Matthew Weitzman

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint A hybrid vector for ligand-directed tumor targeting and molecular imaging
    Amin Hajitou
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 125:385-98. 2006
  2. pmc Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase
    Iñigo Narvaiza
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Pathog 5:e1000439. 2009
  3. pmc The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0
    Caroline E Lilley
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS Pathog 7:e1002084. 2011
  4. ncbi request reprint Vector-omics?
    Matthew D Weitzman
    Laboratory of Genetics, Stalk Institute, La Jolla, CA 92037, USA
    Mol Ther 9:315-7. 2004
  5. ncbi request reprint Functions of the adenovirus E4 proteins and their impact on viral vectors
    Matthew D Weitzman
    Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Front Biosci 10:1106-17. 2005
  6. ncbi request reprint VP22 flips the switch on cell death
    Matthew D Weitzman
    Laboratory of Genetics, Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Ther 7:146-7. 2003
  7. doi request reprint Genomes in conflict: maintaining genome integrity during virus infection
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Microbiol 64:61-81. 2010
  8. pmc Changing the ubiquitin landscape during viral manipulation of the DNA damage response
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    FEBS Lett 585:2897-906. 2011
  9. ncbi request reprint Inactivating intracellular antiviral responses during adenovirus infection
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Oncogene 24:7686-96. 2005
  10. ncbi request reprint Interactions of viruses with the cellular DNA repair machinery
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    DNA Repair (Amst) 3:1165-73. 2004

Research Grants

  1. AAV and the DNA Damage Machinery
    Matthew D Weitzman; Fiscal Year: 2010
  2. INITIAL STEPS IN RAAV TRANSDUCTION
    Matthew Weitzman; Fiscal Year: 2003
  3. DNA Replication and Genome Integrity
    Matthew Weitzman; Fiscal Year: 2004
  4. Interactions of AAV with Cellular Factors
    Matthew Weitzman; Fiscal Year: 2006
  5. DNA Replication and Genome Integrity
    Matthew Weitzman; Fiscal Year: 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A hybrid vector for ligand-directed tumor targeting and molecular imaging
    Amin Hajitou
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 125:385-98. 2006
    ..This new class of targeted hybrid viral particles will enable a wide range of applications in biology and medicine...
  2. pmc Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase
    Iñigo Narvaiza
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA
    PLoS Pathog 5:e1000439. 2009
    ..In summary, our results demonstrate that deaminase activity is not necessary for the antiviral activity of A3A against parvoviruses...
  3. pmc The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0
    Caroline E Lilley
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS Pathog 7:e1002084. 2011
    ....
  4. ncbi request reprint Vector-omics?
    Matthew D Weitzman
    Laboratory of Genetics, Stalk Institute, La Jolla, CA 92037, USA
    Mol Ther 9:315-7. 2004
  5. ncbi request reprint Functions of the adenovirus E4 proteins and their impact on viral vectors
    Matthew D Weitzman
    Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Front Biosci 10:1106-17. 2005
    ..This review will summarize our knowledge of E4 functions and the implications of recent findings on the development of rAd vectors...
  6. ncbi request reprint VP22 flips the switch on cell death
    Matthew D Weitzman
    Laboratory of Genetics, Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Ther 7:146-7. 2003
  7. doi request reprint Genomes in conflict: maintaining genome integrity during virus infection
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Annu Rev Microbiol 64:61-81. 2010
    ..We identify common themes used by viruses in their attempts to commandeer or circumvent the host cell's DNA repair machinery, and highlight potential outcomes of the conflict for both virus and host...
  8. pmc Changing the ubiquitin landscape during viral manipulation of the DNA damage response
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    FEBS Lett 585:2897-906. 2011
    ..We discuss the implications of viral infiltration of this pathway for both the transcriptional program of the virus and for the cellular response to DNA damage...
  9. ncbi request reprint Inactivating intracellular antiviral responses during adenovirus infection
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Oncogene 24:7686-96. 2005
    ....
  10. ncbi request reprint Interactions of viruses with the cellular DNA repair machinery
    Matthew D Weitzman
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    DNA Repair (Amst) 3:1165-73. 2004
    ..Exploring the interactions between viruses and the host DNA repair machinery has revealed novel host responses to virus infections and has provided new tools to study the DNA damage response...
  11. ncbi request reprint Gene therapy: twenty-first century medicine
    Inder M Verma
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Annu Rev Biochem 74:711-38. 2005
    ..Despite some initial success in these trials, vector development remains a seminal concern for improved gene therapy technologies...
  12. ncbi request reprint Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
    Travis H Stracker
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 418:348-52. 2002
    ..This targeting of cellular proteins involved in genomic stability suggests a mechanism for 'hit-and-run' transformation observed for these viral oncoproteins...
  13. pmc Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase
    Rachel A Schwartz
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 83:6269-78. 2009
    ..Our results demonstrate that AAV replication in the presence of Ad helper functions elicits a unique damage response controlled by DNA-PK...
  14. ncbi request reprint Targeted integration by adeno-associated virus
    Matthew D Weitzman
    Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA, USA
    Methods Mol Med 76:201-19. 2003
  15. pmc Viral manipulation of DNA repair and cell cycle checkpoints
    Mira S Chaurushiya
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    DNA Repair (Amst) 8:1166-76. 2009
    ..Studies of viruses have identified key cellular regulators and revealed insights into molecular mechanisms governing DNA repair, cell cycle checkpoints, and transformation...
  16. pmc Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
    Christian T Carson
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 28:652-62. 2009
    ..We propose that immobilization of the MRN damage sensor by E4orf3 protein prevents recognition of viral genomes and blocks detrimental aspects of checkpoint signaling during virus infection...
  17. ncbi request reprint Using or abusing: viruses and the cellular DNA damage response
    Caroline E Lilley
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Microbiol 15:119-26. 2007
    ....
  18. pmc Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins
    Travis H Stracker
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 79:6664-73. 2005
    ..These results reveal surprising differences among the highly conserved E4orf3 proteins from different serotypes in the ability to disrupt the Mre11 complex...
  19. pmc The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication
    Rachel A Schwartz
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Virol 81:12936-45. 2007
    ..Together, our data suggest that AAV is targeted by MRN and has evolved to exploit adenoviral proteins that degrade these cellular factors...
  20. ncbi request reprint Roles of host cell factors in circularization of retroviral dna
    Jennifer M Kilzer
    Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 314:460-7. 2003
    ..None of the cellular mutations showed a strong effect on normal integration, consistent with the idea that the cellular pathways leading to circularization are not involved in productive integration...
  21. pmc The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication
    Travis H Stracker
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 78:441-53. 2004
    ..These results highlight the importance of intranuclear localization and suggest that Rep interaction with multiple ssDBPs allows AAV to replicate under a diverse set of conditions...
  22. pmc Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates
    Rachel A Schwartz
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Virol 82:9043-55. 2008
    ..These mutant proteins will facilitate the determination of the relevance of specific substrates to the functions of E1b55K in promoting infection and inactivating host defenses...
  23. pmc Chromatin at the intersection of viral infection and DNA damage
    Caroline E Lilley
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1799:319-27. 2010
    ..These studies are revealing new complexities of the virus-host interaction, uncovering the potential of chromatin as an anti-viral defense mechanism, and also providing unique insights into the role of chromatin in DNA repair...
  24. pmc DNA repair proteins affect the lifecycle of herpes simplex virus 1
    Caroline E Lilley
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:5844-9. 2005
    ..In neurons, HSV-1 replication centers fail to mature, and the DNA damage response is not initiated. These data suggest that the failure of neurons to mount a DNA damage response to HSV-1 may contribute to the establishment of latency...
  25. ncbi request reprint Enhancement of green fluorescent protein expression in adeno-associated virus with the woodchuck hepatitis virus post-transcriptional regulatory element
    Jonathan E Loeb
    Infectious Disease Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
    Methods Mol Biol 183:331-40. 2002
  26. pmc The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury
    Hideo Yasukawa
    Institute of Molecular Medicine, Department of Medicine, and Division of Cardiothoracic Surgery, University of California at San Diego, La Jolla, California 92093 0613, USA
    J Clin Invest 111:469-78. 2003
    ..These results indicate that strategies directed at inhibition of SOCS in the heart and perhaps other organs can augment the host-cell antiviral system, thus preventing viral-mediated end-organ damage during the early stages of infection...
  27. ncbi request reprint Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors
    Lingling Du
    Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, CA 92103 8892, USA
    Mol Ther 10:604-8. 2004
    ..Our results suggest that adult human cardiac gene therapy may be enhanced by the use of serotype 1-specific AAV vectors...
  28. pmc The Mre11 complex is required for ATM activation and the G2/M checkpoint
    Christian T Carson
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 22:6610-20. 2003
    ..These results demonstrate that the Mre11 complex can function as a damage sensor upstream of ATM/ATR signaling in mammalian cells...
  29. pmc The MRN complex in double-strand break repair and telomere maintenance
    Brandon J Lamarche
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    FEBS Lett 584:3682-95. 2010
    ..In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction...
  30. pmc Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
    Renate König
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 135:49-60. 2008
    ..Taken together, the multiscale approach described here has uncovered multiprotein virus-host interactions that likely act in concert to facilitate the early steps of HIV-1 infection...
  31. pmc Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation
    Seema S Lakdawala
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 920371, USA
    J Virol 82:8362-72. 2008
    ..Understanding how MRN impacts the adenoviral life cycle will provide insights into the functions of this DNA damage sensor...
  32. pmc A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
    Caroline E Lilley
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    EMBO J 29:943-55. 2010
    ..Our study raises the possibility that the ICP0-mediated control of histone ubiquitination may link DNA repair, relief of transcriptional repression, and activation of latent viral genomes...
  33. ncbi request reprint Characterization of a nuclear localization signal in the C-terminus of the adeno-associated virus Rep68/78 proteins
    Geoffrey D Cassell
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Virology 327:206-14. 2004
    ..Together, our results demonstrate that a bipartite NLS exists in the shared part of Rep68 and Rep78, and suggest that an alternate entry mechanism may also contribute to nuclear localization of the Rep78 protein...
  34. pmc Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes
    Felipe D Araujo
    Laboratory of Genetics, Salk Institute for Biological Studies, San Diego, CA 92186 5800, USA
    J Virol 79:11382-91. 2005
    ..These data suggest that E4orf3 can target the Mre11 complex to an aggresome and may explain how the cellular repair complex is inactivated during adenovirus infection...
  35. ncbi request reprint APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons
    Hui Chen
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 16:480-5. 2006
    ..They also highlight the functional differences between APOBEC3 proteins. The APOBEC3 family members have distinct functions and may have evolved to resist various classes of genetic elements...
  36. pmc The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection
    Nicole I Orazio
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Virol 85:1887-92. 2011
    ..We detected BLM localized at discrete foci around viral replication centers. These studies identify BLM as a new substrate for degradation by the adenovirus E1b55K/E4orf6 complex...
  37. ncbi request reprint Breaking the barriers to global gene delivery
    Matthew D Weitzman
    Nat Biotechnol 23:305-6. 2005
  38. ncbi request reprint Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
    Oliver J Müller
    Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Angewandte Tumorvirologie, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Nat Biotechnol 21:1040-6. 2003
    ..This vector targeting strategy has advantages over other combinatorial approaches such as phage display because selection occurs within the context of the capsid and may have a broad range of applications in biotechnology and medicine...
  39. ncbi request reprint Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors
    Danny Chu
    Division of Cardiothoracic Surgery, University of California at San Diego, 200 West Arbor Drive, San Diego, CA 92103 8892, USA
    J Thorac Cardiovasc Surg 126:671-9. 2003
    ..We sought to determine whether adeno-associated virus produces more stable, higher efficiency gene expression in the rodent heart than did previous conventional methods...
  40. pmc Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks
    Matthew H Porteus
    California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Biol 23:3558-65. 2003
    ..The frequencies of gene targeting that we achieved with relatively low MOIs suggest that combining rAAV vectors with DSBs is a promising strategy to broaden the application of gene targeting...
  41. ncbi request reprint Gene delivery to the mammalian heart using AAV vectors
    Danny Chu
    Division of Cardiothoracic Surgery, Department of Surgery, University of California San Diego Medical Center, San Diego, CA, USA
    Methods Mol Biol 246:213-24. 2004
    ..Vectors based on recombinant adeno-associated virus (rAAV) offer a number of attractive features and are emerging as promising gene transfer vehicles for many in vivo applications...
  42. doi request reprint Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins
    Tiziana Cervelli
    Molecular Biology Laboratory, Scuola Normale Superiore, Area della Ricerca del CNR, Via Moruzzi 1, Pisa, Italy
    J Cell Sci 121:349-57. 2008
    ..These findings are consistent with a model whereby cellular DNA-damage-response proteins restrict rAAV transduction by negatively regulating rAAV genome processing...
  43. ncbi request reprint A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1
    Danny Chu
    Division of Cardiothoracic Surgery, University of California, San Diego, California, USA
    Ann Thorac Surg 77:449-56; discussion 456-7. 2004
    ..We hypothesized that targeted overexpresssion of angiopoietin-1 in the lung would cause persistent pulmonary hypertension in an animal model...
  44. ncbi request reprint Custom zinc-finger nucleases for use in human cells
    Stephen Alwin
    Institute of Virology, Charite Medical School, Campus Benjamin Franklin, Berlin, Germany
    Mol Ther 12:610-7. 2005
    ....
  45. pmc Structural and functional analysis of Mre11-3
    L Matthew Arthur
    Radiation Oncology Research Laboratory, Department of Radiation Oncology, Molecular and Cell Biology Graduate Program and Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nucleic Acids Res 32:1886-93. 2004
    ..Together, these results establish that the mre11-3 protein provides an excellent system for dissecting nuclease-dependent and independent functions of the Mre11 complex...
  46. pmc A role for MRE11, NBS1, and recombination junctions in replication and stable maintenance of EBV episomes
    Jayaraju Dheekollu
    The Wistar Institute, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e1257. 2007
    ..We propose that NBS1 and MRE11 promote replication-associated recombination junctions essential for EBV episomal maintenance and genome stability...

Research Grants5

  1. AAV and the DNA Damage Machinery
    Matthew D Weitzman; Fiscal Year: 2010
    ..Therefore, in addition to providing insights into the fundamental process of recognition of damaged DNA, these studies will also have implications for genetic approaches to combat disease. ..
  2. INITIAL STEPS IN RAAV TRANSDUCTION
    Matthew Weitzman; Fiscal Year: 2003
    ..Studying the functions of E4orf6 and its cellular targets will suggest simple ways to increase the efficiency of rAAV vectors. ..
  3. DNA Replication and Genome Integrity
    Matthew Weitzman; Fiscal Year: 2004
    ..Judith Campbell (CalTech), Susan Forsburg (Salk), Geoff Wahl (Salk), and Matthew Weitzman (Salk). This is the third meeting that we have organized on this topic...
  4. Interactions of AAV with Cellular Factors
    Matthew Weitzman; Fiscal Year: 2006
    ..Understanding the role of cellular components in regulating AAV replication and integration will enhance our ability both to produce and utilize this promising vector system. ..
  5. DNA Replication and Genome Integrity
    Matthew Weitzman; Fiscal Year: 2006
    ..investigators from two institutions: Judith Campbell (CalTech), Vicki Lundblad (Salk), Geoff Wahl (Salk), and Matthew Weitzman (Salk)...