Dales S Gregerson

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Immune privilege in the retina
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis 55455 3007, USA
    Ocul Immunol Inflamm 6:257-67. 1998
  2. ncbi request reprint Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA
    J Immunol 163:1073-80. 1999
  3. ncbi request reprint Failure of memory (CD44 high) CD4 T cells to recognize their target antigen in retina
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmunol 120:34-41. 2001
  4. ncbi request reprint Spontaneous induction of immunoregulation by an endogenous retinal antigen
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Invest Ophthalmol Vis Sci 43:2984-91. 2002
  5. ncbi request reprint Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity
    Dales S Gregerson
    Dept of Ophthalmology, LRB Rm 314, University of Minnesota, 2001 6th St SE, Minneapolis, MN 55455, USA
    Int Rev Immunol 21:101-21. 2002
  6. ncbi request reprint CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-gamma or anti-CD40
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota 55455 3007, USA
    Invest Ophthalmol Vis Sci 44:3083-93. 2003
  7. ncbi request reprint The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 172:6587-97. 2004
  8. ncbi request reprint APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients
    Dale S Gregerson
    Department of Opthamology, University of Minnesota, Lions Research Building, Rm 314, 2001 6th Street, S E, Minneapolis, MN 55455, USA
    J Leukoc Biol 76:383-7. 2004
  9. ncbi request reprint Preparation of overlapping peptides of bovine retinal S-antigen and their localization by immunoblotting with peptide-specific antibodies
    S P Fling
    Department of Microbiology, University of Minnesota, Minneapolis 55455
    Curr Eye Res 7:191-9. 1988

Detail Information

Publications9

  1. ncbi request reprint Immune privilege in the retina
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis 55455 3007, USA
    Ocul Immunol Inflamm 6:257-67. 1998
    ..When it fails, active, inducible mechanisms provide backup to protect the integrity of the retina and vision. Some of the observations that led to our hypotheses and their supporting experiments are discussed below...
  2. ncbi request reprint Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA
    J Immunol 163:1073-80. 1999
    ..The results also show that beta-gal can serve as an immunopathogenic neural autoantigen, and that T cells raised by immunization of normal mice with a foreign Ag can be immunopathogenic in certain transgenic recipients...
  3. ncbi request reprint Failure of memory (CD44 high) CD4 T cells to recognize their target antigen in retina
    D S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmunol 120:34-41. 2001
    ..We conclude that sequestration provides a substantial barrier to recognition of Ag in quiet retina, and that insufficient Ag leaves the retina for detectable immune recognition outside of the retina...
  4. ncbi request reprint Spontaneous induction of immunoregulation by an endogenous retinal antigen
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Invest Ophthalmol Vis Sci 43:2984-91. 2002
    ....
  5. ncbi request reprint Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity
    Dales S Gregerson
    Dept of Ophthalmology, LRB Rm 314, University of Minnesota, 2001 6th St SE, Minneapolis, MN 55455, USA
    Int Rev Immunol 21:101-21. 2002
    ..Provision of these antigens outside of the retina provides the opportunity for development of peripheral tolerance, protection from autoimmunity, and potential therapies...
  6. ncbi request reprint CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-gamma or anti-CD40
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota 55455 3007, USA
    Invest Ophthalmol Vis Sci 44:3083-93. 2003
    ....
  7. ncbi request reprint The antigen-presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina
    Dale S Gregerson
    Department of Ophthalmology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 172:6587-97. 2004
    ..The activity of the retinal CD45(+) cells appears to be directed to limiting T cell responses...
  8. ncbi request reprint APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients
    Dale S Gregerson
    Department of Opthamology, University of Minnesota, Lions Research Building, Rm 314, 2001 6th Street, S E, Minneapolis, MN 55455, USA
    J Leukoc Biol 76:383-7. 2004
    ..Instead, APC were recruited from the circulation...
  9. ncbi request reprint Preparation of overlapping peptides of bovine retinal S-antigen and their localization by immunoblotting with peptide-specific antibodies
    S P Fling
    Department of Microbiology, University of Minnesota, Minneapolis 55455
    Curr Eye Res 7:191-9. 1988
    ..Further characterization of these IBA peptides will expedite the location of possible additional uveitogenic epitopes in the amino-terminal half of S-Ag as well as epitopes lost by other peptide generating techniques...