D A Persons

Summary

Affiliation: St. Jude Children's Research Hospital
Country: USA

Publications

  1. doi Solving the problem of γ-retroviral vectors containing long terminal repeats.
    Derek A Persons
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Mol Ther 19:229-31. 2011
  2. doi Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hematology Am Soc Hematol Educ Program . 2009
  3. ncbi Gene therapy for the hemoglobin disorders
    Derek A Persons
    Department of Hematology Oncology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Semin Hematol 41:279-86. 2004
  4. doi The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in beta-thalassemia patients
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Ann N Y Acad Sci 1202:69-74. 2010
  5. ncbi Update on gene therapy for hemoglobin disorders
    Derek A Persons
    St Jude Children s Research Hospital, 332 North Lauderdale Drive, Memphis, TN 38105, USA
    Curr Opin Mol Ther 5:508-16. 2003
  6. ncbi Gene therapy for the hemoglobin disorders
    Derek A Persons
    St Jude Children s Research Hospital, 332 North Lauderdale Drive, Memphis, TN 38105, USA
    Curr Hematol Rep 2:348-55. 2003
  7. ncbi Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 102:506-13. 2003
  8. ncbi In vivo selection to improve gene therapy of hematopoietic disorders
    Derek A Persons
    Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Mol Ther 4:491-8. 2002
  9. ncbi The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 101:2175-83. 2003
  10. ncbi Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy
    D A Persons
    Division of Experimental Hematology, Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 97:3275-82. 2001

Collaborators

Detail Information

Publications32

  1. doi Solving the problem of γ-retroviral vectors containing long terminal repeats.
    Derek A Persons
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Mol Ther 19:229-31. 2011
  2. doi Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Hematology Am Soc Hematol Educ Program . 2009
    ..Here, the development and recent progress of gene therapy for the hemoglobin disorders is reviewed...
  3. ncbi Gene therapy for the hemoglobin disorders
    Derek A Persons
    Department of Hematology Oncology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Semin Hematol 41:279-86. 2004
    ..Here we review progress in each of these areas...
  4. doi The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in beta-thalassemia patients
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Ann N Y Acad Sci 1202:69-74. 2010
    ....
  5. ncbi Update on gene therapy for hemoglobin disorders
    Derek A Persons
    St Jude Children s Research Hospital, 332 North Lauderdale Drive, Memphis, TN 38105, USA
    Curr Opin Mol Ther 5:508-16. 2003
    ..These advances, together with recent information regarding safety issues of retroviral gene transfer, are reviewed here...
  6. ncbi Gene therapy for the hemoglobin disorders
    Derek A Persons
    St Jude Children s Research Hospital, 332 North Lauderdale Drive, Memphis, TN 38105, USA
    Curr Hematol Rep 2:348-55. 2003
    ..We review the developments in several areas that are critical for successful gene therapy of the hemoglobin disorders...
  7. ncbi Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 102:506-13. 2003
    ..These studies demonstrate that MGMT-based in vivo selection may be useful to increase genetically corrected cells to therapeutic levels in patients with beta-thalassemia...
  8. ncbi In vivo selection to improve gene therapy of hematopoietic disorders
    Derek A Persons
    Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Curr Opin Mol Ther 4:491-8. 2002
    ..Herein, we review recent progress in the development of in vivo selection systems, which hold promise in facilitating successful gene therapy...
  9. ncbi The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number
    Derek A Persons
    Division of Experimental Hematology, Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 101:2175-83. 2003
    ..These data establish the potential of using a gamma-globin lentiviral vector for gene therapy of beta-thalassemia...
  10. ncbi Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy
    D A Persons
    Division of Experimental Hematology, Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 97:3275-82. 2001
    ....
  11. ncbi Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis
    D A Persons
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 93:488-99. 1999
    ..There appears to be a critical dose-dependent effect of GATA-2 on blood cell differentiation in that downregulation of GATA-2 expression is necessary for stem cells to contribute to hematopoiesis in vivo...
  12. ncbi Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression
    N Sawai
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee 38105, USA
    Mol Ther 8:376-84. 2003
    ..Strategies that increase self-renewal capacity could increase the efficiency and safety of in vivo selection...
  13. ncbi High-level erythroid lineage-directed gene expression using globin gene regulatory elements after lentiviral vector-mediated gene transfer into primitive human and murine hematopoietic cells
    Hideki Hanawa
    Division of Experimental Hematology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Hum Gene Ther 13:2007-16. 2002
    ..Thus, these newly described vectors provide a means to achieve high-level gene expression, predominantly in erythroid cells, an outcome that may have potential therapeutic application...
  14. ncbi Progress toward safe and effective gene therapy for beta-thalassemia and sickle cell disease
    Jeffrey Lebensburger
    Department of Hematology, St Jude Children s Research Hospital, 332 North Lauderdale Drive, Memphis, TN 38105, USA
    Curr Opin Drug Discov Devel 11:225-32. 2008
    ..In this article, recent developments are reviewed that suggest a successful clinical trial for these hemoglobin disorders will be achieved in the near future...
  15. pmc Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene
    Huifen Zhao
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 113:5747-56. 2009
    ..These data suggest that MGMT-based drug selection holds promise as a modality to improve gene therapy for beta-thalassemia...
  16. ncbi Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia
    Hideki Hanawa
    332 North Lauderdale Dr, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 104:2281-90. 2004
    ..These data emphasize the importance of overcoming detrimental position effects for consistent therapeutic globin vector expression...
  17. pmc Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin
    Tamara I Pestina
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Mol Ther 17:245-52. 2009
    ..These data support the rationale for a gene therapy approach to SCD by permanently enhancing HbF using a gamma-globin lentiviral vector...
  18. ncbi Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors
    Derek A Persons
    Department of Hematology Oncology, Division of Experimental Hematology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 103:796-803. 2004
    ....
  19. doi Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells
    Phillip W Hargrove
    Department of Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Ther 16:525-33. 2008
    ..This is the first direct evidence that lentiviral vectors can cause insertional dysregulation of cellular genes at a frequent rate...
  20. ncbi Development of gene therapy for hemoglobin disorders
    Arthur W Nienhuis
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 996:101-11. 2003
    ..These advances provide essential preclinical data which build toward the development of effective gene therapy for the severe hemoglobin disorders...
  21. pmc Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins
    Yoon Sang Kim
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Ther 18:1310-7. 2010
    ..These results support the use of the VSV-G envelope protein for the development of lentiviral producer cell lines for manufacture of clinical-grade vector...
  22. ncbi Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny
    Massimo Dominici
    Division of Experimental Hematology, Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genesis 42:17-22. 2005
    ..This transgenic strain should be a useful reagent for both murine hematopoiesis studies and functional studies of specific cell types from particular tissues...
  23. ncbi A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells
    Byoung Y Ryu
    Division of Experimental Hematology, Department of Hematology, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Blood Cells Mol Dis 39:221-8. 2007
    ..Promoter activation in K562 cells by vectors containing globin regulatory elements was significantly reduced by addition of flanking insulator elements...
  24. ncbi Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood
    Hideki Hanawa
    Department of Hematology Oncology, Division of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Mol Ther 5:242-51. 2002
    ....
  25. ncbi Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
    D A Persons
    Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Genet 23:159-65. 1999
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  26. pmc An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
    Byoung Y Ryu
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 111:1866-75. 2008
    ..Thus, this system is useful for comparing the safety profiles of vector cassettes with various regulatory elements for their potential for proto-oncogene activation...
  27. pmc Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease
    Jason W Rosch
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Clin Invest 120:627-35. 2010
    ....
  28. pmc Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation
    Massimo Dominici
    Division of Experimental Hematology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 101:11761-6. 2004
    ..Its isolation and characterization may suggest novel treatments for genetic bone diseases and bone injuries...
  29. ncbi Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system
    Hideki Hanawa
    Experimental Hematology Division, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Blood 103:4062-9. 2004
    ..Vector insertion site analysis demonstrated polyclonal reconstitution with vector-containing cells. SIV vectors appear promising for evaluating gene therapy approaches in nonhuman primate models...
  30. pmc Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia
    Ji Zhang
    Department of Biochemistry, St Jude Children s Research Hospital, 332 North Lauderdale St, Memphis, TN 38105 2794, USA
    Blood 107:73-8. 2006
    ..These results suggest that Friend virus activates both sf-STK and the EPOR to cause deregulated erythroid proliferation and differentiation...
  31. pmc Mobilization and mechanism of transcription of integrated self-inactivating lentiviral vectors
    Hideki Hanawa
    Division of Experimental Hematology, Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Mail Stop 272, Memphis, Tennessee 38105, USA
    J Virol 79:8410-21. 2005
    ....
  32. pmc Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
    Peiman Hematti
    Hematology Branch, National Institutes of Health Bethesda, Maryland, USA
    PLoS Biol 2:e423. 2004
    ..These integration patterns suggest different mechanisms for integration as well as distinct safety implications for MLV versus SIV vectors...