Gaetano Romano

Summary

Affiliation: Temple University
Country: USA

Publications

  1. doi request reprint A summary on stem cell research: a report on the 8th Annual Meeting of the International Society for Stem Cell Research
    Gaetano Romano
    Drug Development and Gene Therapy Programs, Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Drug News Perspect 23:465-8. 2010
  2. pmc Development of safer gene delivery systems to minimize the risk of insertional mutagenesis-related malignancies: a critical issue for the field of gene therapy
    Gaetano Romano
    Department of Biology, College of Science and Technology, Temple University, Bio Life Science Building, Suite 456, 1900 N 12th Street, Philadelphia, PA 19122, USA
    ISRN Oncol 2012:616310. 2012
  3. ncbi request reprint American Society of Gene Therapy--tenth annual meeting
    Gaetano Romano
    Temple University, 1801 North Broad Street, Philadelphia, PA 19122, USA
    IDrugs 10:534-7. 2007
  4. ncbi request reprint The standpoint of gene therapy programs
    Gaetano Romano
    College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 20:335-43. 2007
  5. ncbi request reprint Advances in the field of stem cell research
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 20:469-74. 2007
  6. ncbi request reprint An overview on gene therapy programs
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia 19122, USA
    Drug News Perspect 21:345-51. 2008
  7. doi request reprint Artificial reprogramming of human somatic cells to generate pluripotent stem cells: a possible alternative to the controversial use of human embryonic stem cells
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University in Philadelphia, Philadelphia 19122, USA
    Drug News Perspect 21:440-5. 2008
  8. ncbi request reprint The standpoint of stem cell research
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, USA
    Drug News Perspect 21:408-12. 2008
  9. doi request reprint Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 22:185-96. 2009
  10. doi request reprint An update on gene therapy programs
    Gaetano Romano
    College of Science and Technology, Temple University, Philadelphia, USA
    Drug News Perspect 22:435-40. 2009

Collaborators

Detail Information

Publications40

  1. doi request reprint A summary on stem cell research: a report on the 8th Annual Meeting of the International Society for Stem Cell Research
    Gaetano Romano
    Drug Development and Gene Therapy Programs, Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Drug News Perspect 23:465-8. 2010
    ..This report provides an overview on the standpoint of stem cell research programs, which is based on the proceedings of the meeting...
  2. pmc Development of safer gene delivery systems to minimize the risk of insertional mutagenesis-related malignancies: a critical issue for the field of gene therapy
    Gaetano Romano
    Department of Biology, College of Science and Technology, Temple University, Bio Life Science Building, Suite 456, 1900 N 12th Street, Philadelphia, PA 19122, USA
    ISRN Oncol 2012:616310. 2012
    ..On these grounds, it is necessary to develop safer gene delivery systems for the genetic manipulation of mammalian cells. This paper discusses the latest achievements that have been reported in the field of vector design...
  3. ncbi request reprint American Society of Gene Therapy--tenth annual meeting
    Gaetano Romano
    Temple University, 1801 North Broad Street, Philadelphia, PA 19122, USA
    IDrugs 10:534-7. 2007
  4. ncbi request reprint The standpoint of gene therapy programs
    Gaetano Romano
    College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 20:335-43. 2007
    ..A major emphasis was placed on the improvement of vector design and safety issues, such as insertional mutagenesis and host immune responses to gene delivery systems...
  5. ncbi request reprint Advances in the field of stem cell research
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 20:469-74. 2007
    ..This report summarizes the standpoint of stem cell research, based on the proceedings of this meeting...
  6. ncbi request reprint An overview on gene therapy programs
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia 19122, USA
    Drug News Perspect 21:345-51. 2008
    ..In this respect, a major emphasis was placed on safety issues, such as insertional mutagenesis and host immune responses to gene delivery systems...
  7. doi request reprint Artificial reprogramming of human somatic cells to generate pluripotent stem cells: a possible alternative to the controversial use of human embryonic stem cells
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University in Philadelphia, Philadelphia 19122, USA
    Drug News Perspect 21:440-5. 2008
    ..As it stands, the newly developed technology can be used to engineer useful models for the study of human diseases and development of novel therapeutics...
  8. ncbi request reprint The standpoint of stem cell research
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, USA
    Drug News Perspect 21:408-12. 2008
    ..This report summarizes the standpoint of stem cell research, based on the proceedings of the meeting...
  9. doi request reprint Insertional mutagenesis and development of malignancies induced by integrating gene delivery systems: implications for the design of safer gene-based interventions in patients
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Drug News Perspect 22:185-96. 2009
    ..In this respect, a particular emphasis was placed on the engineering of enhancer-less self-inactivating retroviridae-based systems...
  10. doi request reprint An update on gene therapy programs
    Gaetano Romano
    College of Science and Technology, Temple University, Philadelphia, USA
    Drug News Perspect 22:435-40. 2009
    ..In this respect, a major emphasis was placed on safety issues...
  11. ncbi request reprint An overview on stem cell research: a report on the 7th Annual Meeting of the International Society for Stem Cell Research
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Drug News Perspect 22:504-8. 2009
    ..This report provides an overview of stem cell research, based on the proceedings of the meeting...
  12. ncbi request reprint American Society of Gene & Cell Therapy--13th Annual Meeting
    Gaetano Romano
    Temple University, Sbarro Institute for Cancer Research and Molecular Medicine, BioLife Science Building, Suite 456, 1900 North 12th Street, Philadelphia, PA 19122, USA
    IDrugs 13:444-7. 2010
    ....
  13. ncbi request reprint Current development of nonviral-mediated gene transfer
    Gaetano Romano
    College of Science and Technology, Temple University, Philadelphia, Penylvania 19122, USA
    Drug News Perspect 20:227-31. 2007
    ..The purpose of this review is to summarize the standpoint of nonviral vector development...
  14. ncbi request reprint Perspectives and controversies in the field of stem cell research
    Gaetano Romano
    College of Science and Technology, Temple University, Bio Life Science Building, Philadelphia, Pennsylvania 19122, USA
    Drug News Perspect 19:433-9. 2006
    ..The purpose of this report is to summarize the current status of stem cell research, as surmised by the proceedings of this meeting...
  15. ncbi request reprint Advances and perspectives in the field of gene transfer technology
    Gaetano Romano
    College of Science and Technology, Bio Life Science Building, Philadelphia, Pennsylvania 19122, USA
    Drug News Perspect 19:359-68. 2006
    ..Some advances were reported in the field of gene transfer technology; however, safety issues, such as insertional mutagenesis, and improvement of vector design remain at the top of the agenda of gene therapists...
  16. pmc Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems
    Hao Jin
    The Farber Institute for the Neurosciences, Department of Neurology, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, PA 19107, USA
    J Cell Physiol 207:49-57. 2006
    ....
  17. pmc Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene
    Gaetano Romano
    Department of Neurosurgery, Temple University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 211:431-8. 2007
    ..Further analysis of epigenetic programming might lead to the identification of the factors that determine TH gene expression specifically in dopaminergic neurons...
  18. ncbi request reprint Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:155-7. 2004
  19. ncbi request reprint Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:141-8. 2004
  20. doi request reprint Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Cell Cycle 11:1202-16. 2012
    ..This finding also shows that Cdk9 and Cdk7 pathways are not redundant and may have important implications in drug development and for studying the mechanism of chemoresistance in malignant cells...
  21. ncbi request reprint Chaotic dynamic stabilities and instabilities of hematopoietic stem cell growth plasticity
    Andrew Puca
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology College of Science and Technology, Temple University Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 213:672-8. 2007
    ....
  22. ncbi request reprint From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway
    Ang Sun
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA
    J Cell Biochem 102:1400-4. 2007
    ..This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression...
  23. ncbi request reprint Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and beta-galactoside staining
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:149-53. 2004
  24. ncbi request reprint The controversial role of adenoviral-derived vectors in gene therapy programs: where do we stand?
    Gaetano Romano
    Department of Neurosurgery, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, Pennsylvania 19107, USA
    Drug News Perspect 19:99-106. 2006
    ..As it stands, adenoviral-mediated gene transfer is a promising tool for cancer therapy and for genetic immunization programs against infectious diseases, provided that host immune responses are carefully controlled...
  25. ncbi request reprint Carcinogenesis and environment: the cancer stem cell hypothesis and implications for the development of novel therapeutics and diagnostics
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Front Biosci 12:3475-82. 2007
    ....
  26. ncbi request reprint pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 10:8085-93. 2004
    ..The purpose of this study is to investigate the possible role of pRb2/p130 in the sensitivity of ovarian cancer to camptothecin, doxorubicin, and taxol...
  27. ncbi request reprint The role of adult stem cells in carcinogenesis
    Gaetano Romano
    Department of Neurosurgery, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, Pennsylvania 19107, USA
    Drug News Perspect 18:555-9. 2005
    ..This new line of investigation may allow for the development of novel therapeutics and cancer diagnostics...
  28. pmc Genetic and epigenetic alterations in breast cancer: what are the perspectives for clinical practice?
    Alfredo Fucito
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA
    Int J Biochem Cell Biol 40:565-75. 2008
    ..In this respect, the field of cancer research has placed a particular emphasis on the elucidation of genetic and epigenetic alterations that may lead to the pathogenesis of breast cancer and contribute to its progression...
  29. ncbi request reprint Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy
    Antonio Giordano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 213:403-6. 2007
    ..This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment...
  30. ncbi request reprint Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applications
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, College Building, Suite 501, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Eur J Dermatol 13:424-9. 2003
    ..On these grounds, it seems necessary to improve the design of other lentiviral vectors, which derive from viruses that are not pathogenic in humans and are distantly related to primate retroviridae...
  31. ncbi request reprint Current development of lentiviral-mediated gene transfer
    Gaetano Romano
    Department of Neurosurgery, Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Suite 400, 900 Walnut Street, Philadelphia, PA 19107, USA
    Drug News Perspect 18:128-34. 2005
    ..These lentiviruses are not pathogenic in humans and are only distantly related to primate Retroviridae. This review summarizes the achievements in improving the design of lentiviral vector systems that are not based on HIV-1...
  32. ncbi request reprint Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
    Gaetano Romano
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Cell Cycle 7:3664-8. 2008
    ....
  33. doi request reprint A commentary on iPS cells: potential applications in autologous transplantation, study of illnesses and drug screening
    Gaetano Romano
    Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania
    J Cell Physiol 229:148-52. 2014
    ..The field of stem cell research has placed a major emphasis in understanding the genetic and epigenetic codes for pluripotency, in order to control and optimize autologous transplantation techniques and avoid teratoma formation...
  34. ncbi request reprint The complex biology of the receptor for the insulin-like growth factor-1
    Gaetano Romano
    Department of Neurosurgery, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, PA 19107, USA
    Drug News Perspect 16:525-31. 2003
    ..Indeed, the biology of the IGF-1R appears more complex than previously thought. The goal of this review is to describe the multiple functions displayed by IGF-1R in cell biology...
  35. ncbi request reprint Systems for regulated or tissue-specific gene expression
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, Pennsylvania 19107, USA
    Drug News Perspect 17:85-90. 2004
    ..However, the achievement of efficient gene regulation in patients is still an open question. This review describes the main inducible systems and tissue-specific promoters in view of their potential therapeutic applications...
  36. ncbi request reprint Stem cell transplantation therapy: controversy over ethical issues and clinical relevance
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, Pennsylvania 19107, USA
    Drug News Perspect 17:637-45. 2004
    ..A better understanding of stem cell biology would almost certainly allow for the establishment of efficient and reliable cell transplantation experimental programs in the clinic...
  37. pmc Characterization of five evolutionary conserved regions of the human tyrosine hydroxylase (TH) promoter: implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, Philadelphia, Pennsylvania, USA
    J Cell Physiol 204:666-77. 2005
    ..The human TH minimal promoters may provide the opportunity for the selection of TH-positive human embryonic and adult stem cells for brain transplantation experiments in animal models for Parkinson's disease...
  38. ncbi request reprint Gene transfer in experimental medicine
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, Jefferson Hospital for the Neurosciences, 900 Walnut Street Suite 422, Philadelphia, PA 19107, USA
    Drug News Perspect 16:267-76. 2003
    ..This review summarizes the latest achievements and controversies in clinical trials and preclinical studies in the field of gene therapy...