James A Maclean

Summary

Affiliation: Southern Illinois University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The role of Rhox homeobox factors in tumorigenesis
    James A Maclean
    Department of Physiology, School of Medicine, Southern Illinois University 1135 Lincoln Drive, Carbondale, IL 62901, USA
    Front Biosci (Landmark Ed) 18:474-92. 2013
  2. pmc The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis
    James A Maclean
    Department of Physiology, Southern Illinois University, Carbondale, Illinois 62901, USA
    Biol Reprod 86:189. 2012
  3. pmc CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus
    Sarah N Reardon
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
    Biol Reprod 86:141, 1-10. 2012
  4. pmc Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus
    Mallory E Lindberg
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biol Reprod 89:8. 2013
  5. doi request reprint Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice
    Joshua P Welborn
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois
    Biol Reprod 93:8. 2015
  6. pmc The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis
    James A Maclean
    From the Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901
    J Biol Chem 288:34809-25. 2013
  7. pmc Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells
    Raquel M Brown
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biol Reprod 88:126. 2013
  8. pmc WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development
    Kanako Hayashi
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Biol Reprod 84:308-19. 2011
  9. doi request reprint The Rhox genes
    James A Maclean
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901, USA
    Reproduction 140:195-213. 2010
  10. pmc WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway
    Shin Yoshioka
    Department of Physiology, Southern Illinois University School of Medicine, 1135 Lincoln Drive, Carbondale, IL 62901, USA
    Mol Cancer Res 10:469-82. 2012

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The role of Rhox homeobox factors in tumorigenesis
    James A Maclean
    Department of Physiology, School of Medicine, Southern Illinois University 1135 Lincoln Drive, Carbondale, IL 62901, USA
    Front Biosci (Landmark Ed) 18:474-92. 2013
    ..In this review, we will discuss the latest findings on the normal and abnormal roles of the Rhox genes and their potential contributions to the formation and progression of tumors...
  2. pmc The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis
    James A Maclean
    Department of Physiology, Southern Illinois University, Carbondale, Illinois 62901, USA
    Biol Reprod 86:189. 2012
    ..Our results lead us to propose that widespread changes in the region-specific expression pattern of genes over evolutionary time can be the result of alterations of one or only a few master regulatory genes...
  3. pmc CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus
    Sarah N Reardon
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
    Biol Reprod 86:141, 1-10. 2012
    ..CDH1 has a capacity to control cell fate by altering directional cell proliferation and apoptosis...
  4. pmc Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus
    Mallory E Lindberg
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biol Reprod 89:8. 2013
    ..Collectively, these findings suggest that ablation of Pten with Cdh1 in the uterus accelerates cellular invasiveness and angiogenesis and causes early death. ..
  5. doi request reprint Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice
    Joshua P Welborn
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois
    Biol Reprod 93:8. 2015
    ..Taken together, our study underscores the importance of Rhox genes in male fertility and suggests that Sertoli cell-specific expression of Rhox5 and Rhox8 is critical for complete male fertility...
  6. pmc The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis
    James A Maclean
    From the Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901
    J Biol Chem 288:34809-25. 2013
    ....
  7. pmc Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells
    Raquel M Brown
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Biol Reprod 88:126. 2013
    ..In support of this model, transfection of RHOX5 and PGR expression plasmids stimulated, whereas dominant negative and mutant constructs inhibited, Rhox8 promoter activity...
  8. pmc WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development
    Kanako Hayashi
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901, USA
    Biol Reprod 84:308-19. 2011
    ..These results support the idea that a number of different Wnt genes are potential regulators for uterine morphogenesis; however, Wnt11 does not have a direct effect on uterine development...
  9. doi request reprint The Rhox genes
    James A Maclean
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL 62901, USA
    Reproduction 140:195-213. 2010
    ..The founding member of the Rhox gene cluster--Rhox5 (previously known as Pem)--has been studied in the most depth and thus is the focus of this review. We also discuss the unusually rapid evolution of the Rhox gene cluster...
  10. pmc WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway
    Shin Yoshioka
    Department of Physiology, Southern Illinois University School of Medicine, 1135 Lincoln Drive, Carbondale, IL 62901, USA
    Mol Cancer Res 10:469-82. 2012
    ..Collectively, these results suggest that reexpression of WNT7A during malignant transformation of ovarian epithelial cells plays a critical role in ovarian cancer progression mediated by WNT/β-catenin signaling pathway...
  11. pmc Wnt genes in the mouse uterus: potential regulation of implantation
    Kanako Hayashi
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois, USA
    Biol Reprod 80:989-1000. 2009
    ..Especially, single injections of progesterone stimulated Wnt11 mRNA, and estrogen stimulated Wnt4 and Wnt7b. The temporal and spatial alterations in Wnt genes likely play a critical role during implantation and decidualization in mice...