Baruch Frenkel

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Glucocorticoid-Induced Osteoporosis
    Baruch Frenkel
    Department of Orthopaedic Surgery, Keck School of Medicine, Institute for Genetic Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, CA, 90033, USA
    Adv Exp Med Biol 872:179-215. 2015
  2. pmc Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo
    Elisheva Smith
    Department of Orthopaedic Surgery, University of Southern California Los Angeles, CA 90033, USA
    Nucleic Acids Res 33:1298-308. 2005
  3. doi request reprint Regulation of adult bone turnover by sex steroids
    Baruch Frenkel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Cell Physiol 224:305-10. 2010
  4. pmc Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass
    Yankel Gabet
    Department of Biochemistry and Molecular Biology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Blood 116:3964-71. 2010
  5. pmc Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer
    Omar Khalid
    Department of Urology, Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Endocrinology 149:5984-95. 2008
  6. pmc Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity
    Li Jia
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 3:e3645. 2008
  7. ncbi request reprint Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2
    Cynthia A Luppen
    Department of Biochemistry, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:44995-5003. 2003
  8. ncbi request reprint Androgen receptor-mediated repression of novel target genes
    Jennifer Prescott
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 67:1371-83. 2007
  9. pmc GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Los Angeles, CA, USA
    Am J Physiol Cell Physiol 295:C1141-50. 2008
  10. pmc Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, USC Keck School of Medicine, Los Angeles, California 90033, USA
    Prostate 69:392-400. 2009

Research Grants

  1. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2010
  2. Identification of CBFA1 Targets in Osteoblasts
    Baruch Frenkel; Fiscal Year: 2003

Collaborators

Detail Information

Publications54

  1. doi request reprint Glucocorticoid-Induced Osteoporosis
    Baruch Frenkel
    Department of Orthopaedic Surgery, Keck School of Medicine, Institute for Genetic Medicine, University of Southern California, 2250 Alcazar Street, CSC 240, Los Angeles, CA, 90033, USA
    Adv Exp Med Biol 872:179-215. 2015
    ..Future therapeutic approaches may aim at GC targets such as those mentioned above, or newly identified targets including the Notch pathway, the AP-1/Il11 axis and the osteoblast master regulator RUNX2. ..
  2. pmc Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo
    Elisheva Smith
    Department of Orthopaedic Surgery, University of Southern California Los Angeles, CA 90033, USA
    Nucleic Acids Res 33:1298-308. 2005
    ..These transgenic mice, in particular the females, have a high bone mass phenotype, attributable to increased bone formation. These data suggest that many genes may fulfill cryptic functions by LRS...
  3. doi request reprint Regulation of adult bone turnover by sex steroids
    Baruch Frenkel
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Cell Physiol 224:305-10. 2010
    ..Detailed understanding of skeletal site- and gender-dependent mechanisms by which sex steroids protect the adult skeleton will provide the foundation for improved risk assessment, prevention and management of osteoporosis...
  4. pmc Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass
    Yankel Gabet
    Department of Biochemistry and Molecular Biology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA
    Blood 116:3964-71. 2010
    ..Stimulation of Krox20 expression in preosteoclasts may present a viable therapeutic strategy for high-turnover osteoporosis...
  5. pmc Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer
    Omar Khalid
    Department of Urology, Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Endocrinology 149:5984-95. 2008
    ....
  6. pmc Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity
    Li Jia
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS ONE 3:e3645. 2008
    ....
  7. ncbi request reprint Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2
    Cynthia A Luppen
    Department of Biochemistry, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:44995-5003. 2003
    ..The efficacy of short term BMP-2 treatment supports the potential of short-lived BMP vectors for skeletal therapy in both traditional and gene therapeutic approaches...
  8. ncbi request reprint Androgen receptor-mediated repression of novel target genes
    Jennifer Prescott
    Department of Preventive Medicine, Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prostate 67:1371-83. 2007
    ....
  9. pmc GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Los Angeles, CA, USA
    Am J Physiol Cell Physiol 295:C1141-50. 2008
    ..These results suggest that transcriptional activation of AQP5 by GATA-6 is mediated at least in part through cooperative interactions with Sp1 occurring at the proximal promoter...
  10. pmc Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, USC Keck School of Medicine, Los Angeles, California 90033, USA
    Prostate 69:392-400. 2009
    ..Previously, bioinformatic analysis of 62 AR-occupied regions (ARORs) in PCa cells revealed enrichment for both AREs and a TTGGCAAATA-like motif. We undertook the present study to investigate the significance of the TTGGCAAATA-like motif...
  11. pmc Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
    Sanjeev K Baniwal
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Mol Cancer 9:258. 2010
    ..However, little is known about the gene regulatory networks influenced by Runx2 in PCa cells. We therefore investigated genome wide mRNA expression changes in PCa cells in response to Runx2...
  12. pmc Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA
    Sanjeev K Baniwal
    Department Biochemistry and Molecular Biology, Institute of Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Mol Endocrinol 23:1203-14. 2009
    ....
  13. ncbi request reprint Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures
    Nathalie Leclerc
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    J Cell Biochem 103:1938-51. 2008
    ..These findings are consistent with a role for Krox20 in osteoblast function and suggest that this transcription factor may contribute to the opposing effects of GCs and Wnt signaling on bone formation...
  14. pmc Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation
    Steven Pregizer
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California, USA
    J Cell Biochem 105:965-70. 2008
    ..The need for such stringent control is consistent with the severe consequences of Runx2 over-expression in vivo...
  15. pmc Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells
    Claudia Andreu-Vieyra
    Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 31:4648-62. 2011
    ..This allows the recruitment of histone modifiers, chromatin remodelers, and ultimately gene activation. The "receptive" state described here could help explain AR signaling activation under very low ligand concentrations...
  16. pmc Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription
    Daniel J Purcell
    Department of Biochemistry and Molecular Biology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Cell Biochem 113:2406-14. 2012
    ..We conclude that a subset of cancer-related Runx2 target genes require recruitment of G9a for their expression, but do not depend on its histone methyltransferase activity...
  17. pmc Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness
    Nyam Osor Chimge
    Department of Biochemistry, Institute for Genetic Medicine, USC Epigenome Center, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Clin Cancer Res 18:901-11. 2012
    ..To assess the clinical significance of the interaction between estrogen and Runx2 signaling, previously shown in vitro...
  18. pmc An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice
    Man Chun Ting
    Department of Biochemistry and Molecular Biology, Norris Cancer Center, USC Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Dis Model Mech 5:366-74. 2012
    ..Castration-resistant Nkx3.1-positive (CARN) cells were shown by others to function both as stem cells and cells of origin of prostate cancer. Our results thus provide a mechanism by which AcP10 could influence prostate cancer risk...
  19. pmc BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization
    Cynthia A Luppen
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Institute for Genetic Medicine, Los Angeles, CA 90033, USA
    Growth Factors 26:226-37. 2008
    ..In conclusion, GCs regulate Bmp2 via a far-downstream domain, and activation of Smad, not ALP, best predicts the pro-mineralization potential of rhBMPs...
  20. doi request reprint A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer
    Shangxin Yang
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 68:198-205. 2008
    ....
  21. pmc Contextual effect of repression of bone morphogenetic protein activity in prostate cancer
    Linda Kim Pham
    Departments of Molecular Microbiology and Immunology Pathology Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, California 90033, USA Department of Pathology, University of Utah, Salt Lake City, Utah, USA Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Endocr Relat Cancer 20:861-74. 2013
    ....
  22. pmc Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2
    Nyam Osor Chimge
    Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Breast Cancer Res 13:R127. 2011
    ..We asked whether the beneficial effect of estrogen signaling in late-stage BCa is attributable to the recently reported estrogen-mediated antagonism of the pro-metastatic transcription factor Runx2...
  23. pmc Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs
    Hai Yun Yen
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
    Lab Invest 92:802-11. 2012
    ....
  24. pmc Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner
    Tommy Noh
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 4:e5438. 2009
    ..The resistance to Lef1 haploinsufficiency in males with active AR and in old females could be due to the reduced bone turnover in these mice...
  25. ncbi request reprint Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner
    Elisheva Smith
    Department of Orthopedic Surgery and Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 280:2388-94. 2005
    ..These results suggest that inhibition of a PI3K/Akt/GSK3beta/beta-catenin/LEF axis and stimulation of HDAC1 cooperate to mediate the inhibitory effect of DEX on Wnt signaling and the osteoblast differentiation-related cell cycle...
  26. pmc Identification of novel androgen receptor target genes in prostate cancer
    Unnati Jariwala
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, USA
    Mol Cancer 6:39. 2007
    ..The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in disease progression...
  27. ncbi request reprint Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells
    Shangxin Yang
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 65:5769-77. 2005
    ....
  28. doi request reprint Dependence of castration-resistant prostate cancer (CRPC) stem cells on CRPC-associated fibroblasts
    Helty Adisetiyo
    Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California Institute for Genetic Medicine, University of Southern California, Los Angeles, California
    J Cell Physiol 229:1170-6. 2014
    ..Factors released by CRPCAF to regulate CRPCSC may be targeted to develop novel therapeutic approaches to manage advanced prostate cancer...
  29. pmc Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion
    Gillian H Little
    Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 40:3538-47. 2012
    ..Thus, combined analysis of Runx2's transcriptome and genomic occupancy in PCa cells lead to defining its novel role in regulating protein secretion...
  30. doi request reprint Developmentally regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin A transcription in primary osteoblast cultures
    Yankel Gabet
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Cell Physiol 226:991-8. 2011
    ..Our data suggest that GCs attenuate cell cycle progression in osteoblasts in a developmental stage-specific manner by repressing Atf4-dependent cyclin A gene expression...
  31. ncbi request reprint Gene expression profiling of glucocorticoid-inhibited osteoblasts
    Nathalie Leclerc
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, 2250 Alcazar Street, Los Angeles, California 90033, USA
    J Mol Endocrinol 33:175-93. 2004
    ..These and other observations disclose novel gene targets, whose regulation by GCs in osteoblasts may shed light on and provide new therapeutic approaches to osteoporosis...
  32. doi request reprint Identification of transcription factor target genes by ChIP display
    Artem Barski
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Methods Mol Biol 455:177-90. 2008
    ....
  33. pmc RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
    Nyam Osor Chimge
    Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Nat Commun 7:10751. 2016
    ..Finally, RUNX1 loss-mediated deregulation of β-catenin and mitosis is ameliorated by AXIN1 stabilization in vitro, highlighting AXIN1 as a potential target for the management of ER(+) breast cancer. ..
  34. pmc Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association
    Anthony Martin
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1795 Zonal Ave, Los Angeles, CA 90033, USA Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 1795 Zonal Ave, Los Angeles, CA 90033, USA Electronic address
    Bone 75:96-104. 2015
    ..Targeting RUNX2 and/or downstream mechanisms that regulate RANKL trafficking may lead to the development of improved SERMs and possibly non-hormonal therapeutic approaches to high turnover bone disease. ..
  35. pmc ChIP Display: novel method for identification of genomic targets of transcription factors
    Artem Barski
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Nucleic Acids Res 32:e104. 2004
    ..One of them, Osbpl8, was subjected to mRNA and promoter-reporter analyses, which provided functional proof for its regulation by RUNX2. CD will help to assemble the puzzle of interactions between transcription factors and the genome...
  36. pmc Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation
    Sanjeev K Baniwal
    Department of Orthopaedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    J Cell Physiol 227:2276-82. 2012
    ..Our data suggest that Runx2 controls a positive feedback loop between androgen signaling and PIP, and pharmacological inhibition of PIP may be useful to treat PIP positive tumors...
  37. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
    ..1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C (and probably other AT2 cell genes) during transition of AT2 cells to an AT1 cell phenotype...
  38. doi request reprint Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line
    Jia Li Yu
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California
    J Cell Physiol 230:237-41. 2015
    ....
  39. ncbi request reprint Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2
    Steven Pregizer
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    J Cell Biochem 102:1458-71. 2007
    ..Expanding our knowledge of Runx2 target genes, and manipulation of these genes, are warranted to better understand the regulation of osteoblast function and to provide opportunities for the development of new bone anabolics...
  40. pmc A systematic approach to understand the functional consequences of non-protein coding risk regions
    Gerhard A Coetzee
    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Cell Cycle 9:256-9. 2010
    ..Here we describe an integrated framework to allow non-protein coding loci to be annotated with respect to regulatory functions. This will facilitate identification of target genes as well as prioritize variants for functional testing...
  41. ncbi request reprint Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis
    Charalampos Zalavras
    Department of Orthopaedic Surgery, Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Crit Rev Eukaryot Gene Expr 13:221-35. 2003
    ....
  42. pmc Location, location, (ChIP-)location! Mapping chromatin landscapes one immunoprecipitation at a time
    Benjamin P Berman
    USC Epigenome Center, University of Southern California, Los Angeles, California 90033, USA
    J Cell Biochem 107:1-5. 2009
    ....
  43. pmc Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner
    Sanjeev K Baniwal
    Department of Orthopedic Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e62361. 2014
    ..Pharmacological inhibition of PIP may therefore serve the bases for both augmentation of existing therapies for hormone-dependent tumors and the development of novel therapeutic approaches for hormone-resistant BCa...
  44. ncbi request reprint Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures
    Cynthia A Luppen
    Department of Biochemistry, Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Bone Miner Res 18:1186-97. 2003
    ..rhBMP-2 restored mineralization but not condensation or collagen accumulation. These results demonstrate the potential and limitations of BMPs in counteracting glucocorticoids...
  45. doi request reprint Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation
    Eri Morimoto
    Departments of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    J Cell Physiol 232:145-53. 2017
    ..J. Cell. Physiol. 232: 145-153, 2017. © 2016 Wiley Periodicals, Inc. ..
  46. ncbi request reprint Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta
    Elisheva Smith
    Department of Orthopedic Surgery, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 277:18191-7. 2002
    ..GC interfere with this growth-permissive axis by GSK3beta activation, resulting in c-Myc down-regulation and impediment of the G(1)/S cell cycle transition...
  47. doi request reprint Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells
    Theodora Koromila
    Department of Biochemistry and Molecular Biology, Institute for Genetic Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California
    J Cell Biochem 115:27-33. 2014
    ..Investigation of the RUNX2/GR interaction may lead to the development of bone-sparing GC treatment modalities for the management of autoimmune and inflammatory diseases...
  48. ncbi request reprint High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer
    Winston Vuong
    Beckman Research Institute, City of Hope, Duarte, California W V, B Y T, J O J Keck School of Medicine, University of Southern California, Los Angeles, California G H L, B F
    J Pharmacol Exp Ther 359:256-261. 2016
    ..Our assay is amenable to high-throughput screening and can be used to identify inhibitors of the AR-RUNX2 interaction in prostate cancer cells...
  49. doi request reprint Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis
    Josephine H Haduong
    The Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA
    Int J Cancer 137:797-809. 2015
    ..Our study provides a new insight into the role of VEGFA in NBL metastases by pointing to the role of stroma-derived intracrine VEGFA in osteoblastogenesis. ..
  50. pmc Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway
    Rungnapa Warotayanont
    University of Southern California School of Dentistry, Center for Craniofacial Molecular Biology, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Biochem Biophys Res Commun 387:558-63. 2009
    ..We conclude that LRAP activates the canonical Wnt signaling pathway to induce osteogenic differentiation of mouse ES cells through the concerted regulation of Wnt agonists and antagonists...
  51. pmc Runx1-mediated regulation of osteoclast differentiation and function
    Do Y Soung
    New England Musculoskeletal Institute D Y S, J K, C E J G, J L, H D, Department of Orthopaedic Surgery H D, and Department of Medicine C E J G, University of Connecticut Health Center, Farmington, Connecticut 06030 and Department of Orthopaedic Surgery and Biochemistry and Molecular Biology S K B, B F, University of Southern California, Los Angeles, California 90089
    Mol Endocrinol 28:546-53. 2014
    ..These data indicate that Runx1 expression in preosteoclasts negatively regulates osteoclast formation and activity and contributes to overall bone mass. ..
  52. pmc Functional enhancers at the gene-poor 8q24 cancer-linked locus
    Li Jia
    USC Norris Cancer Center, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
    PLoS Genet 5:e1000597. 2009
    ....
  53. ncbi request reprint Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer
    Nathalie Leclerc
    University of Southern California Keck School of Medicine, Los Angeles 90033, USA
    Arthritis Rheum 52:929-39. 2005
    ..Using this gene as a model, the goal of this study was to discover glucocorticoid-sensitive transcriptional mechanisms in osteoblasts...
  54. ncbi request reprint ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells
    Symone M San Miguel
    Bone Laboratory, The Hebrew University of Jerusalem, Israel
    J Biol Chem 280:37495-502. 2005
    ..These data define a novel mitogenic signaling pathway in osteoblasts whereby ERK1/2 stimulation of CREB phosphorylation and transcriptional activity as well as DNA synthesis are critically dependent on de novo Mapkapk2 synthesis...

Research Grants2

  1. KROX 20 AND BONE MASS
    Baruch Frenkel; Fiscal Year: 2010
    ..These studies will elucidate novel regulatory mechanisms that control osteoblast function and bone formation in health and disease, and open new avenues in the pursuit of bone anabolics. ..
  2. Identification of CBFA1 Targets in Osteoblasts
    Baruch Frenkel; Fiscal Year: 2003
    ..Finally, the most intense bands will be eluted from the gel, cloned and sequenced. Genetically adjacent ORFs will be identified and their regulation by CBFA1 validated. ..