Eric Beyer

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Cx30.2 can form heteromeric gap junction channels with other cardiac connexins
    Joanna Gemel
    University of Chicago, Department of Pediatrics MC 4060, 5841 S Maryland Avenue, Chicago, IL 60637 1470, USA
    Biochem Biophys Res Commun 369:388-94. 2008
  2. ncbi request reprint Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins
    E C Beyer
    Section of Pediatric Hematology Oncology, University of Chicago, Chicago, IL 60637 1470, USA
    Braz J Med Biol Res 33:391-7. 2000
  3. ncbi request reprint Heteromeric mixing of connexins: compatibility of partners and functional consequences
    E C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Cell Commun Adhes 8:199-204. 2001
  4. ncbi request reprint Gap junction synthesis and degradation as therapeutic targets
    Eric C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Curr Drug Targets 3:409-16. 2002
  5. pmc Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50
    Bettina C Thomas
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 49:2549-56. 2008
  6. pmc An aberrant sequence in a connexin46 mutant underlies congenital cataracts
    Peter J Minogue
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:40788-95. 2005
  7. pmc A mutant connexin50 with enhanced hemichannel function leads to cell death
    Peter J Minogue
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 50:5837-45. 2009
  8. pmc An intact connexin N-terminus is required for function but not gap junction formation
    John W Kyle
    Department of Medicine, Section of Cardiology, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 121:2744-50. 2008
  9. ncbi request reprint Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation
    Agustin D Martinez
    Department of Pediatrics, University of Chicago, Chicago, Ill, USA
    Circ Res 90:1100-7. 2002
  10. pmc Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 333:1185-93. 2005

Research Grants

  1. INTERCELLULAR COMMUNICATION IN THE HEART
    Eric Beyer; Fiscal Year: 2003

Collaborators

Detail Information

Publications29

  1. pmc Cx30.2 can form heteromeric gap junction channels with other cardiac connexins
    Joanna Gemel
    University of Chicago, Department of Pediatrics MC 4060, 5841 S Maryland Avenue, Chicago, IL 60637 1470, USA
    Biochem Biophys Res Commun 369:388-94. 2008
    ..Our data suggest that connexin30.2 can form heteromers with the other cardiac connexins and that mixed channel formation will influence the gating properties of gap junctions in cardiac regions that co-express these connexins...
  2. ncbi request reprint Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins
    E C Beyer
    Section of Pediatric Hematology Oncology, University of Chicago, Chicago, IL 60637 1470, USA
    Braz J Med Biol Res 33:391-7. 2000
    ..Furthermore, modulation of levels of the co-expressed connexins during cell proliferation or by cytokines may alter the relative abundance of different heteromeric combinations...
  3. ncbi request reprint Heteromeric mixing of connexins: compatibility of partners and functional consequences
    E C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Cell Commun Adhes 8:199-204. 2001
    ....
  4. ncbi request reprint Gap junction synthesis and degradation as therapeutic targets
    Eric C Beyer
    Department of Pediatrics, University of Chicago, IL 60637 1470, USA
    Curr Drug Targets 3:409-16. 2002
    ....
  5. pmc Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50
    Bettina C Thomas
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637 1470, USA
    Invest Ophthalmol Vis Sci 49:2549-56. 2008
    ....
  6. pmc An aberrant sequence in a connexin46 mutant underlies congenital cataracts
    Peter J Minogue
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:40788-95. 2005
    ..These results suggest a novel mechanism in which a mutation causes disease by generating a motif that leads to retention within the synthetic/secretory pathway...
  7. pmc A mutant connexin50 with enhanced hemichannel function leads to cell death
    Peter J Minogue
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, Illinois 60637, USA
    Invest Ophthalmol Vis Sci 50:5837-45. 2009
    ..To determine the consequences of expression of a novel connexin50 (CX50) mutant identified in a child with congenital total cataracts...
  8. pmc An intact connexin N-terminus is required for function but not gap junction formation
    John W Kyle
    Department of Medicine, Section of Cardiology, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 121:2744-50. 2008
    ..We conclude that as much as half the length of the connexin N-terminus can be deleted without affecting formation of gap junction plaques, but an intact N-terminus is required for hemichannel gating and intercellular communication...
  9. ncbi request reprint Connexin43 and connexin45 form heteromeric gap junction channels in which individual components determine permeability and regulation
    Agustin D Martinez
    Department of Pediatrics, University of Chicago, Chicago, Ill, USA
    Circ Res 90:1100-7. 2002
    ..Thus, biochemical and electrophysiological evidence suggests that Cx43 and Cx45 extensively mix to form heteromeric channels; however, individual connexin components dominate aspects of the physiological behavior of these channels...
  10. pmc Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL, USA
    Biochem Biophys Res Commun 333:1185-93. 2005
    ..These data suggest that Cx43del(130-136) produces connexin-specific inhibition of intercellular communication through formation of heteromeric connexons that are non-functional and/or retained in the cytoplasm...
  11. pmc N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26
    Joanna Gemel
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, IL 60637 1470, USA
    J Cell Sci 119:2258-68. 2006
    ....
  12. ncbi request reprint Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells
    Joanna Gemel
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, IL 60637 1470, USA
    J Cell Sci 117:2469-80. 2004
    ....
  13. pmc The N terminus of connexin37 contains an alpha-helix that is required for channel function
    John W Kyle
    Department of Medicine Section of Cardiology, University of Chicago, Chicago, Illinois 60637 1470, USA
    J Biol Chem 284:20418-27. 2009
    ..Taken together, our data suggest that the alpha-helical structure of the connexin37 N terminus may be dispensable for protein localization, but it is required for channel and hemichannel function...
  14. pmc Oxidative stress, lens gap junctions, and cataracts
    Viviana M Berthoud
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    Antioxid Redox Signal 11:339-53. 2009
    ..These observations suggest that oxidative stress-induced damage to connexins (and consequent altered intercellular communication) may contribute to cataract formation...
  15. pmc Transgenic overexpression of connexin50 induces cataracts
    June Chung
    Department of Pediatrics, University of Chicago, IL 60637, USA
    Exp Eye Res 84:513-28. 2007
    ....
  16. pmc The cytoplasmic accumulations of the cataract-associated mutant, Connexin50P88S, are long-lived and form in the endoplasmic reticulum
    Alexandra Lichtenstein
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637 1470, USA
    Exp Eye Res 88:600-9. 2009
    ..The persistence of these particles in the lens may cause light scattering and the pulverulent cataracts observed in affected individuals...
  17. pmc Loss of function and impaired degradation of a cataract-associated mutant connexin50
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Eur J Cell Biol 82:209-21. 2003
    ..Taken together, these results suggest that the P to S mutation at amino acid residue 88 causes a defect that leads to decreased degradation and subsequent accumulation of hCx50P88S in a cellular structure different from aggresomes...
  18. pmc Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels
    Michael C Puljung
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, IL 60637, USA
    J Gen Physiol 124:587-603. 2004
    ..The model for hCx37 voltage gating as polyvalent block/unblock can be expanded to account for observations in the literature regarding hCx37 gap junction channel behavior...
  19. pmc A carboxyl terminal domain of connexin43 is critical for gap junction plaque formation but not for homo- or hetero-oligomerization
    Agustin D Martinez
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Cell Commun Adhes 10:323-8. 2003
    ..These results suggest that the carboxyl tail of Cx43 is not important for oligomerization, but they implicate critical residues in the formation of gap junction plaques...
  20. ncbi request reprint Pathways for degradation of connexins and gap junctions
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Cardiovasc Res 62:256-67. 2004
    ..Degradation of gap junction plaques is proteasome-dependent in some cell types. Degradation may be regulated by ubiquitinylation, phosphorylation, or polypeptide domains that act as sorting signals...
  21. pmc Highly restricted pattern of connexin36 expression in chick somite development
    Viviana M Berthoud
    Department of Pediatrics, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 4060, Chicago, IL 60637, USA
    Anat Embryol (Berl) 209:11-8. 2004
    ....
  22. ncbi request reprint Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis
    Kyung H Seul
    Section of Pediatric Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL 60637 1470, USA
    Biochem Biophys Res Commun 319:1144-51. 2004
    ..These data suggest that connexin-specific alterations of intercellular communication may modulate endothelial cell growth and death...
  23. pmc Connexin43 increases the sensitivity of prostate cancer cells to TNFalpha-induced apoptosis
    Min Wang
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL 60637, USA
    J Cell Sci 120:320-9. 2007
    ..These results demonstrate that TNFalpha induces apoptosis in LNCaP cells by signaling through TNFalpha receptor 1 and that expression of functional Cx43 gap junction channels increases their sensitivity to TNFalpha...
  24. pmc Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions
    Hassan Musa
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Physiol 557:863-78. 2004
    ..Functional reciprocity between Cx40 and Cx43 gap junctions involves other amino acid residues in addition to the E or K 9 and 13 loci located on the amino terminal domain of these two connexins...
  25. ncbi request reprint Redistribution of connexin45 in gap junctions of connexin43-deficient hearts
    Carolyn M Johnson
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cardiovasc Res 53:921-35. 2002
    ..The present study was undertaken to determine (1) whether expression of Cx45 is upregulated and (2) whether gap junction structure and distribution are altered in Cx43-deficient mice...
  26. ncbi request reprint Cardiac gap junction channels show quantitative differences in selectivity
    Virginijus Valiunas
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Circ Res 91:104-11. 2002
    ..Moreover, the data indicate that coexpression of connexins does not generate unique permeability characteristics, but rather results in an intermediate permeability for solutes involved in metabolic/biochemical coupling...
  27. pmc Dynamic model for ventricular junctional conductance during the cardiac action potential
    Xianming Lin
    Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Am J Physiol Heart Circ Physiol 288:H1113-23. 2005
    ..These observations suggest that gap junctions may play a role in the development of conduction block and the genesis and propagation of triggered arrhythmias under conditions of slowed conduction (<10 cm/s)...
  28. ncbi request reprint Plasma membrane channels formed by connexins: their regulation and functions
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Physiol Rev 83:1359-400. 2003
    ..The observed phenotypes range from specific tissue dysfunction to embryonic lethality...
  29. pmc Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5
    Vania L F Linhares
    Laboratório de Cardiologia Celular e Molecular Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 20941 900, Brazil
    Cardiovasc Res 64:402-11. 2004
    ..In this report, we identify cis-acting elements within the mouse Cx40 promoter and unravel part of the complex pathways involved in the cardiac expression of this gene...

Research Grants1

  1. INTERCELLULAR COMMUNICATION IN THE HEART
    Eric Beyer; Fiscal Year: 2003
    ..This study may have significant implications for the elucidation of cardiovascular disease (including arrhythmias) associated with connexins. ..