KENT HILL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes
    Nathan R Hutchings
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 156:867-77. 2002
  2. pmc Social motility in african trypanosomes
    Michael Oberholzer
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 6:e1000739. 2010
  3. ncbi request reprint T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes
    K L Hill
    Department of Biochemistry and Interdepartmental Genetics Ph D Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:39369-78. 2000
  4. pmc Parasites in motion: flagellum-driven cell motility in African trypanosomes
    Kent L Hill
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 13:459-65. 2010
  5. pmc Biology and mechanism of trypanosome cell motility
    Kent L Hill
    Department of Microbiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Eukaryot Cell 2:200-8. 2003
  6. ncbi request reprint A novel protein targeting domain directs proteins to the anterior cytoplasmic face of the flagellar pocket in African trypanosomes
    K L Hill
    Department of Biochemistry, University of Iowa, IA 52242, USA
    J Cell Sci 112:3091-101. 1999
  7. ncbi request reprint Multiple mechanisms of immune evasion by African trypanosomes
    J E Donelson
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    Mol Biochem Parasitol 91:51-66. 1998
  8. pmc Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei
    Katherine S Ralston
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eukaryot Cell 10:884-94. 2011
  9. pmc Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae
    K L Hill
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    J Cell Biol 135:1535-49. 1996
  10. pmc Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes
    Katherine S Ralston
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 2:e101. 2006

Research Grants

Collaborators

  • JOHN DONELSON
  • Katherine S Ralston
  • Desiree M Baron
  • Janine M Bekker
  • Jessica R Colantonio
  • Rachelle H Crosbie
  • Michael Oberholzer
  • Zakayi P Kabututu
  • Christopher E Yi
  • Nathan R Hutchings
  • Neville K Kisalu
  • Miguel A Lopez
  • Bryce T McLelland
  • Stephen J King
  • Andrew D Stephens
  • W Thomas Clarke
  • Alana G Lerner
  • Sarah J Kim
  • Dennis R Diener
  • Kari M Morrissey
  • Gaynor Miller

Detail Information

Publications17

  1. pmc Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes
    Nathan R Hutchings
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    J Cell Biol 156:867-77. 2002
    ..These results indicate that trypanin functions as a cytoskeletal linker protein and offer insights into the mechanisms of flagellum-based cell motility...
  2. pmc Social motility in african trypanosomes
    Michael Oberholzer
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 6:e1000739. 2010
    ..Social motility represents a novel and unexpected aspect of trypanosome biology and offers new paradigms for considering host-parasite interactions...
  3. ncbi request reprint T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes
    K L Hill
    Department of Biochemistry and Interdepartmental Genetics Ph D Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:39369-78. 2000
    ..These findings suggest that TLTF represents a newly defined protein family, whose members contribute to cytoskeleton function in species as diverse as protozoa and mammals...
  4. pmc Parasites in motion: flagellum-driven cell motility in African trypanosomes
    Kent L Hill
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
    Curr Opin Microbiol 13:459-65. 2010
    ....
  5. pmc Biology and mechanism of trypanosome cell motility
    Kent L Hill
    Department of Microbiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Eukaryot Cell 2:200-8. 2003
  6. ncbi request reprint A novel protein targeting domain directs proteins to the anterior cytoplasmic face of the flagellar pocket in African trypanosomes
    K L Hill
    Department of Biochemistry, University of Iowa, IA 52242, USA
    J Cell Sci 112:3091-101. 1999
    ..The finding that TLTF-GFP is restricted to the anterior, cytoplasmic face of the flagellar pocket membrane, suggests that there is structural heterogeneity in the membrane of this organelle...
  7. ncbi request reprint Multiple mechanisms of immune evasion by African trypanosomes
    J E Donelson
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    Mol Biochem Parasitol 91:51-66. 1998
    ....
  8. pmc Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei
    Katherine S Ralston
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eukaryot Cell 10:884-94. 2011
    ..These findings open new avenues for dissecting mechanisms of flagellar protein function and provide an important step in efforts to exploit the potential of the flagellum as a therapeutic target in African sleeping sickness...
  9. pmc Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae
    K L Hill
    Department of Biochemistry, University of Iowa, Iowa City 52242, USA
    J Cell Biol 135:1535-49. 1996
    ..These results present the first demonstration that specific cytoskeletal proteins function in vacuole inheritance...
  10. pmc Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes
    Katherine S Ralston
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 2:e101. 2006
    ....
  11. ncbi request reprint Functional genomics in Trypanosoma brucei identifies evolutionarily conserved components of motile flagella
    Desiree M Baron
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Cell Sci 120:478-91. 2007
    ..brucei as an experimental system for studying flagellar biology...
  12. ncbi request reprint Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex
    Janine M Bekker
    Department of Physiological Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell Motil Cytoskeleton 64:461-73. 2007
    ..IMAD is able to function in either a cis- or trans-orientation with GMAD. The discovery that Gas11 provides a direct linkage to microtubules provides new mechanistic insight into the structural features of the dynein-regulatory complex...
  13. ncbi request reprint Stuck in reverse: loss of LC1 in Trypanosoma brucei disrupts outer dynein arms and leads to reverse flagellar beat and backward movement
    Desiree M Baron
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Cell Sci 120:1513-20. 2007
    ..brucei and C. reinhardtii. Understanding these differences will provide a more robust description of the fundamental mechanisms underlying flagellar motility and will aid efforts to exploit the trypanosome flagellum as a drug target...
  14. pmc The flagellum of Trypanosoma brucei: new tricks from an old dog
    Katherine S Ralston
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Int J Parasitol 38:869-84. 2008
    ..Most notably, the flagellum has been found to be an essential organelle, with critical roles in parasite motility, morphogenesis, cell division and immune evasion. This review highlights recent discoveries on the T. brucei flagellum...
  15. pmc Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily conserved dynein regulatory system
    Katherine S Ralston
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Dr, Los Angeles, CA 90095, USA
    Eukaryot Cell 5:696-711. 2006
    ....
  16. ncbi request reprint Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus
    Jessica R Colantonio
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Traffic 7:538-48. 2006
    ..J Cell Biol 2003;162:47-57) and our findings suggest that components of this axonemal dynein regulatory system have been adapted in mammalian cells to participate in non-axonemal functions...
  17. ncbi request reprint Specific and potent RNA interference in terminally differentiated myotubes
    Christopher E Yi
    Department of Physiological Science, University of California, Los Angeles, 90025, USA
    J Biol Chem 278:934-9. 2003
    ..These findings provide an important molecular tool for the examination of protein function in terminally differentiated muscle cells and provide alternative approaches for generating disease models...

Research Grants2

  1. A NOVEL MICROTUBULE-ASSOCIATED PROTEIN IN TRYPANOSOMES
    KENT HILL; Fiscal Year: 2002
    ....
  2. Biochemical and Functional Analysis of Trypanin
    KENT HILL; Fiscal Year: 2007
    ..Therefore, in addition to addressing fundamental questions in cell biology, this research directly impacts efforts to understand and treat infectious diseases and genetic diseases in humans. ..