Pradipta Ghosh

Summary

Affiliation: University of California
Country: USA

Publications

  1. Bhandari D, López Sánchez I, To A, Lo I, Aznar N, Leyme A, et al. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015;112:E4874-83 pubmed publisher
    ....
  2. Ghosh P, Beas A, Bornheimer S, Garcia Marcos M, Forry E, Johannson C, et al. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010;21:2338-54 pubmed publisher
    ..Thus, inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression. ..
  3. Lin C, Ear J, Midde K, López Sánchez I, Aznar N, Garcia Marcos M, et al. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014;25:3654-71 pubmed publisher
    ....
  4. Garcia Marcos M, Ghosh P, Farquhar M. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem. 2015;290:6697-704 pubmed publisher
    ..We also describe the dysregulation of this mechanism in disease and how its targeting holds promise for novel therapeutics. ..
  5. López Sánchez I, Ma G, Pedram S, Kalogriopoulos N, Ghosh P. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015;468:287-93 pubmed publisher
    ..These findings suggest a role of GIV in coordinating key signaling and trafficking events of metabolic insulin response. ..
  6. Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, et al. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers. FASEB J. 2016;30:3702-3713 pubmed
    ..Dunkel, Y., Diao, K., Aznar, N., Swanson, L., Liu, L., Zhu, W., Mi, X.-Y., Ghosh, P. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers...

Collaborators

Detail Information

Publications6

  1. Bhandari D, López Sánchez I, To A, Lo I, Aznar N, Leyme A, et al. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015;112:E4874-83 pubmed publisher
    ....
  2. Ghosh P, Beas A, Bornheimer S, Garcia Marcos M, Forry E, Johannson C, et al. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010;21:2338-54 pubmed publisher
    ..Thus, inclusion or exclusion of GIV's GEF motif, which activates Galphai, modulates EGFR signaling, generates migration-proliferation dichotomy, and most likely influences cancer progression. ..
  3. Lin C, Ear J, Midde K, López Sánchez I, Aznar N, Garcia Marcos M, et al. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014;25:3654-71 pubmed publisher
    ....
  4. Garcia Marcos M, Ghosh P, Farquhar M. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem. 2015;290:6697-704 pubmed publisher
    ..We also describe the dysregulation of this mechanism in disease and how its targeting holds promise for novel therapeutics. ..
  5. López Sánchez I, Ma G, Pedram S, Kalogriopoulos N, Ghosh P. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015;468:287-93 pubmed publisher
    ..These findings suggest a role of GIV in coordinating key signaling and trafficking events of metabolic insulin response. ..
  6. Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, et al. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers. FASEB J. 2016;30:3702-3713 pubmed
    ..Dunkel, Y., Diao, K., Aznar, N., Swanson, L., Liu, L., Zhu, W., Mi, X.-Y., Ghosh, P. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers...