Arjun Deb

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a
    Arjun Deb
    Division of Cardiovascular Diseases and Mandel Center for Hypertension and Atherosclerosis Research, Department of Medicine, GSRB 2, Box 3178, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 26:35-44. 2008
  2. ncbi Myocardial-cell replacement: the science, the clinic and the future
    Noel M Caplice
    Division of Cardiovascular Diseases, Molecular Medicine Program, Mayo College of Medicine, Rochester, MN, USA
    Nat Clin Pract Cardiovasc Med 1:90-5. 2004
  3. ncbi Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    Nicolas Noiseux
    Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
    Mol Ther 14:840-50. 2006
  4. pmc Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
    Maria Mirotsou
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:1643-8. 2007
  5. pmc Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids
    Jinzhu Duan
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e55757. 2013
  6. pmc Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium
    Jing Huang
    Duke University Medical Center and Health System, DUMC 3701, Durham, NC 27701, USA
    Circ Res 106:1753-62. 2010
  7. pmc Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
    Jinzhu Duan
    Department of Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    EMBO J 31:429-42. 2012
  8. pmc Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a
    Zhongyan Zhang
    Edna and Fred L Mandel, Jr Center for Hypertension and Atherosclerosis Research, Duke University School of Medicine, Durham, NC 27710, USA
    J Mol Cell Cardiol 46:370-7. 2009
  9. pmc Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner
    Costin M Gherghe
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    FASEB J 25:1836-43. 2011
  10. ncbi Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    Robert Wolk
    Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
    Atherosclerosis 183:131-9. 2005

Research Grants

  1. Role of Wnts in Cardiac Repair
    Arjun Deb; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. pmc SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a
    Arjun Deb
    Division of Cardiovascular Diseases and Mandel Center for Hypertension and Atherosclerosis Research, Department of Medicine, GSRB 2, Box 3178, Duke University Medical Center, Durham, North Carolina 27710, USA
    Stem Cells 26:35-44. 2008
    ..The inhibitory effects of Sfrp2 on Wnt3a expression identify Sfrp2 as a "checkpoint gene," which exerts its control on cardiomyogenesis through regulation of Wnt3a transcription...
  2. ncbi Myocardial-cell replacement: the science, the clinic and the future
    Noel M Caplice
    Division of Cardiovascular Diseases, Molecular Medicine Program, Mayo College of Medicine, Rochester, MN, USA
    Nat Clin Pract Cardiovasc Med 1:90-5. 2004
    ..Prospects for more widespread clinical application of myocardial-cell replacement and future hurdles to be overcome in this field will also be addressed...
  3. ncbi Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    Nicolas Noiseux
    Department of Medicine, Brigham and Women s Hospital, Harvard University, Boston, MA 02115, USA
    Mol Ther 14:840-50. 2006
    ....
  4. pmc Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
    Maria Mirotsou
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:1643-8. 2007
    ..These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease...
  5. pmc Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids
    Jinzhu Duan
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e55757. 2013
    ..We demonstrate the role of βcatenin dependent mechanisms in rib fractures and suggest that glucocorticoids, by suppressing RANKL, may have a role in treating bone loss due to aggressive osteoclastogenesis...
  6. pmc Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium
    Jing Huang
    Duke University Medical Center and Health System, DUMC 3701, Durham, NC 27701, USA
    Circ Res 106:1753-62. 2010
    ..However the expression levels of the corresponding chemokine receptors (eg, CCR1, CXCR2) in MSCs are very low. We hypothesized that this discordance may account for the poor MSC engraftment and survival...
  7. pmc Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
    Jinzhu Duan
    Department of Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    EMBO J 31:429-42. 2012
    ..These findings reveal that a pro-fibrotic Wnt1/βcatenin injury response is critically required for preserving cardiac function after acute ischaemic cardiac injury...
  8. pmc Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a
    Zhongyan Zhang
    Edna and Fred L Mandel, Jr Center for Hypertension and Atherosclerosis Research, Duke University School of Medicine, Durham, NC 27710, USA
    J Mol Cell Cardiol 46:370-7. 2009
    ..These results can explain the in vivo protective effect of Sfrp2 and highlight its therapeutic potential for the ischemic heart...
  9. pmc Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF-dependent manner
    Costin M Gherghe
    Department of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
    FASEB J 25:1836-43. 2011
    ....
  10. ncbi Leptin receptor and functional effects of leptin in human endothelial progenitor cells
    Robert Wolk
    Mayo Foundation, St Mary s Hospital, DO 4 350, 1216 Second St SW, Rochester, MN 55902, USA
    Atherosclerosis 183:131-9. 2005
    ..These findings are relevant to leptin-mediated regulation of vasculogenesis in humans, and the association between hyperleptinemia and obesity with cardiovascular disease...
  11. ncbi Primary synovial sarcoma of the mitral valve
    Dylan V Miller
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Cardiovasc Pathol 14:331-3. 2005
    ..The histopathologic diagnosis was supported by the immunohistochemical profile and the presence of the SYT-SSX1 fusion transcript identified by molecular genetic studies...
  12. ncbi Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients
    Arjun Deb
    Division of Cardiovascular Diseases and Molecular Medicine Program, Mayo Clinic, Rochester, Minn 55905, USA
    Circulation 107:1247-9. 2003
    ..Recent studies have identified cardiomyocytes of extracardiac origin in transplanted human hearts, but the exact origin of these myocyte progenitors is currently unknown...

Research Grants2

  1. Role of Wnts in Cardiac Repair
    Arjun Deb; Fiscal Year: 2010
    ..In this proposal, we will determine how Wnt1 regulates scar formation in the injured heart and aim to minimize scar formation and improve cardiac function through manipulation of Wnt signaling. ..