Donald G Phinney

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi Building a consensus regarding the nature and origin of mesenchymal stem cells
    Donald G Phinney
    Center for Gene Therapy and Department of Immunology and Microbiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem Suppl 38:7-12. 2002
  2. doi Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA, USA
    Methods Mol Biol 449:171-86. 2008
  3. ncbi Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Cell Cycle 6:2884-9. 2007
  4. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
  5. ncbi Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Stem Cells Dev 15:437-47. 2006
  6. ncbi Murine mesenchymal and embryonic stem cells express a similar Hox gene profile
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 338:1759-65. 2005
  7. ncbi Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy
    Donald G Phinney
    Center for Gene Therapy and Department of Microbiology and Immunology, SL 99, Room 672 JBJ, Tulane University of the Health Sciences, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Stem Cells 24:186-98. 2006
  8. ncbi Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Curr Pharm Des 11:1255-65. 2005
  9. ncbi Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection
    Melody Baddoo
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem 89:1235-49. 2003
  10. ncbi Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain
    Iryna A Isakova
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:3261-70. 2007

Collaborators

  • D J Prockop
  • Bruce Bunnell
  • Kate C Baker
  • Gary W Hoyle
  • Aline M Betancourt
  • Guoshun Wang
  • Seth B Coffelt
  • Luis A Ortiz
  • Cheul H Kim
  • Naftali Kaminski
  • Iryna A Isakova
  • Katie C Russell
  • Bonnie L Barrilleaux
  • KIM C O'CONNOR
  • Jason Dufour
  • Benjamin W Fischer-Valuck
  • Dina Gaupp
  • Irina A Isakova
  • Veena Krishnappa
  • Julie Bruhn
  • Calvin Lanclos
  • Wen Tzu Lai
  • Jennifer K Gilliam
  • Michelle R Lacey
  • Kevin J Zwezdaryk
  • Soo Kyung Kang
  • Lauren Crigler
  • Bonnie Barrilleaux
  • Melody Baddoo
  • Marcelo J Kuroda
  • H Alan Tucker
  • Kristin E Meyertholen
  • Kyung Sun Kang
  • Juliet Liu
  • Heather L LaMarca
  • Cindy B Morris
  • Luisa Florez
  • Aline B Scandurro
  • Jee Eun Yeo
  • Yanira G Figueroa
  • Maria DuTreil
  • Amy Asawachaicharn
  • Rebecca C Robey
  • Catherine Hughes
  • Gene C Kopen
  • Katy Hill
  • Robin Wilkinson

Detail Information

Publications27

  1. ncbi Building a consensus regarding the nature and origin of mesenchymal stem cells
    Donald G Phinney
    Center for Gene Therapy and Department of Immunology and Microbiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem Suppl 38:7-12. 2002
    ....
  2. doi Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA, USA
    Methods Mol Biol 449:171-86. 2008
    ..Importantly, this immunodepletion method does not employ long-term expansion of plastic adherent cells ex vivo, thereby avoiding the generation of immortalized cell lines...
  3. ncbi Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Cell Cycle 6:2884-9. 2007
    ..Evidence is provided that the biochemical heterogeneity of these subpopulations contributes more significantly to the therapeutic potential of MSCs than their stem-like characteristics...
  4. ncbi Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:2896-902. 2007
    ..Additionally, we argue that this heterogeneity also provides a basis for the broad therapeutic efficacy of MSCs...
  5. ncbi Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Stem Cells Dev 15:437-47. 2006
    ..These subpopulations may represent more potent cellular vectors for treating CNS disorders...
  6. ncbi Murine mesenchymal and embryonic stem cells express a similar Hox gene profile
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 338:1759-65. 2005
    ..This is the first study to catalogue Hox transcripts in murine MSCs and by comparative analyses identify specific Hox genes that may contribute to their stem cell character...
  7. ncbi Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy
    Donald G Phinney
    Center for Gene Therapy and Department of Microbiology and Immunology, SL 99, Room 672 JBJ, Tulane University of the Health Sciences, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Stem Cells 24:186-98. 2006
    ..The restricted expression pattern of these proteins within populations suggests that the cellular composition of marrow stroma and its associated functions are more complex than previously envisioned...
  8. ncbi Plasticity and therapeutic potential of mesenchymal stem cells in the nervous system
    Donald G Phinney
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Curr Pharm Des 11:1255-65. 2005
    ..Based on our analysis of their transcriptome, we also theorize how the varied functions of MSCs and their progeny in bone marrow may extrapolate to a therapeutic benefit in models of neurological disease...
  9. ncbi Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection
    Melody Baddoo
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Cell Biochem 89:1235-49. 2003
    ..Therefore, FGF2 appears to function as a mitogen and self-maintenance factor for murine MSCs enriched from bone marrow by negative selection...
  10. ncbi Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain
    Iryna A Isakova
    Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Stem Cells 25:3261-70. 2007
    ..Moreover, expressed guidance receptors on MSC subpopulations may regulate migration of cells in the host brain. Disclosure of potential conflicts of interest is found at the end of this article...
  11. doi Migratory response of mesenchymal stem cells to macrophage migration inhibitory factor and its antagonist as a function of colony-forming efficiency
    Benjamin W Fischer-Valuck
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA, 70118, USA
    Biotechnol Lett 32:19-27. 2010
    ..These data suggest that MIF and its antagonists may be relevant to the control of MSC homing and efficacy of stem cell therapies in a variety of clinical scenarios...
  12. pmc Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency
    Katie C Russell
    Department of Chemical and Biomolecular Engineering, Tulane University, Boggs Center, Room 300, New Orleans, Louisiana 70118, USA
    Biotechnol Bioeng 108:2716-26. 2011
    ..These results are discussed in the context of the preparation of efficacious MSC therapies by ex vivo expansion...
  13. pmc Cell-dose-dependent increases in circulating levels of immune effector cells in rhesus macaques following intracranial injection of allogeneic MSCs
    Iryna A Isakova
    Department of Surgery, Tulane Medical School, New Orleans, LA, USA
    Exp Hematol 38:957-967.e1. 2010
    ..Herein we evaluated whether administration of major histocompatibility complex (MHC) class I-mismatched MSCs induce an immune response in rhesus macaques...
  14. doi Activation of CD74 inhibits migration of human mesenchymal stem cells
    Bonnie L Barrilleaux
    Department of Chemical and Biomolecular Engineering, Tulane University, Lindy Boggs Center Room 300, New Orleans, LA 70118, USA
    In Vitro Cell Dev Biol Anim 46:566-72. 2010
    ..Targeting CD74 to regulate migration and homing potentially may be a useful strategy to improve the efficacy of a variety of MSC therapies, including those that require ex vivo expansion...
  15. doi In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment
    Katie C Russell
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA
    Stem Cells 28:788-98. 2010
    ..The in vitro assay described herein will likely have numerous applications given the importance of heterogeneity to the therapeutic potential of MSCs...
  16. ncbi Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis
    Lauren Crigler
    SL 99, Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Neurol 198:54-64. 2006
    ..These subpopulations may represent more potent vectors for treating a variety of neurological disorders...
  17. ncbi Preclinical evaluation of adult stem cell engraftment and toxicity in the CNS of rhesus macaques
    Iryna A Isakova
    Center for Gene Therapy, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Mol Ther 13:1173-84. 2006
    ..Therefore, MSC-based therapies represent a safe alternative for clinical intervention of CNS disorders...
  18. pmc Allo-reactivity of mesenchymal stem cells in rhesus macaques is dose and haplotype dependent and limits durable cell engraftment in vivo
    Iryna A Isakova
    Center for Bioenvironmental Research, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 9:e87238. 2014
    ..Therefore the use of unrelated donor MSCs should be carefully evaluated in human patients. ..
  19. doi Small-molecule antagonist of macrophage migration inhibitory factor enhances migratory response of mesenchymal stem cells to bronchial epithelial cells
    Bonnie L Barrilleaux
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA
    Tissue Eng Part A 15:2335-46. 2009
    ....
  20. pmc Fibroblast growth factor 2 (Fgf2) inhibits differentiation of mesenchymal stem cells by inducing Twist2 and Spry4, blocking extracellular regulated kinase activation, and altering Fgf receptor expression levels
    Wen Tzu Lai
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Stem Cells 29:1102-11. 2011
    ..Collectively, these studies demonstrate that inhibition of mouse MSC differentiation by Fgf2 is strongly correlated with upregulation of Twist2 and Spry4 and suppression of Erk1/2 activation...
  21. ncbi Methods and protocols. Preface
    Darwin J Prockop
    Center for Gene Therapy and Department of Biochemistry, Tulane University Health Sciences, New Orleans, LA, USA
    Methods Mol Biol 449:v-vii. 2008
  22. ncbi Erythropoietin, a hypoxia-regulated factor, elicits a pro-angiogenic program in human mesenchymal stem cells
    Kevin J Zwezdaryk
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Hematol 35:640-52. 2007
    ..The hypoxia-regulated factor, EPO, induces angiogenesis in endothelial cells. Here, EPO's pro-angiogenic effect on hMSC was analyzed...
  23. ncbi Review: ex vivo engineering of living tissues with adult stem cells
    Bonnie Barrilleaux
    Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana 70118, USA
    Tissue Eng 12:3007-19. 2006
    ..Future advances in stem cell biology and scaffold design will ultimately improve the efficacy of tissue substitutes as implants, in research, and as extracorporeal devices...
  24. ncbi Mesenchymal Stem Cells Yield Transient Improvements in Motor Function in an Infant Rhesus Macaque With Severe Early-Onset Krabbe Disease
    Irina A Isakova
    Donahue s Consulting Inc, New Orleans, Louisiana, USA
    Stem Cells Transl Med . 2016
    ..Correlative data linking MSC administration to transient improvements in motor function suggest that MSCs should be evaluated further as an experimental therapy for rare neurodegenerative diseases...
  25. ncbi Cytoplasmic extracts from adipose tissue stromal cells alleviates secondary damage by modulating apoptosis and promotes functional recovery following spinal cord injury
    Soo Kyung Kang
    Department of Physiology, College of Medicine, Pusan National University, 1 10 Ami dong, Busan 602 739, South Korea
    Brain Pathol 17:263-75. 2007
    ..The ability of ATSC extracts to prevent secondary pathological events and improve neurologic function after SCI suggests that extracts prepared from autologous cells harvested from SCI patients may have clinical utility...
  26. pmc Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
    Luis A Ortiz
    Division of Occupational Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:8407-11. 2003
    ..Collectively, these studies demonstrate that murine MSCs home to lung in response to injury, adopt an epithelium-like phenotype, and reduce inflammation and collagen deposition in lung tissue of mice challenged with BLM...
  27. pmc Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    Luis A Ortiz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:11002-7. 2007
    ..Identification of IL1RN-expressing human MSC subpopulations may provide a novel cellular vector for treating chronic inflammatory diseases in humans...