Cesar V Borlongan

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. doi request reprint Recent Advances in Stem Cell-Based Therapeutics for Stroke.
    Eleonora Napoli
    Department of Molecular Biosciences, University of California Davis, Davis, CA, USA
    Transl Stroke Res 7:452-457. 2016
  2. ncbi request reprint Stem cell therapy for sequestering neuroinflammation in traumatic brain injury: an update on exosome-targeting to the spleen
    Marci G Crowley
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa FL, USA
    J Neurosurg Sci . 2016
  3. ncbi request reprint Biobridge concept in stem cell therapy for ischemic stroke
    Michael G Liska
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa FL, USA
    J Neurosurg Sci 61:173-179. 2017
  4. pmc A possible new focus for stroke treatment - migrating stem cells
    Robert Sullivan
    University of South Florida College of Medicine, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, 12901 Bruce B Downs Blvd, Tampa, FL, USA 1 813 974 3154 1 813 974 3078
    Expert Opin Biol Ther 15:949-58. 2015
  5. pmc A case with transient refractive change after removal of pituitary tumor
    Hiroto Ishikawa
    Department of Ophthalmology, Hyogo College of Medicine, 1 1 Mukogawa cyo, Nishinomiya, Hyogo 663 8501, Japan
    BMC Ophthalmol 13:65. 2013
  6. pmc Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor
    I Dela Peña
    Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain Repair University of South Florida Morsani College of Medicine Tampa, FL, USA
    J Neurosurg Sci 58:145-9. 2014
  7. pmc Microglia activation as a biomarker for traumatic brain injury
    Diana G Hernandez-Ontiveros
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida Tampa, FL, USA
    Front Neurol 4:30. 2013
  8. pmc Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e91408. 2014
  9. pmc Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e78851. 2013
  10. pmc Peripheral nerve repair with cultured schwann cells: getting closer to the clinics
    Maria Carolina O Rodrigues
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulvard, Tampa, FL 33612, USA
    ScientificWorldJournal 2012:413091. 2012

Collaborators

Detail Information

Publications100

  1. doi request reprint Recent Advances in Stem Cell-Based Therapeutics for Stroke.
    Eleonora Napoli
    Department of Molecular Biosciences, University of California Davis, Davis, CA, USA
    Transl Stroke Res 7:452-457. 2016
  2. ncbi request reprint Stem cell therapy for sequestering neuroinflammation in traumatic brain injury: an update on exosome-targeting to the spleen
    Marci G Crowley
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa FL, USA
    J Neurosurg Sci . 2016
    ..Here, we provide an update on recent scientific evidence supporting the stem cells' novel mechanism of sequestering the inflammation-mediated secondary cell death that closely accompanies the evolution of TBI pathology...
  3. ncbi request reprint Biobridge concept in stem cell therapy for ischemic stroke
    Michael G Liska
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa FL, USA
    J Neurosurg Sci 61:173-179. 2017
    ..This paper discusses the use of stem cell transplantation for stroke with an emphasis on the new biobridge concept. Also discussed are the current challenges faced before this approach can advance to the clinical setting...
  4. pmc A possible new focus for stroke treatment - migrating stem cells
    Robert Sullivan
    University of South Florida College of Medicine, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, 12901 Bruce B Downs Blvd, Tampa, FL, USA 1 813 974 3154 1 813 974 3078
    Expert Opin Biol Ther 15:949-58. 2015
    ..More so, its infliction often leaves patients with lasting morbidity and deficits. Ischemic stroke comprises nearly 90% of incidents and the majority of medical treatment aims at reestablishing perfusion and preventing recurrence...
  5. pmc A case with transient refractive change after removal of pituitary tumor
    Hiroto Ishikawa
    Department of Ophthalmology, Hyogo College of Medicine, 1 1 Mukogawa cyo, Nishinomiya, Hyogo 663 8501, Japan
    BMC Ophthalmol 13:65. 2013
    ..Refractive change can be caused by systemic illnesses such as Lupus erythematosus, thyroid deficiency, and diabetes mellitus. However, refractive change after pituitary tumor removal has so far not been reported...
  6. pmc Stem cells and G-CSF for treating neuroinflammation in traumatic brain injury: aging as a comorbidity factor
    I Dela Peña
    Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain Repair University of South Florida Morsani College of Medicine Tampa, FL, USA
    J Neurosurg Sci 58:145-9. 2014
    ....
  7. pmc Microglia activation as a biomarker for traumatic brain injury
    Diana G Hernandez-Ontiveros
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida Tampa, FL, USA
    Front Neurol 4:30. 2013
    ....
  8. pmc Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e91408. 2014
    ..Despite absence of reduction in infarct volume, NSI-566RSC transplantation produced behavioral improvements possibly via robust engraftment and neuronal differentiation, supporting the use of this NSC line for stroke therapy. ..
  9. pmc Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e78851. 2013
    ..The recognition of this pathological link between TBI and AD should aid in developing novel treatments directed at abrogating cellular injury and extracellular Aβ deposition in the brain. ..
  10. pmc Peripheral nerve repair with cultured schwann cells: getting closer to the clinics
    Maria Carolina O Rodrigues
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulvard, Tampa, FL 33612, USA
    ScientificWorldJournal 2012:413091. 2012
    ..This paper focuses on this new therapeutic approach highlighting its direct translational and clinical utility in promoting regeneration of not only acute but perhaps also chronic cases of peripheral nerve damage...
  11. pmc Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model
    Loren E Glover
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e33646. 2012
    ..That immediate, but not delayed, skull reconstruction may exacerbate TBI-induced cortical tissue damage warrants a careful consideration of aesthetic repair of the skull in TBI...
  12. pmc Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications
    Dae Won Kim
    Department of Neurosurgery, Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, 344 2 Shinyong dong, Iksan 570 749, Korea
    Int J Mol Sci 14:11692-712. 2013
    ..g., cancer, chronic liver disease, cardiovascular diseases, nerve, cartilage and tendon injury). Additional studies are warranted to translate the use of WJ-derived stem cells for clinical applications...
  13. pmc Melatonin-based therapeutics for neuroprotection in stroke
    Kazutaka Shinozuka
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Int J Mol Sci 14:8924-47. 2013
    ..As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application...
  14. pmc Permeating the blood brain barrier and abrogating the inflammation in stroke: implications for stroke therapy
    Cesar V Borlongan
    Department of Neurology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Curr Pharm Des 18:3670-6. 2012
    ..In this review, we propose the combination of mannitol-induced BBB permeation and NF-kB decoy for enhancing the therapeutic benefits of cell therapy in stroke...
  15. pmc Recent preclinical evidence advancing cell therapy for Alzheimer's disease
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Exp Neurol 237:142-6. 2012
    ....
  16. pmc Breaking the barrier in stroke: what should we know? A mini-review
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612 USA
    Curr Pharm Des 18:3615-23. 2012
    ..This minireview captures cutting-edge discoveries establishing BBB as a central target for abetting neuroprotection and neurorestoration in stroke...
  17. pmc Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!
    C V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Leukemia 25:1674-86. 2011
    ..Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke...
  18. pmc Baby STEPS: a giant leap for cell therapy in neonatal brain injury
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    Pediatr Res 70:3-9. 2011
    ..This schema forms the basis of Baby STEPS. Our goal is to resonate the urgent call to enhance the successful translation of cell therapy from the laboratory to the clinic...
  19. pmc The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Neurobiol 95:213-28. 2011
    ..When possible, we also discuss the relevance of this therapeutic regimen in other central nervous system (CNS) disorders...
  20. pmc Menstrual blood cells display stem cell-like phenotypic markers and exert neuroprotection following transplantation in experimental stroke
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Stem Cells Dev 19:439-52. 2010
    ..The present neurostructural and behavioral benefits afforded by transplanted menstrual blood-derived cells support their use as a stem cell source for cell therapy in stroke...
  21. pmc Hibernation-like state induced by an opioid peptide protects against experimental stroke
    Cesar V Borlongan
    National Institutes of Health, National Institute on Drug Abuse Intramural Research Program, Cellular Neurobiology Branch, Baltimore, MD, USA
    BMC Biol 7:31. 2009
    ..In the present study, we investigated the protective effect of DADLE in the central nervous system...
  22. ncbi request reprint Behavioral and histological characterization of intrahippocampal grafts of human bone marrow-derived multipotent progenitor cells in neonatal rats with hypoxic-ischemic injury
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Transplant 15:231-8. 2006
    ..An equally major finding is the observation lending support to the hippocampus as an excellent target brain region for stem cell therapy in treating HI injury...
  23. ncbi request reprint Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion
    Koichi Hara
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    J Neurosci Res 85:1240-51. 2007
    ..Nurr1 cell grafts in ischemic stroke, with in vitro evidence suggesting the cells' excellent neuronal differentiation capability and ability to secrete GDNF as likely mechanisms mediating the observed therapeutic benefits...
  24. pmc Intravenous grafts recapitulate the neurorestoration afforded by intracerebrally delivered multipotent adult progenitor cells in neonatal hypoxic-ischemic rats
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3200, USA
    J Cereb Blood Flow Metab 28:1804-10. 2008
    ..These results show that intravenous delivery of MAPCs is a feasible and efficacious cell therapy with potential for clinical use...
  25. pmc Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
    Noriyuki Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    BMC Neurosci 10:126. 2009
    ..Assessment of the mechanism underlying minocycline neuroprotection should clarify the drug's clinical value in acute stroke setting...
  26. doi request reprint Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke
    Koichi Hara
    Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Prog Neurobiol 85:318-34. 2008
    ..Such highly potent neuronal lineage commitment and neurotrophic factor secretory function of NT2.Nurr1 cells make them an appealing graft source for transplantation therapy...
  27. pmc Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e53376. 2013
    ..Therapeutic intervention at the chronic stage of TBI may confer abrogation of these deleterious cell death processes...
  28. pmc Toward personalized cell therapies: autologous menstrual blood cells for stroke
    Maria Carolina O Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Biomed Biotechnol 2011:194720. 2011
    ..Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient...
  29. doi request reprint Dietary supplementation exerts neuroprotective effects in ischemic stroke model
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Rejuvenation Res 11:201-14. 2008
    ..These data demonstrate the remarkable neuroprotective effects of NT-020 when given prior to stroke, possibly acting via its neurogenic potential...
  30. ncbi request reprint Transplantation of cryopreserved human bone marrow-derived multipotent adult progenitor cells for neonatal hypoxic-ischemic injury: targeting the hippocampus
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Rev Neurosci 17:215-25. 2006
    ..Seven-day old Sprague-Dawley rats were initially subjected to unilateral HI injury, that involved permanent ligation of the right common carotid artery and subsequent exposure to hypoxic environment. At day 7 after HI..
  31. pmc Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, K S, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M Medical Research Institute, Chung Ang University College of Medicine, Seoul, Korea H J L Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D and Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada S U K
    Stroke 44:3473-81. 2013
    ..Here, we examined the role of stem cell-mediated vascular repair in stroke...
  32. pmc Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair and School of Physical Therapy and Rehabilitation Sciences, University of South Florida Morsani College of Medicine, Tampa, Florida 33612, James A Haley Veterans Affairs Hospital, Research Service, Tampa, Florida 33612, and Departments of Molecular Pharmacology and Physiology and Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612
    J Neurosci 34:313-26. 2014
    ..Furthermore, hADSCs showed reduced efficacy in aged rats, which may in part result from decreased homing of the cells to the spleen. ..
  33. doi request reprint Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits
    SeongJin Yu
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1287:157-63. 2009
    ....
  34. doi request reprint Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals
    Takao Yasuhara
    Department of Neurology, Medical College of Georgia, Augusta, Georgia, USA
    Stem Cells Dev 18:1501-14. 2009
    ..The present study demonstrates the potential of Notch-induced BMSC cell therapy for patients presenting with fixed ischemic stroke...
  35. pmc Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury
    Mibel M Pabon
    Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida College of Medicine, Tampa, FL, USA
    CNS Neurosci Ther 22:200-11. 2016
    ..The aim of this study was to examine the histopathological effects of different angles of mechanical injury by manipulating the trajectory of the controlled cortical impact injury (CCI) model in adult Sprague-Dawley rats...
  36. pmc The battle of the sexes for stroke therapy: female- versus male-derived stem cells
    Yuji Kaneko
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair University of South Florida, College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    CNS Neurol Disord Drug Targets 12:405-12. 2013
    ..We highlight the practicality of experimental and clinical application of menstrual blood cells and Sertoli cells to treat stroke, from cell isolation and cryopreservation to administration...
  37. pmc Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e47583. 2012
    ....
  38. pmc Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats
    Naoki Tajiri
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e43779. 2012
    ..This study reports the therapeutic potential of AFS cell transplantation in stroke animals, possibly via enhancement of endogenous repair mechanisms...
  39. pmc Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e74857. 2013
    ....
  40. doi request reprint The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 20:85-94. 2011
    ..Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement, have been detected in both transplanted cells...
  41. pmc Ischemic stroke brain sends indirect cell death signals to the heart
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M and Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D
    Stroke 44:3175-82. 2013
    ..However, it remains uncertain how an ischemic brain contributes to cardiac alternations. Here, we used experimental stroke models to reveal the pathological effects of the ischemic brain on the heart...
  42. ncbi request reprint Limitations of intravenous human bone marrow CD133+ cell grafts in stroke rats
    Cesar V Borlongan
    Department of Neurology, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Brain Res 1048:116-22. 2005
    ..Reduction of cerebral infarct (25%) was only noted in intracerebral transplantation. Intravenous transplantation requires optimization for improved therapeutic outcome of CD133+ cell grafts in stroke...
  43. pmc A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus
    Naoki Tajiri
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    CNS Neurosci Ther 22:306-15. 2016
    ..Traumatic brain injury (TBI) presents with a secondary cell death characterized by neuroinflammation that is putatively regulated by nuclear receptors...
  44. doi request reprint Bone marrow-derived stem cell therapy for metastatic brain cancers
    Yuji Kaneko
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 24:625-30. 2015
    ..Abrogating this leaky BBB-mediated inflammation via stem cell therapy represents a paradigm-shifting approach to treating brain cancer. This review article discusses the pros and cons of cell therapy for melanoma brain metastases. ..
  45. doi request reprint Recent progress in cell therapy for basal ganglia disorders with emphasis on menstrual blood transplantation in stroke
    Maria Carolina Oliveira Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, USA
    Neurosci Biobehav Rev 36:177-90. 2012
    ..We highlight the availability, proliferative capacity, pluripotentiality and angiogenic features of these cells and explore their present and future experimental and clinical applications...
  46. doi request reprint Human umbilical cord blood cell grafts for brain ischemia
    Dong Hyuk Park
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 18:985-98. 2009
    ..Eventually, these multiple protective and restorative effects from umbilical cord blood cell grafts may be interdependent and act in harmony in promoting therapeutic benefits for stroke...
  47. pmc Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats
    Lin Xu
    Department of Neurology, Medical College of Georgia, Augusta GA, 30912, USA
    BMC Neurol 4:7. 2004
    ....
  48. pmc Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy
    Yuji Kaneko
    Center of Excellence for Aging and Brain, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Mol Neurobiol 53:1874-83. 2016
    ....
  49. doi request reprint Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    J Pineal Res 50:272-80. 2011
    ....
  50. pmc Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury
    Darrell Sawmiller
    James A Haley Veteran s Administration Hospital, Tampa, FL 33612, USA
    Int J Mol Sci 15:895-904. 2014
    ..This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI. ..
  51. pmc Vascular damage: a persisting pathology common to Alzheimer's disease and traumatic brain injury
    Max Franzblau
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Med Hypotheses 81:842-5. 2013
    ..If our hypothesis is correct, treatments targeted at repairing the vasculature may prove effective at treating both diseases and preventing the evolution of AD symptoms in TBI victims. ..
  52. pmc Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Brain Res 1559:65-71. 2014
    ..These results suggest a robust, immediate anti-inflammatory response mounted by the contralateral hemisphere of the young brain. ..
  53. ncbi request reprint Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection
    Naoki Tajiri
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Curr Pharm Des 18:3663-9. 2012
    ..To this end, we discuss the laboratory and clinical evidence implicating aneurysm formation in stroke and also provide insights on how stem cell therapy may prove efficacious in combating aneurysm and stroke...
  54. ncbi request reprint Nanotechnology as an adjunct tool for transplanting engineered cells and tissues
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30904, USA
    Curr Mol Med 7:609-18. 2007
    ..This review article discusses recent progress in the field of nanotechnology as a tool for tissue engineering, gene therapy, cell immunoisolation, and cell imaging, highlighting its direct applications in cell transplantation therapy...
  55. doi request reprint Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke.
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine Tampa, FL, USA
    Front Cell Neurosci 8:227. 2014
    ....
  56. doi request reprint Stroke and cardiac cell death: Two peas in a pod
    Chiara Gonzales-Portillo
    University of South Florida, Department of Neurosurgery and Brain Repair, Tampa, FL, USA
    Clin Neurol Neurosurg 142:145-7. 2016
    ....
  57. pmc Regeneration of neuronal cells following cerebral injury
    Travis Dailey
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Front Neurol Neurosci 32:54-61. 2013
    ..Furthermore, we outline specific mechanisms of action along with their clinical potential as therapeutic treatments for ischemic stroke. ..
  58. pmc Epidemiological survey-based formulae to approximate incidence and prevalence of neurological disorders in the United States: a meta-analysis
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 8:e78490. 2013
    ..We report here the incidence and prevalence of the major adult-onset brain disorders in the United States using a meta-analysis approach...
  59. doi request reprint Cyclosporine-A as a neuroprotective agent against stroke: its translation from laboratory research to clinical application
    Mohamed M Osman
    Center of Excellence in Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Neuropeptides 45:359-68. 2011
    ..In this review, we provide an overview of the current laboratory and clinical status of CsA neuroprotection...
  60. ncbi request reprint Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke
    Cesar V Borlongan
    Department of Neurology, School of Medicine, and the Institute of Molecular Medicine and Genetics, School of Graduate Studies, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Stroke 35:2206-10. 2004
    ..Choroid plexus (CP) secretes a cocktail of neurotrophic factors. In the present study, CP from neonatal pigs was encapsulated within alginate microcapsules for in vitro and in vivo neuroprotective studies...
  61. ncbi request reprint Intracerebral transplantation of carotid body in rats with transient middle cerebral artery occlusion
    Guolong Yu
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1015:50-6. 2004
    ..The present study extends the use of CB as efficacious graft source for transplantation...
  62. pmc Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy
    Travis Dailey
    Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, USA
    Neuroreport 24:1067-71. 2013
    ....
  63. pmc Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation
    SeongJin Yu
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e76329. 2013
    ..This study supports the use of stem cells for stroke therapy and implicates a key role of Hsp27 signaling pathway in neuroprotection. ..
  64. pmc Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier
    Gabriel S Gonzales-Portillo
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 23:531-9. 2014
    ..The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy. ..
  65. pmc Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, Florida 33612, USA
    Curr Pharm Des 18:3731-4. 2012
    ..This review article discusses translational challenges associated in cell therapy, emphasizing the need for optimizing both safety and efficacy profiles for advancing the clinical applications of EPC transplantation for stroke patients...
  66. ncbi request reprint Transplantation of carotid body cells in the treatment of neurological disorders
    Guolong Yu
    Department of Neurology, BI 3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3200, USA
    Neurosci Biobehav Rev 28:803-10. 2005
    ....
  67. pmc New hope for stroke patients: mobilization of endogenous stem cells
    Cesar V Borlongan
    Medical College of Georgia Department of Neurology Cell Transplantation, Medical College of Georgia, Augusta, GA 30912 3200, USA
    CMAJ 174:954-5. 2006
  68. doi request reprint Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse
    Tadashi Masuda
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Brain Res 1355:228-39. 2010
    ....
  69. doi request reprint No pain, no gain: lack of exercise obstructs neurogenesis
    Nate Watson
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 24:591-7. 2015
    ..Studies designed to reveal how in vivo stimulation, or lack thereof, alters the stem cell microenvironment are needed to begin to develop treatment strategies for enhancing neurogenesis in bedridden patients. ..
  70. doi request reprint Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats
    Takuro Hayashi
    Department of Neurosurgery, University of South Florida, Tampa, FL 33612, USA
    Brain Res 1280:172-7. 2009
    ..These results demonstrate that alterations in MMPs (i.e., MMP-9) commenced immediately after TBI, suggesting that treatment strategies designed to maintain MMP integrity should be initiated in the acute phase of injury...
  71. pmc Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e90953. 2014
    ..These results suggest that combined treatment rather than monotherapy appears optimal for abrogating histophalogical and motor impairments in chronic TBI. ..
  72. ncbi request reprint Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Stroke 35:2385-9. 2004
    ..Here, we examined whether neuroprotection by systemically delivered human umbilical cord blood (HUCB) cells was dependent on their entry into the central nervous system in a rodent model of acute stroke...
  73. pmc Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy
    Kelsey Duncan
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States
    Brain Res 1623:160-5. 2015
    ..This article is part of a Special Issue entitled SI: Cell Interactions In Stroke. ..
  74. pmc Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida
    J Cell Physiol 230:1024-32. 2015
    ....
  75. pmc Delta opioid receptor and its peptide: a receptor-ligand neuroprotection
    Meaghan Staples
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Int J Mol Sci 14:17410-9. 2013
    ..In its entirety, the delta opioid system represents a promising target for neural therapies. ..
  76. pmc Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e81585. 2013
    ....
  77. doi request reprint A review of laboratory and clinical data supporting the safety and efficacy of cyclosporin A in traumatic brain injury
    Dzenan Lulic
    Center of Excellence in Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Neurosurgery 68:1172-85; discussion 1185-6. 2011
    ....
  78. pmc The immunology of traumatic brain injury: a prime target for Alzheimer's disease prevention
    Brian Giunta
    James A Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    J Neuroinflammation 9:185. 2012
    ..In the end, a better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI to later AD...
  79. pmc DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, USA
    Neurobiol Dis 62:56-61. 2014
    ..DJ-1 was detected immediately after stroke and efficiently translocated into the mitochondria offering a new venue for developing treatment strategies against ischemic stroke. ..
  80. ncbi request reprint Adult stem cell therapy for acute brain injury in children
    James E Carroll
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    CNS Neurol Disord Drug Targets 7:361-9. 2008
    ..Long term safety of the cells should be confirmed in animal models. Finally, multicenter clinical trials should be conducted in highly controlled protocols...
  81. pmc Neurological disorders and the potential role for stem cells as a therapy
    Paul R Sanberg
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33612, USA
    Br Med Bull 101:163-81. 2012
    ..In addition, the use of stem cells to develop disease models should not be overlooked...
  82. ncbi request reprint Healing a broken heart with stem cells
    David M Stern
    School of Medicine, Medical College of Georgia, Augusta, GA 30912 3200, USA
    Cell Transplant 13:725-7. 2004
    ....
  83. pmc A showcase of bench-to-bedside regenerative medicine at the 2010 ASNTR
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    ScientificWorldJournal 11:1842-64. 2011
    ..A few preclinical and clinical cell transplantation trials were also introduced as potential areas of followup in the years to come...
  84. ncbi request reprint Stem cells have the potential to rejuvenate regenerative medicine research
    David J Eve
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Med Sci Monit 16:RA197-217. 2010
    ..A sizeable proportion of the transplantation articles reported on how previously new methods may have aided the ability of the cells or tissue to exert beneficial effects following transplantation...
  85. ncbi request reprint Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells
    Mary B Newman
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Stem Cells Dev 14:29-43. 2005
    ....
  86. doi request reprint Stem cell research in cell transplantation: sources, geopolitical influence, and transplantation
    David J Eve
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Cell Transplant 19:1493-509. 2010
    ..Stem cell research shows considerable promise for the treatment of a number of disorders, some of which have entered clinical trials; over the next few years it will be interesting to see how these treatments progress in the clinic...
  87. pmc Dietary supplementations as neuroprotective therapies: focus on NT-020 diet benefits in a rat model of stroke
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA E Mails Y K L C S A P C B
    Int J Mol Sci 13:7424-44. 2012
    ..We envision dietary supplementation as an adjunct therapy for stroke at acute, subacute, and even chronic periods...
  88. pmc Stroke in the eye of the beholder
    Hiroto Ishikawa
    Department of Neurosurgery and Brain Repair, 12901 Bruce B Downs Blvd, University of South Florida, Tampa, FL 33612, USA
    Med Hypotheses 80:411-5. 2013
    ..That retinal damage is closely associated with ischemic stroke, yet remains neglected in stroke treatment regimen, provides the impetus for recognizing the treatment of retinal damage as a critical component of stroke therapy...
  89. ncbi request reprint Do bone marrow cells generate neurons?
    David C Hess
    Department of Neurology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, and Veterans Affairs Medical Research Service, Augusta 30912, USA
    Arch Neurol 61:483-5. 2004
  90. ncbi request reprint G-CSF-Mobilized human peripheral blood for transplantation therapy in stroke
    Cesar V Borlongan
    Department of Neurology and Institute of Molecular Medicine and Genetics, School of Graduate Studies, Medical College of Georgia, Augusta, GA 30912, USA
    Cell Transplant 12:447-8. 2003
  91. pmc Cell-based therapy in ischemic stroke
    David C Hess
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Expert Rev Neurother 8:1193-201. 2008
    ..An integrated approach of cell-based therapy with early-phase clinical trials and continued preclinical work with focus on mechanisms of action is needed...
  92. pmc Cell therapy for stroke: remaining issues to address before embarking on clinical trials
    Cesar V Borlongan
    Department of Neurology, Medical College of Georgia, BI 3080, Augusta, GA 30912, USA
    Stroke 40:S146-8. 2009
    ..In addressing this issue, I borrow heavily from the conference proceedings of the 2007 STEPS (Stem Cell Therapeutics as an Emerging Paradigm in Stroke)...
  93. ncbi request reprint Amnion: a potent graft source for cell therapy in stroke
    Seong Jin Yu
    Department of Neurology, Medical College of Georgia, Augusta, GA, USA
    Cell Transplant 18:111-8. 2009
    ..In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke...
  94. doi request reprint α-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury
    Md Shahaduzzaman
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA Electronic address
    Med Hypotheses 81:675-80. 2013
    ..Thus this article will present speculative arguments of a genetic component contributing to this TBI and PD pathological overlap. ..
  95. ncbi request reprint Standardized embryonic tissue collaboration and hibernation procedures, and MRI-based graft assessment: advancing neural transplantation therapy for Huntington's disease
    Martin Hadman
    Department of Neurology, Medical College of Georgia and Research and Affiliations Service Line, Augusta VMAC, GA 30912, USA
    Cell Transplant 12:677-8. 2003
  96. ncbi request reprint Transplantation of human umbilical cord blood cells in the repair of CNS diseases
    Mary B Newman
    Center of Excellence for Ageing and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Expert Opin Biol Ther 4:121-30. 2004
    ....
  97. doi request reprint The proliferation and differentiation of stem cell journals
    Paul R Sanberg
    Office of Research and Innovation, University of South Florida, 3702 Spectrum Boulevard, Suite 175, Tampa, FL 33612 9444, USA
    Stem Cell Rev 6:497-9. 2010
    ..We discuss here a prophetic path of survival for these journals which likely will closely mimic the core scientific and translational value of stem cells, namely their capacity to proliferate and differentiate into something meaningful!..
  98. ncbi request reprint Cell transplantation: toward cell therapy
    Agneta Sanmartin
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, University of South Florida, Tampa, FL 33612, USA
    Cell Transplant 15:665-73. 2006
  99. doi request reprint Stem cell transplants at childbirth
    Paul R Sanberg
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Stem Cell Rev 6:27-30. 2010
    ....
  100. ncbi request reprint Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection
    Susan C Fagan
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912 2450, USA
    Exp Neurol 186:248-51. 2004
    ....