Robyn Cunard

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    J Clin Med 4:715-40. 2015
  2. pmc The endoplasmic reticulum stress response and diabetic kidney disease
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA, USA
    Am J Physiol Renal Physiol 300:F1054-61. 2011
  3. ncbi request reprint The potential use of PPARalpha agonists as immunosuppressive agents
    Robyn Cunard
    Research and Medicine Services, Division of Nephrology, San Diego, CA 92161, USA
    Curr Opin Investig Drugs 6:467-72. 2005
  4. ncbi request reprint Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, University of California and Veterans Affairs San Diego Healthcare System 151, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Immunol 172:7530-6. 2004
  5. ncbi request reprint Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 168:2795-802. 2002
  6. ncbi request reprint WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 169:6806-12. 2002
  7. pmc Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
    Volker Vallon
    Department of Medicine, University of California, San Diego, California 92161, USA
    Am J Physiol Renal Physiol 304:F156-67. 2013
  8. doi request reprint PPARalpha ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression
    Elizabeth Morse
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    Mol Immunol 46:3454-61. 2009
  9. ncbi request reprint Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression
    Erin Selim
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    Mol Immunol 44:1218-29. 2007
  10. pmc Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney
    Emily Borsting
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, California
    J Am Soc Nephrol 25:2067-78. 2014

Collaborators

Detail Information

Publications18

  1. pmc Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    J Clin Med 4:715-40. 2015
    ....
  2. pmc The endoplasmic reticulum stress response and diabetic kidney disease
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA, USA
    Am J Physiol Renal Physiol 300:F1054-61. 2011
    ..A better understanding of the molecular pathways regulated during this process in a cell- and disease-specific manner could reveal novel therapeutic strategies in chronic renal diseases, including diabetic kidney disease...
  3. ncbi request reprint The potential use of PPARalpha agonists as immunosuppressive agents
    Robyn Cunard
    Research and Medicine Services, Division of Nephrology, San Diego, CA 92161, USA
    Curr Opin Investig Drugs 6:467-72. 2005
    ..This review focuses on the use of fibrates in inflammatory disease models. It also describes proposed mechanisms of action of PPARalpha ligands and discusses the potential use of these medications as immunosuppressive agents...
  4. ncbi request reprint Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma
    Robyn Cunard
    Research Service and Division of Nephrology Hypertension, University of California and Veterans Affairs San Diego Healthcare System 151, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Immunol 172:7530-6. 2004
    ..These studies suggest that many of the observed anti-inflammatory effects of PPARgamma ligands may be related to direct inhibition of IFN-gamma by PPARgamma...
  5. ncbi request reprint Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 168:2795-802. 2002
    ....
  6. ncbi request reprint WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo
    Robyn Cunard
    Research Service, Veterans Affairs San Diego Healthcare System, Department of Medicine, University of California, San Diego, CA 92161, USA
    J Immunol 169:6806-12. 2002
    ..WY14,643 in vitro induces apoptosis in lymphocytes and this effect appears to occur in a PPARalpha-independent manner. Thus WY14,643, a fibrate, is a profound immunosuppressive agent...
  7. pmc Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
    Volker Vallon
    Department of Medicine, University of California, San Diego, California 92161, USA
    Am J Physiol Renal Physiol 304:F156-67. 2013
    ....
  8. doi request reprint PPARalpha ligands cause lymphocyte depletion and cell cycle block and this is associated with augmented TRB3 and reduced Cyclin B1 expression
    Elizabeth Morse
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    Mol Immunol 46:3454-61. 2009
    ..Reduced cellular divisions and cell cycle arrest may be responsible for some of the immunomodulatory effects of these agents that have been consistently observed in human trials...
  9. ncbi request reprint Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression
    Erin Selim
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    Mol Immunol 44:1218-29. 2007
    ..These studies outline a novel PPARalpha-independent mechanism of action of fibrates and document for the first time the expression of TRB3 in activated lymphocytes...
  10. pmc Tribbles homolog 3 attenuates mammalian target of rapamycin complex-2 signaling and inflammation in the diabetic kidney
    Emily Borsting
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, California
    J Am Soc Nephrol 25:2067-78. 2014
    ..Thus, TRB3 reduces albuminuria and inflammatory gene expression in diabetic kidney disease by a mechanism that may involve inhibition of the mTORC2/AKT pathway and may prove to be a novel therapeutic target. ..
  11. pmc Peroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney
    Emily Borsting
    Research and Medicine Services, Div of Nephrology, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
    Am J Physiol Renal Physiol 302:F540-51. 2012
    ..In summary, TZDs do not increase ENaC mRNA expression in the kidney, and in fact repress the ENaCγ promoter via an indirect transcriptional mechanism...
  12. pmc Podocytes express IL-6 and lipocalin 2/ neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury
    Sarah J Lee
    Research Service and Division of Nephrology Hypertension, Veterans Affairs San Diego Healthcare System, Veterans Medical Research Foundation, San Diego, CA 92161, USA
    Nephron Exp Nephrol 121:e86-96. 2012
    ..Most studies in AKI have focused on the tubulo-interstitium, despite evidence of glomerular involvement. In the following study, our goals were to investigate the expression of IL-6 and its downstream mediators in septic-induced AKI...
  13. pmc Antifibrotic treatment and other new strategies for improving renal outcomes
    Anna Mathew
    Center for Renal Translational Medicine, Division of Nephrology Hypertension, Department of Medicine, University of California San Diego, San Diego, Calif 92093, USA
    Contrib Nephrol 170:217-27. 2011
    ..Larger clinical studies are eagerly awaited to determine if new agents that specifically block kidney fibrosis and inflammation will delay, arrest and possibly reverse progressive renal failure...
  14. pmc SGLT2 mediates glucose reabsorption in the early proximal tubule
    Volker Vallon
    Department of Medicine, University of California San Diego, VA San Diego Healthcare System, 3350 La Jolla Village Drive 9151, San Diego, CA 92161, USA
    J Am Soc Nephrol 22:104-12. 2011
    ..This mouse model mimics and explains the glucosuric phenotype of individuals carrying SLC5A2 mutations...
  15. pmc Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity
    Volker Vallon
    Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive 9151, San Diego, California 92161, USA
    J Am Soc Nephrol 20:721-9. 2009
    ..These data argue against a primary and critical role of ENaC in thiazolidinedione-induced fluid retention...
  16. pmc AMPK mediates the initiation of kidney disease induced by a high-fat diet
    Anne Emilie Declèves
    Center for Renal Translational Medicine, Division of Nephrology Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Am Soc Nephrol 22:1846-55. 2011
    ..In vitro, AMPK activation completely inhibited the induction of MCP-1 by palmitic acid in mesangial cells. In conclusion, these data suggest that the energy sensor AMPK mediates the early renal effects of a high-fat diet...
  17. ncbi request reprint T cells and minimal change disease
    Robyn Cunard
    J Am Soc Nephrol 13:1409-11. 2002