Franco Folli

Summary

Publications

  1. ncbi request reprint The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention
    Giovanna Muscogiuri
    Department of Medicine, Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA
    Curr Vasc Pharmacol 6:301-12. 2008
  2. ncbi request reprint The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach
    Franco Folli
    Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, USA
    Curr Diabetes Rev 7:313-24. 2011
  3. doi request reprint Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study
    Devjit Tripathy
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetologia 56:2153-63. 2013
  4. doi request reprint The mitochondrial Italian Human Proteome Project initiative (mt-HPP)
    Andrea Urbani
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Mol Biosyst 9:1984-92. 2013
  5. pmc Energy expenditure evaluation in humans and non-human primates by SenseWear Armband. Validation of energy expenditure evaluation by SenseWear Armband by direct comparison with indirect calorimetry
    Francesca Casiraghi
    Department of Medicine Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America Department of Biomedical Sciences for Health, University of Milan, Milano, Italy Metabolism Research Center, I R C C S Policlinico San Donato Hospital, Milano, Italy
    PLoS ONE 8:e73651. 2013
  6. pmc Biliary pancreatic diversion and laparoscopic adjustable gastric banding in morbid obesity: their long-term effects on metabolic syndrome and on cardiovascular parameters
    Antonio E Pontiroli
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
    Cardiovasc Diabetol 8:37. 2009
  7. pmc Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
    Alberto O Chavez
    Department of Medicine, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cardiovasc Diabetol 8:22. 2009
  8. doi request reprint Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Alberto O Chavez
    Diabetes Division, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 296:E758-64. 2009
  9. doi request reprint Physiological and molecular determinants of insulin action in the baboon
    Alberto O Chavez
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Diabetes 57:899-908. 2008
  10. pmc Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals
    Alberto O Chavez
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 95:422-9. 2010

Research Grants

Collaborators

Detail Information

Publications46

  1. ncbi request reprint The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention
    Giovanna Muscogiuri
    Department of Medicine, Diabetes Division, University of Texas Health Science Center, San Antonio, TX, USA
    Curr Vasc Pharmacol 6:301-12. 2008
    ....
  2. ncbi request reprint The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach
    Franco Folli
    Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, USA
    Curr Diabetes Rev 7:313-24. 2011
    ....
  3. doi request reprint Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study
    Devjit Tripathy
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetologia 56:2153-63. 2013
    ..Our objective was to evaluate the effect of low-dose PIO (15 mg/day) on glucose metabolism and inflammatory state in obese individuals with type 2 diabetes...
  4. doi request reprint The mitochondrial Italian Human Proteome Project initiative (mt-HPP)
    Andrea Urbani
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Mol Biosyst 9:1984-92. 2013
    ....
  5. pmc Energy expenditure evaluation in humans and non-human primates by SenseWear Armband. Validation of energy expenditure evaluation by SenseWear Armband by direct comparison with indirect calorimetry
    Francesca Casiraghi
    Department of Medicine Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America Department of Biomedical Sciences for Health, University of Milan, Milano, Italy Metabolism Research Center, I R C C S Policlinico San Donato Hospital, Milano, Italy
    PLoS ONE 8:e73651. 2013
    ....
  6. pmc Biliary pancreatic diversion and laparoscopic adjustable gastric banding in morbid obesity: their long-term effects on metabolic syndrome and on cardiovascular parameters
    Antonio E Pontiroli
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Ospedale San Paolo, Milano, Italy
    Cardiovasc Diabetol 8:37. 2009
    ....
  7. pmc Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
    Alberto O Chavez
    Department of Medicine, Diabetes Division, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Cardiovasc Diabetol 8:22. 2009
    ..e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available...
  8. doi request reprint Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans
    Alberto O Chavez
    Diabetes Division, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 296:E758-64. 2009
    ..Plasma RBP4 levels are elevated in T2DM and associated with impaired glucose tolerance, but not associated with obesity or insulin resistance or impaired insulin secretion in Mexican Americans...
  9. doi request reprint Physiological and molecular determinants of insulin action in the baboon
    Alberto O Chavez
    Diabetes Division, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Diabetes 57:899-908. 2008
    ..To quantitate insulin sensitivity in lean and obese nondiabetic baboons and examine the underlying cellular/molecular mechanisms responsible for impaired insulin action to characterize a baboon model of insulin resistance...
  10. pmc Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals
    Alberto O Chavez
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 95:422-9. 2010
    ..Mitochondrial dysfunction has been proposed as an underlying mechanism in the pathogenesis of insulin resistance and type 2 diabetes mellitus...
  11. pmc Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    Alberto O Chavez
    Division of Diabetes, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Diabetes Care 32:1542-6. 2009
    ..FGF-21 may play a role in pathogenesis of hepatic and whole-body insulin resistance in type 2 diabetes...
  12. pmc Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
    Rodolfo Guardado-Mendoza
    Department of Medicine Diabetes Division, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:13992-7. 2009
    ..519, P < 0.0001), and different FPG levels were sensitive and specific to predict IA severity. Finally, a predictive model for islet amyloid severity was generated with age and FPG as required variables...
  13. doi request reprint Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
    Muhammad A Abdul-Ghani
    Division of Diabetes, Univ of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 295:E678-85. 2008
    ..These acquired mitochondrial defects, caused by a physiological increase in the concentration of FFA metabolites, provide a mechanistic link between lipotoxicity, mitochondrial dysfunction, and muscle insulin resistance...
  14. pmc Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo
    Dawn K Coletta
    Division of Diabetes, Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA
    Am J Physiol Endocrinol Metab 294:E910-7. 2008
    ..The results of the present study demonstrate that insulin acutely regulates the levels of mRNAs involved in inflammation and transcription and identifies several candidate genes, including HES1 and BHLHB2, for further investigation...
  15. doi request reprint Membranous nephropathy and cerebellar degeneration with anti-GAD antibodies in type 2 diabetes mellitus
    Franco Folli
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Acta Diabetol 52:897-903. 2015
    ..To study the potential pathogenic significance of the coexistence of membranous nephropathy, cerebellar degeneration and anti-glutamic acid decarboxylase (GAD) autoantibodies in patients with diabetes...
  16. pmc Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation
    Franco Folli
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e9923. 2010
    ..End-stage renal disease (ESRD) worsens most diabetic complications, particularly, the risk of morbidity and mortality from cardiovascular disease is increased several fold...
  17. pmc Effects of weight loss in metabolically healthy obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
    PLoS ONE 6:e17737. 2011
    ..e. MHO vs. IRO subjects...
  18. pmc Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates
    Subhash Kamath
    Department of Medicine Division of Diabetes The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 6:e27617. 2011
    ..The mechanisms of NAFLD are not fully understood, but insulin resistance has been proposed as a key determinant...
  19. ncbi request reprint Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases
    Teresa Vanessa Fiorentino
    Department of Medicine, Division of Diabetes, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Curr Pharm Des 19:5695-703. 2013
    ....
  20. pmc Potential use of exenatide for the treatment of obesity
    Franco Folli
    University of Texas Health Science Center at San Antonio, Division of Diabetes, Department of Medicine, Texas, USA
    Expert Opin Investig Drugs 20:1717-22. 2011
    ..Only bariatric surgery provides a means to increase satiety and/or decrease nutrient absorption in obese patients, in the long term...
  21. ncbi request reprint Metabolic aspects of bariatric surgery
    Franco Folli
    Department of Medicine, Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Med Clin North Am 91:393-414, x. 2007
    ..Further investigations are needed to understand better the mechanisms involved and to define more clearly the appropriate indications and contraindications of the treatments proposed...
  22. doi request reprint Bariatric surgery and bone disease: from clinical perspective to molecular insights
    F Folli
    Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Int J Obes (Lond) 36:1373-9. 2012
    ..Further, we suggest a future research agenda...
  23. pmc Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus
    Franco Folli
    Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America
    PLoS ONE 6:e28050. 2011
    ..Activation of insulin signaling, FoxO1 and proteins in β-cell-cycle progression are attractive therapeutic targets to enhance β-cell regeneration in the treatment of T2DM...
  24. ncbi request reprint Medical therapy of aortic aneurysms: a pathophysiology-based approach
    Giovanna Muscogiuri
    Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, USA
    Curr Vasc Pharmacol 9:572-84. 2011
    ..A new pathophysiology-based therapeutic approach, involving the mechanisms leading to the rupture of the AAs, could represent an additional tool in combination with the current established antihypertensive therapy...
  25. ncbi request reprint White blood cells in obesity and diabetes: effects of weight loss and normalization of glucose metabolism
    Anna Veronelli
    Cattedra di Medicina Interna, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Italy
    Diabetes Care 27:2501-2. 2004
  26. ncbi request reprint The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes
    Monica D'Adamo
    Laboratory of Molecular Medicine, University of Rome, Rome, Italy
    Diabetes 53:1905-10. 2004
    ..84, 95% CI 1.03-3.28; P = 0.037), but not in men. These results indicate that the -866A/A genotype of the UCP2 gene may contribute to diabetes susceptibility by affecting insulin sensitivity...
  27. ncbi request reprint Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study
    Antonio E Pontiroli
    Universita degli Studi di Milano, Cattedra di Medicina Interna, Italy
    J Clin Endocrinol Metab 87:3555-61. 2002
    ....
  28. ncbi request reprint Asymptomatic hyperinsulinemic hypoglycemia after gastric banding
    Marina Scavini
    N Engl J Med 353:2822-3. 2005
  29. ncbi request reprint Effects of carboxypeptidase E overexpression on insulin mRNA levels, regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA
    Luca Polastri
    Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    Cell Transplant 11:803-11. 2002
    ..In conclusion, Cpe overexpression can increase regulated insulin secretion and proinsulin processing in InsGH3 cells; however, such improvements appear quantitatively and qualitatively modest...
  30. ncbi request reprint Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors
    Francesca Galbiati
    Department of Medicine, San Raffaele Scientific Institute, Milan 20132, Italy
    Endocrinology 143:4018-30. 2002
    ..Together, these findings provide the rationale for testing the efficacy of calcitriol in the treatment of patients with solid beta-cell tumors...
  31. ncbi request reprint Plasma leptin levels and coronary heart disease
    Antonio E Pontiroli
    Circulation 106:e42; author reply e42. 2002
  32. ncbi request reprint Laparoscopic gastric banding prevents type 2 diabetes and arterial hypertension and induces their remission in morbid obesity: a 4-year case-controlled study
    Antonio E Pontiroli
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Cattedra di Medicina Interna, Ospedale San Paolo, Via A Di Rudini, 8, 20142 Milano, Italy
    Diabetes Care 28:2703-9. 2005
    ..29 patients) and remission (secondary intervention study; 17 vs. 20 patients) of type 2 diabetes and hypertension in grade 3 obesity in a 4-year study...
  33. ncbi request reprint Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha
    Chiara Chiellini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Cell Physiol 190:251-8. 2002
    ..These results demonstrate that haptoglobin expression in WAT is increased in obesity in rodents and TNFalpha is an important signal for this regulation...
  34. ncbi request reprint Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver
    Jose B C Carvalheira
    Departamento de Clinica Medica, FCM, Universidade Estadual de Campinas, 13081 970 Campinas, SP, Brasil
    Biol Chem 384:151-9. 2003
    ..This indicates that there is a positive cross-talk between insulin and leptin signaling pathways at the level of JAK2 and STAT5b in rat liver...
  35. ncbi request reprint Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans
    Marta L Hribal
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 17:1340-2. 2003
    ..These data suggest that changes in early steps of insulin receptor signaling may play a role in determining beta-cell dysfunction caused by chronic hyperglycemia...
  36. ncbi request reprint Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants
    Paolo Fiorina
    Departments of Medicine and Surgery, San Raffaele Scientific Institute, Milan, Italy
    J Am Soc Nephrol 14:2150-8. 2003
    ..Successful islet transplantation was associated with improvements in kidney graft survival rates and function among uremic patients with type I diabetes mellitus and kidney grafts...
  37. ncbi request reprint Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy
    Lucia Perego
    Divisione di Medicina Interna, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Clin Endocrinol Metab 90:4087-93. 2005
    ..Obesity is frequently associated with left ventricular hypertrophy, even when uncomplicated by hypertension or diabetes mellitus. Left ventricular hypertrophy is an important risk factor for congestive heart failure...
  38. ncbi request reprint Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet
    Giorgio Sesti
    Dipartimento Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Via Campanella, 115, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 90:5064-9. 2005
    ..It is unknown whether genetic factors that play an important role in body weight homeostasis influence the response to laparoscopic adjustable gastric banding (LAGB)...
  39. ncbi request reprint C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance
    Marina Cardellini
    Department of Internal Medicine, University of Rome, Italy
    Diabetes Care 28:2007-12. 2005
    ..We addressed the question of whether the C-174G IL-6 polymorphism contributes to variation of insulin sensitivity...
  40. ncbi request reprint Post-surgery adherence to scheduled visits and compliance, more than personality disorders, predict outcome of bariatric restrictive surgery in morbidly obese patients
    Antonio E Pontiroli
    Università degli Studi di Milano and Ospedale San Paolo, Milano, Italy
    Obes Surg 17:1492-7. 2007
    ..We evaluated a set of predictors of short-term and long-term clinical outcome including psychiatric and psychological variables, as well as measures of post-surgery compliance...
  41. ncbi request reprint Morphological and functional differences in haemostatic axis between kidney transplanted and end-stage renal disease patients
    Paolo Fiorina
    Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy
    Transpl Int 18:1036-47. 2005
    ..Kidney transplant is associated with a better atherothrombotic profile in ESRD, platelet intracellular calcium and cytokines seem to be most influenced by the transplant, while most morphological abnormalities are retained...
  42. ncbi request reprint A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities
    Sabrina Prudente
    CSS Mendel Institute, Rome, Italy
    Diabetes 56:1468-74. 2007
    ..01). Finally, AQP7 expression in adipose tissue decreased from AA to AG to GG individuals (P = 0.036). These data strongly suggest that AQP7 downregulation is pathogenic for obesity and/or type 2 diabetes...
  43. ncbi request reprint Sympathetic overactivity, endothelial dysfunction, inflammation, and metabolic abnormalities cluster in grade III (World Health Organization) obesity: reversal through sustained weight loss obtained with laparoscopic adjustable gastric banding
    Antonio E Pontiroli
    Universita degli Studi di Milano, Ospedale San Paolo, Milan, Italy
    Diabetes Care 29:2735-8. 2006
  44. ncbi request reprint Paraneoplastic insulin resistance syndrome in advanced aggressive fibromatosis (desmoid tumor) treated by imatinib mesylate
    Franco Folli
    Diabetes Care 29:2178-80. 2006
  45. ncbi request reprint The multi-faceted cross-talk between the insulin and angiotensin II signaling systems
    Licio A Velloso
    Department of Internal Medicine, State University of Campinas, SP, Brazil
    Diabetes Metab Res Rev 22:98-107. 2006
    ..This review will focus on the main advances obtained in this field and will discuss the implications of this molecular cross-talk in the common clinical association between diabetes mellitus and hypertension...

Research Grants1