Marta M Alonso

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo
    Marta M Alonso
    Brain Tumor Center, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:8255-63. 2007
  2. doi Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death
    Marta M Alonso
    Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Mol Ther 16:487-93. 2008
  3. ncbi Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter
    Marta M Alonso
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11499-504. 2007
  4. ncbi Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death
    Hong Jiang
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1410-4. 2007
  5. ncbi Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan
    Candelaria Gomez-Manzano
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:556-62. 2006
  6. ncbi Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors
    Melissa V Olson
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:4005-9. 2007
  7. ncbi A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation
    Hong Jiang
    Department of Neuro Oncology, Unit 1002, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    FASEB J 20:2603-5. 2006
  8. ncbi Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas
    Hong Jiang
    University of Texas MD Anderson Cancer Center, Department of Neuro Oncology, 1515 Holcombe Blvd, Box 1002, Houston, TX 77030, USA
    Expert Rev Anticancer Ther 6:1585-92. 2006
  9. ncbi Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix
    Ok Hee Lee
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 4:915-26. 2006
  10. pmc Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype
    Dan Liu
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Oncotarget 1:700-9. 2010

Collaborators

Detail Information

Publications21

  1. ncbi ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo
    Marta M Alonso
    Brain Tumor Center, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:8255-63. 2007
    ..0001), and furthermore, led to 37% of long-term survivors free of disease. The antitumor activity of ICOVIR-5 suggests that it has the potential to be an effective agent in the treatment of gliomas...
  2. doi Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death
    Marta M Alonso
    Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Mol Ther 16:487-93. 2008
    ..This is the first report showing that Delta-24-RGD plus RAD001 causes autophagic cell death, and dramatically increases long-term survival rates of glioma-bearing animals...
  3. ncbi Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter
    Marta M Alonso
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11499-504. 2007
    ..Collectively, our data provide a strong mechanistic rationale for the combination of oncolytic adenoviruses and temozolomide, and should propel the clinical testing of this therapy approach in patients with malignant gliomas...
  4. ncbi Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death
    Hong Jiang
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1410-4. 2007
    ..Our results show for the first time that brain tumor stem cells are susceptible to adenovirus-mediated cell death via autophagy in vitro and in vivo...
  5. ncbi Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan
    Candelaria Gomez-Manzano
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:556-62. 2006
    ..In this study, we sought to determine whether Delta-24 could sensitize glioma cells to the topoisomerase I inhibitor irinotecan (CPT-11) and to identify the mechanisms underlying this enhanced anticancer effect...
  6. ncbi Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors
    Melissa V Olson
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:4005-9. 2007
    ..Thus, this study offers the first evidence for a global role of E2F1 in the formation and maintenance of multilineage brain tumors, irrefutably establishing E2F1 as an oncogene in the brain...
  7. ncbi A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation
    Hong Jiang
    Department of Neuro Oncology, Unit 1002, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    FASEB J 20:2603-5. 2006
    ..Collectively, our data demonstrate the existence of a NES in E1A that is modulated by the phosphorylation of the S89 residue and the NES plays a role for an efficient viral replication in the host cells...
  8. ncbi Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas
    Hong Jiang
    University of Texas MD Anderson Cancer Center, Department of Neuro Oncology, 1515 Holcombe Blvd, Box 1002, Houston, TX 77030, USA
    Expert Rev Anticancer Ther 6:1585-92. 2006
    ..This hypothesis has been supported by promising findings from preclinical and clinical studies...
  9. ncbi Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix
    Ok Hee Lee
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 4:915-26. 2006
    ....
  10. pmc Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotype
    Dan Liu
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Oncotarget 1:700-9. 2010
    ....
  11. pmc Targeting brain tumor stem cells with oncolytic adenoviruses
    Marta M Alonso
    The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Methods Mol Biol 797:111-25. 2012
    ....
  12. pmc Soluble Tie2 overrides the heightened invasion induced by anti-angiogenesis therapies in gliomas
    Nahir Cortes-Santiago
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Oncotarget 7:16146-57. 2016
    ....
  13. pmc Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas
    Marta M Alonso
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 6:e26740. 2011
    ..Altogether, our data underscore the importance of a pleiotropic role of Sox2 and suggest that it could be used as a therapeutic target in GBM...
  14. ncbi Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance
    Marta M Alonso
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1589-600. 2005
    ..Several tumor suppressor pathways have been identified as modulators of telomerase function. We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas...
  15. ncbi Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade
    Juinn Lin Liu
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:11054-63. 2007
    ..This scenario exemplifies a reciprocal regulation between PI3K and PTEN that defines a novel negative-feedback loop in cell cycle progression...
  16. doi E2F1 in gliomas: a paradigm of oncogene addiction
    Marta M Alonso
    Department of Neuro Oncology, Unit 1002, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 263:157-63. 2008
    ..We also consider the clinical relevance of this by examining the role of E2F1 as a prognosis factor and as a target for the development of novel strategies...
  17. ncbi E2F1 and telomerase: alliance in the dark side
    Marta M Alonso
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Cycle 5:930-5. 2006
    ..We also consider the clinical implications of this association in terms of prognostic significance and opportunities for the development of new and more rational therapeutic strategies...
  18. pmc Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses
    Hong Jiang
    Department of Neuro Oncology, Brain Tumor Center, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 7:723-9. 2005
    ..We conclude that the level of E1A protein is a critical determinant of oncolytic phenotype and we propose a completely novel strategy for the design and construction of conditionally replicative adenoviruses...
  19. pmc Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens
    Sarah R Klein
    Department of Neuro Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 11:e0153814. 2016
    ..Our data suggest that combination of adenoviruses with autophagy inducers may enhance the processing and presentation of cancer-specific antigens incorporated into capsid proteins. ..
  20. pmc Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes
    Konrad Gabrusiewicz
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Oncotarget 5:2208-20. 2014
    ....
  21. ncbi Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway
    Manel Cascallo
    Translational Research Laboratory, Institut d Investigació Biomèdica de Bellvitge Institut Català d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
    Mol Ther 15:1607-15. 2007
    ..Dose-response toxicological and efficacy studies after a single systemic administration in pre-clinical models in mice are presented to demonstrate that this virus holds promise for treatment of disseminated cancer...