GEORGIOS HAJISHENGALLIS

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. Hajishengallis G, Harokopakis E. Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?. Front Biosci. 2007;12:4547-57 pubmed
    ..gingivalis for evading innate immune clearance becomes a plausible hypothesis...
  2. Hajishengallis G, Shakhatreh M, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol. 2007;179:2359-67 pubmed
    ..Therefore, CR3 blockade may represent a promising immunomodulatory approach for controlling human periodontitis and possibly associated systemic diseases...
  3. Hajishengallis G, Wang M, Bagby G, Nelson S. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol. 2008;181:4141-9 pubmed
    ..Thus, although TLR2 may mediate destructive effects, as seen in models of experimental periodontitis and atherosclerosis, we have now shown that the same receptor confers protection against P. gingivalis in acute lung infection...
  4. Hajishengallis G, Lambris J. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31:154-63 pubmed publisher
    ..Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease. ..
  5. Hajishengallis G. Too old to fight? Aging and its toll on innate immunity. Mol Oral Microbiol. 2010;25:25-37 pubmed publisher
    ....
  6. Hajishengallis G. Complement and periodontitis. Biochem Pharmacol. 2010;80:1992-2001 pubmed publisher
    ..This information is essential as it may reveal which specific pathways need to be blocked to counteract microbial evasion and inflammatory pathology or, conversely, kept intact to promote host immunity. ..
  7. Hajishengallis G, Krauss J, Liang S, McIntosh M, Lambris J. Pathogenic microbes and community service through manipulation of innate immunity. Adv Exp Med Biol. 2012;946:69-85 pubmed publisher
    ..This review summarizes important immune subversive tactics of P. gingivalis which might enable it to exert a supportive impact on the oral microbial community...
  8. Hajishengallis G, Liang S, Payne M, Hashim A, Jotwani R, Eskan M, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10:497-506 pubmed publisher
    ..The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology...

Locale

Detail Information

Publications8

  1. Hajishengallis G, Harokopakis E. Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?. Front Biosci. 2007;12:4547-57 pubmed
    ..gingivalis for evading innate immune clearance becomes a plausible hypothesis...
  2. Hajishengallis G, Shakhatreh M, Wang M, Liang S. Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivo. J Immunol. 2007;179:2359-67 pubmed
    ..Therefore, CR3 blockade may represent a promising immunomodulatory approach for controlling human periodontitis and possibly associated systemic diseases...
  3. Hajishengallis G, Wang M, Bagby G, Nelson S. Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in mice. J Immunol. 2008;181:4141-9 pubmed
    ..Thus, although TLR2 may mediate destructive effects, as seen in models of experimental periodontitis and atherosclerosis, we have now shown that the same receptor confers protection against P. gingivalis in acute lung infection...
  4. Hajishengallis G, Lambris J. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31:154-63 pubmed publisher
    ..Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease. ..
  5. Hajishengallis G. Too old to fight? Aging and its toll on innate immunity. Mol Oral Microbiol. 2010;25:25-37 pubmed publisher
    ....
  6. Hajishengallis G. Complement and periodontitis. Biochem Pharmacol. 2010;80:1992-2001 pubmed publisher
    ..This information is essential as it may reveal which specific pathways need to be blocked to counteract microbial evasion and inflammatory pathology or, conversely, kept intact to promote host immunity. ..
  7. Hajishengallis G, Krauss J, Liang S, McIntosh M, Lambris J. Pathogenic microbes and community service through manipulation of innate immunity. Adv Exp Med Biol. 2012;946:69-85 pubmed publisher
    ..This review summarizes important immune subversive tactics of P. gingivalis which might enable it to exert a supportive impact on the oral microbial community...
  8. Hajishengallis G, Liang S, Payne M, Hashim A, Jotwani R, Eskan M, et al. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10:497-506 pubmed publisher
    ..The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology...