S K Alahari

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration
    S K Alahari
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 151:1141-54. 2000
  2. ncbi Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK
    Suresh K Alahari
    Department of Pharmacology, CB 7365, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Exp Cell Res 288:415-24. 2003
  3. pmc A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin
    Suresh K Alahari
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Biochem J 377:449-57. 2004
  4. pmc The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK
    Suresh K Alahari
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    EMBO J 23:2777-88. 2004
  5. ncbi Biological aspects of signal transduction by cell adhesion receptors
    Suresh K Alahari
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA
    Int Rev Cytol 220:145-84. 2002
  6. pmc Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion
    Yuemin Ding
    Department of Biochemistry and Molecular Biology, School of Medicine, LSU Health Science Center, New Orleans, LA 70112, USA
    Mol Cell Biol 28:3742-56. 2008

Collaborators

  • Yuemin Ding
  • Tanja Milosavljevic

Detail Information

Publications6

  1. pmc Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration
    S K Alahari
    Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 151:1141-54. 2000
    ..Thus, Nischarin may play a negative role in cell migration by antagonizing the actions of Rac on cytoskeletal organization and cell movement...
  2. ncbi Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK
    Suresh K Alahari
    Department of Pharmacology, CB 7365, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Exp Cell Res 288:415-24. 2003
    ..These results suggest that several pathways contribute to cell migration, but that Nischarin selectively inhibits Rac driven signaling cascades that affect migration through PAK...
  3. pmc A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin
    Suresh K Alahari
    Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7365, USA
    Biochem J 377:449-57. 2004
    ..Further studies demonstrated that the minimal alpha5 binding region of nischarin does not affect cell migration...
  4. pmc The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK
    Suresh K Alahari
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    EMBO J 23:2777-88. 2004
    ..In addition, PAK1 and Nischarin colocalize in membrane ruffles, structures known to be involved in cell motility. Thus, Nischarin may regulate cell migration by forming inhibitory complexes with PAK family kinases...
  5. ncbi Biological aspects of signal transduction by cell adhesion receptors
    Suresh K Alahari
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA
    Int Rev Cytol 220:145-84. 2002
    ..In many cases these molecules impinge on both the regulation of cell movement and on control of apoptosis...
  6. pmc Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion
    Yuemin Ding
    Department of Biochemistry and Molecular Biology, School of Medicine, LSU Health Science Center, New Orleans, LA 70112, USA
    Mol Cell Biol 28:3742-56. 2008
    ..In addition, knock-down of nischarin showed branched projection actin structures. Collectively these data indicate that nischarin siRNA may enhance random migration, resulting in stimulation of invasion...