Celeste C Finnerty

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy
    Laura J Porro
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    J Am Coll Surg 214:489-502; discussion 502-4. 2012
  2. pmc Hypertrophic scarring: the greatest unmet challenge after burn injury
    Celeste C Finnerty
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA The Institute for Translational Sciences, The University of Texas Medical Branch, Galveston, TX, USA the Sealy Center for Molecular Medicine, The University of Texas Medical Branch, Galveston, TX, USA Shriners Hospitals for Children, Galveston, TX, USA Electronic address
    Lancet 388:1427-1436. 2016
  3. pmc Impact of stress-induced diabetes on outcomes in severely burned children
    Celeste C Finnerty
    Shriners Hospitals for Children Galveston, University of Texas Medical Branch, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX Electronic address
    J Am Coll Surg 218:783-95. 2014
  4. pmc Determination of burn patient outcome by large-scale quantitative discovery proteomics
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 41:1421-34. 2013
  5. pmc Proteomics improves the prediction of burns mortality: results from regression spline modeling
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Clin Transl Sci 5:243-9. 2012
  6. pmc Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
  7. pmc Temporal cytokine profiles in severely burned patients: a comparison of adults and children
    Celeste C Finnerty
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Mol Med 14:553-60. 2008
  8. pmc Cytokine expression profile over time in burned mice
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch and Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    Cytokine 45:20-5. 2009
  9. doi request reprint Age differences in inflammatory and hypermetabolic postburn responses
    Marc G Jeschke
    Galveston Burns Unit, Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 121:497-507. 2008
  10. doi request reprint Gender differences in pediatric burn patients: does it make a difference?
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Ann Surg 248:126-36. 2008

Detail Information

Publications80

  1. pmc Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy
    Laura J Porro
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    J Am Coll Surg 214:489-502; discussion 502-4. 2012
    ..This single-center prospective trial determined the long-term effects of 1 year of oxandrolone administration in severely burned children; assessments were continued for up to 4 years post therapy...
  2. pmc Hypertrophic scarring: the greatest unmet challenge after burn injury
    Celeste C Finnerty
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA The Institute for Translational Sciences, The University of Texas Medical Branch, Galveston, TX, USA the Sealy Center for Molecular Medicine, The University of Texas Medical Branch, Galveston, TX, USA Shriners Hospitals for Children, Galveston, TX, USA Electronic address
    Lancet 388:1427-1436. 2016
    ....
  3. pmc Impact of stress-induced diabetes on outcomes in severely burned children
    Celeste C Finnerty
    Shriners Hospitals for Children Galveston, University of Texas Medical Branch, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX Electronic address
    J Am Coll Surg 218:783-95. 2014
    ..Because of frequent hypoglycemic episodes, a less-stringent sliding scale insulin protocol is used to maintain serum glucose levels between 80 and 160 mg/dL after elevations >180 mg/dL...
  4. pmc Determination of burn patient outcome by large-scale quantitative discovery proteomics
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 41:1421-34. 2013
    ....
  5. pmc Proteomics improves the prediction of burns mortality: results from regression spline modeling
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Clin Transl Sci 5:243-9. 2012
    ....
  6. pmc Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
    ..The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children...
  7. pmc Temporal cytokine profiles in severely burned patients: a comparison of adults and children
    Celeste C Finnerty
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Mol Med 14:553-60. 2008
    ....
  8. pmc Cytokine expression profile over time in burned mice
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch and Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    Cytokine 45:20-5. 2009
    ....
  9. doi request reprint Age differences in inflammatory and hypermetabolic postburn responses
    Marc G Jeschke
    Galveston Burns Unit, Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 121:497-507. 2008
    ..The aim of this study was to identify contributors to morbidity and death in severely burned patients <4 years of age...
  10. doi request reprint Gender differences in pediatric burn patients: does it make a difference?
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Ann Surg 248:126-36. 2008
    ..The aim of the present study was to compare hospital course and physiologic markers between severely burned pediatric females and males...
  11. pmc Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Am J Respir Crit Care Med 182:351-9. 2010
    ..However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality...
  12. pmc Survivors versus nonsurvivors postburn: differences in inflammatory and hypermetabolic trajectories
    Marc G Jeschke
    Shriners Hospitals for Children Department of Surgery, University of Texas Medical Branch Institute for Translational Science and Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX Department of Dermatology and Allergy, Ludwig Maximilians University, Munich, Germany Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, Departments of Surgery and Immunology, Division of Plastic Surgery, University of Toronto, Ontario, Canada
    Ann Surg 259:814-23. 2014
    ..To evaluate whether a panel of common biomedical markers can be utilized as trajectories to determine survival in pediatric burn patients...
  13. pmc The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e35465. 2012
    ..Ketoconazole, an anti-fungal agent, inhibits cortisol synthesis. We, therefore, studied the effect of ketoconazole on post-burn cortisol levels and the hyper-catabolic response in a prospective randomized trial (block randomization 2:1)...
  14. pmc Thermal injury activates the eEF2K-dependent eEF2 pathway in pediatric patients
    Juquan Song
    Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    JPEN J Parenter Enteral Nutr 36:596-602. 2012
    ..The aim of this study was to determine the expression of eEF2 and the upstream eEF2-inactivating kinase, eEF2K, in severely burned pediatric patients...
  15. pmc The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn
    Marc G Jeschke
    Shriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Ann Surg 246:351-60; discussion 360-2. 2007
    ..The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied...
  16. doi request reprint Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children
    Marc G Jeschke
    Shriners Hospitals for Children and the Department of Surgery, University Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 9:209-16. 2008
    ..The aim of the present study was to determine whether rhGH plus propranolol improves hypermetabolism and the inflammatory and acute phase response after severe burn without causing adverse side effects...
  17. pmc Long-term propranolol use in severely burned pediatric patients: a randomized controlled study
    David N Herndon
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    Ann Surg 256:402-11. 2012
    ..To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns...
  18. pmc Occurrence of multiorgan dysfunction in pediatric burn patients: incidence and clinical outcome
    Robert Kraft
    Shriners Hospitals for Children Department of Surgery, University of Texas Medical Branch, Galveston, TX Department of Surgery, Division of Plastic Surgery and Immunology, University of Toronto, Ontario, Canada Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada and Sunnybrook Research Institute, Toronto, Canada
    Ann Surg 259:381-7. 2014
    ..To examine the incidence of single or multiple organ failure postburn and its resultant clinical outcomes during acute hospitalization...
  19. pmc Benchmarking outcomes in the critically injured burn patient
    Matthew B Klein
    Department of Surgery, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA Department of Medicine, Massachusetts General Hospital, Boston, MA Department of Surgery, Massachusetts General Hospital, Boston, MA Department of Surgery, Loyola University School of Medicine, Maywood, Il Department of Surgery, University of Texas Medical Branch, Galveston, TX Department of Surgery and Plastic Surgery, University of Toronto, Canada Department of Surgery, Parkland Memorial Hospital, University of Texas, Southwestern Medical Center, Dallas TX Stanford Genome Technology Center, Palo Alto, CA Department of Surgery, Harborview Medical Center, Seattle, WA Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA
    Ann Surg 259:833-41. 2014
    ..To determine and compare outcomes with accepted benchmarks in burn care at 6 academic burn centers...
  20. pmc Long-term persistance of the pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e21245. 2011
    ....
  21. pmc Insulin protects against hepatic damage postburn
    Marc G Jeschke
    Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas, USA
    Mol Med 17:516-22. 2011
    ..These results support the use of insulin therapy after traumatic injury to improve patient outcomes...
  22. pmc Starvation-induced proximal gut mucosal atrophy diminished with aging
    Juquan Song
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    JPEN J Parenter Enteral Nutr 33:411-6. 2009
    ..Starvation induces small bowel atrophy with increased intestinal epithelial apoptosis and decreased proliferation. The authors examined these parameters after starvation in aged animals...
  23. pmc Hypoglycemia is associated with increased postburn morbidity and mortality in pediatric patients
    Marc G Jeschke
    1Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada 2Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada 3Department of Immunology, University of Toronto, Toronto, ON, Canada 4TECC Program Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada 5Shriners Hospitals for Children and University of Texas Medical Branch, Galveston, TX 6Department of Surgery, University of Texas Medical Branch, Galveston, TX 7Sealy Center for Molecular Medicine and the Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX
    Crit Care Med 42:1221-31. 2014
    ..The objective of this study was to determine the prevalence of hypoglycemia after burn injury and whether hypoglycemia is associated with increased postburn morbidity and mortality...
  24. pmc Burn size determines the inflammatory and hypermetabolic response
    Marc G Jeschke
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 11:R90. 2007
    ..The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, protein synthesis, or organ function...
  25. ncbi request reprint The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, Galveston, TX 77550, USA
    Surgery 138:482-9. 2005
    ..The purpose of this study was to determine whether HGF can improve small-bowel homeostasis after injury and the cellular mechanisms by which these changes occur...
  26. pmc Proximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation
    Juquan Song
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    J Surg Res 169:209-13. 2011
    ..In this experiment, we assessed whether starvation-induced atrophy of proximal gut mucosa is associated with the Interleukin-1 receptor (IL-1R) signaling pathway in aged mice...
  27. doi request reprint Acute propranolol infusion stimulates protein synthesis in rabbit skin wound
    Xiao Jun Zhang
    Shriners Hospital for Children, Galveston, TX, USA
    Surgery 145:558-67. 2009
    ..Propranolol administration has been demonstrated to improve cardiac work, decrease energy expenditure, and attenuate lipolysis in burned patients; however, its effect on wound healing has not been reported...
  28. pmc Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury
    Natasha C Brooks
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
    Mol Med 18:707-11. 2012
    ..We conclude that catecholamine release is responsible for the ER stress response and impaired insulin receptor signaling after burn injury...
  29. pmc Calcium and ER stress mediate hepatic apoptosis after burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Cell Mol Med 13:1857-65. 2009
    ..Our results reveal that thermal injury leads to dramatic hepatic disturbances in calcium homeostasis and resultant ER stress leading to mitochondrial abnormalities contributing to hepatic dysfunction and apoptosis after burn injury...
  30. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  31. doi request reprint Characterization of the inflammatory response during acute and post-acute phases after severe burn
    Gerd G Gauglitz
    Shriners Hospital for Children, Galveston, Texas 77550, USA
    Shock 30:503-7. 2008
    ....
  32. ncbi request reprint Sex differences in the long-term outcome after a severe thermal injury
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 27:461-5. 2007
    ..Data indicate that girls have a reduced REE associated with changes in bone content and endogenous anabolic hormones...
  33. pmc The surgically induced stress response
    Celeste C Finnerty
    Department of Surgery, Shriners Hospitals for Children Galveston and the University of Texas Medical Branch, Galveston, Texas
    JPEN J Parenter Enteral Nutr 37:21S-9S. 2013
    ..Although the stress response to acute trauma evolved to confer improved chances of survival following injury, in modern surgical practice the stress response can be detrimental. ..
  34. pmc Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study
    Robert Kraft
    Shriners Hospitals for Children, Galveston, TX, USA
    Lancet 379:1013-21. 2012
    ..This study was designed to identify the burn size associated with significant increases in morbidity and mortality in paediatric patients...
  35. pmc The GH/IGF-1 system in critical illness
    Itoro E Elijah
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, United States
    Best Pract Res Clin Endocrinol Metab 25:759-67. 2011
    ..This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population...
  36. pmc FIVE-YEAR OUTCOMES AFTER LONG-TERM OXANDROLONE ADMINISTRATION IN SEVERELY BURNED CHILDREN: A RANDOMIZED CLINICAL TRIAL
    Patrick T Reeves
    School of Medicine, University of Texas Medical Branch, Galveston, Texas
    Shock 45:367-74. 2016
    ..This study demonstrates that administering oxandrolone for up to 2 years following severe burn injury results in greater improvements in BMC, BMD, and height velocity...
  37. ncbi request reprint Propranolol does not increase inflammation, sepsis, or infectious episodes in severely burned children
    Marc G Jeschke
    Department of Surgery, Shriners Hospitals for Children, University of Texas Medical Branch, TX 77550, USA
    J Trauma 62:676-81. 2007
    ..The purpose of the present study was to determine the effect of propranolol administration on infection, sepsis, and inflammation in severely burned pediatric patients...
  38. pmc Propranolol Reduces Cardiac Index But does not Adversely Affect Peripheral Perfusion in Severely Burned Children
    Paul Wurzer
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas Shriners Hospitals for Children Galveston, Galveston, Texas Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria Sealy Center for Molecular Medicine and the Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas School of Medicine, University of Texas Medical Branch, Galveston, Texas Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas
    Shock 46:486-491. 2016
    ..The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children...
  39. pmc Morbidity and survival probability in burn patients in modern burn care
    Marc G Jeschke
    1Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada 2Programme in Trauma, Emergency, and Critical Care, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 3Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 4Shriners Hospitals for Children, Galveston, TX 5Department of Surgery, University of Texas Medical Branch, Galveston, TX 6Sealy Center for Molecular Medicine and the Institute for Translational Science, University of Texas Medical Branch, Galveston, TX 7Department of Surgery, Loyola University Stritch School of Medicine, Maywood, IL 8Department of Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 9Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX 10Department of Surgery, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, MA
    Crit Care Med 43:808-15. 2015
    ..Although scores have been established to predict mortality, few data addressing other outcomes exist. The objective of this study was to determine burn sizes that are associated with increased mortality and morbidity after burn...
  40. ncbi request reprint Insulin attenuates the cytokine response in a burn wound infection model
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 27:205-8. 2007
    ..05). We conclude, that insulin treatment selectively modulates specific cytokines in a burn wound infection model...
  41. pmc The leading causes of death after burn injury in a single pediatric burn center
    Felicia N Williams
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Crit Care 13:R183. 2009
    ..Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival...
  42. pmc Burns: an update on current pharmacotherapy
    Yesenia Rojas
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Expert Opin Pharmacother 13:2485-94. 2012
    ..Incorporation of pharmacotherapeutics into treatment regimens may further reduce complications of severe burn injuries...
  43. pmc Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?
    Gerd G Gauglitz
    Shriners Hospitals for Children, 815 Market Street, Galveston, Texas, 77550, USA
    Crit Care 12:R81. 2008
    ..Early identification followed by appropriate management of these high-risk patients may lead to improved clinical outcome...
  44. pmc Human herpes viruses in burn patients: A systematic review
    Paul Wurzer
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX, USA Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria Electronic address
    Burns 43:25-33. 2017
    ..This systematic review was undertaken to assess evidence of herpes virus-related morbidity and mortality in burns...
  45. pmc Transpulmonary Thermodilution Versus Transthoracic Echocardiography for Cardiac Output Measurements in Severely Burned Children
    Paul Wurzer
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre and Division of Plastic Surgery, University of Toronto, Toronto, Ontario, Canada Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas Sealy Center for Molecular Medicine and the Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas
    Shock 46:249-53. 2016
    ..However, it is unknown whether, in burned children, the increasingly popular transthoracic echocardiography (TTE) method of CO measurement is as accurate as the widely used transpulmonary thermodilution (TPTD) method...
  46. ncbi request reprint Two-year follow-up of outcomes related to scarring and distress in children with severe burns
    Paul Wurzer
    a Department of Surgery, University of Texas Medical Branch Galveston, Galveston, TX, USA
    Disabil Rehabil . 2016
    ..We assessed the perception of scarring and distress by pediatric burn survivors with burns covering more than one-third of total body surface area (TBSA) for up to 2 years post-burn...
  47. pmc Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation
    Stephanie A Mason
    Department of Surgery, Sunnybrook Health Sciences Centre and Division of General Surgery, University of Toronto, Toronto, Canada Shriners Hospitals for Children Galveston and Department of Surgery, University of Texas Medical Branch, Galveston, TX Sealy Center for Molecular Medicine and the Institute for Translational Science, University of Texas Medical Branch, Galveston, TX Department of Surgery, Loyola University Stritch School of Medicine, Maywood, Il Department of Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX Department of Surgery, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, MA Ross Tilley Burn Centre Sunnybrook Health Sciences Centre and Division of Plastic Surgery University of Toronto, Toronto, ON, Canada
    Ann Surg 264:1142-1147. 2016
    ..To determine whether restrictive fluid resuscitation results in increased rates of acute kidney injury (AKI) or infectious complications...
  48. pmc Reliable scar scoring system to assess photographs of burn patients
    Gabriel A Mecott
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas
    J Surg Res 199:688-97. 2015
    ..Although scoring scars through direct clinical examination is ideal, scars must sometimes be scored from photographs. No scar scale currently exists for the latter purpose...
  49. pmc Adult patients are more catabolic than children during acute phase after burn injury: a retrospective analysis on muscle protein kinetics
    Demidmaa Tuvdendorj
    Department of Surgery, Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77555 1220, USA
    Intensive Care Med 37:1317-22. 2011
    ..This study was performed to determine if there is an age-related specificity in the response of muscle protein metabolism to severe burn injury during acute hospitalization. This is a retrospective analysis of previously published data...
  50. ncbi request reprint Blood transfusions are associated with increased risk for development of sepsis in severely burned pediatric patients
    Marc G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:579-83. 2007
    ..To determine the risk of developing sepsis following transfusion of blood products in severely burned pediatric patients...
  51. ncbi request reprint Effect of insulin on the inflammatory and acute phase response after burn injury
    Marc G Jeschke
    Shriners Hospital for Children, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:S519-23. 2007
    ....
  52. doi request reprint The metabolic stress response to burn trauma: current understanding and therapies
    Craig Porter
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA Shriners Hospitals for Children, Galveston, TX, USA Electronic address
    Lancet 388:1417-1426. 2016
    ..We highlight recent developments and important knowledge gaps that need to be pursued to develop novel therapeutic strategies to improve outcomes in burn survivors...
  53. pmc Reversal of Growth Arrest With the Combined Administration of Oxandrolone and Propranolol in Severely Burned Children
    David N Herndon
    Department of Surgery Institute for Translational Sciences, University of Texas Medical Branch Shriners Hospital for Children Galveston, Galveston, TX Division of Plastic Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria Department of Orthopedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston Department of Surgery, Massachusetts General Hospital, Boston, MA Sealy Center for Molecular Medicine Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston
    Ann Surg 264:421-8. 2016
    ..Here, we determined whether the combined administration of oxandrolone and propranolol has added benefit...
  54. pmc Long-Term Administration of Oxandrolone Improves Lung Function in Pediatric Burned Patients
    Linda E Sousse
    From the Department of Surgery, Institute for Translational Sciences and the Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston and Shriners Hospitals for Children, Galveston, Texas
    J Burn Care Res 37:273-7. 2016
    ..0 ± 8.7 L/min vs 43.7 ± 13.6 with treatment, P = .02). The administration of oxandrolone was associated with improved lung function in pediatric burned patients. ..
  55. pmc Mild obesity is protective after severe burn injury
    Marc G Jeschke
    Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, and Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada Shriners Hospitals for Children, and Department of Surgery, University of Texas Medical Branch, Galveston, TX Sealy Center for Molecular Medicine and the Institute for Translational Science, University of Texas Medical Branch, Galveston, TX Department of Surgery, Loyola University Stritch School of Medicine, Maywood, Il Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX and Department of Surgery, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, MA
    Ann Surg 258:1119-29. 2013
    ..To assess the impact of obesity on morbidity and mortality in severely burned patients...
  56. pmc Optimized fluid management improves outcomes of pediatric burn patients
    Robert Kraft
    Shriners Hospitals for Children, Galveston, Texas Department of Surgery, University Texas Medical Branch, Galveston, Texas
    J Surg Res 181:121-8. 2013
    ....
  57. pmc Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children
    Robert Kraft
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Clin Endocrinol Metab 98:314-21. 2013
    ..Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear...
  58. pmc Role of the PPAR-α agonist fenofibrate in severe pediatric burn
    Itoro E Elijah
    Department of Surgery, The University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, TX 77555 0591, USA
    Burns 38:481-6. 2012
    ..The long term use of fenofibrate in severely burned patients may improve hyperglycemia and insulin resistance, as well as improve wound healing, and reduce apoptosis, and oxidative stress...
  59. ncbi request reprint Cytokine expression profile over time in severely burned pediatric patients
    Celeste C Finnerty
    Galveston Burns Unit and Department of Surgery, Shriners Hospital for Children University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 26:13-9. 2006
    ..Furthermore, the elevation in most serum cytokine levels during the first week after burn may indicate a potential window of opportunity for therapeutic intervention...
  60. ncbi request reprint Serum cytokine differences in severely burned children with and without sepsis
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Shock 27:4-9. 2007
    ..In addition, serum IL-6, IL-12 p70, and TNF can be used to identify burned patients who are at high risk of death from sepsis...
  61. pmc Morbidity and mortality in severely burned children with Clostridium difficile-associated diarrhea
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX Sealy Center for Molecular Medicine and the Institute for Translational Science, University of Texas Medical Branch, Galveston, TX
    Surgery 159:1631-7. 2016
    ..Clostridium difficile is a key culprit underlying nosocomial infectious diarrhea. We investigated the effect of C difficile-associated diarrhea (CDAD) on morbidity and mortality in severely burned children and CDAD risk factors...
  62. pmc Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study
    Robert Kraft
    Shriners Hospitals for Children, and Department of Surgery, Shriners Hospitals for Children Institute for Translational Sciences and Sealy Center for Molecular Medicine, University of Texas Medical Branch and Department of Pathology, Shriners Hospitals for Children, Galveston and Department of Surgery, University of Texas Southwestern, Dallas, Texas and Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Department of Surgery, Division of Plastic Surgery, University of Toronto, Toronto, Ontario, Canada
    Shock 43:222-7. 2015
    ..05). High levels of IL-8 correlated with increased MOF, sepsis, and mortality. These data suggest that serum levels of IL-8 may be a valid biomarker for monitoring sepsis, infections, and mortality in burn patients. ..
  63. pmc Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress
    Labros S Sidossis
    Metabolism Unit, Shriners Hospitals for Children Galveston, 815 Market Street, Galveston, TX 77550, USA Department of Nutrition and Dietetics, Harokopio University, El Venizelou 70, Kallithea 176 76, Greece Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA Institute of Translational Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA Electronic address
    Cell Metab 22:219-27. 2015
    ..Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications. ..
  64. doi request reprint The use of skin substitutes and burn care-a survey
    Paul Wurzer
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria Electronic address
    J Surg Res 201:293-8. 2016
    ..The aim of our Internet survey was to assess the preferences of burn specialists who use skin substitutes in patients with burns covering 20% or more of their total body surface area (TBSA)...
  65. pmc Pulmonary histopathologic abnormalities and predictor variables in autopsies of burned pediatric patients
    Linda E Sousse
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA Shriners Hospitals for Children, Burn Unit, Galveston, TX 77555, USA
    Burns 41:519-27. 2015
    ..Pulmonary abnormalities occur in 30-80% of fatalities after burn. The objective of our study is to investigate lung pathology in autopsy tissues of pediatric burn patients...
  66. pmc Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 242:384-9, discussion 390-1. 2005
    ..To study the efficacy of oxandrolone in severely burned children for 12 months after burn and 12 months after the drug was discontinued...
  67. pmc Clinical microfluidics for neutrophil genomics and proteomics
    Kenneth T Kotz
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:1042-7. 2010
    ....
  68. pmc A genomic storm in critically injured humans
    Wenzhong Xiao
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 208:2581-90. 2011
    ..Based on these transcriptional data, we propose a new paradigm for the human immunological response to severe injury...
  69. pmc Severe burn-induced endoplasmic reticulum stress and hepatic damage in mice
    Juquan Song
    Shriners Hospitals for Children and Departments Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Mol Med 15:316-20. 2009
    ..In summary, thermal injury in mice causes long-term adaptive and deleterious hepatic function alterations characterized by significant upregulation of the ER stress response...
  70. pmc Integrity of airway epithelium in pediatric burn autopsies: Association with age and extent of burn injury
    Robert A Cox
    Departments of Pathology, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX, United States Electronic address
    Burns 41:1435-41. 2015
    ..This study examines the structural integrity of the airway epithelium in autopsy tissues from pediatric burn subjects...
  71. pmc Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults
    Arham Ali
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA
    Crit Care 19:217. 2015
    ..The purpose of this study was to investigate whether wound healing and perioperative hemodynamics are affected by propranolol administration in severely burned adults...
  72. pmc Predictors of insulin resistance in pediatric burn injury survivors 24 to 36 months postburn
    Maria Chondronikola
    From the Department of Preventative Medicine and Community Health, Graduate School of Biomedical Sciences, University of Texas Medical Branch, Galveston Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas Departments of Psychiatry and Department of Psychiatry, University of Texas Medical Branch, Galveston Department of Psychology, Shriners Hospitals for Children, Galveston, Texas Department of Internal Medicine Geriatrics, Institute for Translational Sciences, and Department of Surgery, University of Texas Medical Branch, Galveston and the Department of Clinical Research and Children s Wellness Center, Shriners Hospitals for Children, Galveston, Texas
    J Burn Care Res 35:409-15. 2014
    ..Clinical evaluation and screening for abnormal glucose metabolism should be emphasized in patients with large burns, older age, and survivors with high body fat. ..
  73. ncbi request reprint Changes in liver function and size after a severe thermal injury
    Marc G Jeschke
    Shriners Hospitals for Children and University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Shock 28:172-7. 2007
    ..The treatment to prevent liver enlargement and the improved impaired function may result in a reduction of complications accompanied with liver hypertrophy and failure...
  74. ncbi request reprint The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 127:183-9. 2005
    ..The purpose of this study was to determine whether growth hormone can improve small bowel homeostasis after injury and by which cellular mechanisms these changes occur...
  75. ncbi request reprint Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens
    Cheryl S Watson
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0645, USA
    Steroids 70:364-71. 2005
    ..Clearly individual xenoestrogens must be individually investigated for their differing abilities to activate distinct membrane-initiated signal cascades that lead to a variety of cellular functions...
  76. pmc The IL-6 trans-signaling-STAT3 pathway mediates ECM and cellular proliferation in fibroblasts from hypertrophic scar
    Sutapa Ray
    Department of Internal Medicine, Endocrinology Division, University of Texas Medical Branch, Galveston, Texas 77555 1060, USA
    J Invest Dermatol 133:1212-20. 2013
    ..Taken together, our results suggest that the IL-6 trans-signaling-STAT3 pathway may have an integral role in HS pathogenesis, and disruption of this pathway could be a potential therapeutic strategy for the treatment of post-burn HS...
  77. pmc Increased poly(ADP-ribosyl)ation in skeletal muscle tissue of pediatric patients with severe burn injury: prevention by propranolol treatment
    Gabor Olah
    Department of Anesthesiology, Institute for Translational Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1102, USA
    Shock 36:18-23. 2011
    ..We hypothesize that this response may contribute to the inflammatory responses and cell dysfunction in burns. Some of the clinical benefit of propranolol in burns may be related to its inhibitory effect on PARP activation...
  78. pmc Changes in fat distribution in children following severe burn injury
    Pavankumar Patel
    1 Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas
    Metab Syndr Relat Disord 12:523-6. 2014
    ..Such abnormalities could potentially increase their future risk for developing type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This could be related to changes in body composition and fat distribution...
  79. pmc Cord blood-derived hematopoietic stem/progenitor cells: current challenges in engraftment, infection, and ex vivo expansion
    Katsuhiro Kita
    Department of Surgery, Shriners Hospitals for Children, University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Stem Cells Int 2011:276193. 2011
    ..In this short review, we discuss several recent promising findings related to the technical improvement of cord blood transplantation...
  80. pmc Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care VII--Guidelines for antibiotic administration in severely injured patients
    Michael A West
    Department of Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Trauma 65:1511-9. 2008
    ..It should also be noted that not all patients with increased temperature/WBC have an infection. Discontinuation of antibiotics is appropriate if cultures and other diagnostic studies are negative...