Juan Alfonzo

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc C to U editing at position 32 of the anticodon loop precedes tRNA 5' leader removal in trypanosomatids
    Kirk W Gaston
    Department of Microbiology, The Ohio State RNA Group, The Ohio State University, Columbus, Ohio 43210, USA
    Nucleic Acids Res 35:6740-9. 2007
  2. ncbi request reprint Mitochondrial tRNA import--the challenge to understand has just begun
    Juan D Alfonzo
    Department of Microbiology, Ohio State University Biochemistry Program and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210 1292, USA
    Biol Chem 390:717-22. 2009
  3. pmc Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors
    Juan D Alfonzo
    Department of Microbiology and OSU Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Trends Parasitol 27:235-8. 2011
  4. ncbi request reprint Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase
    Hervé Roy
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 280:38186-92. 2005
  5. ncbi request reprint C to U editing stimulates A to I editing in the anticodon loop of a cytoplasmic threonyl tRNA in Trypanosoma brucei
    Mary Anne T Rubio
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:115-20. 2006
  6. pmc Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with myoclonic epilepsy with ragged red fibers syndrome
    Jiqiang Ling
    Ohio State Biochemistry Program, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15299-304. 2007
  7. pmc Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import
    Mary Anne T Rubio
    Department of Microbiology, Ohio State RNA Group, Ohio State University, Columbus, OH 43210 1292, USA
    Proc Natl Acad Sci U S A 105:9186-91. 2008
  8. pmc Thiolation controls cytoplasmic tRNA stability and acts as a negative determinant for tRNA editing in mitochondria
    Jessica M Wohlgamuth-Benedum
    Department of Microbiology and The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:23947-53. 2009

Collaborators

  • M Ibba
  • Hervé Roy
  • KURT L FREDRICK
  • Mary Anne T Rubio
  • Kirk W Gaston
  • Jessica M Wohlgamuth-Benedum
  • Jiqiang Ling
  • Pavel Poliak
  • Zdenek Paris
  • Julius Lukes
  • Shaojun Long
  • Andreas S Reichert
  • Bethany Krett
  • Stéphane Duvezin-Caubet
  • Dieter Soll
  • Jesse J Rinehart
  • F Nina Papavasiliou
  • Jessica L Spears
  • Irena Pastar
  • Daoming Qin
  • Frank L Ragone

Detail Information

Publications8

  1. pmc C to U editing at position 32 of the anticodon loop precedes tRNA 5' leader removal in trypanosomatids
    Kirk W Gaston
    Department of Microbiology, The Ohio State RNA Group, The Ohio State University, Columbus, Ohio 43210, USA
    Nucleic Acids Res 35:6740-9. 2007
    ..Our data supports the view that C to U editing is more widespread than previously thought and is part of a stepwise process in the maturation of tRNAs in these organisms...
  2. ncbi request reprint Mitochondrial tRNA import--the challenge to understand has just begun
    Juan D Alfonzo
    Department of Microbiology, Ohio State University Biochemistry Program and The Center for RNA Biology, The Ohio State University, Columbus, OH 43210 1292, USA
    Biol Chem 390:717-22. 2009
    ..Here, we review the currently known tRNA import mechanisms, comment on recent discoveries of various import factors, and suggest a rationale for forces that lie behind the evolution of mitochondrial tRNA import...
  3. pmc Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors
    Juan D Alfonzo
    Department of Microbiology and OSU Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Trends Parasitol 27:235-8. 2011
    ..Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined...
  4. ncbi request reprint Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase
    Hervé Roy
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Biol Chem 280:38186-92. 2005
    ....
  5. ncbi request reprint C to U editing stimulates A to I editing in the anticodon loop of a cytoplasmic threonyl tRNA in Trypanosoma brucei
    Mary Anne T Rubio
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 281:115-20. 2006
    ..C to U editing of cytoplasmic tRNA expands the editing repertoire in eukaryotic cells, and when coupled to A to I changes, leads to an interrelation between editing sites...
  6. pmc Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with myoclonic epilepsy with ragged red fibers syndrome
    Jiqiang Ling
    Ohio State Biochemistry Program, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:15299-304. 2007
    ..This variant enzyme displayed significantly improved aminoacylation efficiency for the G34A mutant, suggesting a general strategy to treat certain classes of mitochondrial diseases by modification of the corresponding nuclear gene...
  7. pmc Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import
    Mary Anne T Rubio
    Department of Microbiology, Ohio State RNA Group, Ohio State University, Columbus, OH 43210 1292, USA
    Proc Natl Acad Sci U S A 105:9186-91. 2008
    ..Mutations in mitochondrial tRNA genes have been associated with human disease; the tRNA import system described here could possibly be exploited for the manipulation of defective mitochondria...
  8. pmc Thiolation controls cytoplasmic tRNA stability and acts as a negative determinant for tRNA editing in mitochondria
    Jessica M Wohlgamuth-Benedum
    Department of Microbiology and The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:23947-53. 2009
    ..brucei. This provides a first line of evidence for mitochondrial C to U editing regulation in this system...

Research Grants3

  1. tRNA editing by deamination: Balancing affinity and specificity
    Juan Alfonzo; Fiscal Year: 2009
    ..These studies will also provide functional and evolutionary insights into important members of the cytidine deaminase (CDA) superfamily. ..
  2. tRNA editing by deamination: Balancing affinity and specificity
    Juan D Alfonzo; Fiscal Year: 2010
    ..These studies will also provide functional and evolutionary insights into important members of the cytidine deaminase (CDA) superfamily. ..