Reitz
  • Sumathy Mathialagan
  • Gary Lange
  • Catherine S Tripp
  • James Caroll

Detail Information

Publications3

  1. ncbi Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism
    Q Khai Huynh
    Research and Development, Myogen, Inc, 7575 West 103 rd Ave, Westminster, CO 80021, USA
    Arch Biochem Biophys 450:141-8. 2006
    ..50, 17.54, and 11.98microM for PKD1, PKD2, and PKD3, respectively). These findings define PKD as an HDAC kinase and thus suggest key roles for PKD family members in the control of chromatin structure and gene expression...
  2. ncbi Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer
    Q Khai Huynh
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, Mailzone T3M, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    J Biol Chem 277:12550-8. 2002
    ..87 microm), followed by rhIKK-i (K(IkappaBalpha) = 5.47 microm) and rhIKK-1/rhIKK-2 heterodimers (K(IkappaBalpha) = 0.12 microm). Thus this family of IkappaB kinases has very unique kinetic properties...
  3. ncbi IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, St Louis, Missouri 63167, USA
    J Biol Chem 277:13840-7. 2002
    ..Thus, although these IKKs are structurally similar, their enzymatic properties may provide insights into their unique functions...