Yi Bing Ouyang

Summary

Affiliation: Stanford University
Country: USA

Publications

  1. ncbi request reprint Effect of Bcl-x(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 33:544-51. 2002
  2. pmc Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA, 94305 5117, USA
    Adv Neurobiol 11:171-88. 2014
  3. pmc MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neurochem Int 77:2-8. 2014
  4. pmc Neuroprotection by astrocytes in brain ischemia: importance of microRNAs
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neurosci Lett 565:53-8. 2014
  5. pmc ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Int J Cell Biol 2012:493934. 2012
  6. pmc MicroRNAs regulate the chaperone network in cerebral ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA, 94305 5117, USA
    Transl Stroke Res 4:693-703. 2013
  7. pmc microRNAs: innovative targets for cerebral ischemia and stroke
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA 94305 5117, USA
    Curr Drug Targets 14:90-101. 2013
  8. pmc miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Dis 45:555-63. 2012
  9. pmc miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mitochondrion 12:213-9. 2012
  10. pmc Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stress Chaperones 11:180-6. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Effect of Bcl-x(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Free Radic Biol Med 33:544-51. 2002
    ..There was no increase in [Ca(2+)](i) with 5 h of GD. These data thus dissociate the effect of Bcl-x(L) on calcium homeostasis from effects on ROS, DeltaPsi(m,) and for H(2)O(2) exposure, cell survival...
  2. pmc Role of Astrocytes in Delayed Neuronal Death: GLT-1 and its Novel Regulation by MicroRNAs
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA, 94305 5117, USA
    Adv Neurobiol 11:171-88. 2014
    ..Then we will focus on two recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families), their effects on astrocytic mitochondria and GLT-1 as well as on outcome after cerebral ischemia. ..
  3. pmc MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neurochem Int 77:2-8. 2014
    ....
  4. pmc Neuroprotection by astrocytes in brain ischemia: importance of microRNAs
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA Electronic address
    Neurosci Lett 565:53-8. 2014
    ..This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia. ..
  5. pmc ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Int J Cell Biol 2012:493934. 2012
    ..Here, we review recent research on cerebral ischemia and MAM, with a focus on molecular chaperones and ER-mitochondrial calcium transfer...
  6. pmc MicroRNAs regulate the chaperone network in cerebral ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA, 94305 5117, USA
    Transl Stroke Res 4:693-703. 2013
    ..This review will focus on the new concept of the role of the chaperone network in the organelle network and its novel regulation by miRNA...
  7. pmc microRNAs: innovative targets for cerebral ischemia and stroke
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, S272A and S290, Stanford, CA 94305 5117, USA
    Curr Drug Targets 14:90-101. 2013
    ....
  8. pmc miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Dis 45:555-63. 2012
    ..These data demonstrate that miR-181 levels change in response to stroke and inversely correlate with levels of GRP78. Importantly, reducing or blocking miR-181a protects the brain from stroke...
  9. pmc miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mitochondrion 12:213-9. 2012
    ..Decreased miR-181a levels reduced glucose deprivation induced apoptosis, mitochondrial dysfunction, and loss of mitochondrial membrane potential in astrocytes...
  10. pmc Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell Stress Chaperones 11:180-6. 2006
    ....
  11. ncbi request reprint Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro
    Lijun Xu
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    Neurobiol Aging 27:562-9. 2006
    ..This suggests that strategies to maintain protein solubility and inhibit aggregation in the face of acute insults such as stroke may be a useful protective strategy...
  12. pmc Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California
    Glia 61:1784-94. 2013
    ..Our data suggest that by targeting a pro-apoptotic BCL2 family member, increasing levels of miR-29a might emerge as a strategy for protection against ischemia-reperfusion injury...
  13. ncbi request reprint Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation
    Yi Bing Ouyang
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    Neurosci Lett 380:229-33. 2005
    ..Staining with ubiquitin to identify protein aggregates revealed reduced redistribution of ubiquitin, consistent with reduced protein aggregation likely due at least in part to induction of Hsp70 by GA...
  14. pmc Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Glia 58:1042-9. 2010
    ..Targeting astrocytes is a promising strategy for neuronal preservation following cardiac arrest and resuscitation...
  15. ncbi request reprint Changes in astrocyte mitochondrial function with stress: effects of Bcl-2 family proteins
    Yi Bing Ouyang
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurochem Int 45:371-9. 2004
    ..This mini-review summarizes current knowledge regarding mitochondrial control of cell survival and death in astrocytes and the effects of anti-apoptotic Bcl-2 proteins on astrocyte mitochondrial function...
  16. ncbi request reprint The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitro
    Yunjuan Sun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 26:937-50. 2006
    ..This indicates that neither the ability to fold denatured proteins nor interactions with cochaperones or other proteins that bind the amino-terminal half of Hsp70 are essential to ischemic protection...
  17. ncbi request reprint Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif
    Rona G Giffard
    Department of Anesthesia, S272, Stanford University, Stanford, CA 94305 5117, USA
    Eur J Neurosci 18:2935-45. 2003
    ..These results are a first step towards understanding the regulation of expression and activity of this transporter in the brain...
  18. pmc Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mitochondrion 11:279-86. 2011
    ..We conclude that GRP78 influences ER-mitochondrial Ca(2+) crosstalk to maintain mitochondrial function and protect astrocytes from ischemic injury...
  19. pmc Neuroprotection from stroke in the absence of MHCI or PirB
    Jaimie D Adelson
    Department of Biology and Neurobiology, Stanford University, Stanford, CA 94305 5437, USA
    Neuron 73:1100-7. 2012
    ..Thus, molecules that function in the immune system act not only to limit synaptic plasticity in healthy neurons, but also to exacerbate brain injury after ischemia. These results suggest therapies for stroke by targeting MHCI and PirB...
  20. ncbi request reprint Bcl-XL maintains mitochondrial function in murine astrocytes deprived of glucose
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Cereb Blood Flow Metab 23:275-9. 2003
    ..When Bcl-XL was overexpressed normal state III respiration and mitochondrial morphology were maintained and cytochrome c release was inhibited in the face of glucose deprivation stress...
  21. pmc Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 27:4253-60. 2007
    ..We suggest that greater oxidative stress and loss of GLT-1 function selectively in CA1 astrocytes is central to the well known delayed death of CA1 neurons...
  22. pmc IL-4 Is Required for Sex Differences in Vulnerability to Focal Ischemia in Mice
    Xiaoxing Xiong
    From the Department of Anesthesiology, Perioperative and Pain Medicine X X, L X, R E W, Y B O, R G G and Department of Surgery L W, Stanford University School of Medicine, Stanford, CA Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China X X and Department of Biology, WESTFIELD STATE UNIVERSITY, Westfield, MA R E W
    Stroke 46:2271-6. 2015
    ..Females generally show less injury in response to the same ischemic challenge, but the underlying mechanisms are not fully understood. We tested the importance of IL-4 in female protection using IL-4 knockout (KO) mice...
  23. ncbi request reprint Overexpression of HDJ-2 protects astrocytes from ischemia-like injury and reduces redistribution of ubiquitin staining in vitro
    Yanli Qiao
    Department of Anesthesia, Stanford University School of Medicine, California 94305, USA
    J Cereb Blood Flow Metab 23:1113-6. 2003
    ..When HDJ-2 was overexpressed, the number of cells with evidence of protein aggregation was significantly reduced. Thus, blocking protein aggregation may be an important mechanism by which HDJ-2 protects cells from damage...
  24. pmc Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia
    Li jun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, United States
    Exp Neurol 264:1-7. 2015
    ..The ability to protect the brain with post-treatment with miR-181a antagomir with long lasting effect makes this a promising therapeutic target and may be an innovative and effective new approach for stroke therapy. ..
  25. ncbi request reprint Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes
    Lijun Xu
    Department of Anesthesia, Grant Building S272, Stanford University School of Medicine, Stanford, California 94305, USA
    Neurol Res 25:697-700. 2003
    ..Geldanamycin protection of astrocytes against in vitro ischemia is likely due to upregulation of heat shock protein 70...
  26. pmc The use of microRNAs to modulate redox and immune response to stroke
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California
    Antioxid Redox Signal 22:187-202. 2015
    ..Excessive amounts of reactive oxygen species (ROS) generated by mitochondria and other sources act both as triggers and effectors of inflammation. This review will focus on the interplay between these two mechanisms...
  27. ncbi request reprint Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function
    Yi Bing Ouyang
    Department of Anesthesia, Stanford University School of Medicine, Grant Building S272, Stanford, CA 94305, USA
    Cell Calcium 36:303-11. 2004
    ....
  28. pmc Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia
    Xiaoxing Xiong
    Department of Anesthesia, Stanford University School of Medicine, S272, Stanford, CA 94305, USA
    Stroke 42:2026-32. 2011
    ..We tested the hypothesis that the anti-inflammatory cytokine interleukin-4 (IL-4) reduces injury after stroke using IL-4 knockout (KO) adult male mice...
  29. ncbi request reprint Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex
    Yong Sun Lee
    Department of Anesthesia, S272 Stanford University School of Medicine, Stanford, CA 94305 5117, USA
    FEBS Lett 580:4865-71. 2006
    ..It is concluded that NCBE activity is inhibited by PKA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane...
  30. pmc Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor
    Ru Quan Han
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    Anesth Analg 108:280-7. 2009
    ..We used beta(2)AR knockout mice and a beta(2) selective antagonist to test the effect of loss of beta(2)ARs on outcome from transient focal cerebral ischemia...