Bradford S McGwire

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Leishmaniasis: clinical syndromes and treatment
    B S McGwire
    Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Doan N1145, 410 W 10th Ave, Columbus, OH 43210, USA
    QJM 107:7-14. 2014
  2. doi request reprint Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism
    Bradford S McGwire
    Center for Microbial Interface Biology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Exp Parasitol 126:397-405. 2010
  3. pmc Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity
    Manjusha M Kulkarni
    Division of Infectious Diseases, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 288:8772-84. 2013
  4. pmc Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 284:15496-504. 2009
  5. pmc Mechanisms of cellular invasion by intracellular parasites
    Dawn M Walker
    Department of Microbial Infection and Immunity, Wexner Medical Center, The Ohio State University, Columbus, OH, 43210, USA
    Cell Mol Life Sci 71:1245-63. 2014
  6. pmc Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Infect Immun 76:1738-47. 2008
  7. pmc Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection
    Manjusha M Kulkarni
    Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, OH, USA
    Cell Microbiol 13:913-23. 2011
  8. doi request reprint Voriconazole suppresses the growth of Leishmania species in vitro
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Parasitol Res 112:2095-9. 2013
  9. pmc Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Biomedical Research Tower, Rm 1012, 460 W 12th Ave, Columbus, OH 43210 1240, USA
    Infect Immun 77:2193-200. 2009
  10. pmc Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection
    Manjusha M Kulkarni
    Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, OH, USA Department of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, USA
    Immunology 145:225-31. 2015

Collaborators

Detail Information

Publications11

  1. pmc Leishmaniasis: clinical syndromes and treatment
    B S McGwire
    Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Doan N1145, 410 W 10th Ave, Columbus, OH 43210, USA
    QJM 107:7-14. 2014
    ..This review is a summary of the clinical syndromes caused by Leishmania and treatment regimens currently used for various forms of leishmaniasis. ..
  2. doi request reprint Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism
    Bradford S McGwire
    Center for Microbial Interface Biology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    Exp Parasitol 126:397-405. 2010
    ....
  3. pmc Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity
    Manjusha M Kulkarni
    Division of Infectious Diseases, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 288:8772-84. 2013
    ..This work demonstrates that cyclophilin serves as molecular sensor leading to the evasion and adaptive metabolic response to insect defense peptides...
  4. pmc Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-de pend ent, caspase-independent mitochondrial toxicity
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 284:15496-504. 2009
    ..Flufenamic acid, a nonspecific Ca2+ inhibitor, completely ablated AMP-induced mitochondrial dysfunction and cell death, indicating the importance of dysregulation of Ca2+ in antimicrobial peptide-induced apoptosis...
  5. pmc Mechanisms of cellular invasion by intracellular parasites
    Dawn M Walker
    Department of Microbial Infection and Immunity, Wexner Medical Center, The Ohio State University, Columbus, OH, 43210, USA
    Cell Mol Life Sci 71:1245-63. 2014
    ..Specifically, we focus on four species of protozoan parasites Leishmania, Trypanosoma cruzi, Plasmodium, and Toxoplasma, which are responsible for significant morbidity and mortality. ..
  6. pmc Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Infect Immun 76:1738-47. 2008
    ....
  7. pmc Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection
    Manjusha M Kulkarni
    Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, OH, USA
    Cell Microbiol 13:913-23. 2011
    ..Our results highlight the interplay of antimicrobial peptides and Leishmania that influence the host immune response and the outcome of infection...
  8. doi request reprint Voriconazole suppresses the growth of Leishmania species in vitro
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Parasitol Res 112:2095-9. 2013
    ..Both ketoconazole and voriconazole were active against insect and mammalian stage parasites. This is the first report of the in vitro activity of voriconazole against leishmanial species...
  9. pmc Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Biomedical Research Tower, Rm 1012, 460 W 12th Ave, Columbus, OH 43210 1240, USA
    Infect Immun 77:2193-200. 2009
    ..These results show that TcGP63 is expressed at all life stages and that individual isoforms play a role in host cell infection...
  10. pmc Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection
    Manjusha M Kulkarni
    Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, OH, USA Department of Microbial Infection and Immunity, The Ohio State University Medical Center, Columbus, OH, USA
    Immunology 145:225-31. 2015
    ..The production of IL-17 is particularly enhanced in the absence STAT-1 expression but did not reduce mortality. Overall these results indicate that STAT-1 is important for the control of T. cruzi infection in mice...
  11. ncbi request reprint The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University Medical Center, Columbus, OH, USA
    Mol Microbiol 62:1484-97. 2006
    ..This study serves as a platform for the dissection of the AMP-mediated death pathways of Leishmania and demonstrates the potential that AMP evasion plays during host infection by this parasite...