Noriko Yokoyama

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. pmc Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin
    Noriko Yokoyama
    Departments of Pharmacology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, 11794 8651, USA
    J Mol Signal 7:8. 2012
  2. pmc Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3a
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 2:11. 2007
  3. pmc Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 2:12. 2007
  4. pmc Dishevelled-2 docks and activates Src in a Wnt-dependent manner
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 122:4439-51. 2009
  5. pmc Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:3693-702. 2010
  6. pmc Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Biochemistry 44:8841-9. 2005
  7. ncbi request reprint Purification and enzyme activity of ACK1
    Noriko Yokoyama
    Department of Physiology and Biophysics, SUNY at Stony Brook, NY, USA
    Methods Enzymol 406:250-60. 2006
  8. ncbi request reprint Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    J Biol Chem 278:47713-23. 2003
  9. ncbi request reprint Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, Stony Brook University, New York 11794, USA
    J Biol Chem 280:42219-26. 2005
  10. ncbi request reprint The C terminus of RON tyrosine kinase plays an autoinhibitory role
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Biol Chem 280:8893-900. 2005

Detail Information

Publications12

  1. pmc Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin
    Noriko Yokoyama
    Departments of Pharmacology, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY, 11794 8651, USA
    J Mol Signal 7:8. 2012
    ..In the canonical Wnt/β-catenin pathway specifically, Dvl3 polymerizes to form dynamic protein aggregates, so-called "signalsomes", which propagate signals from the Wnt receptor Frizzled to downstream elements...
  2. pmc Abundance, complexation, and trafficking of Wnt/beta-catenin signaling elements in response to Wnt3a
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 2:11. 2007
    ..Wnt3a regulates a canonical signaling pathway in early development that controls the nuclear accumulation of beta-catenin and its activation of Lef/Tcf-sensitive transcription of developmentally important genes...
  3. pmc Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/beta-catenin signaling
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Mol Signal 2:12. 2007
    ..Wnt3a stimulates cellular trafficking of key signaling elements (e.g., Axin, Dishevelled-2, beta-catenin, and glycogen synthase kinase-3beta) and primitive endoderm formation in mouse F9 embryonic teratocarcinoma cells...
  4. pmc Dishevelled-2 docks and activates Src in a Wnt-dependent manner
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 122:4439-51. 2009
    ..Activated Src, in turn, enhances Wnt activation of the canonical pathway. We show that Dvl2 and beta-catenin are crucially important substrates for tyrosine phosphorylation in the canonical Wnt/beta-catenin pathway...
  5. pmc Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:3693-702. 2010
    ..We establish for the first time the physical and functional nature of very large, supermolecular Dvl3-based complexes...
  6. pmc Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Biochemistry 44:8841-9. 2005
    ..The data suggest that Src family kinase mediated tyrosine phosphorylation of ELMO1 might represent an important regulatory mechanism that controls signaling through the ELMO1/Crk/Dock180 pathway...
  7. ncbi request reprint Purification and enzyme activity of ACK1
    Noriko Yokoyama
    Department of Physiology and Biophysics, SUNY at Stony Brook, NY, USA
    Methods Enzymol 406:250-60. 2006
    ..Purified ACK1 undergoes autophosphorylation at Tyr284, and autophosphorylation increases kinase activity...
  8. ncbi request reprint Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    J Biol Chem 278:47713-23. 2003
    ..Our data suggest that Hck is a novel binding partner for ACK1 that can regulate ACK1 activity by phosphorylation...
  9. ncbi request reprint Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, Stony Brook University, New York 11794, USA
    J Biol Chem 280:42219-26. 2005
    ..In contrast to other dual specificity kinases that more closely resemble Ser/Thr kinases, ACK1 is a tyrosine kinase with an active site that can accommodate both types of hydroxyamino acids in substrates...
  10. ncbi request reprint The C terminus of RON tyrosine kinase plays an autoinhibitory role
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    J Biol Chem 280:8893-900. 2005
    ..Taken together, our data suggest a model in which the C-terminal tail of RON regulates kinase activity via an interaction with the kinase catalytic domain...
  11. pmc Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Biomed Rep 3:9-13. 2015
    ..These results suggest that, in the context of the ALK-C2orf44 gene fusion, WDCP imposes an oligomeric structure on ALK that results in constitutive kinase activation and signaling...
  12. ncbi request reprint Determinants for the interaction between Janus kinase 2 and protein phosphatase 2A
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Arch Biochem Biophys 417:87-95. 2003
    ....