Affiliation: University of Southern California
- Chen L. A global comparison between nuclear and cytosolic transcriptomes reveals differential compartmentalization of alternative transcript isoforms. Nucleic Acids Res. 2010;38:1086-97 pubmed publisher..In contrast, nonsense-mediated decay is significantly more associated with the isoforms enriched in the nucleus than those enriched in the cytosol. ..
- Chen L. Characterization and comparison of human nuclear and cytosolic editomes. Proc Natl Acad Sci U S A. 2013;110:E2741-7 pubmed publisher..This suggests that editing can mediate RNA memory on evolutionary time-scales to maintain ancestral genetic information. ..