SANG WOON CHOI

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. doi request reprint Vitamins B6 and cancer
    SANG WOON CHOI
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:247-64. 2012
  2. ncbi request reprint Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
  3. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
  4. ncbi request reprint Interactions between folate and aging for carcinogenesis
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem Lab Med 43:1151-7. 2005
  5. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
  6. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
  7. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
  8. ncbi request reprint Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:2701-8. 2007
  9. pmc Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    FASEB J 25:3136-45. 2011
  10. ncbi request reprint Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults
    Helen E Gabriel
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:835-41. 2006

Research Grants

Collaborators

Detail Information

Publications53

  1. doi request reprint Vitamins B6 and cancer
    SANG WOON CHOI
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:247-64. 2012
    ..This chapter addressed currently available information regarding the relationship between vitamin B6 and cancer...
  2. ncbi request reprint Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  3. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
    ..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young...
  4. ncbi request reprint Interactions between folate and aging for carcinogenesis
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem Lab Med 43:1151-7. 2005
    ..These studies have further indicated that modest folate supplementation may reverse or partially ameliorate those adverse effects induced by folate depletion and aging...
  5. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
    ..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation...
  6. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
    ..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate...
  7. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
    ....
  8. ncbi request reprint Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 137:2701-8. 2007
    ....
  9. pmc Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    FASEB J 25:3136-45. 2011
    ..05). In summary, mild depletion of multiple B vitamins produces in vivo activation of colonic Wnt signaling, implicating it as a key pathway by which B-vitamin inadequacies enhance intestinal tumorigenesis...
  10. ncbi request reprint Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults
    Helen E Gabriel
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 83:835-41. 2006
    ..Because folate is instrumental in DNA synthesis and repair, it is a determinant of genetic stability and therefore might attenuate the genotoxic effects of smoking...
  11. pmc Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines
    Jimmy W Crott
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 19:328-35. 2008
    ..Folate-depletion-induced changes in the Wnt/APC pathway as well as in genes involved in cell adhesion, migration and invasion may underlie observed relationships between folate status and cancer risk...
  12. ncbi request reprint Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins
    Haifa Ghandour
    Vitamin Metabolism, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1357-60. 2002
    ..568). The importance of these observations is discussed...
  13. ncbi request reprint Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Carcinogenesis 25:69-76. 2004
    ....
  14. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
    ..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...
  15. ncbi request reprint In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific
    Silvina F Choumenkovitch
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:2157-60. 2002
    ....
  16. ncbi request reprint Genetic and epigenetic interactions between folate and aging in carcinogenesis
    Hyeran Jang
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 135:2967S-2971S. 2005
    ..However, folate supplementation appears to reverse these adverse effects of aging, which is potentially of substantial import because the latter is an unmodifiable risk factor...
  17. pmc Aging and alcohol interact to alter hepatic DNA hydroxymethylation
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts
    Alcohol Clin Exp Res 38:2178-85. 2014
    ..Furthermore, it has not been tested whether aging and alcohol interact to modify this epigenetic phenomenon, thereby having an independent effect on gene expression...
  18. pmc β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
    Anita R Iskandar
    Nutrition and Cancer Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Cancer Prev Res (Phila) 6:309-20. 2013
    ..In addition, our study establishes a relevant animal lung cancer model for studying tumor growth within emphysematous microenvironments...
  19. ncbi request reprint A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Anal Chem 74:4526-31. 2002
    ..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise...
  20. ncbi request reprint Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, United States
    Mutat Res 626:171-9. 2007
    ..The induction of p53 strand breaks by folate depletion does not impair p53 expression or action within all human cell lines...
  21. doi request reprint Nutritional influences on epigenetics and age-related disease
    Lara K Park
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 71:75-83. 2012
    ..Future work in this field seeks to characterise the epigenetic pattern of healthy aging to ultimately identify nutritional measures to achieve this pattern...
  22. pmc DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging
    Kyong Chol Kim
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 20:917-26. 2009
    ..In this review, we address the effect of folate on early development and aging through an epigenetic mechanism, DNA methylation...
  23. ncbi request reprint Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Eur J Nutr . 2015
    ....
  24. ncbi request reprint Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 3117, USA
    Mutat Res 570:63-70. 2005
    ..Furthermore, in contrast to previous work, we report that the common 4.8 kb deletion was not modulated by age, but is reduced by folate supplementation in the liver of rats...
  25. pmc Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats
    Ala Al Rajabi
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 142:841-5. 2012
    ..These data demonstrate that MK-4 is the predominant form of vitamin K in multiple tissues, but there appears to be a tissue-specific regulation for the conversion of PK to MK-4...
  26. pmc Too much folate: a risk factor for cancer and cardiovascular disease?
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Clin Nutr Metab Care 12:30-6. 2009
    ..The intent of this evidence-based review is to analyze the role of folate in chronic diseases, focusing on cancer and cardiovascular disease...
  27. pmc Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cancer 123:519-25. 2008
    ....
  28. ncbi request reprint The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer
    Yuri Kim
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Int J Cancer 120:1847-54. 2007
    ..Differential expression of IGFBP-3 in different tissues indicates that caution should be taken when using plasma IGFBP-3 as a biomarker of tissue status...
  29. ncbi request reprint A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers
    Helen E Gabriel
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Cancer Epidemiol Biomarkers Prev 15:993-9. 2006
    ..Such effects may be important because these nutrients, as well as retinoids, are putative chemoprotective agents...
  30. pmc Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice
    Anna C Pfalzer
    Cancer Cluster, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 10:e0135758. 2015
    ..Adenosine and P. distasonis have previously been shown to be anti-inflammatory in the colon and we postulate their reduction could promote tumorigenesis by de-repressing inflammation. ..
  31. doi request reprint S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages
    Anna C Pfalzer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, and
    Physiol Genomics 46:617-23. 2014
    ..Our data indicate that SAM modulates the expression of inflammatory genes in association with changes in specific gene promoter DNA methylation. ..
  32. pmc Nutritional epigenomics: a portal to disease prevention
    SANG WOON CHOI
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA
    Adv Nutr 4:530-2. 2013
    ..Aging and cancer demonstrate profound genome-wide DNA methylation changes, suggesting that nutrition may affect the aging process and cancer development through epigenetic mechanisms. ..
  33. ncbi request reprint Effects of alcohol on folate metabolism: implications for carcinogenesis
    Joel B Mason
    Vitamins and Carcinogenesis Laboratory, U S D A Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Alcohol 35:235-41. 2005
    ....
  34. ncbi request reprint Gene-nutrient interactions and DNA methylation
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2382S-2387S. 2002
    ....
  35. ncbi request reprint Folate status: effects on pathways of colorectal carcinogenesis
    SANG WOON CHOI
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2413S-2418S. 2002
    ....
  36. pmc Iron Supplementation Reverses the Reduction of Hydroxymethylcytosine in Hepatic DNA Associated With Chronic Alcohol Consumption in Rats
    Stephanie A Tammen
    Friedman School of Nutrition Science and Policy Tufts University, Boston, MA, USA
    J Cancer Prev 21:264-270. 2016
    ..In the present study we aimed to determine the effects of alcohol on DNA hydroxymethylation and further effects of iron on alcohol associated epigenetic changes...
  37. pmc Epigenetics: the link between nature and nurture
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University, Boston, MA 02111, USA
    Mol Aspects Med 34:753-64. 2013
    ..The interaction between types of epigenetic modifications in response to environmental factors and how environmental cues affect epigenetic patterns will further elucidate how gene transcription can be affectively altered...
  38. ncbi request reprint LC/ESI-MS demonstrates the absence of 5-methyl-2'-deoxycytosine in Plasmodium falciparum genomic DNA
    SANG WOON CHOI
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Mol Biochem Parasitol 150:350-2. 2006
  39. pmc Measurement of menadione in urine by HPLC
    Ala Al Rajabi
    USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA ala al
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2457-60. 2010
    ..Using this method, urinary menadione was shown to increase in response to 3 years of phylloquinone supplementation. This HPLC method is a sensitive and reproducible way to detect menadione in urine...
  40. doi request reprint Dietary modulators of statin efficacy in cardiovascular disease and cognition
    Huifen Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
    Mol Aspects Med 38:1-53. 2014
    ..Nevertheless, this area is important because were the effects of statins and diet additive or synergistic harnessing the effect could potentially lead to the use of a lower intensity statin or dose. ..
  41. pmc Epigenetics: A New Bridge between Nutrition and Health
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111
    Adv Nutr (Bethesda) 1:8-16. 2010
    ....
  42. pmc High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats
    Sudipta Veeramachaneni
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 138:1329-35. 2008
    ..These data indicate an interaction between chronic alcohol ingestion and lycopene supplementation and suggest a need for caution among individuals consuming high amounts of both alcohol and lycopene...
  43. doi request reprint Vitamin B6 and cardiovascular disease
    Simonetta Friso
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:265-90. 2012
    ....
  44. ncbi request reprint The potential cocarcinogenic effect of vitamin B12 deficiency
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Clin Chem Lab Med 43:1158-63. 2005
    ....
  45. ncbi request reprint Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
    Br J Nutr 97:617-21. 2007
    ....
  46. ncbi request reprint Gene-nutrient interactions in one-carbon metabolism
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico Giambattista Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Curr Drug Metab 6:37-46. 2005
    ....
  47. ncbi request reprint The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico Giambattista Rossi, Piazza Ludovico Antonio Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 14:938-43. 2005
    ..Further mechanistic studies are warranted to investigate how single polymorphisms as well as MTHFR combined genotypes exert their effect on cancer susceptibility...
  48. ncbi request reprint S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF rats
    Cheng Ji Jin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Nutr 137:339-44. 2007
    ..752, P<0.001). In conclusion, SAM treatment increased mtDNA density in the skeletal muscle, improved whole body insulin sensitivity, and prevented body weight gain in OLETF rats...
  49. ncbi request reprint DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia
    Allen S Yang
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:5495-503. 2006
    ..In conclusion, we show dose-dependent hypomethylation after decitabine at low doses. Increasing the dose, which has been shown previously to result in a reduced response rate, was not accompanied by further hypomethylation...
  50. pmc Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation
    Mathieu Gissot
    Albert Einstein College of Medicine, Ullmann 1225, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Eukaryot Cell 7:537-40. 2008
    ..To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA...
  51. doi request reprint Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Atherosclerosis 199:323-7. 2008
    ..Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension...
  52. pmc Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women
    Unhee Lim
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
    Gastroenterology 134:47-55. 2008
    ..We examined genomic methylation of leukocyte DNA in relation to colorectal adenoma (CRA) among asymptomatic women (40-79 years of age) participating in a multicenter colonoscopy screening study (CONCeRN Study, 2000-2002)...
  53. ncbi request reprint Coagulation parameters and plasma total homocysteine levels in Behcet's disease
    Yun Jong Lee
    Department of Internal Medicine, Clinical Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea
    Thromb Res 106:19-24. 2002
    ..857, p<0.01). Therefore, coagulation abnormality did not contribute to thrombotic complications, and higher levels of homocysteine may play a role in the hypercoagulablity of BD patients...

Research Grants2

  1. Effect of aging on folate metabolism in the colon
    SANG WOON CHOI; Fiscal Year: 2003
    ....
  2. Epigenetic effects of chronic alcohol consumption on colonic mucosa
    SANG WOON CHOI; Fiscal Year: 2007
    ..If those studies can precisely define the epigenetic mechanism for alcohol-associated carcinogenesis, we can develop a new chemopreventive strategy for those cancers. [unreadable] [unreadable] [unreadable]..