George Dickinson

Summary

Affiliation: University of California, Irvine
Location: Irvine, USA

Publications

  1. ncbi request reprint Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate
    Georgina Berridge
    Department of Pharmacology, University of Oxford, Mansfield Road, United Kingdom
    J Biol Chem 277:43717-23. 2002
  2. pmc Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations
    George D Dickinson
    The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 375:805-12. 2003
  3. pmc Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels
    Dev Churamani
    Department of Physiology, University College London, The Old Squash Courts, London WC1E 6BT, UK
    Biochem J 380:449-54. 2004
  4. pmc NAADP binding to its target protein in sea urchin eggs requires phospholipids
    Dev Churamani
    The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 386:497-504. 2005
  5. pmc Time sensing by NAADP receptors
    Dev Churamani
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 397:313-20. 2006
  6. pmc Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation
    George D Dickinson
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 285:13321-5. 2010
  7. pmc Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels
    Soichiro Yamaguchi
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    J Biol Chem 286:22934-42. 2011
  8. pmc The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    Biophys J 102:1826-36. 2012
  9. pmc Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Sci Signal 9:ra108. 2016
  10. pmc Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, CA Electronic address
    Biophys J 105:2474-84. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate
    Georgina Berridge
    Department of Pharmacology, University of Oxford, Mansfield Road, United Kingdom
    J Biol Chem 277:43717-23. 2002
    ....
  2. pmc Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations
    George D Dickinson
    The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 375:805-12. 2003
    ..Our results are consistent with the observation of multiple conformations of the NAADP receptor that are readily revealed in low K+-containing media...
  3. pmc Determination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels
    Dev Churamani
    Department of Physiology, University College London, The Old Squash Courts, London WC1E 6BT, UK
    Biochem J 380:449-54. 2004
    ..Our improved method for the quantification of NAADP should prove useful in the further assessment of its signalling role within cells...
  4. pmc NAADP binding to its target protein in sea urchin eggs requires phospholipids
    Dev Churamani
    The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 386:497-504. 2005
    ..Our data highlight the importance of the lipid environment for interaction of NAADP with its target protein...
  5. pmc Time sensing by NAADP receptors
    Dev Churamani
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 397:313-20. 2006
    ..NAADP receptors, however, failed to stabilize at reduced temperature. We conclude that NAADP receptors possess a simple molecular memory endowing them with the remarkable ability to detect the duration of their activation...
  6. pmc Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation
    George D Dickinson
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 285:13321-5. 2010
    ..Our data suggest that deregulated lysosomal Ca(2+) signaling through NAADP may contribute to neuronal dysfunction and highlight the usefulness of lysosomal hydrolase inhibition in probing NAADP action...
  7. pmc Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels
    Soichiro Yamaguchi
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    J Biol Chem 286:22934-42. 2011
    ..We conclude that although TRPML1 and TPCs are present in the same complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are the targets for NAADP...
  8. pmc The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    Biophys J 102:1826-36. 2012
    ....
  9. pmc Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Sci Signal 9:ra108. 2016
    ..The predicted range of action of IP3 (<5 μm) is thus smaller than the size of typical mammalian cells, indicating that IP3 should better be considered as a local rather than a global cellular messenger...
  10. pmc Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, CA Electronic address
    Biophys J 105:2474-84. 2013
    ..The spatial extent of puffs increased with their amplitude, and puffs of similar size were of similar width, independent of cluster size...
  11. pmc Temperature dependence of IP3-mediated local and global Ca2+ signals
    George D Dickinson
    Department of Neurobiology and Behavior, University of California, Irvine, California, USA
    Biophys J 104:386-95. 2013
    ..Conversely, further cooling may be advantageous to improve the optical resolution of channel gating kinetics...