Drucy Borowitz

Summary

Affiliation: State University of New York at Buffalo
Country: USA

Publications

  1. doi request reprint Nutritional Status Improved in Cystic Fibrosis Patients with the G551D Mutation After Treatment with Ivacaftor
    Drucy Borowitz
    Department of Pediatrics, University at Buffalo, State University of New York, Women and Children s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA
    Dig Dis Sci 61:198-207. 2016
  2. doi request reprint Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: a reconsideration
    Drucy Borowitz
    State University of New York at Buffalo School of Medicine and Biomedical Sciences, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, NY, United States Electronic address
    J Cyst Fibros 12:784-5. 2013
  3. doi request reprint Liprotamase long-term safety and support of nutritional status in pancreatic-insufficient cystic fibrosis
    Drucy Borowitz
    Division of Pediatric Pulmonology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 54:248-57. 2012
  4. ncbi request reprint Update on the evaluation of pancreatic exocrine status in cystic fibrosis
    Drucy Borowitz
    Department of Clinical Pediatrics, State University of New York at Buffalo, New York 14222, USA
    Curr Opin Pulm Med 11:524-7. 2005
  5. ncbi request reprint Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis
    Drucy Borowitz
    Women and Children s Hospital of Buffalo, Division of Pediatric Pulmonology, State University of New York at Buffalo, Buffalo, NY 14222, USA
    J Pediatr 149:658-662. 2006
  6. ncbi request reprint Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients
    Drucy Borowitz
    CF Therapeutics Development Network, Seattle, Wash, USA
    Pancreas 32:258-63. 2006
  7. ncbi request reprint Comparison of monoclonal and polyclonal ELISAs for fecal elastase in patients with cystic fibrosis and pancreatic insufficiency
    Drucy Borowitz
    Department of Pediatrics, State University of New York at Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 44:219-23. 2007
  8. doi request reprint International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients
    Drucy Borowitz
    Division of Pediatric Pulmonology, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, Buffalo, NY 14222, USA
    J Cyst Fibros 10:443-52. 2011
  9. ncbi request reprint Use of fecal elastase-1 to classify pancreatic status in patients with cystic fibrosis
    Drucy Borowitz
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    J Pediatr 145:322-6. 2004
  10. ncbi request reprint Pancreatic enzyme therapy and clinical outcomes in patients with cystic fibrosis
    Susan S Baker
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, USA
    J Pediatr 146:189-93. 2005

Detail Information

Publications27

  1. doi request reprint Nutritional Status Improved in Cystic Fibrosis Patients with the G551D Mutation After Treatment with Ivacaftor
    Drucy Borowitz
    Department of Pediatrics, University at Buffalo, State University of New York, Women and Children s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA
    Dig Dis Sci 61:198-207. 2016
    ..Ivacaftor, an oral CFTR potentiator, increases the channel-open probability...
  2. doi request reprint Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: a reconsideration
    Drucy Borowitz
    State University of New York at Buffalo School of Medicine and Biomedical Sciences, Department of Pediatrics, Women and Children s Hospital of Buffalo, Buffalo, NY, United States Electronic address
    J Cyst Fibros 12:784-5. 2013
    ..We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown. ..
  3. doi request reprint Liprotamase long-term safety and support of nutritional status in pancreatic-insufficient cystic fibrosis
    Drucy Borowitz
    Division of Pediatric Pulmonology, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 54:248-57. 2012
    ..This study of liprotamase is the first ever long-term trial of a PERT to evaluate safety and nutritional parameters...
  4. ncbi request reprint Update on the evaluation of pancreatic exocrine status in cystic fibrosis
    Drucy Borowitz
    Department of Clinical Pediatrics, State University of New York at Buffalo, New York 14222, USA
    Curr Opin Pulm Med 11:524-7. 2005
    ..This paper reviews recent progress in the development of noninvasive, indirect tests of pancreatic function for use as diagnostic tools for patients with cystic fibrosis...
  5. ncbi request reprint Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis
    Drucy Borowitz
    Women and Children s Hospital of Buffalo, Division of Pediatric Pulmonology, State University of New York at Buffalo, Buffalo, NY 14222, USA
    J Pediatr 149:658-662. 2006
    ....
  6. ncbi request reprint Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients
    Drucy Borowitz
    CF Therapeutics Development Network, Seattle, Wash, USA
    Pancreas 32:258-63. 2006
    ..We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and amylase, to determine its safety and preliminary efficacy in cystic fibrosis...
  7. ncbi request reprint Comparison of monoclonal and polyclonal ELISAs for fecal elastase in patients with cystic fibrosis and pancreatic insufficiency
    Drucy Borowitz
    Department of Pediatrics, State University of New York at Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 44:219-23. 2007
    ..We sought to compare these assays in patients with cystic fibrosis and to correlate these with the coefficient of fat absorption (CFA)...
  8. doi request reprint International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients
    Drucy Borowitz
    Division of Pediatric Pulmonology, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, Buffalo, NY 14222, USA
    J Cyst Fibros 10:443-52. 2011
    ..Liprotamase, a novel non-porcine PERT containing highly purified biotechnology-derived lipase, protease, and amylase, has successfully undergone initial efficacy and safety testing...
  9. ncbi request reprint Use of fecal elastase-1 to classify pancreatic status in patients with cystic fibrosis
    Drucy Borowitz
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    J Pediatr 145:322-6. 2004
    ..To test the hypothesis that some patients with cystic fibrosis (CF) are misclassified as pancreatic insufficient, using fecal elastase-1 (FE-1) to define pancreatic status...
  10. ncbi request reprint Pancreatic enzyme therapy and clinical outcomes in patients with cystic fibrosis
    Susan S Baker
    Department of Pediatrics, Women and Children s Hospital of Buffalo, State University of New York at Buffalo, USA
    J Pediatr 146:189-93. 2005
    ..To assess the relationship between pancreatic enzyme therapy (PET) and the clinical outcomes of growth, abdominal pain, constipation, gassiness, and number of stools in cystic fibrosis (CF)...
  11. doi request reprint Evolution of pancreatic function during the first year in infants with cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Pediatr 162:808-812.e1. 2013
    ..To describe pancreatic function during the first year of life in infants diagnosed with cystic fibrosis (CF) using serial fecal elastase measurements...
  12. doi request reprint Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis
    Drucy Borowitz
    Women and Children s Hospital of Buffalo, State University of New York at Buffalo, NY, USA
    J Pediatr 155:S73-93. 2009
    ..These guidelines encompass monitoring and treatment recommendations for infants diagnosed with CF and are intended to help guide families, primary care providers, and specialty care centers in the care of infants with CF...
  13. ncbi request reprint Pancreatic exocrine function in patients with cystic fibrosis
    Susan S Baker
    Digestive Diseases and Nutrition Center, Women and Children s Hospital, 219 Bryant Street, Buffalo, NY 14222, USA
    Curr Gastroenterol Rep 7:227-33. 2005
    ..Growth, number of stools, frequency of abdominal pain, and flatulence cannot be used to adjust enzyme doses...
  14. doi request reprint Standardization of Research-Quality Anthropometric Measurement of Infants and Implementation in a Multicenter Study
    Christine Coburn-Miller
    Women and Children s Hospital of Buffalo, Buffalo, New York, USA
    Clin Transl Sci 8:330-3. 2015
    ..We report here the methods to standardize and implement research-quality anthropometric measurement of infants with cystic fibrosis in the Baby Observational Nutrition Study multicenter trial. ..
  15. doi request reprint Intestinal complications of cystic fibrosis
    Drucy Borowitz
    Department of Pediatrics, State University of New York at Buffalo, New York, USA
    Curr Opin Pulm Med 19:676-80. 2013
    ..The article reviews advances in gastrointestinal aspects of cystic fibrosis (CF) published in the literature over the past year, and highlights new and interesting research...
  16. doi request reprint Gastrointestinal complications of cystic fibrosis
    Daniel Gelfond
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York, USA
    Clin Gastroenterol Hepatol 11:333-42; quiz e30-1. 2013
    ..This review outlines pathophysiology and common gastrointestinal ailments in the CF population along with current medical and surgical management...
  17. doi request reprint Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis
    Elizabeth H Yen
    Department of Pediatrics, Harvard Medical School, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA, USA
    J Pediatr 162:530-535.e1. 2013
    ..To evaluate the relationship between nutritional status early in life and the timing and velocity of height growth, lung function, complications of cystic fibrosis, and survival...
  18. ncbi request reprint Consensus report on nutrition for pediatric patients with cystic fibrosis
    Drucy Borowitz
    Digestive Disease and Nutrition Center, Children s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    J Pediatr Gastroenterol Nutr 35:246-59. 2002
  19. doi request reprint Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule
    Daniel Gelfond
    Department of Pediatrics, Digestive Diseases and Nutrition Center, Women and Children s Hospital of Buffalo, State University of New York at Buffalo School of Medicine and Biomedical Sciences, 219 Bryant Street, Buffalo, NY 14222, USA
    Dig Dis Sci 58:2275-81. 2013
    ..We utilized a wireless motility capsule (WMC) to study intestinal pH profile and gastrointestinal transit profile in CF subjects...
  20. doi request reprint Cystic Fibrosis Foundation practice guidelines for the management of infants with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome during the first two years of life and beyond
    Drucy Borowitz
    Women and Children s Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY, USA
    J Pediatr 155:S106-16. 2009
    ..This document aims to help guide the monitoring and care of individuals with CRMS while our knowledge base on appropriate management evolves...
  21. pmc Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis
    Scott D Sagel
    Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    J Pediatr 154:183-8. 2009
    ..To assess the effects of Pseudomonas aeruginosa and Staphylococcus aureus infection on lower airway inflammation and clinical status in young children with cystic fibrosis (CF)...
  22. doi request reprint CFTR, bicarbonate, and the pathophysiology of cystic fibrosis
    Drucy Borowitz
    University at Buffalo, State University of New York, Buffalo, New York
    Pediatr Pulmonol 50:S24-S30. 2015
    ..Basic and applied research that focuses on the role of CFTR-mediated bicarbonate secretion helps explain many of the diverse clinical manifestations that are CF...
  23. ncbi request reprint The presence of mucoid pseudomonas is not pathognomonic for cystic fibrosis
    Meeghan Hart
    Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Clin Pediatr (Phila) 43:279-81. 2004
  24. ncbi request reprint Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 - 1G --> A)
    Dawn Simon
    Department of Pediatrics, Children s Hospital of Buffalo, State University of New York, 219 Bryant Street, Buffalo, NY 14222, USA
    Pediatr Pulmonol 33:315-7. 2002
    ..The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF...
  25. doi request reprint Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review
    Virginia A Stallings
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    J Am Diet Assoc 108:832-9. 2008
    ..These Registry data-based recommendations are presented...
  26. ncbi request reprint Gastrointestinal outcomes and confounders in cystic fibrosis
    Drucy Borowitz
    J Pediatr Gastroenterol Nutr 41:273-85. 2005
  27. pmc Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003
    André M Cantin
    Pulmonary Division, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Quebec, Canada J1H 5N4
    Free Radic Biol Med 42:15-31. 2007
    ..These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed...