Robert M Greene

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Divergence of epidermal growth factor - transforming growth factor beta signaling in embryonic orofacial tissue
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    In Vitro Cell Dev Biol Anim 39:257-61. 2003
  2. pmc BMP signaling dynamics in embryonic orofacial tissue
    Partha Mukhopadhyay
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Physiol 216:771-9. 2008
  3. ncbi request reprint Recent advances in understanding transforming growth factor beta regulation of orofacial development
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA
    Hum Exp Toxicol 24:1-12. 2005
  4. ncbi request reprint Perspectives on growth factors and orofacial development
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA
    Curr Pharm Des 10:2701-17. 2004
  5. ncbi request reprint Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 324:70-6. 2004
  6. ncbi request reprint Identification of novel Smad binding proteins
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 312:1185-90. 2003
  7. ncbi request reprint Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005
  8. ncbi request reprint PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Biochim Biophys Acta 1773:814-20. 2007
  9. pmc CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, KY 40292, USA
    Int J Dev Biol 53:1097-104. 2009
  10. ncbi request reprint Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1)
    Xiaolong Yin
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, KY 40292, USA
    J Interferon Cytokine Res 25:321-7. 2005

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Divergence of epidermal growth factor - transforming growth factor beta signaling in embryonic orofacial tissue
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    In Vitro Cell Dev Biol Anim 39:257-61. 2003
    ..Collectively, data from this study suggest that the EGF and TGFbeta signal transduction pathways do not converge in murine embryonic maxillary mesenchymal cells...
  2. pmc BMP signaling dynamics in embryonic orofacial tissue
    Partha Mukhopadhyay
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Physiol 216:771-9. 2008
    ..Collectively, these data document the existence of a functional Smad-mediated BMP signaling system in cells of the developing murine orofacial region...
  3. ncbi request reprint Recent advances in understanding transforming growth factor beta regulation of orofacial development
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA
    Hum Exp Toxicol 24:1-12. 2005
    ....
  4. ncbi request reprint Perspectives on growth factors and orofacial development
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, USA
    Curr Pharm Des 10:2701-17. 2004
    ..Consideration is also given to evidence implicating developmental contributions from members of the bone morphogenetic protein and fibroblast growth factor families...
  5. ncbi request reprint Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 324:70-6. 2004
    ..This offers a means of enhancing TGFbeta-mediated cellular responses in developing orofacial tissue...
  6. ncbi request reprint Identification of novel Smad binding proteins
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 312:1185-90. 2003
    ..The identification of these proteins as Smad binding partners allows exploration of new mechanisms whereby TGFbeta signaling may be regulated, and reveals additional potential interactions with other signaling pathways...
  7. ncbi request reprint Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005
    ....
  8. ncbi request reprint PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Biochim Biophys Acta 1773:814-20. 2007
    ..Taken together, these results demonstrate that PRDM16/MEL1 is a Smad binding protein that may be important for development of orofacial structures through modulation of the TGFbeta signaling pathway...
  9. pmc CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, KY 40292, USA
    Int J Dev Biol 53:1097-104. 2009
    ..Target genes, and pathways that promote cranial neural tube fusion that are activated by CBP/p300/Carm1/Cited2/Cart1-containing transcriptional complexes await elucidation...
  10. ncbi request reprint Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1)
    Xiaolong Yin
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, KY 40292, USA
    J Interferon Cytokine Res 25:321-7. 2005
    ....
  11. pmc Developmental profiles of the murine palatal methylome
    Ratnam S Seelan
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, 501 S Preston Street, Louisville, KY 40202, USA
    Birth Defects Res A Clin Mol Teratol 97:171-86. 2013
    ..Identification of genes that are methylated during development of the secondary palate will contribute to a better understanding of the gene-environment link contributing to CP...
  12. pmc MicroRNA gene expression signatures in the developing neural tube
    Partha Mukhopadhyay
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Louisville, KY 40292, USA
    Birth Defects Res A Clin Mol Teratol 91:744-62. 2011
    ..To define potential roles of miRNAs in development of the murine neural tube (NT), miRNA microarray analysis was conducted to establish expression profiles, and identify miRNA target genes and functional gene networks...
  13. ncbi request reprint Interaction of Smads with collagen types I, III, and V
    Leslie R Ellis
    Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 310:1117-23. 2003
    ..Moreover, TGFbeta is a potent regulator of collagen synthesis and turnover during mammalian orofacial development. These data thus suggest an important means of feedback regulation of the TGFbeta signaling cascade...
  14. pmc Prenatal exposure to environmental tobacco smoke alters gene expression in the developing murine hippocampus
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Louisville, Kentucky 40292, USA
    Reprod Toxicol 29:164-75. 2010
    ..Little is known about the effects of passive smoke exposures on the developing brain...
  15. ncbi request reprint Neural crest and mesoderm lineage-dependent gene expression in orofacial development
    Vasker Bhattacherjee
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Differentiation 75:463-77. 2007
    ....
  16. ncbi request reprint Developmental gene expression profiling of mammalian, fetal orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky, KY 40292, USA
    Birth Defects Res A Clin Mol Teratol 70:912-26. 2004
    ..DNA microarray technology presents an efficient means of acquiring novel and valuable information regarding the expression, regulation, and function of a panoply of genes involved in mammalian orofacial development...
  17. ncbi request reprint Temporal Expression of miRNAs in Laser Capture Microdissected Palate Medial Edge Epithelium from Tgfβ3(-/-) Mouse Fetuses
    DENNIS WARNER
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 S Preston St, Suite 350, University of Louisville, Louisville, Kentucky, 40202, USA
    Microrna 4:64-71. 2015
    ..Moreover, analysis of the Tgfβ3 knockout mouse model has enabled identification of miRNAs with altered expression that may contribute to the cleft palate phenotype. ..
  18. pmc Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice
    Dennis R Warner
    Birth Defects Center, University of Louisville, 501 South Preston Street, Suite 350, Louisville, KY 40202, USA
    Cell Tissue Res 351:445-52. 2013
    ..These data suggest that one function of Prdm16 is the regulation of genes that play a role in the differentiation of mesenchymal cells into chondro-/osteocytes...
  19. pmc Epigenetic regulation of Sox4 during palate development
    Ratnam S Seelan
    University of Louisville, Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, 501 S Preston St, Suite 350, Louisville, KY 40202, USA
    Epigenomics 5:131-46. 2013
    ..In this study, we have examined if the differential expression of Sox4 in the palate is due to changes in DNA methylation...
  20. pmc Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development
    Saurabh Singh
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, Kentucky 40292, USA
    Birth Defects Res A Clin Mol Teratol 79:35-44. 2007
    ..The present study examined the expression patterns of members of the MAPK family in developing murine orofacial tissue...
  21. pmc Expression profiling of transforming growth factor beta superfamily genes in developing orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, Kentucky 40292, USA
    Birth Defects Res A Clin Mol Teratol 76:528-43. 2006
    ....
  22. pmc TGFβ-1 and Wnt-3a interact to induce unique gene expression profiles in murine embryonic palate mesenchymal cells
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, Louisville, KY 40292, USA
    Reprod Toxicol 31:128-33. 2011
    ..In the current study we tested the hypothesis that unique gene expression profiles are induced in murine embryonic palate mesenchymal cells as a result of this cross-talk between the TGFβ and Wnt signal transduction pathways...
  23. ncbi request reprint Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cells
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, 501 South Preston Street, Suite 301, Louisville, KY 40292, United States
    FEBS Lett 579:3539-46. 2005
    ..These data demonstrate a functional interaction between the TGFbeta and Wnt signaling pathways and suggest that Wnt activation of the canonical pathway is an important mediator of MEMM cell growth...
  24. ncbi request reprint Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
    ..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways...
  25. ncbi request reprint Intracellular dynamics of Smad-mediated TGFbeta signaling
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, ULSD, Louisville, Kentucky, USA
    J Cell Physiol 197:261-71. 2003
    ..Collectively, these data point to the presence of a functional Smad-mediated TGFbeta signaling system in cells of the developing murine palate...
  26. doi request reprint Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM16 in murine embryonic palate mesenchymal cells
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 237:387-94. 2012
    ..These results suggest that PRDM16 may play a role in differentiation of mesenchymal cells in the embryonic secondary palate that contribute to the anterior, bony palate and posterior, muscular palate...
  27. pmc Strain-specific modifier genes governing craniofacial phenotypes
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
    Birth Defects Res A Clin Mol Teratol 94:162-75. 2012
    ..c-Ski is a transcriptional regulator. Ski(-/-) mice on a C57BL6J (B6) background exhibit facial clefting, while Ski(-/-) mice on a 129P3 (129) background present with exencephaly...
  28. pmc Expression of Wnts in the developing murine secondary palate
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
    Int J Dev Biol 53:1105-12. 2009
    ..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny...
  29. pmc Determinants of Orofacial Clefting I: Effects of 5-Aza-2/-deoxycytidine on Cellular Processes and Gene Expression during Development of the First Branchial Arch
    Partha Mukhopadhyay
    Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY 40202, USA Electronic address
    Reprod Toxicol . 2016
    ..CpG methylation analysis suggested that the effects of AzaD on gene expression were likely indirect...
  30. pmc Developmental cigarette smoke exposure: hippocampus proteome and metabolome profiles in low birth weight pups
    Rachel E Neal
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA Birth Defects Center, University of Louisville, Louisville, KY, USA Electronic address
    Toxicology 317:40-9. 2014
    ..CSE impacted glycolysis, oxidative phosphorylation, fatty acid metabolism, and neurodevelopment pathways within the developing hippocampus...
  31. pmc Developmental epigenetics of the murine secondary palate
    Ratnam S Seelan
    Department of Molecular, Cellular and Craniofacial Biology, Birth Defects Center, ULSD, University of Louisville, 501 S Preston Street, Louisville, KY 40202, USA
    ILAR J 53:240-52. 2012
    ..Specifically, we present the salient features of the embryonic palatal methylome and profile the expression of numerous microRNAs that regulate protein-encoding genes crucial to normal orofacial ontogeny...
  32. pmc Developmental microRNA expression profiling of murine embryonic orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular Cellular and Craniofacial Biology, ULSD, University of Louisville, Kentucky, USA
    Birth Defects Res A Clin Mol Teratol 88:511-34. 2010
    ..MicroRNA gene expression profiling is an effective means of acquiring novel and valuable information regarding the expression and regulation of genes, under the control of miRNA, involved in mammalian orofacial development...
  33. pmc Suppression of chondrogenesis by Id helix-loop-helix proteins in murine embryonic orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular Cellular and Craniofacial Biology, ULSD, University of Louisville, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Differentiation 77:462-72. 2009
    ....
  34. pmc Developmental cigarette smoke exposure II: Hippocampus proteome and metabolome profiles in adult offspring
    Rachel E Neal
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA Birth Defects Center, University of Louisville, Louisville, KY, USA Electronic address
    Reprod Toxicol 65:436-447. 2016
    ..These findings indicate developmental CSE-induced systemic glucose availability may limit both organism growth and developmental trajectory, including the capacity for learning and memory...
  35. pmc Developmental cigarette smoke exposure II: Kidney proteome profile alterations in 6 month old adult offspring
    Rachel E Neal
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, United States Birth Defects Center, University of Louisville, Louisville, KY, United States Electronic address
    Reprod Toxicol 65:425-435. 2016
    ..Key findings of this study include a persistence of impact of developmental CSE past the original exposure period on the nucleic acid and carbohydrate metabolism networks and oxidant scavenging pathways...
  36. pmc Palate morphogenesis: current understanding and future directions
    Robert M Greene
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, ULSD, Louisville, Kentucky 40292, USA
    Birth Defects Res C Embryo Today 90:133-54. 2010
    ....
  37. pmc The effect of cigarette smoke exposure on developing folate binding protein-2 null mice
    Kristin H Horn
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, Louisville, KY 40292 USPS 40202 Courier Delivery, United States
    Reprod Toxicol 26:203-9. 2008
    ..These data confirm an association between sidestream smoke exposure and fetal growth restriction, but do not suggest that loss of Folr2 increased susceptibility to these effects...
  38. pmc Arsenate-induced apoptosis in murine embryonic maxillary mesenchymal cells via mitochondrial-mediated oxidative injury
    Saurabh Singh
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, Kentucky 40292, USA
    Birth Defects Res A Clin Mol Teratol 88:25-34. 2010
    ..However, the molecular mechanisms by which arsenic induces cytotoxicity in murine embryonic maxillary mesenchymal (MEMM) cells are undefined...
  39. pmc Determinants of orofacial clefting II: Effects of 5-Aza-2'-deoxycytidine on gene methylation during development of the first branchial arch
    Ratnam S Seelan
    Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY 40202, USA Electronic address
    Reprod Toxicol 67:100-110. 2016
    ..This may result in the dysregulation of key signaling pathways during palatogenesis, causing CP...
  40. pmc MicroRNA expression profiling of the developing murine upper lip
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, Louisville, Kentucky, USA
    Dev Growth Differ 56:434-47. 2014
    ..Integration of these data with corresponding proteomic datasets will lead to a greater appreciation of epigenetic regulation of lip development and provide a better understanding of potential causes of cleft lip. ..
  41. pmc Alcohol modulates expression of DNA methyltranferases and methyl CpG-/CpG domain-binding proteins in murine embryonic fibroblasts
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY 40202, USA
    Reprod Toxicol 37:40-8. 2013
    ..These data support a potential epigenetic molecular mechanism underlying the pathogenesis of FAS during mammalian development...
  42. pmc MmPalateMiRNA, an R package compendium illustrating analysis of miRNA microarray data
    Guy N Brock
    Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA
    Source Code Biol Med 8:1. 2013
    ..As with mRNA expression profiling arrays, miRNA microarrays come in a variety of platforms from numerous manufacturers, and there are a multitude of techniques available for reducing and analyzing these data...
  43. doi request reprint Altered signal transduction in Folr1-/- mouse embryo fibroblasts
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, KY 40292, U S A
    Cell Biol Int 35:1253-9. 2011
    ..These results demonstrate that under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered...
  44. pmc Novel folate binding protein-1 interactions in embryonic orofacial tissue
    M Michele Pisano
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, KY 40292, United States
    Life Sci 86:275-80. 2010
    ..To identify proteins with which FolBp1 may interact within lipid rafts in tissue derived from embryonic orofacial tissue...
  45. pmc PRDM16 expression in the developing mouse embryo
    Kristin H Horn
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
    Acta Histochem 113:150-5. 2011
    ..The expression pattern is consistent with a role for PRDM16 in the development of multiple tissues. Collectively, these studies are the first to characterize the expression of the PRDM16 gene during early murine development...
  46. pmc Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression
    Dennis R Warner
    University of Louisville Birth Defects Center, School of Dentistry, 501 South Preston Street, Louisville, KY 40202, United States
    Exp Cell Res 342:32-8. 2016
    ..These results suggest that p300 histone acetyltransferase activity is critical for Wnt-dependent palate mesenchymal cell proliferation and migration, both processes that play a significant role in morphogenesis of the palate. ..
  47. pmc Chemokine-mediated migration of mesencephalic neural crest cells
    Francine Rezzoug
    University of Louisville, Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, 501 S Preston St, Suite 350, Louisville, KY 40202, USA
    Cytokine 56:760-8. 2011
    ....
  48. pmc Differential methylation of the gene encoding myo-inositol 3-phosphate synthase (Isyna1) in rat tissues
    Ratnam S Seelan
    Molecular, Cellular and Craniofacial Biology, Birth Defects Center, University of Louisville, 501 S Preston St, KY 40292, USA
    Epigenomics 3:111-24. 2011
    ..Very little is known about the mechanisms regulating Isyna1 expression in brain and other tissues. In this study, we have examined the role of DNA methylation in regulating Isyna1 expression in rat tissues...
  49. ncbi request reprint Laser capture microdissection of fluorescently labeled embryonic cranial neural crest cells
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, Louisville, Kentucky 40292, USA
    Genesis 39:58-64. 2004
    ..The molecular genetic strategy delineated in this report will facilitate future embryo-genomic and -proteomic analyses of mammalian NCC that will serve to further our understanding of these pluripotent embryonic progenitor cells...
  50. pmc Developmental cigarette smoke exposure II: Hepatic proteome profiles in 6 month old adult offspring
    Rachel E Neal
    Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, United States Birth Defects Center, University of Louisville, Louisville, KY, United States Electronic address
    Reprod Toxicol 65:414-424. 2016
    ..Together these findings indicate inappropriately timed gluconeogenesis that may reflect impaired insulin signaling in mature offspring exposed to 'active' developmental CSE...
  51. pmc Epigenetic analysis of laser capture microdissected fetal epithelia
    Ratnam S Seelan
    Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, KY 40202, USA
    Anal Biochem 442:68-74. 2013
    ..These studies describe an optimized approach for employing LCM of epithelial cells from fresh frozen fetal tissue that enables quantitative analyses of microRNA expression levels and CpG methylation. ..
  52. pmc An animal model of cigarette smoke-induced in utero growth retardation
    Emily R Esposito
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Toxicology 246:193-202. 2008
    ..The data also identify a period of susceptibility to in utero cigarette smoke exposure-induced growth retardation and LBW during pre-/peri-implantation embryonic development...
  53. pmc Cigarette smoke induces proteasomal-mediated degradation of DNA methyltransferases and methyl CpG-/CpG domain-binding proteins in embryonic orofacial cells
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, KY 40202, United States
    Reprod Toxicol 58:140-8. 2015
    ..Collectively, these data allow the suggestion of a potential epigenetic mechanism underlying maternal cigarette smoke exposure-induced orofacial clefting. ..
  54. doi request reprint Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development
    Jiu Zhen Jin
    Laboratory of Vertebrate Embryogenesis, Department of Molecular, Cellular and Craniofacial Biology and Birth Defects Center, University of Louisville, Louisville, Kentucky
    Dev Dyn 243:1536-43. 2014
    ..Transforming growth factor-β3 (TGF-β3) plays a central role in mediating secondary palate fusion along the facial midline. However, the mechanisms by which TGF-β3 functions during secondary palate fusion are still poorly understood...
  55. ncbi request reprint Identification of three novel Smad binding proteins involved in cell polarity
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    FEBS Lett 539:167-73. 2003
    ....
  56. ncbi request reprint Increased susceptibility to retinoid-induced teratogenesis in TGF-beta2 knockout mice
    Paul Nugent
    Birth Defects Center, University of Louisville School of Dentistry, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Reprod Toxicol 16:741-7. 2002
    ..We conclude that the genotype of the dam and embryo with respect to TGF-beta2 affects the incidence of RA-induced teratogenesis...
  57. ncbi request reprint Phosphatase regulation of gene expression during development of the palate
    Wayde M Weston
    Pulmonary Diabetes Therapeutic Unit, UP4310, SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426, USA
    Life Sci 71:1849-62. 2002
    ..These results demonstrate that transcriptional regulation of CREB in embryonic palatal issue is dependent on the coordinate activity of specific kinases and phosphatases...