V M Berthoud

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Gap junction synthesis and degradation as therapeutic targets
    Eric C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Curr Drug Targets 3:409-16. 2002
  2. pmc An aberrant sequence in a connexin46 mutant underlies congenital cataracts
    Peter J Minogue
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:40788-95. 2005
  3. pmc Focus on lens connexins
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, IL, USA
    BMC Cell Biol 18:6. 2017
  4. pmc The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses
    Viviana M Berthoud
    From the Department of Pediatrics and
    J Biol Chem 291:17569-78. 2016
  5. pmc Connexin23 deletion does not affect lens transparency
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, IL, USA Electronic address
    Exp Eye Res 146:283-8. 2016
  6. pmc Roles and regulation of lens epithelial cell connexins
    Viviana M Berthoud
    Department of Pediatrics and Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, United States Electronic address
    FEBS Lett 588:1297-303. 2014
  7. pmc Oxidative stress, lens gap junctions, and cataracts
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:339-53. 2009
  8. ncbi request reprint PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication
    V M Berthoud
    Department of Pediatrics, University of Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 41:850-8. 2000
  9. pmc Highly restricted pattern of connexin36 expression in chick somite development
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Anat Embryol (Berl) 209:11-8. 2004
  10. ncbi request reprint Pathways for degradation of connexins and gap junctions
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Cardiovasc Res 62:256-67. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Gap junction synthesis and degradation as therapeutic targets
    Eric C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Curr Drug Targets 3:409-16. 2002
    ....
  2. pmc An aberrant sequence in a connexin46 mutant underlies congenital cataracts
    Peter J Minogue
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:40788-95. 2005
    ..These results suggest a novel mechanism in which a mutation causes disease by generating a motif that leads to retention within the synthetic/secretory pathway...
  3. pmc Focus on lens connexins
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, IL, USA
    BMC Cell Biol 18:6. 2017
    ..Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components...
  4. pmc The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses
    Viviana M Berthoud
    From the Department of Pediatrics and
    J Biol Chem 291:17569-78. 2016
    ....
  5. pmc Connexin23 deletion does not affect lens transparency
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, IL, USA Electronic address
    Exp Eye Res 146:283-8. 2016
    ..These results suggest that although Cx23 expression can influence the abundance of the co-expressed lens fiber connexins, heterozygous or homozygous expression of a Cx23-null allele does not alter lens transparency. ..
  6. pmc Roles and regulation of lens epithelial cell connexins
    Viviana M Berthoud
    Department of Pediatrics and Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, United States Electronic address
    FEBS Lett 588:1297-303. 2014
    ..Cx43 and Cx50 hemichannels and gap junction channels are regulated by multiple different agents. Lens epithelial cell connexins contribute to both normal lens physiology and pathology. ..
  7. pmc Oxidative stress, lens gap junctions, and cataracts
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:339-53. 2009
    ..These observations suggest that oxidative stress-induced damage to connexins (and consequent altered intercellular communication) may contribute to cataract formation...
  8. ncbi request reprint PKC isoenzymes in the chicken lens and TPA-induced effects on intercellular communication
    V M Berthoud
    Department of Pediatrics, University of Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 41:850-8. 2000
    ....
  9. pmc Highly restricted pattern of connexin36 expression in chick somite development
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Anat Embryol (Berl) 209:11-8. 2004
    ....
  10. ncbi request reprint Pathways for degradation of connexins and gap junctions
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Cardiovasc Res 62:256-67. 2004
    ..Degradation of gap junction plaques is proteasome-dependent in some cell types. Degradation may be regulated by ubiquitinylation, phosphorylation, or polypeptide domains that act as sorting signals...
  11. ncbi request reprint Gap junctions in the chicken pineal gland
    V M Berthoud
    Section of Pediatrics Hematology Oncology, University of Chicago, 4851 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Brain Res 861:257-70. 2000
    ....
  12. ncbi request reprint Heteromeric connexons formed by the lens connexins, connexin43 and connexin56
    V M Berthoud
    Department of Pediatrics, University of Chicago, IL 60637, USA
    Eur J Cell Biol 80:11-9. 2001
    ....
  13. pmc Loss of function and impaired degradation of a cataract-associated mutant connexin50
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Eur J Cell Biol 82:209-21. 2003
    ..Taken together, these results suggest that the P to S mutation at amino acid residue 88 causes a defect that leads to decreased degradation and subsequent accumulation of hCx50P88S in a cellular structure different from aggresomes...
  14. pmc A mutant connexin50 with enhanced hemichannel function leads to cell death
    Peter J Minogue
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 50:5837-45. 2009
    ..To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts...
  15. pmc Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50
    Bettina C Thomas
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 49:2549-56. 2008
    ....
  16. ncbi request reprint Heteromeric mixing of connexins: compatibility of partners and functional consequences
    E C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Cell Commun Adhes 8:199-204. 2001
    ....
  17. pmc The N terminus of connexin37 contains an alpha-helix that is required for channel function
    John W Kyle
    Department of Medicine Section of Cardiology, University of Chicago, Chicago, Illinois 60637 1470, USA
    J Biol Chem 284:20418-27. 2009
    ..Taken together, our data suggest that the alpha-helical structure of the connexin37 N terminus may be dispensable for protein localization, but it is required for channel and hemichannel function...
  18. pmc An intact connexin N-terminus is required for function but not gap junction formation
    John W Kyle
    Department of Medicine, Section of Cardiology, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 121:2744-50. 2008
    ..We conclude that as much as half the length of the connexin N-terminus can be deleted without affecting formation of gap junction plaques, but an intact N-terminus is required for hemichannel gating and intercellular communication...
  19. pmc The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum
    Alexandra Lichtenstein
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637 1470, USA
    Exp Eye Res 88:600-9. 2009
    ..The persistence of these particles in the lens may cause light scattering and the pulverulent cataracts observed in affected individuals...
  20. pmc Transgenic overexpression of connexin50 induces cataracts
    June Chung
    Department of Pediatrics, University of Chicago, IL 60637, USA
    Exp Eye Res 84:513-28. 2007
    ....
  21. pmc Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels
    Michael C Puljung
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, IL 60637, USA
    J Gen Physiol 124:587-603. 2004
    ..The model for hCx37 voltage gating as polyvalent block/unblock can be expanded to account for observations in the literature regarding hCx37 gap junction channel behavior...
  22. pmc Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 333:1185-93. 2005
    ..These data suggest that Cx43del(130-136) produces connexin-specific inhibition of intercellular communication through formation of heteromeric connexons that are non-functional and/or retained in the cytoplasm...
  23. pmc Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 120:320-9. 2007
    ..These results demonstrate that TNFalpha induces apoptosis in LNCaP cells by signaling through TNFalpha receptor 1 and that expression of functional Cx43 gap junction channels increases their sensitivity to TNFalpha...
  24. ncbi request reprint Biophysical evidence that connexin-36 forms functional gap junction channels between pancreatic mouse beta-cells
    Alonso P Moreno
    Krannert Institue of Cardiology, Indiana School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Endocrinol Metab 288:E948-56. 2005
    ..Cell type-specific mechanisms that may account for these differences are discussed...
  25. ncbi request reprint Plasma membrane channels formed by connexins: their regulation and functions
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Physiol Rev 83:1359-400. 2003
    ..The observed phenotypes range from specific tissue dysfunction to embryonic lethality...