CAROLYN GIBSON

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
  2. ncbi request reprint DNA sequences of amelogenin genes provide clues to regulation of expression
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania, School of Dental Medicine, Philadelphia 19104, USA
    Eur J Oral Sci 106:292-8. 1998
  3. pmc The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    Cells Tissues Organs 189:169-74. 2009
  4. ncbi request reprint The amelogenin "enamel proteins" and cells in the periodontium
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Crit Rev Eukaryot Gene Expr 18:345-60. 2008
  5. ncbi request reprint Transgenic mice that express normal and mutated amelogenins
    C W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Dent Res 86:331-5. 2007
  6. ncbi request reprint Nested genes: biological implications and use of AFM for analysis
    Carolyn W Gibson
    University of Pennsylvania School of Dental Medicine, Department of Anatomy and Cell Biology, 240 S 40th Street, Philadelphia, PA 19104, USA
    Gene 350:15-23. 2005
  7. ncbi request reprint The use of animal models to explore amelogenin variants in amelogenesis imperfecta
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cells Tissues Organs 181:196-201. 2005
  8. pmc Amelogenesis imperfecta due to a mutation of the enamelin gene: clinical case with genotype-phenotype correlations
    Rochelle G Lindemeyer
    Pediatric Dentistry, School of Dental Medicine, The University of Pennsylvania, USA
    Pediatr Dent 32:56-60. 2010
  9. ncbi request reprint Quantifying labial blood flow using optical Doppler tomography
    Linda L Otis
    Department of Oral Medicine, The University of Pennsylvania School of Dental Medicine, Philadelphia 19104 6030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:189-94. 2004
  10. pmc Partial rescue of the amelogenin null dental enamel phenotype
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Biol Chem 283:15056-62. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
    ..These null mice will be useful for understanding the functions of amelogenin proteins during enamel formation and for developing therapeutic approaches for treating this developmental defect that affects the enamel...
  2. ncbi request reprint DNA sequences of amelogenin genes provide clues to regulation of expression
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania, School of Dental Medicine, Philadelphia 19104, USA
    Eur J Oral Sci 106:292-8. 1998
    ....
  3. pmc The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    Cells Tissues Organs 189:169-74. 2009
    ..Because many amelogenin proteins are present in developing enamel due to RNA alternative splicing and proteolytic processing, understanding the function of individual amelogenins has been challenging...
  4. ncbi request reprint The amelogenin "enamel proteins" and cells in the periodontium
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Crit Rev Eukaryot Gene Expr 18:345-60. 2008
    ....
  5. ncbi request reprint Transgenic mice that express normal and mutated amelogenins
    C W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Dent Res 86:331-5. 2007
    ..The phenotype argues for dominant-negative activity for the P70T amelogenin, and for the robust nature of the process of amelogenesis...
  6. ncbi request reprint Nested genes: biological implications and use of AFM for analysis
    Carolyn W Gibson
    University of Pennsylvania School of Dental Medicine, Department of Anatomy and Cell Biology, 240 S 40th Street, Philadelphia, PA 19104, USA
    Gene 350:15-23. 2005
    ..The potential of this technology includes a greater molecular understanding of cellular decision making processes, leading to enhanced opportunities to intervene in disease progression through use of novel treatment modalities...
  7. ncbi request reprint The use of animal models to explore amelogenin variants in amelogenesis imperfecta
    Carolyn W Gibson
    Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cells Tissues Organs 181:196-201. 2005
    ..Future studies are expected to answer remaining questions concerning structure/function relationships among these 'enamel proteins'...
  8. pmc Amelogenesis imperfecta due to a mutation of the enamelin gene: clinical case with genotype-phenotype correlations
    Rochelle G Lindemeyer
    Pediatric Dentistry, School of Dental Medicine, The University of Pennsylvania, USA
    Pediatr Dent 32:56-60. 2010
    ..The purpose of this article was to report the genotype-phenotype correlations for a 9-year, 11-month-old boy with a homozygous ENAM mutation (c.1258_1259insAG)...
  9. ncbi request reprint Quantifying labial blood flow using optical Doppler tomography
    Linda L Otis
    Department of Oral Medicine, The University of Pennsylvania School of Dental Medicine, Philadelphia 19104 6030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:189-94. 2004
    ..The objective of this study was to determine the feasibility of ODT to image labial blood flow. A prototype ODT imaging system was constructed that characterized and measured labial blood flow in healthy subjects...
  10. pmc Partial rescue of the amelogenin null dental enamel phenotype
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, 240 S 40th Street, Philadelphia, PA 19104 6030, USA
    J Biol Chem 283:15056-62. 2008
    ..Rescue was not observed in the molars from the TgP70TKO mice. It was concluded that a single amelogenin protein was able to significantly rescue the KO phenotype and that one amino acid change abrogated this function during development...
  11. ncbi request reprint Comparison of body weight and gene expression in amelogenin null and wild-type mice
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    Eur J Oral Sci 114:190-3; discussion 201-2, 381. 2006
    ..The smaller size of AmelX null mice could potentially be explained by the lack of LRAP expression in some of these tissues, leading to a delay in development...
  12. ncbi request reprint Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts
    Yong Li
    Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philadelphia, 19104 6030, USA
    Arch Oral Biol 50:681-8. 2005
    ..It was concluded from immunohistochemistry, RT-PCR and confocal approaches that the components of the Rho pathway are present in ameloblasts, and that the response to fluoride involves the Rho/ROCK pathway...
  13. ncbi request reprint Amelogenins regulate expression of genes associated with cementoblasts in vitro
    Erica C Swanson
    University of Washington, School of Dentistry, Seattle, WA 98195, USA
    Eur J Oral Sci 114:239-43; discussion 254-6, 381-2. 2006
    ..These data, along with our previous results demonstrating similar activity with full-length amelogenin and leucine-rich amelogenin peptide (LRAP), suggest that amelogenin-like molecules regulate mesenchymal cell behavior...
  14. ncbi request reprint Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix
    Alexandre R Espírito Santo
    Department of Morphology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil
    Connect Tissue Res 48:39-45. 2007
    ..0000). The results presented here support growing evidence for the idea that the birefringence of secretory-stage enamel organic ECM is influenced by the ordered supramolecular organization of its components...
  15. ncbi request reprint Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis
    Fernanda Boabaid
    Department of Periodontics, School of Dentistry, University of Washington, Seattle, WA 98195 7444, USA
    J Periodontol 75:1126-36. 2004
    ..Here, we focused on determining whether or not leucine-rich amelogenin peptide (LRAP), translated from an alternatively spliced amelogenin RNA, altered cementoblast behavior...
  16. doi request reprint Physiological implications of DLX homeoproteins in enamel formation
    Frederic Lezot
    INSERM, UMR 872, Paris, F 75006 France
    J Cell Physiol 216:688-97. 2008
    ....
  17. ncbi request reprint A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel
    John D Bartlett
    Department of Cytokine Biology, Forsyth Institute, Boston, MA 02115, USA
    Eur J Oral Sci 114:18-23; discussion 39-41, 379. 2006
    ..Both genes are essential for the generation of full-thickness enamel containing the characteristic decussating prism pattern...
  18. ncbi request reprint Amelogenin: a potential regulator of cementum-associated genes
    Hema L Viswanathan
    Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI, USA
    J Periodontol 74:1423-31. 2003
    ..Amelogenins have been reported to induce expression of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial products can regulate the activity of mesenchyme-derived cells...
  19. ncbi request reprint The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice
    Junko Hatakeyama
    Functional Genomics Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:35743-8. 2003
    ..These findings indicate that the amelogenin splice variants, M180 and LRAP, are critical in preventing abnormal resorption of cementum...
  20. ncbi request reprint Imaging RNA polymerase-amelogenin gene complexes with single molecule resolution using atomic force microscopy
    Neal Crampton
    School of Physics and Astronomy, University of Leeds, and Department of Oral Biology, Leeds Dental Institute, UK
    Eur J Oral Sci 114:133-8; discussion 164-5, 380-1. 2006
    ....

Research Grants2

  1. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  2. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
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