Thomas Getchell

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Identification of gene expression patterns using planned linear contrasts
    Hao Li
    Department of Statistics, University of Kentucky, Lexington, KY 40536 0027, USA
    BMC Bioinformatics 7:245. 2006
  2. ncbi request reprint In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neurosci Res 77:430-52. 2004
  3. ncbi request reprint Leptin regulates olfactory-mediated behavior in ob/ob mice
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Physiol Behav 87:848-56. 2006
  4. ncbi request reprint Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablation
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, 40536 0230, USA
    J Neurosci Res 80:309-29. 2005
  5. ncbi request reprint Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice
    Thomas V Getchell
    Department of Physiology, 309 Sanders Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Ageing Res Rev 2:211-43. 2003
  6. ncbi request reprint Target ablation-induced regulation of macrophage recruitment into the olfactory epithelium of Mip-1alpha-/- mice and restoration of function by exogenous MIP-1alpha
    Kevin Kwong
    Department of Physiology, University of Kentucky, Lexington 40536 0230, USA
    Physiol Genomics 20:73-86. 2004
  7. ncbi request reprint Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
    R Lakshman Chelvarajan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    J Leukoc Biol 79:1314-27. 2006
  8. ncbi request reprint Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 94:380-92. 2005
  9. ncbi request reprint Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages
    Lakshman Chelvarajan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Leukoc Biol 82:403-16. 2007
  10. ncbi request reprint Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis
    Aaron S Borders
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Comp Neurol 501:206-18. 2007

Research Grants

  1. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005

Collaborators

Detail Information

Publications19

  1. pmc Identification of gene expression patterns using planned linear contrasts
    Hao Li
    Department of Statistics, University of Kentucky, Lexington, KY 40536 0027, USA
    BMC Bioinformatics 7:245. 2006
    ..In addition, multiple testing problems are complicated in experiments with multi-level treatments when thousands of genes are involved...
  2. ncbi request reprint In silico analysis of gene expression profiles in the olfactory mucosae of aging senescence-accelerated mice
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neurosci Res 77:430-52. 2004
    ....
  3. ncbi request reprint Leptin regulates olfactory-mediated behavior in ob/ob mice
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Physiol Behav 87:848-56. 2006
    ..Our results strongly suggest that leptin acting through leptin receptors modulates olfactory-mediated pre-ingestive behavior...
  4. ncbi request reprint Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablation
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, 40536 0230, USA
    J Neurosci Res 80:309-29. 2005
    ..These studies are an important first step in defining early time-dependent changes in gene expression after target ablation that lead to neurogenesis in the olfactory sensory epithelium...
  5. ncbi request reprint Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice
    Thomas V Getchell
    Department of Physiology, 309 Sanders Brown Center on Aging, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Ageing Res Rev 2:211-43. 2003
    ....
  6. ncbi request reprint Target ablation-induced regulation of macrophage recruitment into the olfactory epithelium of Mip-1alpha-/- mice and restoration of function by exogenous MIP-1alpha
    Kevin Kwong
    Department of Physiology, University of Kentucky, Lexington 40536 0230, USA
    Physiol Genomics 20:73-86. 2004
    ..The results illustrated that MIP-1alpha played a key role in recruitment of macrophages to the OE and provided insight into the genomic regulation involved in OE remodeling...
  7. ncbi request reprint Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
    R Lakshman Chelvarajan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    J Leukoc Biol 79:1314-27. 2006
    ..Low doses of a p38 MAPK inhibitor (SB203580) enhanced proinflammatory cytokine production by Mphi and reduced IL-10 levels, indicating that increased p38 MAPK activity has a role in cytokine dysregulation in the aged mouse Mphi...
  8. ncbi request reprint Proteomic identification of differentially expressed proteins in the aging murine olfactory system and transcriptional analysis of the associated genes
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 94:380-92. 2005
    ..Our transcriptional analysis provides insight into possible mechanisms by which protein expression may be regulated in the OE and OB. The results are discussed in relation to the decrement in olfactory sensitivity with aging...
  9. ncbi request reprint Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages
    Lakshman Chelvarajan
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Leukoc Biol 82:403-16. 2007
    ..The anti-inflammatory phenotype of the neonatal Mphi may be unique to the developing organism, although it compromises the neonate's ability to respond to encapsulated bacteria...
  10. ncbi request reprint Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis
    Aaron S Borders
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Comp Neurol 501:206-18. 2007
    ..These results indicate that macrophages modulate the OSN population in the normal and target-ablated murine OE by influencing neuronal survival and basal cell proliferation, resulting in neurogenesis and replacement of mature OSNs...
  11. ncbi request reprint Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation
    Thomas V Getchell
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0230, USA
    J Neurosci Res 67:246-54. 2002
    ....
  12. pmc Quadratic regression analysis for gene discovery and pattern recognition for non-cyclic short time-course microarray experiments
    Hua Liu
    Department of Statistics, University of Kentucky, Lexington, KY 40506, USA
    BMC Bioinformatics 6:106. 2005
    ..However, in general, these methods do not take advantage of the fact that time is a continuous variable, and existing clustering methods often group biologically unrelated genes together...
  13. pmc Analysis of oligonucleotide array experiments with repeated measures using mixed models
    Hao Li
    Department of Statistics, 815 Patterson Office Tower, University of Kentucky, Lexington, Kentucky 40506 0027, USA
    BMC Bioinformatics 5:209. 2004
    ..In addition, multiple testing problems are more complicated in experiments with multi-level treatments or treatment combinations...
  14. ncbi request reprint Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1alpha and monocyte chemoattractant protein-1
    Thomas V Getchell
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0230, USA
    J Neurosci Res 70:784-93. 2002
    ..Our data support the hypothesis that MIP-1alpha and MCP-1 are chemoattractant chemokines associated with the recruitment of macrophages into the olfactory epithelium shortly after target ablation...
  15. ncbi request reprint Expression of TGF-beta type II receptors in the olfactory epithelium and their regulation in TGF-alpha transgenic mice
    Marilyn L Getchell
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    Brain Res 945:232-41. 2002
    ..Taken together, these results indicate that TGF-beta signaling regulates terminal differentiation of ORNs in vivo and suggest ways in which interactions between TGF-alpha and TGF-beta signaling pathways may interact in the OE...
  16. ncbi request reprint Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice
    H Fai Poon
    Department of Chemistry, Center of Mambrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1010-9. 2006
    ..Our results establish an initial basis for understanding protein alterations that may lead to age-related cellular dysfunction in the brain...
  17. ncbi request reprint Oxidative stress in the aging murine olfactory bulb: redox proteomics and cellular localization
    Radhika A Vaishnav
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 85:373-85. 2007
    ..These results indicate that specific carbonylated proteins, including those in astrocytes and mitral/tufted neurons, and nitrated proteins in the vasculature are molecular substrates of age-related olfactory dysfunction...
  18. ncbi request reprint Cellular and molecular characterization of oxidative stress in olfactory epithelium of Harlequin mutant mouse
    Radhika A Vaishnav
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurosci Res 86:165-82. 2008
    ..Our results strongly support the Hq/Y mutant mouse being a novel model for mechanistic studies of oxidative stress-associated olfactory aging...
  19. ncbi request reprint Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death
    Devin S Gary
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Exp Neurol 176:266-8. 2002
    ..These findings provide the first evidence that olfactory input affects the vulnerability of neurons to excitotoxic death...

Research Grants1

  1. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005
    ..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..